Description : Choose the drug which blocks basal as well as stimulated gastric acid secretion without affecting cholinergic, histaminergic or gastrin receptors: A. Famotidine B. Loxatidine C. Omeprazole D. Pirenzepine
Last Answer : C. Omeprazole
Description : ntacids administered concurrently reduce efficacy of the following antipeptic ulcer drug: A. Cimetidine B. Colloidal bismuth C. Sucralfate D. Pirenzepine
Last Answer : C. Sucralfate
Description : The following antiulcer drug does not act by reducing the secretion of or neutralizing gastric acid: A. Magaldrate B. Sucralfate C. Misoprostol D. Omeprazol
Last Answer : B. Sucralfate
Description : Choose the antiulcer drug that inhibits gastric acid secretion, stimulates gastric mucus and bicarbonate secretion and has cytoprotective action on gastric mucosa: A. Misoprostol B. Sucralfate C. Carbenoxolone sodium D. Colloidal bismuth subcitrate
Last Answer : A. Misoprostol
Description : The following statement is true about misoprostol: A. It relieves peptic ulcer pain, but does not promote ulcer healing B. It heals nonsteroidal antiinflammatory drug induced gastric ulcer not responding ... side effects than H2 blockers D. It is the most effective drug for preventing ulcer relapse
Last Answer : B. It heals nonsteroidal antiinflammatory drug induced gastric ulcer not responding to H2 blockers
Description : Omeprazole exerts practically no other action except inhibition of gastric acid secretion because: A. It transforms into the active cationic forms only in the acidic pH of the gastric juice B. Its ... forms are unable to diffuse out from the gastric parietal cell canaliculi D. All of the above
Last Answer : D. All of the above
Description : Choose the correct statement about H2 receptor blockers: A. They are the most efficacious drugs in inhibiting gastric acid secretion B. They cause fastest healing of duodenal ulcers C. They prevent stress ulcers in the stomach D. They afford most prompt relief of ulcer pain
Last Answer : C. They prevent stress ulcers in the stomach
Description : Which of the following medications represents the category proton (gastric acid) pump inhibitors? a) Omeprazole (Prilosec) Omeprazole decreases gastric acid by slowing the hydrogenpotassium-adenosine ... antagonist. d) Metronidazole (Flagyl) Metronidazole is an antibiotic, specifically an amebicide.
Last Answer : a) Omeprazole (Prilosec) Omeprazole decreases gastric acid by slowing the hydrogenpotassium-adenosine-triphosphatase pump on the surface of the parietal cells.
Description : Choose the relatively vasicoselective anticholinergic drug used for urinary frequency and urge incontinence due to detrusor instability: A. Pirenzepine B. Oxybutynin C. Oxyphenonium D. Glycopyrolate
Last Answer : B. Oxybutynin
Description : ndicate the drug which does not improve lower esophageal sphincter tone or prevent gastroesophageal reflux, but is used as first line treatment of gastroesophageal reflux disease: A. Sodium alginate + aluminium hydroxide gel B. Omeprazole C. Mosapride D. Famotidine
Last Answer : B. Omeprazole
Description : The following drug reduces the effect of oral anticoagulants: A. Broad spectrum antibiotic B. Cimetidine C. Aspirin D. Oral contraceptive
Last Answer : D. Oral contraceptive
Description : The following drug displaces plasma protein bound phenytoin as well as decreases its metabolism: A. Carbamazepine B. Sodium valproate C. Cimetidine D. Chloramphenicol
Last Answer : B. Sodium valproate
Description : Concurrent use of the following drug is likely to cause failure of oral contraception: A. Isoniazid B. Rifampicin C. Cimetidine D. Propranolol
Last Answer : C. Cimetidin
Description : The following is correct about antipsychotic drugs except: A. They only control symptoms of schizophrenia without affecting the basic disorder B. Combination of two or more antipsychotic drugs is ... psychosis high potency drugs are preferred over low potency drugs D. They donot produce dependence
Last Answer : B. Combination of two or more antipsychotic drugs is more efficacious than any single drug
Description : Which of the following is an efficacious antiinflammatory drug but a relatively weak inhibitor of cyclooxygenase: A. Nimesulide B. Paracetamol C. Ketoprofen D. Indomethacin
Last Answer : A. Nimesulide
Description : The following statement(s) is/are true concerning initial microbiologic diagnostic techniques. a. Appropriate expeditious transport of specimens to the microbiology laboratory is essential for obtaining accurate ... a 4-to 8-fold increase over the MIC to be considered clinically efficacious.
Last Answer : Answer: a, c, d Because most surgical infections are polymicrobial, specimens should be cultured for aerobic and anaerobic bacteria, as well as fungi. Although aerobic and aerotolerant ... fold increase over MIC during the peak serum level have been demonstrated to be clinically efficacious
Description : The following cytotoxic drug acts by inhibiting depolymerization of tubulin and thus producing abnormal arrays of microtubules: A. Paclitaxel B. Vinblastine C. Etoposide D. Mitoxantrone (p. 774) 60.9 C 60.10 B 60.11 D 60.12 A Ai
Last Answer : A. Paclitaxel
Description : Select the drug that acts by inhibiting HIV protease enzyme: A. Zalcitabine B. Efavirenz C. Stavudine D. Nelfinavi
Last Answer : D. Nelfinavir
Description : Select the drug that is fungicidal and acts by inhibiting fungal squalene epoxidase enzyme: A. Ketoconazole B. Terbinafine C. Tolnaftate D. Hamycin
Last Answer : B. Terbinafine
Description : The antiparkinsonian drug which acts by inhibiting the degradation of dopamine in the brain is: A. Carbidopa B. Amantadine C. Selegiline D. Bromocriptine
Last Answer : C. Selegiline
Description : Compared to H2 blockers, omeprazole affords the following: A. Faster relief of ulcer pain B. Faster healing of duodenal ulcer C. Higher efficacy in healing reflux esophagitis D. All of the above
Description : The following is true of anti-H.pylori therapy except: A. It is indicated in all patients of peptic ulcer B. Resistance to any single antimicrobial drug develops rapidly C. Concurrent ... efficacy of the regimen D. Colloidal bismuth directly inhibits H.pylori but has poor patient acceptability
Last Answer : A. It is indicated in all patients of peptic ulcer
Description : The following class of gastric antisecretory drug also reduce gastric motility and have primary effect on juice volume, with less marked effect on acid and pepsin A. Histamine H2 blockers B. Anticholinergics C. Proton pump inhibitors D. Prostaglandins
Last Answer : B. Anticholinergics
Description : Ranitidine differs from cimetidine in the following respect: A. It is less potent B. It is shorter acting C. It does not have antiandrogenic action D. It produces more CNS side effect
Last Answer : C. It does not have antiandrogenic action
Description : Which histamine H2 blocker has most marked inhibitory effect on microsomal cytochrome P-450 enzyme: A. Cimetidine B. Ranitidine C. Roxatidine D. Famotidine
Last Answer : A. Cimetidine
Description : Gynaecomastia can occur as a side effect of: A. Bromocriptine B. Cimetidine C. Famotidine D. Levodopa
Last Answer : B. Cimetidine
Description : 16.13 Gynaecomastia can be treated with: A. Chlorpromazine B. Cimetidine C. Bromocriptine D. Metoclopramide
Last Answer : C. Bromocriptine
Description : Which of the following drugs attenuates the antihypertensive action of β-blockers: A. Cimetidine B. Indomethacin C. Chlorpromazine D. Imipramine
Last Answer : B. Indomethacin
Description : Relatively higher dose of theophylline is required to attain therapeutic plasma concentration in: A. Smokers B. Congestive heart failure patients C. Those receiving erythromycin D. Those receiving cimetidine
Last Answer : A. Smokers
Description : Which of the following drugs attenuates the antihypertensive action of β -blockers: A. Cimetidine B. Indomethacin C. Chlorpromazine D. Imipramine
Description : The newer lipid formulations of amphotericin B differ from the conventional formulation in the following respects except: A. They are more efficacious B. They produce milder acute reaction C. They are less nephrotoxic D. They produce milder anaemia
Last Answer : A. They are more efficacious
Description : Select the correct statement regarding the antiemetic efficacy of the three prokinetic drugs metoclopramide, domperidone and cisapride: A. Cisapride is the most effective B. Metoclopramide is the most effective C. Domperidone is the most effective D. All three are equally efficacious
Last Answer : B. Metoclopramide is the most effective
Description : Choose the most potent and most efficacious LDLcholesterol lowering HMG-CoA reductase inhibitor: A. Lovastatin B. Simvastatin C. Pravastatin D. Atorvastatin
Last Answer : D. Atorvastatin
Description : The following is not itself an efficacious diuretic, and is used only as an adjuvant/corrective to other diuretics: A. Acetazolamide B. Metolazone C. Spironolactone D. Indapamide
Last Answer : C. Spironolactone
Description : The most important reason for the thiazides being only moderately efficacious diuretics is: A. About 9/10th of glomerular filtrate is reabsorbed proximal to their site of action B. Compensatory ... these drugs C. They decrease glomerular filtration D. They have relatively flat dose response curve
Last Answer : A. About 9/10th of glomerular filtrate is reabsorbed proximal to their site of action
Description : Select the diuretic which is orally active, efficacious in acidosis as well as alkalosis, causes diuresis even in renal failure and has additional carbonic anhydrase inhibitory action: A. Mannitol B. Benzthiazide C. Indapamide D. Furosemide
Last Answer : D. Furosemide
Description : ndapamide differs from other diuretics in that: A. It has selective antihypertensive action at doses which cause little diuresis B. It is a more efficacious antihypertensive C. Its antihypertensive action develops more rapidly D. All of the above
Last Answer : A. It has selective antihypertensive action at doses which cause little diuresis
Description : The most efficacious inhibitor of catecholamine synthesis in the body is: A. α-methyl-p-tyrosine B. α-methyldopa C. α-methyl-norepinephrine D. Entacapone
Last Answer : A. α-methyl-p-tyrosine
Description : Penicillins interfere with bacterial cell wall synthesis by: A. Inhibiting synthesis of N-acetyl muramic acid pentapeptide B. Inhibiting conjugation between N-acetyl muramic acid and N-acetyl ... cross link the peptidoglycan residues D. Counterfeiting for D-alanine in the bacterial cell wall
Last Answer : C. Inhibiting transpeptidases and carboxypeptidases which cross link the peptidoglycan residues
Description : That sulfonamides act by inhibiting folate synthesis in bacteria is supported by the following findings except: A. Paraaminobenzoic acid antagonises the action of sulfonamides B. Methionine antagonises ... . Bacteria that utilise folic acid taken up from the medium are insensitive to sulfonamides
Last Answer : B. Methionine antagonises the action of sulfonamides
Description : Diazoxide is an effective hypotensive, but is not used in the long-term treatment of hypertension because: A. It impairs glucose tolerance by inhibiting insulin release B. It inhibits uric acid ... causes marked Na+ and water retention leading to development of tolerance D. All of the above
Description : In diabetic patients, round the clock tight control of hyperglycaemia achieved by multiple daily insulin injections or insulin pumps: A. Prevents macrovascular disease more effectively B. Is recommended ... Is associated with higher incidence of hypoglycaemic reactions D. Both A and C are correct
Last Answer : D. Both A and C are correct
Description : Select the drug(s) which afford(s) relief in gastroesophageal reflux by increasing lower esophageal sphincter tone and promoting gastric emptying, but without affecting acidity of gastric contents: A. Sodium alginate B. Metoclopramide C. Cisapride D. Both ‘B’ and ‘C
Last Answer : D. Both ‘B’ and ‘C’
Description : A patient returning from dinner party meets with road accident and has to be urgently operated upon under general anaesthesia. Which drug can be injected intramuscularly to hasten his gastric emptying: A. Methylpolysiloxane B. Promethazine C. Metoclopramide D. Apomorphine
Last Answer : C. Metoclopramide
Description : Select the drug which is an inhibitor of gastric mucosal proton pump: A. Carbenoxolone sodium B. Sucralfate C. Famotidine D. Lansoprazole
Last Answer : D. Lansoprazole
Description : Vinca alkaloids exert antitumor activity by: A. Activating topoisomerase II to cause breaks in DNA strands B. Crosslinking DNA strands C. Inhibiting DNA mediated RNA synthesis D. Inhibiting polymerization of tubulin to form intracellular microtubules
Last Answer : D. Inhibiting polymerization of tubulin to form intracellular microtubules
Description : Choose the correct statement(s) about retroviral protease inhibitors: A. They act at an early step in HIV replication B. They are more active in inhibiting HIV than zidovudine C. They inhibit CYP3A4 and interact with many other drugs D. Both 'B' and 'C' are correct
Last Answer : D. Both 'B' and 'C' are correct
Description : The polyene antibiotics act by: A. Inhibiting fungal cytochrome P450 enzyme B. Binding to ergosterol and creating micropores in fungal cell membrane C. Inhibiting fungal DNA synthesis D. Disorienting microtubules in fungal cells
Last Answer : B. Binding to ergosterol and creating micropores in fungal cell membrane
Description : Rifampin kills tubercle bacilli by: A. Binding to mycobacterial DNA dependent RNA polymerase B. Inhibiting mycobacterial DNA synthesis C. Inhibiting synthesis of mycolic acids in mycobacteria D. Damaging mycobacterial mitochondria
Last Answer : A. Binding to mycobacterial DNA dependent RNA polymerase