Description : Which of the following medications represents the category proton (gastric acid) pump inhibitors? a) Omeprazole (Prilosec) Omeprazole decreases gastric acid by slowing the hydrogenpotassium-adenosine ... antagonist. d) Metronidazole (Flagyl) Metronidazole is an antibiotic, specifically an amebicide.
Last Answer : a) Omeprazole (Prilosec) Omeprazole decreases gastric acid by slowing the hydrogenpotassium-adenosine-triphosphatase pump on the surface of the parietal cells.
Description : Choose the antiulcer drug that inhibits gastric acid secretion, stimulates gastric mucus and bicarbonate secretion and has cytoprotective action on gastric mucosa: A. Misoprostol B. Sucralfate C. Carbenoxolone sodium D. Colloidal bismuth subcitrate
Last Answer : A. Misoprostol
Description : Histamine H2 blockers attenuate the gastric secretory response to acetylcholine and pentagastrin as well because: A. H2 blockers block gastric mucosal cholinergic and gastrin receptors as well B. H2 ... acetylcholine and gastrin all act through the phospholipase C-IP3:DAG pathway in gastric mucosa
Last Answer : C. Acetylcholine and gastrin act partly by releasing histamine in gastric mucosa
Description : Choose the drug which blocks basal as well as stimulated gastric acid secretion without affecting cholinergic, histaminergic or gastrin receptors: A. Famotidine B. Loxatidine C. Omeprazole D. Pirenzepine
Last Answer : C. Omeprazole
Description : The following antiulcer drug does not act by reducing the secretion of or neutralizing gastric acid: A. Magaldrate B. Sucralfate C. Misoprostol D. Omeprazol
Last Answer : B. Sucralfate
Description : The following class of gastric antisecretory drug also reduce gastric motility and have primary effect on juice volume, with less marked effect on acid and pepsin A. Histamine H2 blockers B. Anticholinergics C. Proton pump inhibitors D. Prostaglandins
Last Answer : B. Anticholinergics
Description : Proton pump inhibitors like omeprazole and lansoprazole contain the following ring system : (A) Pyrimidine (B)Benzimidazole (C) Benzothiazole (D) Oxindole
Last Answer : (B)Benzimidazole
Description : ndicate the drug which does not improve lower esophageal sphincter tone or prevent gastroesophageal reflux, but is used as first line treatment of gastroesophageal reflux disease: A. Sodium alginate + aluminium hydroxide gel B. Omeprazole C. Mosapride D. Famotidine
Last Answer : B. Omeprazole
Description : Sucralfate promotes healing of duodenal ulcer by: A. Enhancing gastric mucus and bicarbonate secretion B. Coating the ulcer and preventing the action of acid-pepsin on ulcer base C. Promoting regeneration of mucosa D. Both ‘A’ and ‘B’ are correct
Last Answer : B. Coating the ulcer and preventing the action of acid-pepsin on ulcer base
Description : The following is true of proton pump inhibitors except: A. They are the most effective drugs for Zolinger Ellison syndrome B. Their prolonged use can cause atrophy of gastric mucosa C. They inhibit growth of H. pylori in stomach D. They have no effect on gastric motilit
Last Answer : B. Their prolonged use can cause atrophy of gastric mucosa
Description : Select the drug(s) which afford(s) relief in gastroesophageal reflux by increasing lower esophageal sphincter tone and promoting gastric emptying, but without affecting acidity of gastric contents: A. Sodium alginate B. Metoclopramide C. Cisapride D. Both ‘B’ and ‘C
Last Answer : D. Both ‘B’ and ‘C’
Description : The fastest symptomatic relief as well as highest healing rates in reflux esophagitis are obtained with: A. Prokinetic drugs B. H2 receptor blockers C. Proton pump inhibitors D. Sodium alginate
Last Answer : C. Proton pump inhibitors
Description : ntacids administered concurrently reduce efficacy of the following antipeptic ulcer drug: A. Cimetidine B. Colloidal bismuth C. Sucralfate D. Pirenzepine
Last Answer : C. Sucralfate
Description : The primary mechanism by which prostaglandins promote ulcer healing is: A. Inhibition of gastric acid secretion B. Augmentation of bicarbonate buffered mucus layer covering gastroduodenal mucosa C. Increased bicarbonate secretion in gastric juice D. Increased turnover of gastric mucosal cell
Last Answer : B. Augmentation of bicarbonate buffered mucus layer covering gastroduodenal mucosa
Description : Select the most appropriate hypolipidemic drug for a patient with raised LDL-cholesterol level but normal triglyceride level: A. A HMG-CoA reductase inhibitor B. A fibric acid derivative C. Gugulipid D. Nicotinic acid
Last Answer : A. A HMG-CoA reductase inhibitor
Description : Select the anticonvulsant drug that acts as a GABAtransaminase inhibitor: A. Gabapentin B. Vigabatrin C. Lamotrig
Last Answer : B. Vigabatrin
Description : years old male diagnosis as case of gastric ulcer , culture -ve h.pylori pathology –ve of cancer ttt: proton pumb inhibitor antihistamine after 6-8 wk do endoscope after therapy referral to surgery
Last Answer : proton pumb inhibitor
Description : Which histamine H2 blocker has most marked inhibitory effect on microsomal cytochrome P-450 enzyme: A. Cimetidine B. Ranitidine C. Roxatidine D. Famotidine
Last Answer : A. Cimetidine
Description : Gynaecomastia can occur as a side effect of: A. Bromocriptine B. Cimetidine C. Famotidine D. Levodopa
Last Answer : B. Cimetidine
Description : The preferred regimen for preventing duodenal ulcer relapse is: A. Maintenance antacid regimen B. Maintenance H2 blocker regimen C. On demand intermittent H2 blocker regimen D. Maintenance sucralfate regimen
Last Answer : B. Maintenance H2 blocker regimen
Description : The most important drawback of sucralfate in the treatment of duodenal ulcer is: A. Low ulcer healing efficacy B. Poor relief of ulcer pain C. High incidence of side effects D. Need for taking a big tablet four times a day
Last Answer : D. Need for taking a big tablet four times a day
Description : Of the following categories of medications, which is used in combination with bismuth salts to eradicate Helicobacter pylori? a) Antibiotics Antibiotics and bismuth salts are given to eradicate ... antagonists Histamine-2 receptor antagonists are given to decrease the acid secretion in the stomach.
Last Answer : a) Antibiotics Antibiotics and bismuth salts are given to eradicate H. pylori.
Description : Select the drug which is a potassium channel opener as well as nitric oxide donor: A. Diazoxide B. Sodium nitroprusside C. Minoxidil D. Nicorandil
Last Answer : D. Nicorandil
Description : Select the drug having a narrow spectrum antiepileptic activity restricted to absence seizures: A. Lamotrigine B. Ethosuccimide C. Sodium valproate D. Primidone
Last Answer : . Ethosuccimide
Description : Select the drug that is neither bronchodilator nor antiinflammatory, but has antihistaminic and mast cell stabilizing activity: A. Sodium cromoglycate B. Ketotifen C. Beclomethasone dipropionate D. Chlorpheniramine
Last Answer : B. Ketotifen
Description : Select the most appropriate drug for regular prophylactic therapy in a 10 year old child who suffers from exercise induced asthma: A. Oral salbutamol B. Oral theophylline C. Inhaled sodium cromoglycate D. Inhaled salmeterol
Last Answer : C. Inhaled sodium cromoglycate
Description : The following thyroid inhibitor does not produce goiter when given in over dose: A. Propyl thiouracil B. Carbimazole C. Radioactive iodine D. Sodium thiocyanat
Last Answer : C. Papillary carcinoma of thyroid
Description : The following thyroid inhibitor does not produce goiter when given in over dose: A. Propyl thiouracil B. Carbimazole C. Radioactive iodine D. Sodium thiocyanate
Last Answer : C. Radioactive iodine
Description : Choose the correct statement about topotecan: A. It is a DNA topoisomerase I inhibitor which causes single strand DNA breaks B. It is a cell cycle specific anticancer drug C. It is a COMT-inhibitor used in advanced parkinsonism D. Both 'A' and 'B' are correc
Last Answer : D. Both 'A' and 'B' are correct
Description : The following antineoplastic drug is a mitotic inhibitor and causes metaphase arrest: A. Busulfan B. Vincristine C. Cytarabine D. Procarbazine
Last Answer : B. Vincristine
Description : Fluconazole differs from ketoconazole in that: A. It is not active by the oral route B. It is a more potent inhibitor of drug metabolism C. It is not effective in cryptococcal meningitis D. It is unlikely to produce anti-androgenic side effects
Last Answer : D. It is unlikely to produce anti-androgenic side effects
Description : Choose the selective serotonin reuptake inhibitor that is less likely to inhibit CYP2D6 and CYP3A4 resulting in fewer drug interactions: A. Sertraline B. Paroxetine C. Fluoxetine D. Fluvoxamine
Last Answer : A. Sertraline
Description : The following drug of abuse is a hallucinogen: A. Cocaine B. Cannabis C. Heroin D. Methaqualone (p. 403) 31.1 Which of the following is a selective MAO-B inhibitor: A. Selegiline
Last Answer : B. Cannabis
Description : Which of the following is an efficacious antiinflammatory drug but a relatively weak inhibitor of cyclooxygenase: A. Nimesulide B. Paracetamol C. Ketoprofen D. Indomethacin
Last Answer : A. Nimesulide
Description : The following nonsteroidal antiinflammatory drug is a preferential cyclooxygenase-2 (COX-2) inhibitor: A. Tenoxicam B. Meloxicam C. Diclofenac sod. D. Ketoprofen
Last Answer : B. Meloxicam
Description : Select the correct statement abut donepezil: A. It is a topical carbonic anhydrase inhibitor used in glaucoma B. It is a catechol-'O'-methyl transferase inhibitor used as adjuvant in ... affords symptomatic improvement in Alzheimer's disease D. It is a synthetic cannabinoid with antiemetic property
Last Answer : C. It is a cerebroselective anticholinesterase that affords symptomatic improvement in Alzheimer's diseas
Description : The following is true of loperamide except: A. It is absorbed from intestines and exerts centrally mediated antidiarrhoeal action B. It acts on the opioid receptors in the gut C. It increases ... of the intestines D. It inhibits intestinal secretion by binding to calmodulin in the mucosal cells
Last Answer : A. It is absorbed from intestines and exerts centrally mediated antidiarrhoeal action
Description : Cyclic nucleotides exert the following action on salt transport across intestinal mucosal cells: A. Both cyclic AMP and cyclic GMP enhance Cland HCO3 - secretion B. Cyclic AMP enhances but cyclic GMP ... Cl- reabsorption D. Both cyclic AMP and cyclic GMP enhance Na+ and Cl- reabsorption
Last Answer : A. Both cyclic AMP and cyclic GMP enhance Cland HCO3 – secreti
Description : The following purgative stimulates intestinal motility independent of its action on mucosal fluid dynamics: A. Castor oil B. Senna C. Docusates D. Sod.pot. tartrate
Last Answer : B. Senna
Description : In the iron deficient state, transferrin receptors increase in number on the: A. Intestinal mucosal cells B. Erythropoietic cells C. Reticuloendothelial cells D. All of the above
Last Answer : cells B
Description : The gut controls the entry of ingested iron in the body by: A. Regulating the availability of apoferritin which acts as the carrier of iron across the mucosal cell B. Regulating the turnover of ... mucosal cell and is shed off D. Regulating the number of transferrin receptors on the mucosal cell
Last Answer : C. Complexing excess iron to form ferritin which remains stored in the mucosal cell and is shed off
Description : In the treatment of chronic inflammatory diseases, the most important limitation of aspirin is (a) Acid – base and electrolytc disturbances (b) Hypersensitivity and idiosyncratic reactions (c) Gastric mucosal damage (d) Salicylism
Last Answer : Ans: C
Description : In the treatment of chronic inflammatory diseases, the most important limitation of aspirin is: A. Acid-base and electrolyte disturbances B. Hypersensitivity and idiosyncratic reactions C. Gastric mucosal damage D. Salicylism
Last Answer : C. Gastric mucosal damage
Description : Inhibitors of prostaglandin synthesis share the following features except: A. Prolongation of bleeding time B. Prolongation of prothrombin time C. Prolongation of labour D. Gastric mucosal damage
Last Answer : B. Prolongation of prothrombin time
Description : A patient returning from dinner party meets with road accident and has to be urgently operated upon under general anaesthesia. Which drug can be injected intramuscularly to hasten his gastric emptying: A. Methylpolysiloxane B. Promethazine C. Metoclopramide D. Apomorphine
Last Answer : C. Metoclopramide
Description : The following is true of anti-H.pylori therapy except: A. It is indicated in all patients of peptic ulcer B. Resistance to any single antimicrobial drug develops rapidly C. Concurrent ... efficacy of the regimen D. Colloidal bismuth directly inhibits H.pylori but has poor patient acceptability
Last Answer : A. It is indicated in all patients of peptic ulcer
Description : The following statement is true about misoprostol: A. It relieves peptic ulcer pain, but does not promote ulcer healing B. It heals nonsteroidal antiinflammatory drug induced gastric ulcer not responding ... side effects than H2 blockers D. It is the most effective drug for preventing ulcer relapse
Last Answer : B. It heals nonsteroidal antiinflammatory drug induced gastric ulcer not responding to H2 blockers
Description : The most efficacious drug for inhibiting round the clock gastric acid output is: A. Omeprazole B. Cimetidine C. Pirenzepine D. Misoprostol
Last Answer : A. Omeprazole
Description : 3 Select the antiemetic that prevents activation of emetogenic afferents in the gut and their central relay in chemoreceptor trigger zone/nucleus tractus solitarious, but has no effect on gastric motility: A. Ondansetron B. Domperidone C. Metoclopramide D. Cisaprid
Last Answer : A. Ondansetron
Description : The success of oral rehydration therapy of diarrhoea depends upon the following process in the intestinal mucosa: A. Sodium pump mediated Na+ absorption B. Glucose coupled Na+ absorption C. Bicarbonate coupled Na+ absorption D. Passive Na+ diffusion secondary to nutrient absorption
Last Answer : B. Glucose coupled Na+ absorption