Description : Select the antifungal drug which is administered only by the oral route: A. Amphotericin B B. Ketoconazole C. Griseofulvin D. Tolnaftate
Last Answer : C. Griseofulvin
Description : The following are topical antifungal drugs except: A. Ciclopirox olamine B. Tolnaftate C. Crotamiton D. Terbinafine
Last Answer : C. Crotamiton
Description : In biosynthesis of cholesterol triparanol inhibits the activity of the enzyme: (A) ∆24 Reductase (B) Oxidosqualene-lanosterol cyclase (C) Isomerase (D) Squalene epoxidase ENZYMES 155
Last Answer : Answer : A
Description : Select the drug that acts by inhibiting HIV protease enzyme: A. Zalcitabine B. Efavirenz C. Stavudine D. Nelfinavi
Last Answer : D. Nelfinavir
Description : The following drugs are effective in systemic mycosis except: A. Terbinafine B. Itraconazole C. Ketoconazole D. Fluconazol
Last Answer : A. Terbinafine
Description : The polyene antibiotics act by: A. Inhibiting fungal cytochrome P450 enzyme B. Binding to ergosterol and creating micropores in fungal cell membrane C. Inhibiting fungal DNA synthesis D. Disorienting microtubules in fungal cells
Last Answer : B. Binding to ergosterol and creating micropores in fungal cell membrane
Description : The following is applicable to itraconazole except: A. It has largely replaced ketoconazole for treatment of systemic mycosis B. It does not inhibit human steroid hormone synthesis C. It is ... the treatment of fungal meningitis D. It can interact with terfenadine to produce ventricular arrhythmias
Last Answer : C. It is preferred for the treatment of fungal meningitis
Description : The following statement is true about ketoconazole except: A. It is less toxic than amphotericin B B. It produces a slower response than amphotericin B in systemic mycosis C. Given orally it is the first line treatment for vaginal candidiasis D. It is not effective in fungal meningitis
Last Answer : C. Given orally it is the first line treatment for vaginal candidiasis
Description : Choose the drug that can be used orally for intestinal amoebiasis, intravaginally for trichomonas vaginitis and topically for dermatophytosis: A. Quiniodochlor B. Furazolidone C. Ornidazole D. Hamycin
Last Answer : A. Quiniodochlor
Description : Which of the following drugs acts by inhibiting an enzyme in the body: A. Atropine B. Allopurinol C. Levodopa D. Metoclopramide
Last Answer : B. Allopurinol
Description : The following cytotoxic drug acts by inhibiting depolymerization of tubulin and thus producing abnormal arrays of microtubules: A. Paclitaxel B. Vinblastine C. Etoposide D. Mitoxantrone (p. 774) 60.9 C 60.10 B 60.11 D 60.12 A Ai
Last Answer : A. Paclitaxel
Description : The antiparkinsonian drug which acts by inhibiting the degradation of dopamine in the brain is: A. Carbidopa B. Amantadine C. Selegiline D. Bromocriptine
Last Answer : C. Selegiline
Description : What is true about use of amphotericin B in kala azar: A. It is currently the drug of choice B. It is more effective than ketoconazole C. It is indicated only in cases not responding to sodium stibogluconate D. Both 'B' and 'C' are correct
Last Answer : D. Both 'B' and 'C' are correct
Description : The drug of choice for Kala azar is: A. Pentamidine B. Amphotericin B C. Sodium stibogluconate D. Ketoconazole
Last Answer : C. Sodium stibogluconat
Description : The only azole antifungal drug which has some activity against moulds like Aspergillus is: A. Itraconazole B. Fluconazole C. Miconazole D. Ketoconazole
Last Answer : A. Itraconazole
Description : Fluconazole differs from ketoconazole in that: A. It is not active by the oral route B. It is a more potent inhibitor of drug metabolism C. It is not effective in cryptococcal meningitis D. It is unlikely to produce anti-androgenic side effects
Last Answer : D. It is unlikely to produce anti-androgenic side effects
Description : Choose the azole antifungal drug which is used only topically: A. Ketoconazole B. Fluconazole C. Itraconazole D. Econazole
Last Answer : D. Econazole
Description : The drug of choice for monilial diarrhoea is: A. Flucytosine B. Nystatin C. Natamycin D. Ketoconazole
Last Answer : B. Nystatin
Description : The following prokinetic drug has been implicated in causing serious ventricular arrhythmias, particularly in patients concurrently receiving erythromycin or ketoconazole: A. Domperidone B. Cisapride C. Mosapride D. Metoclopramide
Last Answer : B. Cisapride
Description : Indicate the antifungal antibiotic which is used intravenously for systemic mycosis: A. Griseofulvin B. Nystatin C. Amphotericin B D. Hamycin
Last Answer : C. Amphotericin
Description : The distinctive feature of terbinafine is: A. It is highly effective in histoplasmosis B. It can be used topically as well as orally for dermatophytosis C. It inhibits Mucor and Aspergillus as well D. Applied intravaginally it cures both candida as well as trichomonas vaginitis
Last Answer : B. It can be used topically as well as orally for dermatophytosis
Description : What is true of Quinupristin-Dalfopristin: A. It is a synergistic combination of two similar antibiotics B. It acts by inhibiting bacterial protein synthesis C. It is active against most resistant coccal infections D. All of the above are correct
Last Answer : D. All of the above are correct
Description : The following is true of vancomycin except: A. It is a bactericidal antibiotic active primarily against gram positive bacteria B. It acts by inhibiting bacterial protein synthesis C. It is an alternative to penicillin for enterococcal endocarditis D. It can cause deafness as a dose related toxicity
Last Answer : B. It acts by inhibiting bacterial protein synthesis
Description : Furosemide acts by inhibiting the following in the renal tubular cell: A. Na+-K+-2Cl– cotransporter B. Na+-Cl– symporter C. Na+-H+ antiporter D. Na+ K+ ATPase
Last Answer : A. Na+-K+-2Cl– cotransporter
Description : Methyldopa lowers BP by: A. Inhibiting dopa decarboxylase in adrenergic nerve endings B. Generating α-methyl noradrenaline in brain which reduces sympathetic tone C. Generating α-methyl ... as a false transmitter in peripheral adrenergic nerve endings D. Activating vascular dopamine receptors
Last Answer : B. Generating α-methyl noradrenaline in brain which reduces sympathetic tone
Description : Features of µ (Mu) opioid receptor include the following except: A. Acts by inhibiting cAMP formation B. Mediates miotic action C. Mediates low ceiling respiratory depression D. Mediates high ceiling supraspinal analgesia
Last Answer : C. Mediates low ceiling respiratory depression
Description : The following is true about entacapone except: A. It acts by inhibiting degradation of dopamine in the brain B. If prolongs the therapeutic effect of levodopacarbidopa in parkinsonism C. It can accentuate levodopa induced dyskinesias D. It can cause diarrhoea as a side effec
Last Answer : A. It acts by inhibiting degradation of dopamine in the brain
Description : Entacapone differs from tolcapone in the following respect/respects: A. It is shorter acting B. It acts only by inhibiting peripheral metabolism of levodopa C. It is not hepatotoxic D. All of the above are correct
Description : Carbimazole acts by inhibiting: A. Iodide trapping B. Oxidation of iodide C. Proteolysis of thyroglobulin D. Synthesis of thyroglobulin protein
Last Answer : B. Oxidation of iodide
Description : Corticosteroids exert antiinflammatory action by inhibiting the following enzyme: A. Cyclooxygenase B. Lipoxygenase C. Phospholipase-A D. Phosphodiesterase
Last Answer : C. Phospholipase-A
Description : Select the anticonvulsant drug that acts as a GABAtransaminase inhibitor: A. Gabapentin B. Vigabatrin C. Lamotrig
Last Answer : B. Vigabatrin
Description : The most efficacious drug for inhibiting round the clock gastric acid output is: A. Omeprazole B. Cimetidine C. Pirenzepine D. Misoprostol
Last Answer : A. Omeprazole
Description : Select the drug that reversibly inhibits the enzyme COMT and is useful as an adjuvant medication in advanced parkinson's disease: A. Pramipexole B. Entacapone C. Pergolide D. Piribedil
Last Answer : B. Entacapone
Description : Fluconazole offers the following advantage(s) over ketoconazole: A. It is longer acting B. Its absorption from stomach is not dependent on gastric acidity C. It produces fewer side effects D. All of the above
Last Answer : D. All of the above
Description : Adverse effects of ketoconazole include the following except: A. Gynaecomastia B. Oligozoospermia C. Kidney damage D. Menstrual irregularities
Last Answer : C. Kidney damage
Description : Which antifungal agent is effective in both dermatophytosis as well as systemic mycosis: A. Amphotericin B B. Griseofulvin C. Clotrimazole D. Ketoconazole
Last Answer : D. Ketoconazole
Description : Circulating testosterone levels in men are elevated during treatment with: A. Danazol B. Finasteride C. Flutamide D. Ketoconazole
Last Answer : C. Flutamide
Description : The following second generation anti-histaminic is not likely to produce ventricular arrhythmias when administered along with ketoconazole: A. Mizolastine B. Ebastine C. Terfenadine D. Astemizole
Last Answer : A. Mizolastine
Description : A drug which prevents uric acid synthesis by inhibiting the enzyme Xanthine oxidase is (A) Aspirin (B) Allopurinal (C) Colchicine (D) Phenyl benzoate
Last Answer : Answer : B
Description : A drug which prevents uric acid synthesis by inhibiting the enzyme xanthine oxidase is (A) Aspirin (B) Allopurinol (C) Colchicine (D) Probenecid
Last Answer : B
Last Answer : (B) Allopurinol
Description : Which anthelmintic drug acts through a specific glutamate gated Cl– ion channel found only in nematodes: A. Ivermectin B. Niclosamide C. Pyrantel pamoate D. Praziquantel
Last Answer : A. Ivermectin
Description : As an antitubercular drug, isoniazid has the following advantages except: A. It is tuberculocidal B. It acts on both extra and intracellular bacilli C. Tubercle bacilli do not develop resistance against it D. It is cheap
Last Answer : C. Tubercle bacilli do not develop resistance against it
Description : Choose the correct statement about trimetazidine: A. It is a novel calcium channel blocker B. It improves tissue perfusion by modifying rheological property of blood C. It is an antianginal drug which acts by nonhaemodynamic mechanisms D. Both 'A' and 'B' are correct
Last Answer : C. It is an antianginal drug which acts by nonhaemodynamic mechanisms
Description : Choose the correct statement about lamotrigine: A. It is a dopaminergic agonist used in parkinsonism B. It acts by blocking NMDA-type of glutamate receptors C. It is a broad spectrum antiepileptic drug D. It suppresses tonic-clonic seizures, but worsens absence seizures
Last Answer : C. It is a broad spectrum antiepileptic drug
Description : Choose the correct statement about nateglinide: A. It is a long acting oral hypoglycaemic drug B. Taken just before a meal, it limits postprandial hyperglycaemia in type 2 diabetes mellitus C. It lowers ... 1 and type 2 diabetes mellitus D. It acts by opening K+ channels in myocytes and adipocytes
Last Answer : B. Taken just before a meal, it limits postprandial hyperglycaemia in type 2 diabetes mellitus
Description : Select the opioid analgesic which acts primarily through κ (kappa) opioid receptor: A. Pentazocine B. Methadone C. Buprenorphine D. Pethidine
Last Answer : A. Pentazocine
Description : Select the analgesic which acts through opioid as well as additional spinal monoaminergic mechanisms: A. Tramadol B. Ethoheptazine C. Dextropropoxyphene D. Alfentanil
Last Answer : A. Tramado
Description : Vinca alkaloids exert antitumor activity by: A. Activating topoisomerase II to cause breaks in DNA strands B. Crosslinking DNA strands C. Inhibiting DNA mediated RNA synthesis D. Inhibiting polymerization of tubulin to form intracellular microtubules
Last Answer : D. Inhibiting polymerization of tubulin to form intracellular microtubules