Select the drug that is fungicidal and acts by inhibiting
fungal squalene epoxidase enzyme:
A. Ketoconazole
B. Terbinafine
C. Tolnaftate
D. Hamycin

1 Answer

Answer :

B. Terbinafine

Related questions

Description : Select the antifungal drug which is administered only by the oral route: A. Amphotericin B B. Ketoconazole C. Griseofulvin D. Tolnaftate

Last Answer : C. Griseofulvin

Description : The following are topical antifungal drugs except: A. Ciclopirox olamine B. Tolnaftate C. Crotamiton D. Terbinafine

Last Answer : C. Crotamiton

Description : In biosynthesis of cholesterol triparanol inhibits the activity of the enzyme: (A) ∆24 Reductase (B) Oxidosqualene-lanosterol cyclase (C) Isomerase (D) Squalene epoxidase ENZYMES 155

Last Answer : Answer : A

Description : Select the drug that acts by inhibiting HIV protease enzyme: A. Zalcitabine B. Efavirenz C. Stavudine D. Nelfinavi

Last Answer : D. Nelfinavir

Description : The following drugs are effective in systemic mycosis except: A. Terbinafine B. Itraconazole C. Ketoconazole D. Fluconazol

Last Answer : A. Terbinafine

Description : The polyene antibiotics act by: A. Inhibiting fungal cytochrome P450 enzyme B. Binding to ergosterol and creating micropores in fungal cell membrane C. Inhibiting fungal DNA synthesis D. Disorienting microtubules in fungal cells

Last Answer : B. Binding to ergosterol and creating micropores in fungal cell membrane

Description : The following is applicable to itraconazole except: A. It has largely replaced ketoconazole for treatment of systemic mycosis B. It does not inhibit human steroid hormone synthesis C. It is ... the treatment of fungal meningitis D. It can interact with terfenadine to produce ventricular arrhythmias

Last Answer : C. It is preferred for the treatment of fungal meningitis

Description : The following statement is true about ketoconazole except: A. It is less toxic than amphotericin B B. It produces a slower response than amphotericin B in systemic mycosis C. Given orally it is the first line treatment for vaginal candidiasis D. It is not effective in fungal meningitis

Last Answer : C. Given orally it is the first line treatment for vaginal candidiasis

Description : Choose the drug that can be used orally for intestinal amoebiasis, intravaginally for trichomonas vaginitis and topically for dermatophytosis: A. Quiniodochlor B. Furazolidone C. Ornidazole D. Hamycin

Last Answer : A. Quiniodochlor

Description : Which of the following drugs acts by inhibiting an enzyme in the body: A. Atropine B. Allopurinol C. Levodopa D. Metoclopramide

Last Answer : B. Allopurinol

Description : The following cytotoxic drug acts by inhibiting depolymerization of tubulin and thus producing abnormal arrays of microtubules: A. Paclitaxel B. Vinblastine C. Etoposide D. Mitoxantrone (p. 774) 60.9 C 60.10 B 60.11 D 60.12 A Ai

Last Answer : A. Paclitaxel

Description : The antiparkinsonian drug which acts by inhibiting the degradation of dopamine in the brain is: A. Carbidopa B. Amantadine C. Selegiline D. Bromocriptine

Last Answer : C. Selegiline

Description : What is true about use of amphotericin B in kala azar: A. It is currently the drug of choice B. It is more effective than ketoconazole C. It is indicated only in cases not responding to sodium stibogluconate D. Both 'B' and 'C' are correct

Last Answer : D. Both 'B' and 'C' are correct

Description : The drug of choice for Kala azar is: A. Pentamidine B. Amphotericin B C. Sodium stibogluconate D. Ketoconazole

Last Answer : C. Sodium stibogluconat

Description : The only azole antifungal drug which has some activity against moulds like Aspergillus is: A. Itraconazole B. Fluconazole C. Miconazole D. Ketoconazole

Last Answer : A. Itraconazole

Description : Fluconazole differs from ketoconazole in that: A. It is not active by the oral route B. It is a more potent inhibitor of drug metabolism C. It is not effective in cryptococcal meningitis D. It is unlikely to produce anti-androgenic side effects

Last Answer : D. It is unlikely to produce anti-androgenic side effects

Description : Choose the azole antifungal drug which is used only topically: A. Ketoconazole B. Fluconazole C. Itraconazole D. Econazole

Last Answer : D. Econazole

Description : The drug of choice for monilial diarrhoea is: A. Flucytosine B. Nystatin C. Natamycin D. Ketoconazole

Last Answer : B. Nystatin

Description : The following prokinetic drug has been implicated in causing serious ventricular arrhythmias, particularly in patients concurrently receiving erythromycin or ketoconazole: A. Domperidone B. Cisapride C. Mosapride D. Metoclopramide

Last Answer : B. Cisapride

Description : Indicate the antifungal antibiotic which is used intravenously for systemic mycosis: A. Griseofulvin B. Nystatin C. Amphotericin B D. Hamycin

Last Answer : C. Amphotericin

Description : The distinctive feature of terbinafine is: A. It is highly effective in histoplasmosis B. It can be used topically as well as orally for dermatophytosis C. It inhibits Mucor and Aspergillus as well D. Applied intravaginally it cures both candida as well as trichomonas vaginitis

Last Answer : B. It can be used topically as well as orally for dermatophytosis

Description : What is true of Quinupristin-Dalfopristin: A. It is a synergistic combination of two similar antibiotics B. It acts by inhibiting bacterial protein synthesis C. It is active against most resistant coccal infections D. All of the above are correct

Last Answer : D. All of the above are correct

Description : The following is true of vancomycin except: A. It is a bactericidal antibiotic active primarily against gram positive bacteria B. It acts by inhibiting bacterial protein synthesis C. It is an alternative to penicillin for enterococcal endocarditis D. It can cause deafness as a dose related toxicity

Last Answer : B. It acts by inhibiting bacterial protein synthesis

Description : Furosemide acts by inhibiting the following in the renal tubular cell: A. Na+-K+-2Cl– cotransporter B. Na+-Cl– symporter C. Na+-H+ antiporter D. Na+ K+ ATPase

Last Answer : A. Na+-K+-2Cl– cotransporter

Description : Methyldopa lowers BP by: A. Inhibiting dopa decarboxylase in adrenergic nerve endings B. Generating α-methyl noradrenaline in brain which reduces sympathetic tone C. Generating α-methyl ... as a false transmitter in peripheral adrenergic nerve endings D. Activating vascular dopamine receptors

Last Answer : B. Generating α-methyl noradrenaline in brain which reduces sympathetic tone

Description : Features of µ (Mu) opioid receptor include the following except: A. Acts by inhibiting cAMP formation B. Mediates miotic action C. Mediates low ceiling respiratory depression D. Mediates high ceiling supraspinal analgesia

Last Answer : C. Mediates low ceiling respiratory depression

Description : The following is true about entacapone except: A. It acts by inhibiting degradation of dopamine in the brain B. If prolongs the therapeutic effect of levodopacarbidopa in parkinsonism C. It can accentuate levodopa induced dyskinesias D. It can cause diarrhoea as a side effec

Last Answer : A. It acts by inhibiting degradation of dopamine in the brain

Description : Entacapone differs from tolcapone in the following respect/respects: A. It is shorter acting B. It acts only by inhibiting peripheral metabolism of levodopa C. It is not hepatotoxic D. All of the above are correct

Last Answer : D. All of the above are correct

Description : Carbimazole acts by inhibiting: A. Iodide trapping B. Oxidation of iodide C. Proteolysis of thyroglobulin D. Synthesis of thyroglobulin protein

Last Answer : B. Oxidation of iodide

Description : Corticosteroids exert antiinflammatory action by inhibiting the following enzyme: A. Cyclooxygenase B. Lipoxygenase C. Phospholipase-A D. Phosphodiesterase

Last Answer : C. Phospholipase-A

Description : Select the anticonvulsant drug that acts as a GABAtransaminase inhibitor: A. Gabapentin B. Vigabatrin C. Lamotrig

Last Answer : B. Vigabatrin

Description : The most efficacious drug for inhibiting round the clock gastric acid output is: A. Omeprazole B. Cimetidine C. Pirenzepine D. Misoprostol

Last Answer : A. Omeprazole

Description : Select the drug that reversibly inhibits the enzyme COMT and is useful as an adjuvant medication in advanced parkinson's disease: A. Pramipexole B. Entacapone C. Pergolide D. Piribedil

Last Answer : B. Entacapone

Description : Which of the following drugs acts by inhibiting an enzyme in the body: A. Atropine B. Allopurinol C. Levodopa D. Metoclopramide

Last Answer : B. Allopurinol

Description : Fluconazole offers the following advantage(s) over ketoconazole: A. It is longer acting B. Its absorption from stomach is not dependent on gastric acidity C. It produces fewer side effects D. All of the above

Last Answer : D. All of the above

Description : Adverse effects of ketoconazole include the following except: A. Gynaecomastia B. Oligozoospermia C. Kidney damage D. Menstrual irregularities

Last Answer : C. Kidney damage

Description : Which antifungal agent is effective in both dermatophytosis as well as systemic mycosis: A. Amphotericin B B. Griseofulvin C. Clotrimazole D. Ketoconazole

Last Answer : D. Ketoconazole

Description : Circulating testosterone levels in men are elevated during treatment with: A. Danazol B. Finasteride C. Flutamide D. Ketoconazole

Last Answer : C. Flutamide

Description : The following second generation anti-histaminic is not likely to produce ventricular arrhythmias when administered along with ketoconazole: A. Mizolastine B. Ebastine C. Terfenadine D. Astemizole

Last Answer : A. Mizolastine

Description : A drug which prevents uric acid synthesis by inhibiting the enzyme Xanthine oxidase is (A) Aspirin (B) Allopurinal (C) Colchicine (D) Phenyl benzoate

Last Answer : Answer : B

Description : A drug which prevents uric acid synthesis by inhibiting the enzyme xanthine oxidase is (A) Aspirin (B) Allopurinol (C) Colchicine (D) Probenecid

Last Answer : B

Description : A drug which prevents uric acid synthesis by inhibiting the enzyme xanthine oxidase is (A) Aspirin (B) Allopurinol (C) Colchicine (D) Probenecid

Last Answer : (B) Allopurinol

Description : Which anthelmintic drug acts through a specific glutamate gated Cl– ion channel found only in nematodes: A. Ivermectin B. Niclosamide C. Pyrantel pamoate D. Praziquantel

Last Answer : A. Ivermectin

Description : As an antitubercular drug, isoniazid has the following advantages except: A. It is tuberculocidal B. It acts on both extra and intracellular bacilli C. Tubercle bacilli do not develop resistance against it D. It is cheap

Last Answer : C. Tubercle bacilli do not develop resistance against it

Description : Choose the correct statement about trimetazidine: A. It is a novel calcium channel blocker B. It improves tissue perfusion by modifying rheological property of blood C. It is an antianginal drug which acts by nonhaemodynamic mechanisms D. Both 'A' and 'B' are correct

Last Answer : C. It is an antianginal drug which acts by nonhaemodynamic mechanisms

Description : Choose the correct statement about lamotrigine: A. It is a dopaminergic agonist used in parkinsonism B. It acts by blocking NMDA-type of glutamate receptors C. It is a broad spectrum antiepileptic drug D. It suppresses tonic-clonic seizures, but worsens absence seizures

Last Answer : C. It is a broad spectrum antiepileptic drug

Description : Choose the correct statement about nateglinide: A. It is a long acting oral hypoglycaemic drug B. Taken just before a meal, it limits postprandial hyperglycaemia in type 2 diabetes mellitus C. It lowers ... 1 and type 2 diabetes mellitus D. It acts by opening K+ channels in myocytes and adipocytes

Last Answer : B. Taken just before a meal, it limits postprandial hyperglycaemia in type 2 diabetes mellitus

Description : Select the opioid analgesic which acts primarily through κ (kappa) opioid receptor: A. Pentazocine B. Methadone C. Buprenorphine D. Pethidine

Last Answer : A. Pentazocine

Description : Select the analgesic which acts through opioid as well as additional spinal monoaminergic mechanisms: A. Tramadol B. Ethoheptazine C. Dextropropoxyphene D. Alfentanil

Last Answer : A. Tramado

Description : Vinca alkaloids exert antitumor activity by: A. Activating topoisomerase II to cause breaks in DNA strands B. Crosslinking DNA strands C. Inhibiting DNA mediated RNA synthesis D. Inhibiting polymerization of tubulin to form intracellular microtubules

Last Answer : D. Inhibiting polymerization of tubulin to form intracellular microtubules