Description : Select the antimicrobial drug which is used orally only for urinary tract infection or for bacterial diarrhoeas: A. Nalidixic acid B. Azithromycin C. Bacampicillin D. Pefloxacin
Last Answer : A. Nalidixic acid
Description : Which fluoroquinolone is highly active against Mycobact. leprae and is being used in alternative multidrug therapy regimens: A. Norfloxacin B. Ofloxacin C. Ciprofloxacin D. Lomefloxacin
Last Answer : B. Ofloxacin
Description : Select the fluoroquinolone which has high oral bioavailability, longer elimination half-life and which does not inhibit metabolism of theophylline: A. Norfloxacin B. Pefloxacin C. Lomefloxacin D. Ciprofloxacin
Last Answer : C. Lomefloxacin
Description : Teicoplanin has the following feature(s): A. Antimicrobial activity and indications similar to vancomycin B. Long elimination half-life C. Efficacy in systemic infections by oral route D. Both ‘A’ and ‘B’ are correct
Last Answer : D. Both ‘A’ and ‘B’ are correct
Description : The fluoroquinolones have improved over nalidixic acid in the following respect(s): A. They have higher antimicrobial potency B. They have extended antimicrobial spectrum C. Development of bacterial resistance against them is slow and infrequent D. All of the above
Last Answer : D. All of the above
Description : Nalidixic acid is primarily active against: A. Cocci B. Bacilli C. Gram positive bacteria D. Gram negative bacteria
Last Answer : D. Gram negative bacteria
Description : Select the drug combination which does not exhibit supraadditive synergism: A. Nalidixic acid + Nitrofurantoin B. Amoxicillin + Clavulanic acid C. Pyrimethamine + Sulfadoxine D. Sulfamethoxazole + Trimethoprim
Last Answer : A. Nalidixic acid + Nitrofurantoin
Description : Choose the correct statement in relation to treatment of urinary tract infection (UTI): A. Majority of UTIs are caused by gram positive bacteria B. Smaller doses of the antimicrobial agent ... drug gets concentrated in urine D. Most acute UTIs are treated with a combination antimicrobial regimen
Last Answer : B. Smaller doses of the antimicrobial agent suffice for lower UTI
Description : Select the antimicrobial agent that can be used to treat with both methicillin resistant and vancomycin resistant Staphylococcus aureus infection: A. Clarithromycin B. Clindamycin C. Linezolid D. Lincomycin
Last Answer : C. Linezolid
Description : The following fluoroquinolones have augmented activity against gram positive bacteria except: A. Lomefloxacin B. Levofloxacin C. Gatifloxacin D. Moxifloxacin
Last Answer : A. Lomefloxacin
Description : A single dose rifampin + ofloxacin + minocycline treatment has been recommended for: A. All cases of paucibacillary leprosy B. All relapse cases of paucibacillary leprosy C. Single skin lesion paucibacillary leprosy D. None of the above
Last Answer : C. Single skin lesion paucibacillary leprosy
Description : If a multibacillary leprosy patient treated with standard fixed duration multidrug therapy relapses, he should be treated with: A. The same rifampin + dapsone + clofazimine regimen B. ... + minocycline C. Clofazimine + ofloxacin + clarithromycin D. Ofloxacin + minocycline + clarithromycin
Last Answer : . The same rifampin + dapsone + clofazimine regimen
Description : Indicate the second line antitubercular drug that is being preferred to supplement ethambutol + streptomycin in case of hepatotoxicity due to isoniazid/ rifampin/pyrazinamide: A. Ethionamide B. Cycloserine C. Ofloxacin D. Capreomycin
Last Answer : C. Ofloxacin
Description : Indicate the drug which attains therapeutic antibacterial concentration in the urinary tract but not in other tissues: A. Pefloxacin B. Amikacin C. Nitrofurantoin D. Cephalexin
Last Answer : C. Nitrofurantoin
Description : Which fluoroquinolone has enhanced activity against gram positive bacteria and anaerobes: A. Pefloxacin B. Ciprofloxacin C. Sparfloxacin D. Norfloxacin
Last Answer : C. Sparfloxacin
Description : Which antifungal agent is effective in both dermatophytosis as well as systemic mycosis: A. Amphotericin B B. Griseofulvin C. Clotrimazole D. Ketoconazole
Last Answer : D. Ketoconazole
Description : The following is true of anti-H.pylori therapy except: A. It is indicated in all patients of peptic ulcer B. Resistance to any single antimicrobial drug develops rapidly C. Concurrent ... efficacy of the regimen D. Colloidal bismuth directly inhibits H.pylori but has poor patient acceptability
Last Answer : A. It is indicated in all patients of peptic ulcer
Description : Clarithromycin and erythromycin have very similar spectrums of antimicrobial activity. The major advantage of clarithromytcin is that it (a) Eradicates mycoplasmal infections in a single dose (b ... not inhibit live drug-metabolizing enzymes (e) Acts on methicillin-resistant strains of staphylococci
Last Answer : Ans: C
Description : The therapeutic effect of sulfasalazine in ulcerative colitis is exerted by: A. Inhibitory action of the unabsorbed drug on the abnormal colonic flora B. Breakdown of the drug in ... locally C. Release of sulfapyridine having antibacterial property D. Systemic immunomodulatory action of the drug
Last Answer : B. Breakdown of the drug in colon to release 5-aminosalicylic acid which suppresses inflammation locally
Description : Choose the correct statement about magaldrate: A. It is a mixture of magnesium and aluminium hydroxides B. It has a rapid as well as sustained acid neutralizing action C. Its acid neutralizing capacity is 2 m Eq/g D. It causes systemic alkalosis
Last Answer : B. It has a rapid as well as sustained acid neutralizing action
Description : Adrenaline is inactive orally because it is: A. Not absorbed from the gastrointestinal tract B. Destroyed by gastric acid C. Completely metabolized in the intestinal mucosa and liver before reaching systemic circulation D. Taken up by adrenergic nerve endings of the intestinal wall, liver and lungs
Last Answer : C. Completely metabolized in the intestinal mucosa and liver before reaching systemic circulation
Description : Choose the correct statement about methenamine (hexamine): A. It acts by getting converted to mandelic acid in the urinary tract B. It releases formaldehyde in acidic urine which inturn kills ... acute urinary tract infections D. It is the preferred urinary antiseptic in patients with liver disease
Last Answer : B. It releases formaldehyde in acidic urine which inturn kills bacteria
Description : Features of phenoxymethyl penicillin include the following: A. It is acid stable and orally active B. Its antibacterial spectrum is similar to that of benzyl penicillin C. It is used for less serious penicillin G sensitive infections D. All of the above are correct
Last Answer : D. All of the above are correct
Description : Compared to erythromycin, azithromycin has: A. Extended antimicrobial spectrum B. Better gastric tolerance C. Longer duration of action D. All of the above
Description : A patient of bronchial asthma maintained on theophylline developed upper respiratory tract infection. Which antimicrobial if used can increase the risk of developing theophylline toxicity: A. Ampicillin B. Cephalexin C. Cotrimoxazole D. Erythromycin
Last Answer : D. Erythromycin
Description : The most important mechanism by which tetracycline antibiotics exert antimicrobial action is: A. They chelate Ca2+ ions and alter permeability of bacterial cell membrane B. They bind to 30S ribosomes ... peptide chain in the bacteria D. They interfere with DNA mediated RNA synthesis in bacteria
Last Answer : B. They bind to 30S ribosomes and inhibit bacterial protein synthesis
Description : Which of the following is not likely to be the cause of failure of antimicrobial therapy of an acute infection: A. Improper selection of drug and dose B. Acquisition of resistance during treatment C. Failure to drain the pus D. Uncontrolled diabetes mellitus
Last Answer : B. Acquisition of resistance during treatment
Description : Antimicrobial prophylaxis is regularly warranted in the following: A. Chronic obstructive lung disease patients B. Neonates delivered by forceps C. Anastomotic intestinal surgery D. All of the above
Last Answer : C. Anastomotic intestinal surgery
Description : Which type of antimicrobial drug combination is most likely to exhibit antagonism: A. Bactericidal + Bactericidal B. Bactericidal + Bacteriostatic for a highly sensitive organism C. Bactericidal + Bacteriostatic for a marginally sensitive organism D. Bacteriostatic + Bacteriostatic
Last Answer : B. Bactericidal + Bacteriostatic for a highly sensitive organism
Description : Antimicrobial drug combinations are aimed at achieving the following except: A. Faster and more complete elimination of the infecting organism B. Treat infection when nature and sensitivity of the infecting organism is not definite C. Prevent emergence of resistant strains D. Prevent superinfection
Last Answer : D. Prevent superinfection
Description : Which antimicrobial should be avoided in patients of liver disease: A. Tetracycline B. Cotrimoxazole C. Cephalexin D. Ethambutol
Last Answer : A. Tetracycline
Description : The following organism is notorious for developing antimicrobial resistance rapidly: A. Streptococcus pyogenes B. Meningococcus C. Treponema palli
Last Answer : D. Escherichia coli
Description : Choose the antimicrobial which acts by interfering with DNA function in the bacteria: A. Chloramphenicol B. Ciprofloxacin C. Streptomycin D. Vancomycin
Last Answer : B. Ciprofloxacin
Description : 4 Choose the correct statement about the role of opioid antimotility drugs in the management of diarrhoeas: A. They are used to control diarrhoea irrespective of its etiology B. They should ... antimicrobial therapy of diarrhoea D. They are the drugs of choice in irritable bowel syndrome diarrhoea
Last Answer : B. They should be used only as a short-term measure after ensuring that enteroinvasive organisms are not involved
Description : The following diarrhoea is consistently benefited by antimicrobial therapy: A. Irritable bowel syndrome B. Cholera C. Salmonella diarrhoeas D. Traveller’s diarrhoea
Last Answer : B. Cholera
Description : Antimicrobial treatment does not alter the course of the following diarrhoeas except: A. Mild enterotoxigenic E.coli diarrhoea B. Campylobacter diarrhoea C. Coeliac disease diarrhoea D. Food poisoning diarrhoea
Last Answer : B. Campylobacter diarrhoea
Description : An adult patient of acute diarrhoea presents with abdominal pain, fever, mucus and blood in stools and is suspected to be suffering from Shigella enteritis. What antimicrobial treatment would be most appropriate: A. No antimicrobial treatment B. Metronidazole C. Norfloxacin D. Chloramphenicol
Last Answer : C. Norfloxacin
Description : Institution of oral rehydration therapy has the following beneficial effect in diarrhoea: A. Stops further diarrhoea B. Restores hydration and electrolyte balance without affecting diarrhoea C. Hastens clearance of the enteropathogen D. Obviates the need for specific antimicrobial therapy
Last Answer : B. Restores hydration and electrolyte balance without affecting diarrhoea
Description : Along with effective antimicrobial therapy, corticosteroids are indicated in the following infective conditions except: A. Tubercular meningitis B. Severe P. carinii pneumonia in AIDS patient C. Herpes simplex keratitis D. Erythema nodosum leprosum
Last Answer : C. Herpes simplex keratitis
Description : The use of prophylactic antibiotics has become commonplace. Which of the following statement(s) is/are true concerning the prophylactic use of antibiotics? a. The appropriate use of prophylactic ... d. The topical use of antimicrobial agents is of no advantage in the prophylactic setting
Last Answer : Answer: a Intravenous administration of an antibiotic is clearly indicated for patients undergoing clean contaminated operations. These antibiotics should be administered prior to surgery ... of antimicrobial agents is equivalent to the administration of intravenous antimicrobial agent antibiotics
Description : Why is microbial control necessary and what are some of the factors that go into the choice of a particular antimicrobial agent?
Last Answer : The control of microorganisms is an important way of preventing pathogens from reaching the body.Sterilizing laboratory equipment, hospital supplies, and industrial apparatus helps contain contamination.The choice of a ... , the acidity or alkalinity of the area, and the presence of organic matter.
Description : _____ is when an antimicrobial drug should harm the infectious agent but not the host. a. Selective toxicity b. Toxic dose c. Therapeutic dose d. Chemotherapeutic index
Last Answer : a. Selective toxicity
Description : The following drugs are effective in systemic mycosis except: A. Terbinafine B. Itraconazole C. Ketoconazole D. Fluconazol
Last Answer : A. Terbinafine
Description : Fluconazole is more effective than intraconazole in the following systemic fungal disease: A. Pulmonary histoplasmosis B. Cryptococcal meningitis C. Nonmeningeal blastomycosis D. Disseminated sporotrichosis
Last Answer : B. Cryptococcal meningitis
Description : The following is applicable to itraconazole except: A. It has largely replaced ketoconazole for treatment of systemic mycosis B. It does not inhibit human steroid hormone synthesis C. It is ... the treatment of fungal meningitis D. It can interact with terfenadine to produce ventricular arrhythmias
Last Answer : C. It is preferred for the treatment of fungal meningitis
Description : The following statement is true about ketoconazole except: A. It is less toxic than amphotericin B B. It produces a slower response than amphotericin B in systemic mycosis C. Given orally it is the first line treatment for vaginal candidiasis D. It is not effective in fungal meningitis
Last Answer : C. Given orally it is the first line treatment for vaginal candidiasis
Description : Indicate the antifungal antibiotic which is used intravenously for systemic mycosis: A. Griseofulvin B. Nystatin C. Amphotericin B D. Hamycin
Last Answer : C. Amphotericin
Description : Indicate the attribute that is common to both polymyxin B and bacitracin: A. Both are active against gram negative bacteria B. Both are too toxic for systemic use C. Both act by inhibiting bacterial cell wall synthesis D. Both a
Last Answer : B. Both are too toxic for systemic use
Description : What is the most important reason for the restricted use of systemic chloramphenicol: A. Emergence of chloramphenicol resistance B. Its potential to cause bone marrow depression C. Its potential to cause superinfections D. Its potential to inhibit the metabolism of many drugs
Last Answer : B. Its potential to cause bone marrow depression