Description : The following drug may cure typhoid fever, but does not prevent development of carrier state: A. Ciprofloxacin B. Cotrimoxazole C. Chloramphenicol D. Ceftriaxone
Last Answer : C. Chloramphenicol
Description : Currently the drug of choice for emperic treatment of typhoid fever is: A. Chloramphenicol B. Cotrimoxazole C. Ciprofloxacin D. Ampicillin
Last Answer : C. Ciprofloxacin
Description : A single oral dose of the following drug can cure most cases of uncomplicated gonorrhoea: A. Ciprofloxacin B. Cotrimoxazole C. Spectinomycin D. Doxycycline
Last Answer : A. Ciprofloxacin
Description : The drug of choice for atypical pneumonia due to Mycoplasma pneumoniae is: A. Doxycycline B. Ciprofloxacin C. Ceftriaxone D. Gentamicin
Last Answer : A. Doxycycline
Description : A patient of congestive heart failure was being treated with furosemide and digoxin. He developed urinary tract infection. Which of the following antimicrobials should be avoided: A. Ampicillin B. Gentamicin C. Norfloxacin D. Cotrimoxazole
Last Answer : B. Gentamicin
Description : Regarding the antibacterial action of gentamicin, which one of the following statements is most accurate? (a) Efficacy is directly proportionate to the time that the plasma level of the drug is ... an inhibitor of cell wall synthesis (e) The antibacterial action of gentamicin is time - dependent
Last Answer : Ans: C
Description : A single oral dose of the following drug can cure most cases of uncomplicated gonorrhoea (a) Ciprofloxacin (b) Cotrimoxazole (c) Spectinomycin (d) Doxycycline
Last Answer : Ans: A
Description : The therapeutic effect of sulfasalazine in ulcerative colitis is exerted by: A. Inhibitory action of the unabsorbed drug on the abnormal colonic flora B. Breakdown of the drug in ... locally C. Release of sulfapyridine having antibacterial property D. Systemic immunomodulatory action of the drug
Last Answer : B. Breakdown of the drug in colon to release 5-aminosalicylic acid which suppresses inflammation locally
Description : Indicate the drug which attains therapeutic antibacterial concentration in the urinary tract but not in other tissues: A. Pefloxacin B. Amikacin C. Nitrofurantoin D. Cephalexin
Last Answer : C. Nitrofurantoin
Description : Select the drug combination which does not exhibit supraadditive synergism: A. Nalidixic acid + Nitrofurantoin B. Amoxicillin + Clavulanic acid C. Pyrimethamine + Sulfadoxine D. Sulfamethoxazole + Trimethoprim
Last Answer : A. Nalidixic acid + Nitrofurantoin
Description : The following drug can cause rickets in children by interfering with vitamin D action: A. Tetracycline B. Digoxin C. Phenytoin D. Ciprofloxacin
Last Answer : C. Phenytoin
Description : The following is true for gentamicin: A. It is more active in acidic medium B. It has a wide margin of safety C. It is excreted unchanged, mainly by glomerular filtration D. It primarily inhibits gram positive bacteria
Last Answer : C. It is excreted unchanged, mainly by glomerular filtration
Description : Select the drug which is active against a variety of diarrhoea producing organisms like Giardia, Shigella, Salmonella as well as S. typhi and Trichomonas vaginalis, but is not a first line treatment for any of these: A. Metronidazole B. Mepacrine C. Cotrimoxazole D. Furazolidone
Last Answer : D. Furazolidone
Description : Select the antibiotic which inhibits drug metabolizing isoenzyme CYP3A4 resulting in potentially fatal drug interaction with terfenadine: A. Erythromycin B. Clindamycin C. Gentamicin D. Vancomycin
Last Answer : A. Erythromycin
Description : The antibacterial action of aminoglycoside antibiotics is characterized by: A. Concentration dependent rate of bacterial cell killing B. Concentration dependent prolonged postantibiotic effect C. More pronounced bactericidal effect in anaerobic medium D. Both 'A' and 'B' are correct
Last Answer : D. Both 'A' and 'B' are correct
Description : The characteristic feature(s) of penicillin G is/are: A. It is unstable in aqueous solution B. Its antibacterial action is unaffected by pus and tissue fluids C. It is equally active against resting and multiplying bacteria D. Both ‘A’ and ‘B’ are correc
Last Answer : D. Both ‘A’ and ‘B’ are correct
Description : A single oral dose of the following antibiotic is curative in most patients of nonspecific urethritis due to Chlamydia trachomatis: A. Doxycycline B. Azithromycin C. Erythromycin D. Cotrimoxazole
Last Answer : B. Azithromycin
Description : A patient of bronchial asthma maintained on theophylline developed upper respiratory tract infection. Which antimicrobial if used can increase the risk of developing theophylline toxicity: A. Ampicillin B. Cephalexin C. Cotrimoxazole D. Erythromycin
Last Answer : D. Erythromycin
Description : Indicate the condition in which neither trimethoprim nor sulfamethoxazole alone are effective, but their combination cotrimoxazole is: A. Prostatitis B. Lymphogranuloma venereum C. Pneumocystis carinii pneumonia D. Bacillary dysentery
Last Answer : C. Pneumocystis carinii pneumonia
Description : Which antimicrobial should be avoided in patients of liver disease: A. Tetracycline B. Cotrimoxazole C. Cephalexin D. Ethambutol
Last Answer : A. Tetracycline
Description : Choose the correct statement about methenamine (hexamine): A. It acts by getting converted to mandelic acid in the urinary tract B. It releases formaldehyde in acidic urine which inturn kills ... acute urinary tract infections D. It is the preferred urinary antiseptic in patients with liver disease
Last Answer : B. It releases formaldehyde in acidic urine which inturn kills bacteria
Description : Weakly acidic drugs: A. Are bound primarily to α1 acid glycoprotein in plasma B. Are excreted faster in alkaline urine C. Are highly ionized in the gastric juice D. Do not cross blood-brain barrier
Last Answer : B. Are excreted faster in alkaline urine
Description : Select the antibiotic which is equally effective whether injected 8 hourly or 24 hourly, provided the total daily dose remains the same: A. Gentamicin B. Sod. penicillin G C. Cefazolin D. Vancomycin
Last Answer : A. Gentamicin
Description : Gentamicin differs from streptomycin in that: A. It is less nephrotoxic B. It is used for pseudomonas infections C. It is not effective in tuberculosis D. Both ‘B’ and ‘C’ are correct
Last Answer : D. Both ‘B’ and ‘C’ are correct
Description : 60-year-old patient with creatinine clearance 50 ml/min has to be treated with gentamicin. His daily dose of gentamicin should be reduced to the following percentage of the usual adult dose: A. 70% B. 50% C. 40% D. 30%
Last Answer : B. 50%
Description : A 60-year-old patient with creatinine clearance 50 ml/min has to be treated with gentamicin. His daily dose of gentamicin should be reduced to the following percentage of the usual adult dose: A. 70% B. 50% C. 40% D. 30%
Description : Which aminoglycoside antibiotic causes more hearing loss than vestibular disturbance as toxic effect: A. Streptomycin B. Gentamicin C. Kanamycin D. Sisomicin
Last Answer : C. Kanamycin
Description : The following antibiotic penetrates blood-CSF barrier the best: A. Erythromycin B. Gentamicin C. Tetracycline D. Chloramphenicol
Last Answer : D. Chloramphenicol
Description : An 8-year-old child presented with brownish discoloured and deformed anterior teeth. History of having received an antibiotic about 4 years earlier was obtained. Which antibiotic could be responsible for the condition: A. Chloramphenicol B. Tetracycline C. Erythromycin D. Gentamicin
Last Answer : Tetracycline
Description : Features of phenoxymethyl penicillin include the following: A. It is acid stable and orally active B. Its antibacterial spectrum is similar to that of benzyl penicillin C. It is used for less serious penicillin G sensitive infections D. All of the above are correct
Last Answer : D. All of the above are correct
Description : Dorzolamide is a: A. Topically applied ocular carbonic anhydrase inhibitor B. Second generation sulfonylurea hypoglycaemic C. Topical sulfonamide antibacterial D. Luminal amoebicide
Last Answer : A. Topically applied ocular carbonic anhydrase inhibitor
Description : Which fluoroquinolone is highly active against Mycobact. leprae and is being used in alternative multidrug therapy regimens: A. Norfloxacin B. Ofloxacin C. Ciprofloxacin D. Lomefloxacin
Last Answer : B. Ofloxacin
Description : The drugs used to treat Mycobact. avium complex infection in AIDS patients include the following except: A. Isoniazid B. Clarithromycin C. Ethambutol D. Ciprofloxacin
Last Answer : A. Isoniazid
Description : Mycobact. tuberculosis infection in a HIV infected patient is treated with: A. The same antitubercular regimen as HIV negative patient B. Four first line antitubercular drugs for 2 months followed ... line antitubercular drugs for 9 months D. Clarithromycin + Ciprofloxacin + Rifabutin for 12 months
Last Answer : B. Four first line antitubercular drugs for 2 months followed by a longer continuation phase of 7 months with rifampin + isoniazid
Description : First line antitubercular drugs include the following except: A. Ciprofloxacin B. Streptomycin C. Pyrazinamide D. Ethambutol
Description : The following antibiotic is highly active against anaerobic bacteria including Bacteroides fragilis: A. Ciprofloxacin B. Clarithromycin C. Clindamycin D. Tobramycin
Last Answer : C. Clindamycin
Description : Concurrent use of an aminoglycoside antibiotic should be avoided with the following antibiotic: A. Ampicillin B. Vancomycin C. Ciprofloxacin D. Rifampin
Last Answer : B. Vancomycin
Description : A premature neonate suffered respiratory distress and was given an antibiotic 100 mg/kg/day orally. Over the next two days his condition worsened, he become dull, stopped feeding, developed ... most likely antibiotic given to him: A. Ampicillin B. Chloramphenicol C. Erythromycin D. Ciprofloxacin
Last Answer : B. Chloramphenico
Description : In the treatment of typhoid fever, ciprofloxacin has the following advantage(s): A. It is effective in nearly all cases B. Early abetment of fever and other symptoms C. Development of carrier state is unlikely D. All of the above
Last Answer : D. All of the above
Description : The distinctive feature(s) of sparfloxacin compared to ciprofloxacin is/are: A. Enhanced activity against gram positive bacteria B. Lack of pharmacokinetic interaction with theophylline and warfarin C. Higher incidence of phototoxic reaction D. All of the above
Description : Important microbiological features of ciprofloxacin include the following except: A. Long postantibiotic effect B. Marked suppression of intestinal anaerobes C. MBC values close to MIC values D. Slow development of resistance
Last Answer : B. Marked suppression of intestinal anaerobes
Description : Ciprofloxacin is not active against: A. H.influenzae B. E.coli C. Enterobacter spp. D. Bacteroides fragilis
Last Answer : D. Bacteroides fragilis
Description : Which fluoroquinolone has enhanced activity against gram positive bacteria and anaerobes: A. Pefloxacin B. Ciprofloxacin C. Sparfloxacin D. Norfloxacin
Last Answer : C. Sparfloxacin
Description : Select the fluoroquinolone which has high oral bioavailability, longer elimination half-life and which does not inhibit metabolism of theophylline: A. Norfloxacin B. Pefloxacin C. Lomefloxacin D. Ciprofloxacin
Last Answer : C. Lomefloxacin
Description : Adverse effects of ciprofloxacin are referable primarily to the following except: A. Gastrointestinal tract B. Kidney C. Skin D. Nervous system
Last Answer : B. Kidney
Description : Choose the antimicrobial which acts by interfering with DNA function in the bacteria: A. Chloramphenicol B. Ciprofloxacin C. Streptomycin D. Vancomycin
Last Answer : B. Ciprofloxacin
Description : Omeprazole exerts practically no other action except inhibition of gastric acid secretion because: A. It transforms into the active cationic forms only in the acidic pH of the gastric juice B. Its ... forms are unable to diffuse out from the gastric parietal cell canaliculi D. All of the above
Description : Choose the correct statement in relation to treatment of urinary tract infection (UTI): A. Majority of UTIs are caused by gram positive bacteria B. Smaller doses of the antimicrobial agent ... drug gets concentrated in urine D. Most acute UTIs are treated with a combination antimicrobial regimen
Last Answer : B. Smaller doses of the antimicrobial agent suffice for lower UTI
Description : The following drug reduces urine volume in both pituitary origin as well as renal diabetes insipidus and is orally active: A. Vasopressin B. Hydrochlorothiazide C. Chlorpropamide D. Carbamazepine
Last Answer : B. Hydrochlorothiazide