he dominant pharmacokinetic feature of penicillin
G is:
A. It is equally distributed extra- and intracellularly
B. It is rapidly secreted by proximal renal
tubules
C. It has low oral bioavailability due to high
first pass metabolism in liver
D. It does not cross blood–CSF barrier even
when meninges are inflamed

1 Answer

Answer :

B. It is rapidly secreted by proximal renal
tubules

Related questions

Description : Drugs which undergo high degree of first-pass metabolism in liver: A. Have low oral bioavailability B. Are excreted primarily in bile C. Are contraindicated in liver disease D. Exhibit zero order kinetics of elimination

Last Answer : A. Have low oral bioavailability

Description : Drugs which undergo high degree of first-pass metabolism in liver: A. Have low oral bioavailability B. Are excreted primarily in bile C. Are contraindicated in liver disease D. Exhibit zero order kinetics of elimination

Last Answer : A. Have low oral bioavailability

Description : Which of the following is not a primary/fundamental, but a derived pharmacokinetic parameter: A. Bioavailability B. Volume of distribution C. Clearance D. Plasma half life

Last Answer : D. Plasma half life

Description : Among all cardiac glycosides, digoxin is the most commonly used, because: A. It is the most potent and fastest acting glycoside B. It has the highest and most consistent oral ... so that dose adjustments are possible every 2-3 days and toxicity abates rather rapidly after discontinuatio

Last Answer : D. It has intermediate plasma half life so that dose adjustments are possible every 2-3 days and toxicity abates rather rapidly after discontinuatio

Description : Choose the correct statement about rifampin: A. It is the most active drug on slow growing tubercle bacilli B. Its antitubercular efficacy is lower than that of isoniazid C. It is active against many atypical mycobacteria D. It does not effectively cross blood-CSF barrier

Last Answer : C. It is active against many atypical mycobacteria

Description : The characteristic feature(s) of penicillin G is/are: A. It is unstable in aqueous solution B. Its antibacterial action is unaffected by pus and tissue fluids C. It is equally active against resting and multiplying bacteria D. Both ‘A’ and ‘B’ are correc

Last Answer : D. Both ‘A’ and ‘B’ are correct

Description : The distinctive feature(s) of methadone compared to morphine is/are: A. High oral bioavailability B. High plasma protein and tissue binding C. Delayed and milder withdrawal symptoms in dependent subjects D. All of the above

Last Answer : D. All of the above

Description : 06. A hydrophilic medicinal agent has the following property: a) Low ability to penetrate through the cell membrane lipids b) Penetrate through membranes by means of endocytosis c) Easy permeation through the blood-brain barrier d) High reabsorption in renal tubules

Last Answer : a) Low ability to penetrate through the cell membrane lipids

Description : Bioavailability differences among oral formulations of a drug are most likely to occur if the drug: A. Is freely water soluble B. Is completely absorbed C. Is incompletely absorbed D. Undergoes little first-pass metabolism

Last Answer : C. Is incompletely absorbed

Description : Bioavailability differences among oral formulations of a drug are most likely to occur if the drug: A. Is freely water soluble B. Is completely absorbed C. Is incompletely absorbed D. Undergoes little first-pass metabolism

Last Answer : C. Is incompletely absorbed

Description : 15.45 To be a useful inhaled glucocorticoid the drug should have: A. High oral bioavailability B. Low oral bioavailability C. Additional bronchodilator activity

Last Answer : B. Low oral bioavailability

Description : The following antibiotic penetrates blood-CSF barrier the best: A. Erythromycin B. Gentamicin C. Tetracycline D. Chloramphenicol

Last Answer : D. Chloramphenicol

Description : If a patient gives history of urticaria, itching and swelling of lips following injection of penicillin G, then: A. He will develop similar reaction whenever penicillin is injected ... oral phenoxymethyl penicillin safely D. All natural and semisynthetic penicillins are contraindicated for him

Last Answer : D. All natural and semisynthetic penicillins are contraindicated for him

Description : Limitations of typical tricyclic antidepressants include the following except: A. Narrow safety margin B. Low oral bioavailability C. Frequent side effects D. Long latent period for response

Last Answer : B. Low oral bioavailability

Description : Select the antibiotic which is equally effective whether injected 8 hourly or 24 hourly, provided the total daily dose remains the same: A. Gentamicin B. Sod. penicillin G C. Cefazolin D. Vancomycin

Last Answer : A. Gentamicin

Description : The distinctive feature(s) of sparfloxacin compared to ciprofloxacin is/are: A. Enhanced activity against gram positive bacteria B. Lack of pharmacokinetic interaction with theophylline and warfarin C. Higher incidence of phototoxic reaction D. All of the above

Last Answer : D. All of the above

Description : The following is true of simvastatin except: A. It is more potent than lovastatin B. At the highest recommended dose, it causes greater LDL-cholesterol lowering than lovastatin C. It does not undergo ... metabolism in liver D. It can raise HDL-cholesterol level when the same is low at base line

Last Answer : C. It does not undergo first pass metabolism in liver

Description : The following are true about aldosterone: a. it is secreted by the adrenal medulla b. its secretion is stimulated by decreased blood volume c. it stimulates active reabsorption of sodium in the distal renal tubules. d. it causes increased secretion of potassium by the distal renal tubules.

Last Answer : it causes increased secretion of potassium by the distal renal tubules.

Description : Which of the following is not an attribute of amlodipine: A. Generation of an active metabolite B. Large volume of distribution C. High and consistent oral bioavailability D. Long elimination half life

Last Answer : A. Generation of an active metabolit

Description : Which of the following is not a primary/fundamental, but a derived pharmacokinetic parameter: A. Bioavailability B. Volume of distribution C. Clearance D. Plasma half life

Last Answer : D. Plasma half life

Description : The characteristic feature of phenytoin pharmacokinetics is: A. High first pass metabolism B. Nonsaturation kinetics of metabolism C. Capacity limited metabolism saturating at higher therapeutic concentration range D. Extrahepatic metabolism

Last Answer : C. Capacity limited metabolism saturating at higher therapeutic concentration range

Description : Select the organic nitrate which undergoes minimal first-pass metabolism in the liver: A. Glyceryl trinitrate B. Isosorbide dinitrate C. Isosorbide mononitrate D. Erythrityl tetranitrate

Last Answer : C. Isosorbide mononitrate

Description : Aldosterone enhances Na+ reabsorption in renal tubules by: A. Stimulating carbonic anhydrase B. Activating Na+ K+ ATPase C. Inducing the synthesis of Na+ K+ ATPase D. Inducing renal prostaglandin synthesis

Last Answer : C. Inducing the synthesis of Na+ K+ ATPase

Description : The following is not true of morphine: A. Its 2-glucuronide metabolite is an active analgesic B. Its active metabolite penetrates blood-brain barrier better than morphine C. Its oral: parenteral activity ratio is 1:4 D. It undergoes enterohepatic cycling

Last Answer : B. Its active metabolite penetrates blood-brain barrier better than morphine

Description : High content copper amalgam . . . a. generally requires greater energy to accomplish trituration b. should be placed rapidly in large increments c. Continues to leak since the ... not cause galvanism in oral environment e. is equally effective as conventional alloys in clinical studies

Last Answer : a. generally requires greater energy to accomplish trituration

Description : Which of the following is associated with Hyperuricaemia? 1) is usually due to an excess purine consumption 2) occurs in association with acute lymphoblastic leukaemia 3) in primary gout is inherited in ... with low dose aspirin therapy 5) can be treated with uricosuric drugs even in renal failure

Last Answer : Answers-2 Hyperuricaemia may be due to increased purine intake, urate production or reduced urate clearance, and is most commonly due to the latter. Therefore it can occur in association with enhanced ... . Many of the uricosuric drugs may be detrimental in renal failure and may not be effective.

Description : The following statements are true about imipenem except: A. It is a β-lactam antibiotic, but neither a penicillin nor a cephalosporin B. It is rapidly degraded in the kidney C. It is safe in epileptics D. It is always given in combination with cilastatin

Last Answer : C. It is safe in epileptics

Description : Choose the correct statement about topical NSAID preparations: A. They produce high drug levels in the blood by avoiding hepatic first pass metabolism B. They produce high drug levels in ... a strong placebo effect D. Interindividual variability in clinical response to these preparations is minimal

Last Answer : C. They elicit symptomatic relief in soft tissue rheumatism mainly by a strong placebo effect

Description : Select the fluoroquinolone which has high oral bioavailability, longer elimination half-life and which does not inhibit metabolism of theophylline: A. Norfloxacin B. Pefloxacin C. Lomefloxacin D. Ciprofloxacin

Last Answer : C. Lomefloxacin

Description : To be a useful inhaled glucocorticoid the drug should have (a) High oral bioavailability (b) Low oral bioavailability (c) Additional bronchodilator activity (d) Prodrug character

Last Answer : Ans: B

Description : Glucose entry into the cells of the following organ/ tissue is highly dependent on the presence of insulin: A. Brain B. Liver C. Adipose tissue D. Kidney tubules

Last Answer : C. Adipose tissue

Description : he current therapeutic indication of acetazolamide is: A. Congestive heart failure B. Renal insufficiency C. Cirrhosis of liver D. Glaucoma

Last Answer : D. Glaucoma

Description : The plasma half life of penicillin-G is longer in the new born because their: A. Plasma protein level is low B. Drug metabolizing enzymes are immature C. Glomerular filtration rate is low D. Tubular transport mechanisms are not well developed

Last Answer : D. Tubular transport mechanisms are not well developed

Description : Enalapril differs from captopril in the following features except: A. It is dose to dose more potent B. Its oral absorption is not affected by food in stomach C. It acts more rapidly D. It has longer duration of action

Last Answer : D. Lisinopri

Description : Which of the following processes plays the major role in terminating the action of phenobarbitone: A. Biliary excretion B. Renal excretion C. Hepatic metabolism D. Redistribution

Last Answer : B. Renal excretion

Description : Which out of the following antibiotics penetrates blood-CSF barrier the best (a) Erythromycin (b) Gentamicin (c) Tetracycline (d) Chloramphenicol

Last Answer : Ans: D

Description : 08. What does the term bioavailability mean? a) Plasma protein binding degree of substance b) Permeability through the brain-blood barrier c) Fraction of an uncharged drug reaching the systemic ... following any route administration d) Amount of a substance in urine relative to the initial doze

Last Answer : C

Description : Neuromuscular blocking drugs do not produce central actions because: A. They do not cross the blood-brain barrier B. Nicotinic receptors are not present in the brain C. They are sequestrated in the periphery by tight binding to the skeletal muscles D. They do not ionise at the brain pH

Last Answer : A. They do not cross the blood-brain barrier

Description : Weakly acidic drugs: A. Are bound primarily to α1 acid glycoprotein in plasma B. Are excreted faster in alkaline urine C. Are highly ionized in the gastric juice D. Do not cross blood-brain barrier

Last Answer : B. Are excreted faster in alkaline urine

Description : Low molecular weight heparins have the following advantages over unfractionated heparin except: A. Higher efficacy in arterial thrombosis B. Less frequent dosing C. Higher and more consistent subcutaneous bioavailability D. Laboratory monitoring of response not required

Last Answer : A. Higher efficacy in arterial thrombosis

Description : Oral neomycin is beneficial in hepatic coma because: A. In hepatic failure patients it is absorbed from the intestines B. It decreases ammonia production by gut bacteria C. It reacts chemically with ... gut to prevent its diffusion into blood D. It induces ammonia detoxifying enzymes in the liver

Last Answer : B. It decreases ammonia production by gut bacteria

Description : The following feature disfavours use of oral hypoglycaemics in diabetes mellitus: A. Age at onset of disease over 40 years B. Insulin requirement more than 40 U/day C. Fasting blood sugar level between 100–200 mg/dl D. Associated obesity

Last Answer : B. Insulin requirement more than 40 U/day

Description : If a patient gives history of urticaria, itching and swelling of lips following injection of penicillin G, then (a) He will develop similar reaction whenever penicillin is injected ( ... oral phenoxymethyl penicillin safely (d) All natural and semisynthetic penicillins are contraindicated for him

Last Answer : Ans: D

Description : Ceftriaxone has all the following attributes except: A. It has a long plasma half life of 8 hours B. It can cause bleeding by prolonging prothrombin time C. It has attained high cure rates in multiresistant typhoid infection D. It penetrates CSF poorly and therefore not effective in meningitis

Last Answer : D. It penetrates CSF poorly and therefore not effective in meningitis

Description : At low blood glucose concentration, brain but not liver will take up glucose. It is due to the (A) Low Km of hexokinase (B) Low Km of glucokinase (C) Specificity of glucokinase (D) Blood brain barrier

Last Answer : Answer : A

Description : What structure is between the proximal and distal convoluted tubules?

Last Answer : Need answer

Description : Furosemide inhibits reabsorption of sodium and chloride in (A) Proximal convoluted tubules (B) Loop of Henle (C) Distal convoluted tubules (D) Collecting ducts

Last Answer : Answer : B

Description : Aldosterone increases reabsorption of sodium in (A) Proximal convoluted tubules (B) Ascending limb of loop of Henle (C) Descending limb of loop of Henle (D) Distal convoluted tubules

Last Answer : Answer : D

Description : Antidiuretic hormone: a. decreases the osmolarity of urine b. decreases the volume of urine c. increases the reabsorption of water in the proximal tubules d. is synthesized in the posterior pituitary gland

Last Answer : decreases the volume of urine