A drug (200 mg dose) administered in tablet form and as intravenous injection (50 mg dose) showed AUG of 100 and 200 microgram hr/mL, respectively. The absolute availability of the drug through oral administration is : (A) 125% (B) 250 % (C) 12.5% (D) 1.25%

A drug (200 mg dose) administered in tablet form and as intravenous injection (50 mg dose) showed AUG of 100 and 200 microgram hr/mL, respectively. The absolute availability of the drug through oral administration is : (A) 125% (B) 250 % (C) 12.5% (D) 1.25%
by

1 Answer

Answer :

(C) 12.5%
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The Volume of distribution of a drug administered at a dose of 300 mg and exhibiting 30 microgram/mL instantaneous concentration in plasma shall be (A)10 L (B) 100 L (C) 1.0 L (D) 0.10 L

Description : The Volume of distribution of a drug administered at a dose of 300 mg and exhibiting 30 microgram/mL instantaneous concentration in plasma shall be (A)10 L (B) 100 L (C) 1.0 L (D) 0.10 L

Last Answer : (A)10 L

It is required to maintain a therapeutic concentration of 10 microgram/mL for 12 hours of a drug having half life of 1.386 hr and Vd of 5 L. The dose required in a sustained release product will be (A) 600 mg (B) 300 mg (C) 30 mg (D) 60 mg

Description : It is required to maintain a therapeutic concentration of 10 microgram/mL for 12 hours of a drug having half life of 1.386 hr and Vd of 5 L. The dose required in a sustained release product will be (A) 600 mg (B) 300 mg (C) 30 mg (D) 60 mg

Last Answer : (B) 300 mg

A patient of acute myocardial infarction being treated in intensive care unit developed left ventricular failure with raised central venous pressure. It was decided to use glyceryl trinitrate. Which route/method of administration would be most suitable. (a) Sublingual (b) Oral (c) Intravenous bolus injection (d) Slow intravenous infusion

Description : A patient of acute myocardial infarction being treated in intensive care unit developed left ventricular failure with raised central venous pressure. It was decided to use glyceryl trinitrate. Which route/ ... (a) Sublingual (b) Oral (c) Intravenous bolus injection (d) Slow intravenous infusion

Last Answer : Ans: D

What quantities of 95 % v/v and 45 % v/v alcohols are to be mixed to make 800 mL of 65 % v/v alcohol? (A) 480 mL of 95 % and 320 mL of 45 % alcohol (B) 320 mL of 95 % and 480 mL of 45 % alcohol (C) 440 mL of 95 % and 360 mL of 45 % alcohol (D)360 mL of 95 % and 440 mL of 45 % alcohol

Description : What quantities of 95 % v/v and 45 % v/v alcohols are to be mixed to make 800 mL of 65 % v/v alcohol? (A) 480 mL of 95 % and 320 mL of 45 % alcohol (B) 320 mL of 95 % and 480 mL of 45 % alcohol (C) 440 mL of 95 % and 360 mL of 45 % alcohol (D)360 mL of 95 % and 440 mL of 45 % alcohol

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Last Answer : (C) Area under the curve is not proportional to the dose

The population of Muslims in Kenya is what per cent of the population of Christians in Somalia? 1) 325% 2) 225% 3) 125% 4) 25% 5) 12.5%

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Potassium content of muscle tissue in mg/100 ml is about (A) 50–100 (B) 100–150 (C) 250–400 (D) 150–200

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In organic molecules, fluorescence seldom results from absorption of UV radiation of wavelengths lower than (A) 350 nm (B) 200 nm (C) 300 nm (D) 250 nm

Description : In organic molecules, fluorescence seldom results from absorption of UV radiation of wavelengths lower than (A) 350 nm (B) 200 nm (C) 300 nm (D) 250 nm

Last Answer : (A) 350 nm

Which one of the following is the commonly used bulking agent in the formulation of freeze dried low dose drug products? (A) Sodium chloride (B) Mannitol (C) Starch (D) HPMC

Description : Which one of the following is the commonly used bulking agent in the formulation of freeze dried low dose drug products? (A) Sodium chloride (B) Mannitol (C) Starch (D) HPMC

Last Answer : (B) Mannitol

Ketorolac: A. Is a nonsteroidal anti-inflammatory drug (NSAID) approved for intravenous, intramuscular, and oral administration. B. Can be used indefinitely for postoperative analgesia. C. Can cause renal dysfunction. D. May decrease surgical blood loss.

Description : Ketorolac: A. Is a nonsteroidal anti-inflammatory drug (NSAID) approved for intravenous, intramuscular, and oral administration. B. Can be used indefinitely for postoperative analgesia. C. Can cause renal dysfunction. D. May decrease surgical blood loss.

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11. Which route of drug administration is most likely to lead to the first-pass effect? a) Sublingual b) Oral c) Intravenous d) Intramuscular

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Last Answer : b) Oral

In addition to slow intravenous infusion, which of the following routes of administration allows for titration of the dose of a drug with the response: A. Sublingual B. Transdermal C. Inhalational D. Nasal insufflation

Description : In addition to slow intravenous infusion, which of the following routes of administration allows for titration of the dose of a drug with the response: A. Sublingual B. Transdermal C. Inhalational D. Nasal insufflation

Last Answer : C. Inhalational

In addition to slow intravenous infusion, which of the following routes of administration allows for titration of the dose of a drug with the response: A. Sublingual B. Transdermal C. Inhalational D. Nasal insufflation

Description : In addition to slow intravenous infusion, which of the following routes of administration allows for titration of the dose of a drug with the response: A. Sublingual B. Transdermal C. Inhalational D. Nasal insufflation

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Bioavailability of drug refers to: A. Percentage of administered dose that reaches systemic circulation in the unchanged form B. Ratio of oral to parenteral dose C. Ratio of orally administered drug to that excreted in the faeces D. Ratio of drug excreted unchanged in urine to that excreted as metabolites

Description : Tricyclic antidepressants can alter the oral absorption of many drugs by: A. Complexing with the other drug in the intestinal lumen B. Altering gut motility C. Altering gut flora D. Damaging gut mucosa

Last Answer : C. Altering gut flora

Bioavailability of drug refers to: A. Percentage of administered dose that reaches systemic circulation in the unchanged form B. Ratio of oral to parenteral dose C. Ratio of orally administered drug to that excreted in the faeces D. Ratio of drug excreted unchanged in urine to that excreted as metabolites

Description : Bioavailability of drug refers to: A. Percentage of administered dose that reaches systemic circulation in the unchanged form B. Ratio of oral to parenteral dose C. Ratio of orally administered drug to ... in the faeces D. Ratio of drug excreted unchanged in urine to that excreted as metabolites

Last Answer : A. Percentage of administered dose that reaches systemic circulation in the unchanged form

Bioavailability of drug refers to: A. Percentage of administered dose that reaches systemic circulation in the unchanged form B. Ratio of oral to parenteral dose C. Ratio of orally administered drug to that excreted in the faeces D. Ratio of drug excreted unchanged in urine to that excreted as metabolites

Description : Bioavailability of drug refers to: A. Percentage of administered dose that reaches systemic circulation in the unchanged form B. Ratio of oral to parenteral dose C. Ratio of orally administered drug to ... in the faeces D. Ratio of drug excreted unchanged in urine to that excreted as metabolites

Last Answer : A. Percentage of administered dose that reaches systemic circulation in the unchanged form

The normal concentration of chlorine in mg/100 ml of C.S.F is about (A) 200 (B) 250 (C) 300 (D) 440

Description : The normal concentration of chlorine in mg/100 ml of C.S.F is about (A) 200 (B) 250 (C) 300 (D) 440

Last Answer : Answer : D

The normal concentration of chloride in mg/100 ml of whole blood is about (A) 200 (B) 250 (C) 400 (D) 450

Description : The normal concentration of chloride in mg/100 ml of whole blood is about (A) 200 (B) 250 (C) 400 (D) 450

Last Answer : Answer : B

The normal concentration of sodium (in mg/100 ml) of human plasma is (A) 100 (B) 200 (C) 250 (D) 330

Description : The normal concentration of sodium (in mg/100 ml) of human plasma is (A) 100 (B) 200 (C) 250 (D) 330

Last Answer : Answer : D

Noradrenaline is administered by (a) Subcutaneous injection (b) Intramuscular injection (c) Slow intravenous infusion (d) All of the above routes

Description : Noradrenaline is administered by (a) Subcutaneous injection (b) Intramuscular injection (c) Slow intravenous infusion (d) All of the above routes

Last Answer : Ans: C

Noradrenaline is administered by: A. Subcutaneous injection B. Intramuscular injection C. Slow intravenous infusion D. All of the above routes

Description : Noradrenaline is administered by: A. Subcutaneous injection B. Intramuscular injection C. Slow intravenous infusion D. All of the above routes

Last Answer : C. Slow intravenous infusion

Noradrenaline is administered by: A. Subcutaneous injection B. Intramuscular injection C. Slow intravenous infusion D. All of the above routes

Description : Noradrenaline is administered by: A. Subcutaneous injection B. Intramuscular injection C. Slow intravenous infusion D. All of the above routes

Last Answer : C. Slow intravenous infusion

If the depletion of oxygen is found to be 2.5 mg/litre after incubating 2.5 ml of sewage diluted to 250 ml for 5 days at 20°C, B.O.D. of the sewage is A. 50 mg/l B. 100 mg/l C. 150 mg/l D. 250 mg/l

Description : If the depletion of oxygen is found to be 2.5 mg/litre after incubating 2.5 ml of sewage diluted to 250 ml for 5 days at 20°C, B.O.D. of the sewage is A. 50 mg/l B. 100 mg/l C. 150 mg/l D. 250 mg/l

Last Answer : ANS: D

The preferred route of administration of medication in the most acute care situations is which of the following routes? a) Intravenous The IV route is the preferred parenteral route in most acute care situations because it is much more comfortable for the patient, and peak serum levels and pain relief occur more rapidly and reliably. b) Epidural Epidural administration is used to control postoperative and chronic pain. c) Subcutaneous Subcutaneous administration results in slow absorption of medication. d) Intramuscular Intramuscular administration of medication is absorbed more slowly than intravenously administered medication.

Description : The preferred route of administration of medication in the most acute care situations is which of the following routes? a) Intravenous The IV route is the preferred ... ) Intramuscular Intramuscular administration of medication is absorbed more slowly than intravenously administered medication.

Last Answer : a) Intravenous The IV route is the preferred parenteral route in most acute care situations because it is much more comfortable for the patient, and peak serum levels and pain relief occur more rapidly and reliably.

A patient of liver cirrhosis with ascitis was treated with hydrochlorothiazide 50 mg twice daily. He responded initially, but over a couple of months the diuretic action gradually diminished and ascitis again appeared. Select the measure to reinduce diuresis: A. Increase hydrochlorothiazide dose to 100 mg twice daily B. Add acetazolamide 250 mg twice daily C. Add spironolactone 50 mg thrice daily D. Substitute hydrochlorothiazide by spironolactone 50 mg 6 hourly

Description : A patient of liver cirrhosis with ascitis was treated with hydrochlorothiazide 50 mg twice daily. He responded initially, but over a couple of months the diuretic action gradually diminished ... Add spironolactone 50 mg thrice daily D. Substitute hydrochlorothiazide by spironolactone 50 mg 6 hourly

Last Answer : C. Add spironolactone 50 mg thrice daily

Tests of coagulation are used to monitor anticoagulation treatment and detect intrinsic abnormalities in coagulation. Which of the following statement(s) is/are true concerning coagulation tests? a. Prothrombin time (PT) measures both the intrinsic and extrinsic clotting pathways and fibrinogen b. Activated partial thromboplastin time (aPTT) can be used to monitor both oral anticoagulation with Warfarin and intravenous anticoagulation with heparin c. Thrombin clotting time (TCT) is a measurement of the time it takes for exogenously administered thrombin to turn plasma fibrinogen into fibrin clot d. Whole blood activated clotting time (ACT) is a measurement of the ability of whole blood to clot and is used to monitor heparin levels intraoperatively during cardiovascular and peripheral vascu

Description : Tests of coagulation are used to monitor anticoagulation treatment and detect intrinsic abnormalities in coagulation. Which of the following statement(s) is/are true concerning ... is used to monitor heparin levels intraoperatively during cardiovascular and peripheral vascular operations

Last Answer : Answer: a, c, d Coagulation tests include prothrombin time (PT), which measures the intrinsic and extrinsic pathways of fibrinogen production and is the most common method for ... more while for peripheral vascular applications, values of 250 seconds or greater are considered appropriate

Glyceryl trinitrate is administered by the following routes except: A. Oral B. Sublingual C. Intramuscular D. Intravenous

Description : Glyceryl trinitrate is administered by the following routes except: A. Oral B. Sublingual C. Intramuscular D. Intravenous

Last Answer : C. Intramuscular

The amount of barbaloin present in Aloe vera is (A) <1% (B) 3.5-4% (c) 1-1.5% (D) 2-2.5%

Description : The amount of barbaloin present in Aloe vera is (A)

Last Answer : (B) 3.5-4%

Digitalis toxicity is enhanced by co-administration of (A) Potassium (B) Quinidine (C) Diuretics (D) Antacids

Description : Digitalis toxicity is enhanced by co-administration of (A) Potassium (B) Quinidine (C) Diuretics (D) Antacids

Last Answer : Ans. B & C

How many mL of a 1:500 w/v stock solution should be used to make 5 liters of 1:2000 w/v solution? (A) 750 mL (B) 1000 mL (c) 1250 mL (D) 1500 mL

Description : How many mL of a 1:500 w/v stock solution should be used to make 5 liters of 1:2000 w/v solution? (A) 750 mL (B) 1000 mL (c) 1250 mL (D) 1500 mL

Last Answer : (c) 1250 mL

Select the route of administration which carries the highest risk of adversely affecting vital functions: A. Intra arterial injection B. Intrathecal injection C. Intravenous injection D. Intramuscular injection

Description : Select the route of administration which carries the highest risk of adversely affecting vital functions: A. Intra arterial injection B. Intrathecal injection C. Intravenous injection D. Intramuscular injection

Last Answer : C. Intravenous injection

Select the route of administration which carries the highest risk of adversely affecting vital functions: A. Intra arterial injection B. Intrathecal injection C. Intravenous injection D. Intramuscular injection

Description : Select the route of administration which carries the highest risk of adversely affecting vital functions: A. Intra arterial injection B. Intrathecal injection C. Intravenous injection D. Intramuscular injection

Last Answer : C. Intravenous injection

The following procedure for rapid lowering of BP in hypertensive urgency/emergency has been abandoned: A. Sublingual/oral nifedipine B. Intravenous glyceryl trinitrate infusion C. Intravenous sodium nitroprusside infusion D. Intravenous esmolol injection

Description : The following procedure for rapid lowering of BP in hypertensive urgency/emergency has been abandoned: A. Sublingual/oral nifedipine B. Intravenous glyceryl trinitrate infusion C. Intravenous sodium nitroprusside infusion D. Intravenous esmolol injection

Last Answer : A. Sublingual/oral nifedipine

A patient of acute myocardial infarction being treated in intensive care unit developed left ventricular failure with raised central venous pressure. It was decided to use glyceryl trinitrate. Which route/method of administration would be most suitable: A. Sublingual B. Oral C. Intravenous bolus injection D. Slow intravenous infusion

Description : A patient of acute myocardial infarction being treated in intensive care unit developed left ventricular failure with raised central venous pressure. It was decided to use glyceryl trinitrate. Which route ... suitable: A. Sublingual B. Oral C. Intravenous bolus injection D. Slow intravenous infusion

Last Answer : D. Slow intravenous infusion

X-ray crystallographic analysis of an optically active compound determines its (A) Optical rotatory dispersive power (B) Absolute configuration (C) Relative configuration (D) Optical purity

Description : X-ray crystallographic analysis of an optically active compound determines its (A) Optical rotatory dispersive power (B) Absolute configuration (C) Relative configuration (D) Optical purity

Last Answer : (B) Absolute configuration

One mg of Lycopodium spores used in quantitative microscopy contains an average of (A) 94,000 spores (B) 92,000 spores (C) 90,000 spores (D) 91,000 spores

Description : One mg of Lycopodium spores used in quantitative microscopy contains an average of (A) 94,000 spores (B) 92,000 spores (C) 90,000 spores (D) 91,000 spores

Last Answer : (A) 94,000 spores

6 A patient of chronic bronchial asthma was maintained on oral prednisolone 20 mg/day for 3 months. It was decided to switch him over to inhaled beclomethasone dipropionate 200 μg 4 times a day. What should be done to the oral prednisolone medication after starting inhaled beclomethasone: A. It should be stopped immediately B. Its dose should be tapered from the next day C. It should be given at the same dose for one week and then tapered D. Its dose should be doubled for one week and then tapered (p. 2

Description : 6 A patient of chronic bronchial asthma was maintained on oral prednisolone 20 mg/day for 3 months. It was decided to switch him over to inhaled beclomethasone dipropionate 200 μg 4 times a day. What should ... week and then tapered D. Its dose should be doubled for one week and then tapered (p. 2

Last Answer : C. It should be given at the same dose for one week and then tapered

The normal concentration of potassium in whole blood is (A) 50 mg/100 ml (B) 100 mg/100 ml (C) 150 mg/100 ml (D) 200 mg/100 ml

Description : The normal concentration of potassium in whole blood is (A) 50 mg/100 ml (B) 100 mg/100 ml (C) 150 mg/100 ml (D) 200 mg/100 ml

Last Answer : Answer : D

The normal serum of concentration of copper in mg/100 ml varies between (A) 0–5 (B) 50–100 (C) 100–200 (D) 200–300

Description : The normal serum of concentration of copper in mg/100 ml varies between (A) 0–5 (B) 50–100 (C) 100–200 (D) 200–300

Last Answer : Answer : C

Which of the following statements concerning perioperative nutrition is true concerning the above-described patient? a. Since the patient’s weight had been stable with no preoperative nutritional deficit, 5% dextrose intravenous solutions are adequate for the initial postoperative source of nutrition b. Preoperative immunologic status should be determined including total peripheral lymphocyte count and delayed hypersensitivity reaction to determine skin-test response to common antigens c. Routine postoperative fluid administration with intravenous 5% glucose solutions can provide the calories to meet basal energy requirements d. A jejunal feeding catheter should be placed at the time of surgery for postoperative enteral feeding

Description : Which of the following statements concerning perioperative nutrition is true concerning the above-described patient? a. Since the patient's weight had been stable with no preoperative nutritional deficit ... feeding catheter should be placed at the time of surgery for postoperative enteral feeding

Last Answer : Answer: a Most patients undergoing elective operations are adequately nourished. Unless the patient has suffered significant preoperative malnutrition, characterized by weight loss greater than ... gastrointestinal surgery, this technique would not appear indicated in the patient described above

Thrombolytic therapy has become a useful adjunct in the management of peripheral arterial occlusion. In this setting, direct intraarterial administration rather than intravenous has been advocated to decrease the risk of systemic bleeding. Which of the following true statement(s) concerning the use of thrombolytic agents for arterial occlusion is/are true? a. A standard technique involves infusing high-dose urokinase, 4000 units per minute for 1–2 hours, directly into the clot by a catheter embedded in the thrombus b. If progress is made, further fibrinolytic therapy is given at 1000 to 2000 units per minute until clot lysis has occurred c. The usual infusion time by the above-stated technique is usually in excess of 24 hours d. Successful clot lysis occurs more frequently in arterial graf

Description : Thrombolytic therapy has become a useful adjunct in the management of peripheral arterial occlusion. In this setting, direct intraarterial administration rather than intravenous has been advocated ... may be indicated for situations where complete clot evacuation cannot be accomplished surgically

Last Answer : Answer: a, b, e The most popular method for intraarterial thrombolytic therapy for arterial occlusion involves passing a guidewire through the thrombus with arteriographic guidance and ... acute arterial occlusion) or when distal vasculative is occluded and precludes appropriate inflow patency

Which of the following statements are true of a patient with hyperglycemia and hyponatremia? A. The sodium concentration must be corrected by 5 mEq. per 100 mg. per 100 ml. elevation in blood glucose. B. With normal renal function, this patient is likely to be volume overloaded. C. Proper fluid therapy would be unlikely to include potassium administration. D. Insulin administration will increase the potassium content of cells. E. Early in treatment adequate urine output is a reliable measure of adequate volume resuscitation.

Description : Which of the following statements are true of a patient with hyperglycemia and hyponatremia? A. The sodium concentration must be corrected by 5 mEq. per 100 mg. per 100 ml. elevation in blood ... . E. Early in treatment adequate urine output is a reliable measure of adequate volume resuscitation.

Last Answer : Answer: D DISCUSSION: Each 100-mg. per 100 ml. elevation in blood glucose causes a fall in serum sodium concentration of approximately 2 mEq. per liter. Excess serum glucose ... correction of the patient's associated acidosis produce movement of potassium ions into the intracellular compartment

The temperature condition for storage of drug products under cold temperature is given as : (A) temperature between 8°C and 25°C (B) temperature below 20 C (C) temperature at 0°C (D) temperature between 2c C and S: C

Description : The temperature condition for storage of drug products under cold temperature is given as : (A) temperature between 8°C and 25°C (B) temperature below 20 C (C) temperature at 0°C (D) temperature between 2c C and S: C

Last Answer : (D) temperature between 2c C and S: C

Nicotinic action of acetylcholine is blocked by the drug (A) Atropine (B) Carvedilol (C) Neostigmine ( D ) d-Tubocurarine

Description : Nicotinic action of acetylcholine is blocked by the drug (A) Atropine (B) Carvedilol (C) Neostigmine ( D ) d-Tubocurarine

Last Answer : ( D ) d-Tubocurarine

Measurement of inulin renal clearance is a measure for (A) Effective renal blood flow (B) Renal drug excretion rate (C) Active renal secretion (D) Glomerular filtration rate

Description : Measurement of inulin renal clearance is a measure for (A) Effective renal blood flow (B) Renal drug excretion rate (C) Active renal secretion (D) Glomerular filtration rate

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Which one of the following is a flocculating agent for a negatively charged drug? (A) Aluminium chloride (B) Bentonite (C) Tragacanth (D) Sodium biphosphate

Description : Which one of the following is a flocculating agent for a negatively charged drug? (A) Aluminium chloride (B) Bentonite (C) Tragacanth (D) Sodium biphosphate

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Identify the drug which is NOT used in the treatment of malaria caused by Plasmodium falciparum : (A.) Artemisinin (B) Primaquine (C) Quinine (D) Mefloquine

Description : Identify the drug which is NOT used in the treatment of malaria caused by Plasmodium falciparum : (A.) Artemisinin (B) Primaquine (C) Quinine (D) Mefloquine

Last Answer : (B) Primaquine

In an anaesthetized dog, repeated intravenous injection of ephedrine shows the phenomenon of: A. Anaphylaxis B. Tachyphylaxis C. Idiosyncrasy D. Drug resistance

Description : In an anaesthetized dog, repeated intravenous injection of ephedrine shows the phenomenon of: A. Anaphylaxis B. Tachyphylaxis C. Idiosyncrasy D. Drug resistance

Last Answer : B. Tachyphylaxis

5 A nonvolatile, highly lipid soluble drug is metabolized at a rate of 15% per hour. On intravenous injection it produces general anaesthesia for 10 min. Which process is responsible for termination of its action: A. Metabolism in liver B. Plasma protein binding C. Excretion by kidney D. Redistribution

Description : 5 A nonvolatile, highly lipid soluble drug is metabolized at a rate of 15% per hour. On intravenous injection it produces general anaesthesia for 10 min. Which process is responsible for termination ... : A. Metabolism in liver B. Plasma protein binding C. Excretion by kidney D. Redistribution

Last Answer : D. Redistribution

A nonvolatile, highly lipid soluble drug is metabolized at a rate of 15% per hour. On intravenous injection it produces general anaesthesia for 10 min. Which process is responsible for termination of its action: A. Metabolism in liver B. Plasma protein binding C. Excretion by kidney D. Redistribution

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Last Answer : D. Redistribution