Streptomycin can NOT be given orally for treatment of tuberculosis because
(A) it gets degraded in the GIT (B) it causes severe diarrhoea
(C) it causes metallic taste in the mouth (D) it is not absorbed from the GIT

1 Answer

Answer :

(D) it is not absorbed from the GIT

Related questions

Description : Streptomycin sulfate is not absorbed orally because it is (a) Degraded by gastrointestinal enzymes (b) Destroyed by gastric acid (c) Highly ionized at a wide range of pH values (d) Insoluble in water

Last Answer : Ans: C

Description : Streptomycin sulfate is not absorbed orally because it is: A. Degraded by gastrointestinal enzymes B. Destroyed by gastric acid C. Highly ionized at a wide range of pH values D. Insoluble in water

Last Answer : C. Highly ionized at a wide range of pH values

Description : Ganciclovir is mainly used for the treatment of infection caused by (A) Cytomegalovirus (B) Candida albicans (C) Herpes zoster virus (D) Hepatitis B virus

Last Answer : Ans. A & C

Description : Select the correc: combination of drugs for the treatment of patients suffering from Hepatitis C : (A) Interferon with Ribavirin (B) Interferon with Zidovudine (C) Interferon with Stavudine (D) Interferon with Lamivudine

Last Answer : (B) Interferon with Zidovudine

Description : Identify the drug which is NOT used in the treatment of malaria caused by Plasmodium falciparum : (A.) Artemisinin (B) Primaquine (C) Quinine (D) Mefloquine

Last Answer : (B) Primaquine

Description : Which one of the following drugs is prescribed for the treatment of Philadelphia chromosome positive patients with Chronic myeloid Leukemia? (A) Pentostatin (B) Methotrexate (C) Imatinib (D) L-Asparaginase

Last Answer : (C) Imatinib

Description : Sildenafil is used for treatment of one of the following disorders : (A) Systolic hypertension (B) Unstable angina (C) Pulmonary hypertension (D) Hypertension due to eclampsia

Last Answer : (C) Pulmonary hypertension

Description : The temperature condition for storage of drug products under cold temperature is given as : (A) temperature between 8°C and 25°C (B) temperature below 20 C (C) temperature at 0°C (D) temperature between 2c C and S: C

Last Answer : (D) temperature between 2c C and S: C

Description : The given antibiotic is an example of ansamycins : (A) Roxythromycin (B) Adriamycin (C) Aureomycin (D) Rifamycin

Last Answer : (D) Rifamycin

Description : Compared to older tetracyclines, doxycycline produces a lower incidence of superinfection diarrhoea because (a) It is completely absorbed in the small intestines so that drug concentration in the colonic ... (d) It is a potent tetracycline and inhibits the superinfection causing microbes as well

Last Answer : Ans: A

Description : Compared to older tetracyclines, doxycycline produces a lower incidence of superinfection diarrhoea because: A. It is completely absorbed in the small intestines so that drug concentration in the colonic contents ... the microbes of the normal gut flora D. It is a potent tetracycline and inhibits

Last Answer : A. It is completely absorbed in the small intestines so that drug concentration in the colonic contents is low

Description : Adrenaline is inactive orally because it is: A. Not absorbed from the gastrointestinal tract B. Destroyed by gastric acid C. Completely metabolized in the intestinal mucosa and liver before reaching systemic circulation D. Taken up by adrenergic nerve endings of the intestinal wall, liver and lungs

Last Answer : C. Completely metabolized in the intestinal mucosa and liver before reaching systemic circulation

Description : Neostigmine is preferred over physostigmine for treating myasthenia gravis because: A. It is better absorbed orally B. It has longer duration of action C. It has additional direct agonistic action on nicotinic receptors at the muscle end plate D. It penetrates blood-brain barrier

Last Answer : C. It has additional direct agonistic action on nicotinic receptors at the muscle end plate

Description : Adrenaline is inactive orally because it is: A. Not absorbed from the gastrointestinal tract B. Destroyed by gastric acid C. Completely metabolized in the intestinal mucosa and liver before reaching systemic circulation D. Taken up by adrenergic nerve endings of the intestinal wall, liver and lungs

Last Answer : C. Completely metabolized in the intestinal mucosa and liver before reaching systemic circulation

Description : Neostigmine is preferred over physostigmine for treating myasthenia gravis because: A. It is better absorbed orally B. It has longer duration of action C. It has additional direct agonistic action on nicotinic receptors at the muscle end plate D. It penetrates blood-brain barrier

Last Answer : C. It has additional direct agonistic action on nicotinic receptors at the muscle end plate

Description : Despite having anticonvulsant action, diazepam is not used in the treatment of epilepsy because: A. It is not effective orally B. It causes sedation C. Its anticonvulsant action wanes off with chronic use D. Both ‘B’ and ‘C’ are correct

Last Answer : D. Both ‘B’ and ‘C’ are correct

Description : Which one of the following drugs is most likely to be effective against multidrug – resistant strains of M tuberculosis, including those resistant to streptomycin? (a) Amikacin (b) Clarithromycin (c) Gentamicin (d) Meropenem (e) Spectinomycin

Last Answer : Ans: A

Description : Which of the following is effective against tuberculosis? (1) Penicillin (2) Chloromycetin (3) Terramycin (4) Streptomycin

Last Answer : (4) Streptomycin Explanation: Streptomycin is an antibiotic drug, the first of a class of drugs called amino glycosides to be discovered, and it was the first antibiotic remedy for ... antibiotic. Streptomycin cannot be given orally, but must be administered by regular intramuscular injections.

Description : A patient of pulmonary tuberculosis treated with rifampin + isoniazid + pyrazinamide developed parasthesias, weakness, dizziness, ataxia and depressed tendon reflexes. Which of the following ... with thiacetazone C. Substitute pyrazinamide with ethambutol D. Substitute rifampin with streptomycin

Last Answer : A. Temporarily discontinue isoniazid and add pyridoxine

Description : Gentamicin differs from streptomycin in that: A. It is less nephrotoxic B. It is used for pseudomonas infections C. It is not effective in tuberculosis D. Both ‘B’ and ‘C’ are correct

Last Answer : D. Both ‘B’ and ‘C’ are correct

Description : Which of the following is effective against tuberculosis ? (1) Penicillin (2) Chloromycetin (3) Terramycin (4) Streptomycin

Last Answer : Streptomycin

Description : In which of the following techniques the sample is kept below triple point? (A) Lyophilization (B) Spray drying (C) Spray congealing (D) Centrifugation

Last Answer : (A) Lyophilization

Description : Which one of the following is NOT an ex-officio member of Pharmacy Council of India? (A) The Director General of Health Services (B) The Director of Central Drugs Laboratory (C) The Drugs Controller General of India (D) The Director of Pharmacopoeia Laboratory

Last Answer : (D) The Director of Pharmacopoeia Laboratory

Description : It is required to maintain a therapeutic concentration of 10 microgram/mL for 12 hours of a drug having half life of 1.386 hr and Vd of 5 L. The dose required in a sustained release product will be (A) 600 mg (B) 300 mg (C) 30 mg (D) 60 mg

Last Answer : (B) 300 mg

Description : The Volume of distribution of a drug administered at a dose of 300 mg and exhibiting 30 microgram/mL instantaneous concentration in plasma shall be (A)10 L (B) 100 L (C) 1.0 L (D) 0.10 L

Last Answer : (A)10 L

Description : How many mL of a 1:500 w/v stock solution should be used to make 5 liters of 1:2000 w/v solution? (A) 750 mL (B) 1000 mL (c) 1250 mL (D) 1500 mL

Last Answer : (c) 1250 mL

Description : Class 100 area is referred to (A) Manufacturing area (B) Aseptic area (C) Clean room (D) Ware house

Last Answer : (B) Aseptic area

Description : Geriatric population should be included in the following Phase of clinical trials (A) Phase I (B) Phase II (C) Phase III (D) Phase

Last Answer : (B) Phase II

Description : A drug (200 mg dose) administered in tablet form and as intravenous injection (50 mg dose) showed AUG of 100 and 200 microgram hr/mL, respectively. The absolute availability of the drug through oral administration is : (A) 125% (B) 250 % (C) 12.5% (D) 1.25%

Last Answer : (C) 12.5%

Description : Rabies vaccine (living) is prepared using (A) Sheep blood (B) Mice lymph (C) Horse plasma (D) Fertile eggs

Last Answer : (D) Fertile eggs

Description : In nail polish, following polymer is used as a film-former : (A) Nitrocellulose (B) Polylactic acid (C) Hydroxypropyl methylcellulose (D) Cellulose acetate phthalate

Last Answer : (A) Nitrocellulose

Description : Drugs in suspensions and semi-solid formulations always degrade by (A) first order kinetics (B)second order kinetics (C) zero order kinetics (D) non-linear kinetics

Last Answer : (C) zero order kinetics

Description : The following protein/polypeptide has a quaternary structure : (A) cc-Chymotrypsin (B) Hemoglobin (C) Insulin (D) Myoglobin

Last Answer : (B) Hemoglobin

Description : Many xenobiotics are oxidized by cytochrome P450 in order to (A) increase their biological activity (B) increase their disposition in lipophilic compartments of the body (C) increase their aqueous solubility (D) all of the above

Last Answer : (D) all of the above

Description : Drugs following one compartment open model pharmacokinetics eliminate (A) bi-exponentially (B) tri-exponentially (C) non-exponentially (D) mono-exponentially

Last Answer : (D) mono-exponentially

Description : Coulter counter is used in determination of (A) particle surface area (B) particle size (C) particle volume (D)all of A, B, C

Last Answer : (D)all of A, B, C

Description : Oxidative phosphorylation involves (A) Electron transport system (B) Substrate level phosphorylation (C) Reaction catalyzed by succinic thiokinase in TCA cycle (D) None of the above

Last Answer : (A) Electron transport system

Description : In Gas-Liquid Chromatography, some of the samples need to be derivatized in order to increase their (A) volatility (B) solubility (C)thermal conductivity (D) polarizability

Last Answer : (D) polarizability

Description : Glass transition temperature is detected through (A) X-Ray diffractometery (B) Solution calorimetery (C) Differential scanning calorimetery (D) Thermogravimetric analysis

Last Answer : (C) Differential scanning calorimetery

Description : In organic molecules, fluorescence seldom results from absorption of UV radiation of wavelengths lower than (A) 350 nm (B) 200 nm (C) 300 nm (D) 250 nm

Last Answer : (A) 350 nm

Description : In thiazides following substituent is essential for diuretic activity : (A) Chloro group at position 6 (B) Methyl group at position 2 (C) Sulphamoyl group at position 7 (D) Hydrophobic group at position 3

Last Answer : (C) Sulphamoyl group at position 7

Description : One of the following statements is NOT true : (A) Accuracy expresses the correctness of measurement (B) Precision represents reproducibility of measurement (C) High degree of precision implies high degree of accuracy also (D) High degree of accuracy implies high degree of precesion also

Last Answer : (C) High degree of precision implies high degree of accuracy also

Description : Indicate the HPLC detector that is most sensitive to change in temperature : (A) PDA detector (B) Refractive Index detector (C) Electrochemical detector (D) Fluorescence detector

Last Answer : (B) Refractive Index detector

Description : Artemisinin contains the following group in its structure : (A) an endoperoxide (B) an exoperoxide (C) an epoxide (D) an acid hydrazide

Last Answer : (A) an endoperoxide

Description : Cyclophosphamide as anticancer agent acts as (A) alkylating agent before metabolism (B)alkylating agent after metabolism (C) phosphorylating agent after metabolism (D) DNA intercalating agent

Last Answer : (B)alkylating agent after metabolism

Description : A metabolite obtained from Aspergillus terreus that can bind very tightly to HMG CoA reductase enzyme is (A) Fluvastatin (B) Cerivastatin (C) Lovastatin (D) Somatostatin

Last Answer : (C) Lovastatin

Description : Proton pump inhibitors like omeprazole and lansoprazole contain the following ring system : (A) Pyrimidine (B)Benzimidazole (C) Benzothiazole (D) Oxindole

Last Answer : (B)Benzimidazole

Description : Selective serotonin reuptake inhibitor is (A) Imipramine (B) Iproniazide (C) Fluoxetin (D)Naphazoline

Last Answer : (C) Fluoxetin

Description : Barbiturates with substitution at the following position possess acceptable hypnotic activity : (A) 1,3-Disubstitution (B) 5,5-Disubstitution (C) 1,5-Disubstitution (D) 3,3-Disubstitution

Last Answer : (B) 5,5-Disubstitution