Description : Which of the following statement(s) is/are true concerning the management of a patient with hemophilia A undergoing an elective surgical operation? a. Concentrates of factor VIII should be given ... observed e. A new recombinant preparation of factor VIII offers the advantage of being virus-free
Last Answer : Answer: b, c, e Although the half-life of factor VIII is 2.9 days in normal individuals, the half-life of factor VIII concentrates is 9 to l8 hours. Levels of 80% to ... infection in the hemophilia population. A new recombinant preparation of factor VIII offers the advantage of being virus-free
Description : The abnormal isoenzyme need not (A) Be an oxidoreductase (B) Have any coenzyme (C) Require ATP (D) Be localized intracellularly (E) Be a catalyst
Last Answer : Answer : A
Description : This abnormal metabolite may be responsible for the neurological manifestation of pernicious anemia. (A) Taurine (B) Methyl malonic acid (C) Xanthurenic acid (D) Phenyl pyruvic acid
Last Answer : Answer : B
Description : This abnormal metabolite may be responsible for the neurological manifestation of pernicious anemia: (A) Taurine (B) Methyl malonic acid (C) Xantherunic acid (D) Phenyl pyruvic acid
Description : Abnormal chain of amino acids in sickle cell anaemia is (A) Alpha chain (B) Beta chain (C) Delta chain (D) Gama chain
Description : Abnormal chain of aminoacids in sickle cell anemia is (A) β-chain (B) β-chain (C) γ-chain (D) r-chain
Description : Abnormal chain of amino acids in sickle cells anaemia is (A) Alpha chain (B) Beta chain (C) Gama chain (D) Delta chain
Description : Xanthuric acid is an abnormal metabolite of (A) Xanthine (B) Uric acid (C) Tyrosine (D) Tryptophan
Last Answer : Answer : D
Description : Abnormal collagen structure is seen in all of the following except (A) I-cell disease (B) Osteogenesis imperfecta (C) Menke’s disease (D) Ehlers-Danlos sydrome
Description : An 16-year-old man presents with polyuria and polydipsia. Which of the following may confirm the diagnosis of diabetes mellitus? 1) A random plasma glucose of >7.5 mmol/L 2) A finding of 3+ ketonuria 3) An HbA1c of 7.0% 4) A fasting plasma glucose of 7.5 mmol/L 5) An abnormal glucose tolerance test
Last Answer : Answers-4 The diagnosis is usually relatively easy to confirm in a symptomatic subject. A random glucose of >11.1 mmol/L or a fasting glucose of >7.0 mmol/L would be regarded as ... haemoglobin (HbA1c) is also highly suggestive but not diagnostic. A glucose tolerance test is rarely needed.
Description : Which of the following is a recognised feature of abetalipoproteinaemia? 1) a high serum cholesterol 2) palmar xanthomas 3) advanced atherosclerotic vascular disease 4) abnormal red blood cell morphology 5) severe mental retardation
Last Answer : Answers-4 Acanthocytes are seen in abetalipoproteinaemia. Retinitis pigmentosa is seen in abetalipoproteinaemia. Mental retardation is not present but motor abnormalities and neurodegenerative are seen.
Description : Abnormal transketolase leads to what clinical condition?
Last Answer : The occurrence of Wernickís encephalopathy (seen in alcoholics and in thiamine deficiency) is due to a genetic defect in the enzyme transketolase. It occurs owing to the enzyme having low binding capacity for TPP.
Description : Which of the following is transcribed during repression? (A) Structural gene (B) Promoter gene (C) Regulator gene (D) Operator gene
Last Answer : Answer : C
Description : The region of the Lac operon which must be free from structural gene transcription to occur is (A) The operator locus (B) The promoter site (C) The ‘a’ gene (D) The ‘i’ gene
Description : Which of the following genes of the E.coli “Lac operon” codes for a constitutive protein? (A) The ‘a’ gene (B) The ‘i’ gene (C) The ‘c’ gene (D) The ‘z’ gene
Description : A Gene is (A) A single protein molecule (B) A group of chromosomes (C) An instruction for making a protein molecule (D) A bit of DNA molecule
Description : Cancer cells may become resistant to amethopterin by (A) Developing mechanisms to destroy amethopterin (B) Amplification of dihydrofolate reducatse gene (C) Mutation in the dihydrofolate reductase ... is no longer inhibited by amethopterin (D) Developing alternate pathway of thymidylate synthesis
Description : RB 1 gene is (A) A tumour suppressor gene (B) Oncogene (C) Proto-oncogene (D) Activated proto-oncogene
Description : Amplification of dihydrofolate reductase gene in a cancer cell makes the cell (A) Susceptible to folic acid deficiency (B) Less malignant (C) Resistant to amethopterin therapy (D) Responsive to amethopterin therapy
Description : All the following statements about retino blastoma are true except (A) At least two mutations are required for its development (B) One mutation can be inherited from a parent (C) Children ... mutation develop retinoblastoma at a younger age (D) RB 1 gene promotes the development of retinoblastoma
Description : Retinoblastoma can result from a mutation in (A) ras proto-oncogene (B) erbB proto-oncogene (C) p 53 gene (D) RB 1 gene
Description : P 53 gene: (A) A proto-oncogene (B) An oncogene (C) A tumour suppressor gene (D) None of these
Description : Ras proto-oncogene is converted into oncogene by (A) A point mutation (B) Chromosomal translocation (C) Insertion of a viral promoter upstream of the gene (D) Gene amplification
Description : Marfan’s syndrome results from a mutation in the gene coding: (A) Collagen (B) Elastin (C) Fibrillin (D) Keratin
Description : Transgenic animals may be prepared by introducing a foreign gene into (A) Somatic cells of young animals (B) Testes and ovaries of animals (C) A viral vector and infecting the animals with the viral vector (D) Fertilised egg and implanting the egg into a foster mother
Description : The plasmid pBR322 has (A) Ampicillin resistance gene (B) Tetracycline resistance gene (C) Both (A) and (B) (D) None of these
Description : Trials for gene therapy in human beings were first carried out, with considerable success, in a genetic disease called (A) Cystic fibrosis (B) Thalassemia (C) Adenosine deaminase deficiency (D) Lesch-Nyhan syndrome
Description : For production of eukaryotic protein by recombinant DNA technology in bacteria, the template used is (A) Eukaryotic gene (B) hnRNA (C) mRNA (D) All of these
Description : Mutations in promoter regions of genes can cause (A) Premature termination of translation (B) Change in reading frame of downstream structural gene (C) Decreased efficiency of transcription (D) All of these
Description : Insertion of a base in a gene can cause (A) Change in reading frame (B) Garbled amino acid sequence in the encoded protein (C) Premature termination of translation (D) All of these
Description : The coding sequences in lac operon include (A) i gene (B) i gene, operator locus and promoter (C) z, y and a genes (D) i, z, y and a genes
Description : Lactose or its analogues act as positive regulators of lac operon by (A) Attaching to i gene and preventing its expression (B) Increasing the synthesis of catabolite gene activator protein (C) ... holoenzyme (D) Binding to repressor subunits so that the repressor cannot attach to the operator locus
Description : Binding of RNA polymerase holoenzyme to the promoter region of lac operon is facilitated by (A) Catabolite gene activator protein (CAP) (B) cAMP (C) CAP-cAMP complex (D) None of these
Description : The enzymes encoded by z, y and a genes of lac operon are inducible, and their inducer is (A) Lactose (B) Allo-lactose (C) Catabolite gene activator protein (D) All of these
Description : Transcription of structural genes of lac operon is prevented by binding of the repressor tetramer to (A) i gene (B) Operator locus (C) Promoter (D) z gene
Description : RNA polymerase holoenzyme binds to lac operon at the following site: (A) i gene (B) z gene (C) Operator locus (D) Promoter region
Description : The regulatory i gene of lac operon (A) Is inhibited by lacotse (B) Is inhibited by its own product, the repressor protein (C) Forms a regulatory protein which increases the expression of downstream structural genes (D) Is constitutively expressed
Description : Lac operon is a cluster of (A) Three structural genes (B) Three structural genes and their promoter (C) A regulatory gene, an operator and a promoter (D) A regulatory gene, an operator, a promoter and three structural genes
Description : Amplification of dihydrofolate reductase gene may be brought about by (A) High concentrations of folic acid (B) Deficiency of folic acid (C) Low concentration of thymidylate (D) Amethopterin
Description : Enhancer elements have all the following features except (A) They increase gene expression through a promoter (B) Each enhancer activates a specific promoter (C) They may be located far away from the promoter (D) They may be upstream or downstream from the promoter
Description : Non-coding sequences in a gene are known as (A) Cistrons (B) Nonsense codons (C) Introns (D) Exons
Description : All of the following statements about eukaryotic promoters are true except (A) They may be located upstream or down stream from the structural gene (B) They have two consensus sequences ( ... (D) Mutations in promoter region can decrease the efficiency of transcription of the structural gene
Description : The catabolite repression is mediated by a catabolite gene activator protein (CAP) in conjunction with (A) AMP (B) GMP (C) cAMP (D) Cgmp
Description : To commence structural gene transcription the region which should be free on lac operation is (A) Promoter site (B) Operator locus (C) Y gene (D) A gene
Description : The gene of lac operon which has constitutive expression is (A) i (B) c (C) z (D) p
Description : The gene which is transcribed during repression is (A) Structural (B) Regulator (C) Promoter (D) Operator
Description : The smallest unit of DNA capable of coding for the synthesis of a polypeptide is (A) Operon (B) Repressor gene (C) Cistron (D) Replicon
Description : Binding of growth hormone to its receptor results in increased transcription of (A) c-fos gene (B) c-myc gene (C) p-53 gene (D) None of these
Description : The human insulin gene located on the short arm of chromosome: (A) 11 (B) 17 (C) 18 (D) 20
Description : Which one of the following statements concerning glucose-6-phosphate dehydrogenase deficiency is correct? (A) Young R.B.Cs, particularly reticulocytes, contain the highest enzyme activity cells show less enzyme ... PD gene (D) G-6-PD deficiency is precipitated by ingestion of drugs such as aspirin