A patient of pulmonary tuberculosis treated with rifampin + isoniazid + pyrazinamide developed parasthesias, weakness, dizziness, ataxia and depressed tendon reflexes. Which of the following measures would you recommend: A. Temporarily discontinue isoniazid and add pyridoxine B. Substitute isoniazid with thiacetazone C. Substitute pyrazinamide with ethambutol D. Substitute rifampin with streptomycin

A patient of pulmonary tuberculosis treated with
rifampin + isoniazid + pyrazinamide developed parasthesias, weakness, dizziness, ataxia and depressed tendon reflexes. Which of the following
measures would you recommend:
A. Temporarily discontinue isoniazid and add
pyridoxine
B. Substitute isoniazid with thiacetazone
C. Substitute pyrazinamide with ethambutol
D. Substitute rifampin with streptomycin
by

1 Answer

Answer :

A. Temporarily discontinue isoniazid and add
pyridoxine
by

Related questions

According to the current WHO guidelines, new (untreated) sputum smear positive cases of pulmonary tuberculosis are to be treated with the following regimen: A. Isoniazid + Rifampin + Pyrazinamide for 6 months B. Isoniazid + Thiacetazone + Rifampin for 2 months followed by isoniazid + thiacetazone for 6 months C. Isoniazid + Rifampin for 6 months with additional Pyrazinamide + Ethambutol/Streptomycin during the initial 2 months D. Isoniazid + Rifampin for 6 months with additional Pyrazinamide during the initial 2 months

Description : According to the current WHO guidelines, new (untreated) sputum smear positive cases of pulmonary tuberculosis are to be treated with the following regimen: A. Isoniazid + Rifampin + Pyrazinamide ... D. Isoniazid + Rifampin for 6 months with additional Pyrazinamide during the initial 2 months

Last Answer : C. Isoniazid + Rifampin for 6 months with additional Pyrazinamide + Ethambutol/Streptomycin during the initial 2 months

Addition of pyrazinamide and ethambutol for the first two months to the isoniazid + rifampin therapy of tuberculosis serves the following purpose(s): A. Reduces the total duration of therapy to 6 months B. Produces more rapid sputum conversion C. Permits reduction of rifampin dose D. Both ‘A’ and ‘B’ are correct

Description : Addition of pyrazinamide and ethambutol for the first two months to the isoniazid + rifampin therapy of tuberculosis serves the following purpose(s): A. Reduces the total duration of therapy to 6 months B. ... sputum conversion C. Permits reduction of rifampin dose D. Both A' and B' are correct

Last Answer : D. Both ‘A’ and ‘B’ are correc

ifampin + pyrazinamide for initial 2 months followed by isoniazid + rifampin for another 4 months for the following category of tubercular patients: A. New sputum positive cases of pulmonary tuberculosis B. New sputum negative cases of pulmonary tuberculosis C. Sputum positive patients of pulmonary tuberculosis who have interrupted treatment for more than 2 months D. Tubercular meningitis patients

Description : ifampin + pyrazinamide for initial 2 months followed by isoniazid + rifampin for another 4 months for the following category of tubercular patients: A. New sputum positive cases of ... pulmonary tuberculosis who have interrupted treatment for more than 2 months D. Tubercular meningitis patients

Last Answer : B. New sputum negative cases of pulmonary tuberculosis

Indicate the second line antitubercular drug that is being preferred to supplement ethambutol + streptomycin in case of hepatotoxicity due to isoniazid/ rifampin/pyrazinamide: A. Ethionamide B. Cycloserine C. Ofloxacin D. Capreomycin

Description : Indicate the second line antitubercular drug that is being preferred to supplement ethambutol + streptomycin in case of hepatotoxicity due to isoniazid/ rifampin/pyrazinamide: A. Ethionamide B. Cycloserine C. Ofloxacin D. Capreomycin

Last Answer : C. Ofloxacin

Which first line antitubercular drug is only tuberculostatic and not tuberculocidal: A. Rifampin B. Isoniazid C. Ethambutol D. Pyrazinamide

Description : Which first line antitubercular drug is only tuberculostatic and not tuberculocidal: A. Rifampin B. Isoniazid C. Ethambutol D. Pyrazinamide

Last Answer : C. Ethambutol

The intermittently multiplying (spurter) tubercle bacilli present within caseous material having low oxygen tension are most susceptible to: A. Ethambutol B. Rifampin C. Streptomycin D. Pyrazinamide

Description : The intermittently multiplying (spurter) tubercle bacilli present within caseous material having low oxygen tension are most susceptible to: A. Ethambutol B. Rifampin C. Streptomycin D. Pyrazinamide

Last Answer : B. Rifampin

Under the WHO guidelines for treatment of new cases of tuberculosis, when isoniazid + ethambutol are used in the continuation phase instead of isoniazid + rifampin,, the duration of this phase is: A. 2 months B. 4 months C. 6 months D. 8 month

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Last Answer : C. 6 months

Mycobact. tuberculosis infection in a HIV infected patient is treated with: A. The same antitubercular regimen as HIV negative patient B. Four first line antitubercular drugs for 2 months followed by a longer continuation phase of 7 months with rifampin + isoniazid C. All 5 first line antitubercular drugs for 9 months D. Clarithromycin + Ciprofloxacin + Rifabutin for 12 months

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Last Answer : B. Four first line antitubercular drugs for 2 months followed by a longer continuation phase of 7 months with rifampin + isoniazid

Which of the following antitubercular drugs is not hepatotoxic: A. Isoniazid B. Rifampicin C. Pyrazinamide D. Ethambutol

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A 60-year-old patient presented with anorexia, weakness, paresthesia and mental changes. His tongue was red, tendon reflexes were diminished, haemoglobin was 6 g% with large red cells and neutrophils had hypersegmented nuclei. Endoscopy revealed atrophic gastritis. Deficiency of which factor is likely to be responsible for his condition: A. Folic acid B. Vitamin B12 C. Pyridoxine D. Riboflavin

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First line antitubercular drugs include the following except: A. Ciprofloxacin B. Streptomycin C. Pyrazinamide D. Ethambutol

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In a patient of pulmonary tuberculosis, pyrazinamide is most active on the following subpopulation of tubercle bacilli: A. Rapidly multiplying bacilli located on cavity walls B. Slow growing bacilli within macrophages and at sites showing inflammatory response C. Intermittently multiplying bacilli within caseous material D. Dormant bacilli

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Last Answer : B. Slow growing bacilli within macrophages and at sites showing inflammatory response

Multidrug resistant (MDR) tuberculosis is defined as resistance to: A. Any two or more antitubercular drugs B. Isoniazid + any other antitubercular drug C. Isoniazid + Rifampin + any one or more antitubercular drugs D. All five first line antitubercular drugs

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Last Answer : C. Isoniazid + Rifampin + any one or more antitubercular drugs

The antitubercular action of thiacetazone has the following feature(s): A. It is a low efficacy antitubercular drug B. It is combined with isoniazid to improve anti-tubercular efficacy of the latter C. It is combined with isoniazid to prevent development of resistant infection D. Both ‘A’ and ‘C’ are correc

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In the short course regimen for treatment of tuberculosis, pyrazinamide and ethambutol are used for: A. Initial one month B. Initial two months C. Last two months D. Throughout the course

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Isoniazid and ethambutol are used to treat a. Cholera. b. Influenza. c. MRSA.d. Tuberculosis.

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A patient of liver cirrhosis with ascitis was treated with hydrochlorothiazide 50 mg twice daily. He responded initially, but over a couple of months the diuretic action gradually diminished and ascitis again appeared. Select the measure to reinduce diuresis: A. Increase hydrochlorothiazide dose to 100 mg twice daily B. Add acetazolamide 250 mg twice daily C. Add spironolactone 50 mg thrice daily D. Substitute hydrochlorothiazide by spironolactone 50 mg 6 hourly

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The drugs used to treat Mycobact. avium complex infection in AIDS patients include the following except: A. Isoniazid B. Clarithromycin C. Ethambutol D. Ciprofloxacin

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Last Answer : C. It is active against many atypical mycobacteria

Which of the following terms refers to muscular hypertonicity with increased resistance to stretch? a) Spasticity Spasticity is often associated with weakness, increased deep tendon reflexes, and diminished superficial reflexes.

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Last Answer : a) Spasticity Spasticity is often associated with weakness, increased deep tendon reflexes, and diminished superficial reflexes.

If a multibacillary leprosy patient treated with standard fixed duration multidrug therapy relapses, he should be treated with: A. The same rifampin + dapsone + clofazimine regimen B. Clofazimine + ofloxacin + minocycline C. Clofazimine + ofloxacin + clarithromycin D. Ofloxacin + minocycline + clarithromycin

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Last Answer : . The same rifampin + dapsone + clofazimine regimen

A patient treated with capsule oxytetracycline 500 mg 6 hourly complained of epigastric pain. Which of the following measures will you recommend to counteract the side effect: A. Take the capsules with milk B. Take the capsules with meals C. Take aluminium hydroxide gel 15 minutes before the capsules D. None of the above measures is suitable. Change the antibiotic if pain is distressing

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Last Answer : D. None of the above measures is suitable. Change the antibiotic if pain is distressing

The drug which abolishes the therapeutic effect of levodopa in parkinsonism, but not that of levodopacarbidopa combination is: A. Metoclopramide B. Pyridoxine C. Chlorpromazine D. Isoniazid

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Last Answer : B. Pyridoxine

A patient of megaloblastic anaemia was treated with oral folic acid 5 mg daily. After 2 weeks he reported back with cognitive deficit, sensory disturbance, depressed knee jerk, while blood picture and haemoglobin level were improved. What could be the most likely explanation: A. Folic acid was not adequately absorbed resulting in partial response B. Folate therapy has precipitated vitamin B12 deficiency in the neural tissue C. Folate therapy has unmasked pyridoxine deficiency D. Patient has folate reductase abnormality in the nervous system

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Last Answer : D. Patient has folate reductase abnormality in the nervous system

Occurrence of the following adverse reaction absolutely contraindicates further use of rifampin in the treatment of tuberculosis: A. Respiratory syndrome B. Cutaneous syndrome C. Flu syndrome D. Abdominal syndrome

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Last Answer : A. Respiratory syndrome

A patient of chronic bronchial asthma maintained on oral prednisolone 20 mg daily and inhaled salbutamol as required develops chest infection. Which of the following measures is recommended: A. Stop prednisolone B. Reduce prednisolone dose to 5 mg/day C. No change/increase in prednisolone dose D. Substitute prednisolone with inhaled budesonid

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Gentamicin differs from streptomycin in that: A. It is less nephrotoxic B. It is used for pseudomonas infections C. It is not effective in tuberculosis D. Both ‘B’ and ‘C’ are correct

Description : Gentamicin differs from streptomycin in that: A. It is less nephrotoxic B. It is used for pseudomonas infections C. It is not effective in tuberculosis D. Both ‘B’ and ‘C’ are correct

Last Answer : D. Both ‘B’ and ‘C’ are correct

A woman aged 25 years is diagnosed to be suffering from pulmonary tuberculosis. She is also 8 weeks pregnant. Antitubercular therapy for her should be: A. Started immediately B. Delayed till end of first trimester C. Delayed till end of second trimester D. Delayed till after confinement

Description : A woman aged 25 years is diagnosed to be suffering from pulmonary tuberculosis. She is also 8 weeks pregnant. Antitubercular therapy for her should be: A. Started immediately B. Delayed till end of first trimester C. Delayed till end of second trimester D. Delayed till after confinement

Last Answer : . Started immediately

As per WHO guidelines, treatment of failure or relapse (category II) patients of smear positive pulmonary tuberculosis differs from that of new cases in the following respect(s): A. All 5 first line antitubercular drugs are given in the initial intensive phase B. Duration of intensive phase is increased to 5 months C. Three drugs (HRE) are given in the continuation phase instead of two (HR) D. Both 'A' and 'C'

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Last Answer : D. Both 'A' and 'C'

Heparin is contraindicated in patients suffering from the following diseases except: A. Pulmonary tuberculosis B. Bleeding due to defibrination syndrome C. Subacute bacterial endoc

Description : Heparin is contraindicated in patients suffering from the following diseases except: A. Pulmonary tuberculosis B. Bleeding due to defibrination syndrome C. Subacute bacterial endoc

Last Answer : B. Bleeding due to defibrination syndrome

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Last Answer : B. All three drugs should be stopped or substituted simultaneously

A patient of congestive heart failure was being treated with furosemide and digoxin. He developed urinary tract infection. Which of the following antimicrobials should be avoided: A. Ampicillin B. Gentamicin C. Norfloxacin D. Cotrimoxazole

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Last Answer : B. Gentamicin

A patient of acute myocardial infarction being treated in intensive care unit developed left ventricular failure with raised central venous pressure. It was decided to use glyceryl trinitrate. Which route/method of administration would be most suitable: A. Sublingual B. Oral C. Intravenous bolus injection D. Slow intravenous infusion

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Last Answer : D. Slow intravenous infusion

A patient of chronic renal failure maintained on intermittent haemodialysis has anaemia not responding to iron therapy. Which of the following additional drug is indicated: A. Epoetin B. Cyanocobalamin C. Folic acid D. Pyridoxine

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Last Answer : c. amantadine and acyclovir

In Argyll-Robertson's pupils: a. the pupils are irregular b. iris atrophy are common c. there are absent tendon reflexes d. the lesion is in the mid-brain

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Last Answer : the pupils are irregular

Structural and motor changes related to aging that may be assessed in geriatric patients during an examination of neurologic function include which of the following? a) Decreased or absent deep tendon reflexes Structural and motor changes related to aging that may be assessed in geriatric patients include decreased or absent deep tendon reflexes.

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Isoniazid is a primary antitubercular agent that (a) Requires pyridoxine supplementation (b) May discolor the tears, saliva, urine or feces orange-red (c) Causes ocular complications that are reversible if the drug is discontinued (d) May be ototoxic and nephrotoxic (e) Should never be used due to hepatotoxic potential

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Last Answer : Ans: A

Which of the following is advised when a woman on combined oral contraceptive pill misses a dose: A. Continue with the course without regard to the missed dose B. Take 2 pills the next day and continue with the course C. Take 2 pills everyday for the remaining part of the course D. Discontinue the course and use alternative method of contraception

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An epileptic woman controlled by phenytoin therapy conceives. Which of the following measures is most appropriate: A. Medical termination of pregnancy B. Withdraw phenytoin therapy C. Gradually reduce phenytoin dose to the lowest effective level D. Substitute phenytoin with a combination of carbamazepine and sodium valproate

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A 70-year-old patient presented with weakness, tiredness and muscle cramps. The ECG showed Q-T prolongation, flattening of T wave and occasional A-V block. His serum K+ was low (2.8 mEq/L). He admitted taking a laxative every day for the past several months. Which laxative could be responsible for the above condition: A. Bisacodyl B. Liquid paraffin C. Methylcellulose D. Bran

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Last Answer : A. Bisacodyl

Chemoprophylaxis for tuberculosis is recommended in the following category of subjects except: A. Mantoux positive child in the family of a tuberculosis patient B. All Mantoux positive adult contacts of tubercular patients C. Adult contacts of sputum positive tuberculosis patient who show Mantoux conversion D. HIV positive subjects with a positive Mantoux test

Description : Chemoprophylaxis for tuberculosis is recommended in the following category of subjects except: A. Mantoux positive child in the family of a tuberculosis patient B. All Mantoux positive adult ... tuberculosis patient who show Mantoux conversion D. HIV positive subjects with a positive Mantoux test

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What is true of DOTS strategy for treatment of tuberculosis: A. It consists of an initial intensive phase and a later continuation phase B. The dose of antitubercular drugs is reduced after clinical response occurs C. The patient himself is made responsible for administering antitubercular drugs D. All of the above are correct

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The drug isoniazid is used widely in contemporary medicine to a. Treat tuberculosis. b. Prevent fungal overgrowth in the intestine. c. Clear away wound infections. d. Eliminate infections due to gram-negative bacteria.

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Last Answer : a. Treat tuberculosis.

The characteristic toxicity of ethambutol is: A. Hepatitis B. Visual defects C. Vestibular disturbance D. Renal damage

Description : The characteristic toxicity of ethambutol is: A. Hepatitis B. Visual defects C. Vestibular disturbance D. Renal damage

Last Answer : B. Visual defects