The antianginal effect of propranolol may be attributed to which one of the following (a) Block of exercise – induced tachycardia (b) Decreased end – diastolic ventricular volume (c) Dilation of consticted coronary vessels (d) Increased cardiac force (e) Increased resting heart rate

The antianginal effect of propranolol may be attributed to which one of the following (a) Block of exercise – induced tachycardia (b) Decreased end – diastolic ventricular volume (c) Dilation of consticted coronary vessels (d) Increased cardiac force (e) Increased resting heart rate
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Nitroglycerin, either directly or through reflexes, results in which one of the following effects (a) Decreased heart rate (b) Decreased venous capacitance (c) Increased afterload (d) Increased cardiac force (e) Increased diastolic intramyocardial fiber tension

Description : Nitroglycerin, either directly or through reflexes, results in which one of the following effects (a) Decreased heart rate (b) Decreased venous capacitance (c) Increased afterload (d) Increased cardiac force (e) Increased diastolic intramyocardial fiber tension

Last Answer : Ans: D

The major common determinant of myocardial oxygen consumption is (a) Blood volume (b) Cardiac output (c) Diastolic blood pressure (d) Heart rate (e) Myocardial fiber tension

Description : The major common determinant of myocardial oxygen consumption is (a) Blood volume (b) Cardiac output (c) Diastolic blood pressure (d) Heart rate (e) Myocardial fiber tension

Last Answer : Ans: E

A patient has been taking digoxin for several years for chronic heart failure is about to receive atropine for another condition. A common effect of digoxin (at therapeutic blood levels) that can be almost entirely blocked by atropine is (a) Decreased appetite (b) Increased atrial contractility (c) Increased PR interval on the ECG (d) Headaches (e) Tachycardia

Description : A patient has been taking digoxin for several years for chronic heart failure is about to receive atropine for another condition. A common effect of digoxin (at therapeutic blood levels) that can ... Increased atrial contractility (c) Increased PR interval on the ECG (d) Headaches (e) Tachycardia

Last Answer : Ans: C

Major beneficial effect of nitrates in classical angina is due to (a) Dilation of veins more than arteries (b) Increase in total coronary blood flow (c) An increase in the end diastolic size of the heart (d) An increase in the heart rate

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Last Answer : Ans: A

A friend has very severe hypertension and asks about a drug her doctor wishes to prescribe. Her physician has explained that this drug is associated with tachycardia and fluid retention (which may be marked) and increased hair growth. Which of the following is most likely to produce the effects that your friend has described? (a) Captopril (b) Guanethidine (c) Minoxidil (d) Prazosin (e) Propranolol

Description : A friend has very severe hypertension and asks about a drug her doctor wishes to prescribe. Her physician has explained that this drug is associated with tachycardia and fluid retention (which may be marked ... has described? (a) Captopril (b) Guanethidine (c) Minoxidil (d) Prazosin (e) Propranolol

Last Answer : Ans: C

Which one of the following can be blocked by atropine? (a) Decreased blood pressure caused by hexamethonium (b) Increased blood pressure caused by nicotine (c) Increased skeleton muscle strength caused by neostigmine (d) Tachycardia caused by exercise (e) Tachycardia caused by infusion of acetylcholine

Description : Which one of the following can be blocked by atropine? (a) Decreased blood pressure caused by hexamethonium (b) Increased blood pressure caused by nicotine (c) Increased skeleton muscle ... by neostigmine (d) Tachycardia caused by exercise (e) Tachycardia caused by infusion of acetylcholine

Last Answer : Ans: E

A 16-year-old-girl is found to have paroxysmal attacks of rapid heart rate. The antiarrhythmic of choice in most cases of acute AV nodal tachycardia is (a) Adenosine (b) Amiodarone (c) Flecainide (d) Propranolol (e) Quinidine

Description : A 16-year-old-girl is found to have paroxysmal attacks of rapid heart rate. The antiarrhythmic of choice in most cases of acute AV nodal tachycardia is (a) Adenosine (b) Amiodarone (c) Flecainide (d) Propranolol (e) Quinidine

Last Answer : Ans: A

Full activation of the sympathetic nervous system, as in maximal exercise, can produce all of the following responses except (a) Bronchial relaxation (b) Decreases intestinal motility (c) Increased renal blood flow (d) Mydriasis (e) Increased heart rate (tachycardia)

Description : Full activation of the sympathetic nervous system, as in maximal exercise, can produce all of the following responses except (a) Bronchial relaxation (b) Decreases intestinal motility (c) Increased renal blood flow (d) Mydriasis (e) Increased heart rate (tachycardia)

Last Answer : Ans: C

In a patient given a cardiac glycoside, important effects of the drug on the heart include which of the following? (a) Decreased atrioventricular conduction velocity (b) Decreased ejection time (c) Increased ectopic automaticity (d) Increased ectopic automaticity (e) All of the above

Description : In a patient given a cardiac glycoside, important effects of the drug on the heart include which of the following? (a) Decreased atrioventricular conduction velocity (b) Decreased ejection time (c) Increased ectopic automaticity (d) Increased ectopic automaticity (e) All of the above

Last Answer : Ans: E

Propranolol is useful in all of the following except (a) Angina (b) Familial tremor (c) Hypertension (d) Idiopathic hypertrophic subaortic cardiomyopathy (e) Partial atrioverntricular heart block

Description : Propranolol is useful in all of the following except (a) Angina (b) Familial tremor (c) Hypertension (d) Idiopathic hypertrophic subaortic cardiomyopathy (e) Partial atrioverntricular heart block

Last Answer : Ans: E

Which of the following adrenergic inhibitors acts directly on the blood vessels, producing vasodilation? a) Prazosin hydrochloride (Minipress) Minipress is a peripheral vasodilator acting directly on the blood vessel. It is not used in angina and coronary artery disease, however, because it induces tachycardia if not preceded by administration of propranolol and a diuretic.

Description : Which of the following adrenergic inhibitors acts directly on the blood vessels, producing vasodilation? a) Prazosin hydrochloride (Minipress) Minipress is a peripheral vasodilator acting ... through centrally mediated alpha-adrenergic stimulation in the brain, producing blood pressure reduction.

Last Answer : a) Prazosin hydrochloride (Minipress) Minipress is a peripheral vasodilator acting directly on the blood vessel. It is not used in angina and coronary artery disease, however, because it induces tachycardia if not preceded by administration of propranolol and a diuretic.

Atropine overdose may cause which one of the following (a) Gastrointestinal smooth muscle crampine (b) Increased cardiac rate (c) Increased gastric secretion (d) Pupillary constriction (e) Urinary frequency

Description : Atropine overdose may cause which one of the following (a) Gastrointestinal smooth muscle crampine (b) Increased cardiac rate (c) Increased gastric secretion (d) Pupillary constriction (e) Urinary frequency

Last Answer : Ans: B

Choose the incorrect statement from the following (a) Sympathetic system increases rate of SA node (b) Sympathetic system causes constriction of coronary arteries (c) Sympathetic system causes increased motility of GIT smooth muscles (d) Sympathetic system causes constriction of sphincter in GIT

Description : Choose the incorrect statement from the following (a) Sympathetic system increases rate of SA node (b) Sympathetic system causes constriction of coronary arteries (c) Sympathetic system causes increased motility of GIT smooth muscles (d) Sympathetic system causes constriction of sphincter in GIT

Last Answer : Ans: C

ignocaine is effective in the following cardiac arrhythmia(s): A. Atrial fibrillation B. Paroxysmal supraventricular tachycardia C. Digitalis induced ventricular extrasystoles D. All of the above

Description : ignocaine is effective in the following cardiac arrhythmia(s): A. Atrial fibrillation B. Paroxysmal supraventricular tachycardia C. Digitalis induced ventricular extrasystoles D. All of the above

Last Answer : C. Digitalis induced ventricular extrasystoles

Propranolol does not block the following action of adrenaline (a) Bronchodilation (b) Lipolysis (c) Muscle tremor (d) Mydriasis

Description : Propranolol does not block the following action of adrenaline (a) Bronchodilation (b) Lipolysis (c) Muscle tremor (d) Mydriasis

Last Answer : Ans: D

Your patient is to receive a selective ß2 stimulant drug ß2 selective stimulant are often effective in (a) Angina due to coronary insufficiency (b) Asthma (c) Chronic heart failure (d) Delayed or insufficiently strong labor (e) All of the above

Description : Your patient is to receive a selective ß2 stimulant drug ß2 selective stimulant are often effective in (a) Angina due to coronary insufficiency (b) Asthma (c) Chronic heart failure (d) Delayed or insufficiently strong labor (e) All of the above

Last Answer : Ans: B

When pupillary dilation-but not cycloplegia-is desired, a good choice is (a) Homatropine (b) Isoproterenol (c) Phenylephrine (d) Pilocarpine (e) Tropicamide

Description : When pupillary dilation-but not cycloplegia-is desired, a good choice is (a) Homatropine (b) Isoproterenol (c) Phenylephrine (d) Pilocarpine (e) Tropicamide

Last Answer : Ans: C

All of the following contribute to the antihypertensive action of propranolol except: A. Direct vasodilatation B. Decreased renin release from kidney C. Adaptation of blood vessels to reduced cardiac output D. Less noradrenaline release from sympathetic nerve endings

Description : All of the following contribute to the antihypertensive action of propranolol except: A. Direct vasodilatation B. Decreased renin release from kidney C. Adaptation of blood vessels to reduced cardiac output D. Less noradrenaline release from sympathetic nerve endings

Last Answer : A. Direct vasodilatation

All of the following contribute to the antihypertensive action of propranolol except: A. Direct vasodilatation B. Decreased renin release from kidney C. Adaptation of blood vessels to reduced cardiac output D. Less noradrenaline release from sympathetic nerve endings

Description : All of the following contribute to the antihypertensive action of propranolol except: A. Direct vasodilatation B. Decreased renin release from kidney C. Adaptation of blood vessels to reduced cardiac output D. Less noradrenaline release from sympathetic nerve endings

Last Answer : A. Direct vasodilatation

Infusion of potassium chloride is indicated in digitalis toxicity when the manifestation(s) is/are: A. Vomiting, hyperapnoea and visual disturbance B. Pulsus bigeminus with heart rate 110/min in a patient on maintenance digoxin therapy C. Ventricular tachycardia in a child who has accidentally ingested 10 digoxin tablets D. 2:1 A-V block with occasional ventricular extrasystoles

Description : Infusion of potassium chloride is indicated in digitalis toxicity when the manifestation(s) is/are: A. Vomiting, hyperapnoea and visual disturbance B. Pulsus bigeminus with heart rate 110/min ... accidentally ingested 10 digoxin tablets D. 2:1 A-V block with occasional ventricular extrasystoles

Last Answer : B. Pulsus bigeminus with heart rate 110/min in a patient on maintenance digoxin therapy

Drugs that block the a receptor on effector cells at adrenergic nerve endings (a) Antagonize the effects of isoproterenol on the heart rate (b) Antagonize some of the effects of epinephrine on the blood pressure (c) Antagonize the effects of epinephrine on adenylyl cyclase (d) Cause mydriasis (e) Decreases blood glucose levels

Description : Drugs that block the a receptor on effector cells at adrenergic nerve endings (a) Antagonize the effects of isoproterenol on the heart rate (b) Antagonize some of the effects of epinephrine on ... the effects of epinephrine on adenylyl cyclase (d) Cause mydriasis (e) Decreases blood glucose levels

Last Answer : Ans: B

What would be the heart rate of a person if the cardiac output is 5 L, blood volume in the ventricles at the end of diastole is 100 mL and at the end of ventricular systole is 50 mL ? (a) 125 beats per minute (b) 50 beats per minute (c) 75 beats per minute (d) 100 beats per minute

Description : What would be the heart rate of a person if the cardiac output is 5 L, blood volume in the ventricles at the end of diastole is 100 mL and at the end of ventricular systole is 50 mL ? (a) 125 beats per minute (b) 50 beats per minute (c) 75 beats per minute (d) 100 beats per minute

Last Answer : (d) 100 beats per minute

Which of the following has been shown to prolong life in patient with chronic congestive failure but has a negative inotropic effect on cardiac contractility? (a) Carvedilol (b) Digitoxin (c) Digoxin (d) Dobutamine (e) Enalapril

Description : Which of the following has been shown to prolong life in patient with chronic congestive failure but has a negative inotropic effect on cardiac contractility? (a) Carvedilol (b) Digitoxin (c) Digoxin (d) Dobutamine (e) Enalapril

Last Answer : Ans: A

A 70-year-old man has severe urinary hesitancy associated with benign prostatic hyperplasia. He has tried alpha blockers with little relief. His physician recommends a drug that blocks 5a - reductase in the prostate and writes a prescription for (a) Atropine (b) Clonidine (c) Hydralazine (d) Neostigmine (e) Propranolol

Description : A 70-year-old man has severe urinary hesitancy associated with benign prostatic hyperplasia. He has tried alpha blockers with little relief. His physician recommends a drug that blocks 5a - reductase in ... prescription for (a) Atropine (b) Clonidine (c) Hydralazine (d) Neostigmine (e) Propranolol

Last Answer : Ans: B

A visitor from another city comes to your office complaining of incessant cough. He has diabetes and hypertension and has recently started taking a different antihypertensive medication. The most likely cause of his cough is (a) Enalapril (b) Losartan (c) Minoxidil (d) Propranolol (e) Verapamil

Description : A visitor from another city comes to your office complaining of incessant cough. He has diabetes and hypertension and has recently started taking a different antihypertensive medication. The most likely cause of his cough is (a) Enalapril (b) Losartan (c) Minoxidil (d) Propranolol (e) Verapamil

Last Answer : Ans: A

Digoxin is contraindicated in: A. Angina pectoris patients B. Ventricular tachycardia C. Hypertensive patients D. Complete heart-block

Description : Digoxin is contraindicated in: A. Angina pectoris patients B. Ventricular tachycardia C. Hypertensive patients D. Complete heart-block

Last Answer : B. Ventricular tachycardia

When used as an antiarrhythmic drug, Lidocaine typically (a) Increases action potential duration (b) Increases contractility (c) Increses PR interval (d) Reduces abnormal automaticity (e) Reduces resting potential

Description : When used as an antiarrhythmic drug, Lidocaine typically (a) Increases action potential duration (b) Increases contractility (c) Increses PR interval (d) Reduces abnormal automaticity (e) Reduces resting potential

Last Answer : Ans: D

Dobutamine differs from dopamine in that (a) It does not activate peripheral dopaminergic receptors (b) It does not activate adrenergic ß receptors (c) It causes pronounced tachycardia (d) It has good blood-brain barrier penetrability

Description : Dobutamine differs from dopamine in that (a) It does not activate peripheral dopaminergic receptors (b) It does not activate adrenergic ß receptors (c) It causes pronounced tachycardia (d) It has good blood-brain barrier penetrability

Last Answer : Ans: A

The vessels that supply blood to the heart are (a) vasa vasorum (b) cardiac (c) coronoid (d) coronary

Description : The vessels that supply blood to the heart are (a) vasa vasorum (b) cardiac (c) coronoid (d) coronary

Last Answer : Ans:(a)

Which of the following antianginal drugs is most likely to produce tachycardia as a side effect ? (a) Amlodipine (b) Nifedipine (c) Diltiazem (d) Verapamil

Description : Which of the following antianginal drugs is most likely to produce tachycardia as a side effect ? (a) Amlodipine (b) Nifedipine (c) Diltiazem (d) Verapamil

Last Answer : Ans: B

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Last Answer : B. Nifedipine

A 68-year-old male who underwent a repair of an abdominal aortic aneurysm 5 days ago, develops tachycardia, tachypnea, hypotension with cool, pale, mottled cyanotic extremities. He is agitated and complains of shortness of breath. Which of the following statement(s) is/ are correct concerning his diagnosis and management? a. Myocardial ischemia secondary to preexisting coronary artery disease is most likely the underlying cause of this problem b. Invasive hemodynamic monitoring with a Swan-Gantz catheter will demonstrate a low cardiac output, a high systemic vascular resistance, and elevated cardiac filling pressures c. The use of morphine sulphate and nitrates should be part of the initial management d. The primary pharmacologic treatment involves the use of moderate doses of inotropic ag

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Reserprine, an alkaloid derived from the root of Rauwolfia serpentina (a) Can be used to control hyperglycemia (b) Can cause severe depression of mood (c) Can decrease gastrointestinal secretion and motility (d) Has no cardiac effects (e) A spare receptor agonist

Description : Reserprine, an alkaloid derived from the root of Rauwolfia serpentina (a) Can be used to control hyperglycemia (b) Can cause severe depression of mood (c) Can decrease gastrointestinal secretion and motility (d) Has no cardiac effects (e) A spare receptor agonist

Last Answer : Ans: B

Which of the following effects of epinephrine would be blocked by phentolamine but not by metoprolol ? (a) Cardiac stimulation (b) Contractionof radial smooth muscle in the iris (c) Increase of camp in fat (d) Relaxation of bronchial smooth muscle (e) Relaxation of the uterus

Description : Which of the following effects of epinephrine would be blocked by phentolamine but not by metoprolol ? (a) Cardiac stimulation (b) Contractionof radial smooth muscle in the iris (c) Increase of camp in fat (d) Relaxation of bronchial smooth muscle (e) Relaxation of the uterus

Last Answer : Ans: B

n a failing heart therapeutic dose of digoxin has no effect on the following parameter: A. Cardiac output B. Heart rate C. Tone of ventricular fibres D. Cardiac vagal tone

Description : n a failing heart therapeutic dose of digoxin has no effect on the following parameter: A. Cardiac output B. Heart rate C. Tone of ventricular fibres D. Cardiac vagal tone

Last Answer : C. Tone of ventricular fibres

Which of the following is a perfect match? (1) Coronary attack - vascular dilation (2) Atherosclerosis - blockage of arteries (3) Hypertension - low blood pressure (4) Hypotension - heart attack

Description : Which of the following is a perfect match? (1) Coronary attack - vascular dilation (2) Atherosclerosis - blockage of arteries (3) Hypertension - low blood pressure (4) Hypotension - heart attack

Last Answer : (4) Hypotension - heart attack Explanation: In physiology and medicine, hypotension is abnormally low blood pressure, especially in the arteries of the systemic circulation. Hypotension is the opposite of ... force of blood pushing against the walls of the arteries as the heart pumps out blood.

Which of the following is a perfect match ? (1) Coronary attack – vascular dilation (2) Atherosclerosis – blockage of arteries (3) Hypertension – low blood pressure (4) Hypotension – heart attack

Description : Which of the following is a perfect match ? (1) Coronary attack – vascular dilation (2) Atherosclerosis – blockage of arteries (3) Hypertension – low blood pressure (4) Hypotension – heart attack

Last Answer : Hypotension – heart attack

Typical results of beta-receptor activation include which one of the following? (a) Hypoglycemia (b) Lipolysis (c) Glycogen synthesis (d) Decreased skeletal muscle tremor (e) Decreased rennin secretion

Description : Typical results of beta-receptor activation include which one of the following? (a) Hypoglycemia (b) Lipolysis (c) Glycogen synthesis (d) Decreased skeletal muscle tremor (e) Decreased rennin secretion

Last Answer : Ans: B

The cardiac muscarinic receptors (a) Are of the M1 subtype (b) Are of the M2 subtype (c) Are selectively blocked by pirenzepine (d) Function through the PIP2 ? IP3/DAG pathway

Description : The cardiac muscarinic receptors (a) Are of the M1 subtype (b) Are of the M2 subtype (c) Are selectively blocked by pirenzepine (d) Function through the PIP2 ? IP3/DAG pathway

Last Answer : Ans: B

In a patient of hypertension, the dose of propranolol that normalized blood pressure, reduced resting heart rate to 50/min. Which of the following β blockers will be most suitable for him as an alternative so that heart rate is not markedly reduced: A. Pindolol B. Celiprolol C. Bisoprolol D. Atenolol

Description : In a patient of hypertension, the dose of propranolol that normalized blood pressure, reduced resting heart rate to 50/min. Which of the following β blockers will be most suitable for him as an ... so that heart rate is not markedly reduced: A. Pindolol B. Celiprolol C. Bisoprolol D. Atenolol

Last Answer : A. Pindolol

In a patient of hypertension, the dose of propranolol that normalized blood pressure, reduced resting heart rate to 50/min. Which of the following β blockers will be most suitable for him as an alternative so that heart rate is not markedly reduced: A. Pindolol B. Celiprolol C. Bisoprolol D. Atenolol

Description : In a patient of hypertension, the dose of propranolol that normalized blood pressure, reduced resting heart rate to 50/min. Which of the following β blockers will be most suitable for him as an ... so that heart rate is not markedly reduced: A. Pindolol B. Celiprolol C. Bisoprolol D. Atenolol

Last Answer : A. Pindolol

A patient of CHF was treated with furosemide and digoxin. He became symptom-free and is stable for the last 3 months with resting heart rate 68/min in sinus rhythm but left ventricular ejection fraction is low. Which of the following lines of action is warranted: A. Stop above medication and start an ACE inhibitor B. Continue all medication as before C. Continue the diuretic but stop digoxin D. Continue digoxin but stop the diuretic

Description : A patient of CHF was treated with furosemide and digoxin. He became symptom-free and is stable for the last 3 months with resting heart rate 68/min in sinus rhythm but left ventricular ... medication as before C. Continue the diuretic but stop digoxin D. Continue digoxin but stop the diuretic

Last Answer : A. Stop above medication and start an ACE inhibitor

Shortacting nifedipine formulation is not recommended now for treatment of hypertension because: A. It tends to increase heart rate and cardiac work B. It invokes pronounced reflex sympathetic discharges C. It can impair haemodynamics in patients with diastolic dysfunction D. All of the above

Description : Shortacting nifedipine formulation is not recommended now for treatment of hypertension because: A. It tends to increase heart rate and cardiac work B. It invokes pronounced reflex sympathetic discharges C. It can impair haemodynamics in patients with diastolic dysfunction D. All of the above

Last Answer : D. All of the above

The effect of noradrenaline on the heart include: a. tachycardiac b. increased duration of the cardiac action potential c. decreased potassium conductance of the membranes of pacemaker cells d. increased strength of cardiac contraction

Description : The effect of noradrenaline on the heart include: a. tachycardiac b. increased duration of the cardiac action potential c. decreased potassium conductance of the membranes of pacemaker cells d. increased strength of cardiac contraction

Last Answer : increased strength of cardiac contraction

The most likely mechanism of antihypertensive action of thiazide diuretics in the long-term is: A. Reduction of circulating blood volume B. Reduction in cardiac output C. Decreased sympathetic tone D. Reduction in total peripheral vascular resistance and improved compliance of resistance vessels

Description : The most likely mechanism of antihypertensive action of thiazide diuretics in the long-term is: A. Reduction of circulating blood volume B. Reduction in cardiac output C. Decreased sympathetic tone D. Reduction in total peripheral vascular resistance and improved compliance of resistance vessels

Last Answer : D. Reduction in total peripheral vascular resistance and improved compliance of resistance vessels