Description : A patient has been taking digoxin for several years for chronic heart failure is about to receive atropine for another condition. A common effect of digoxin (at therapeutic blood levels) that can ... Increased atrial contractility (c) Increased PR interval on the ECG (d) Headaches (e) Tachycardia
Last Answer : Ans: C
Description : Which one of the following drugs predictably prolongs the PR interval and increases cardiac contractility? (a) Digoxin (b) Lidocaine (c) Propranolol (d) Quinidine (e) Verapamil
Last Answer : Ans: A
Description : Which of the following is an orally active drug that blocks sodium channels and decreases action potential duration? (a) Adenosine (b) Amiodarone (c) Disopyramide (d) Esmolol (e) Mexiletine
Last Answer : Ans: E
Description : In a patient given a cardiac glycoside, important effects of the drug on the heart include which of the following? (a) Decreased atrioventricular conduction velocity (b) Decreased ejection time (c) Increased ectopic automaticity (d) Increased ectopic automaticity (e) All of the above
Description : Which of the following is the drug of choice in treating suicidal overdose of digitoxin ? (a) Digoxin antibodies (b) Lidocaine (c) Magnesium (d) Potassium (e) Quinidine
Description : Which of the following has been shown to prolong life in patient with chronic congestive failure but has a negative inotropic effect on cardiac contractility? (a) Carvedilol (b) Digitoxin (c) Digoxin (d) Dobutamine (e) Enalapril
Description : Which of the following has the longest half-life of all antiarrhythmic drugs? (a) Adenosine (b) Amiodarone (c) Disopyramide (d) Esmolol (e) Flecainide
Last Answer : Ans: B
Description : A 16-year-old-girl is found to have paroxysmal attacks of rapid heart rate. The antiarrhythmic of choice in most cases of acute AV nodal tachycardia is (a) Adenosine (b) Amiodarone (c) Flecainide (d) Propranolol (e) Quinidine
Description : The following action of digoxin is responsible for beneficial effect in auricular fibrillation: A. Increased myocardial contractility B. Suppression of SA node C. Depression of A-V conduction D. Enhanced Purkinje fibre automaticity
Last Answer : C. Depression of A-V conduction
Description : In the autonomic regulation of blood pressure (a) Cardiac output is maintained constant at the expense of other hemodynamic variables (b) Elevation of blood pressure results in elevated ... the sensitivity of the sensory baroreceptor nerve endings might cause an increase in sympathetic discharge
Last Answer : Ans: D
Description : Ephedrine is similar to adrenaline in the following feature (a) Potency (b) Inability to penetrate blood-brain barrier (c) Duration of action (d) Producing both a and ß adrenergic effects
Description : In cardiac cells, adenosine (a) Causes shortening of action potential duration (b) Depolarization (c) Increase in normal automaticity (d) All of the above
Description : Which of the following drugs depresses automaticity of SA node as well as ectopic foci, abbreviates action potential duration of Purkinje fibres, and slows atrioventricular conduction: A. Propranolol B. Lignocaine C. Procainamide D. Bretylium
Last Answer : A. Propranolol
Description : Lidocaine is the preferred antiarrhythmic for emergency control of cardiac arrhythmias following acute myocardial infarction because (a) It has a rapidly developing and titratable antiarrhythmic action (b) It casues ... efficacy in atrial as well as ventricular arrhythmias (d) Both (a) and (b)
Description : The antianginal effect of propranolol may be attributed to which one of the following (a) Block of exercise – induced tachycardia (b) Decreased end – diastolic ventricular volume (c) Dilation of consticted coronary vessels (d) Increased cardiac force (e) Increased resting heart rate
Description : The most significant feature of the antiarrhythmic action of lignocaine is: A. Suppression of phase-4 depolarization in ventricular ectopic foci B. Prolongation of action potential duration C. Prolongation of effective refractory period D. Depression of membrane responsiveness
Last Answer : A. Suppression of phase-4 depolarization in ventricular ectopic foci
Description : Glycopyrrolate is the preferred antimuscannic drug for use before and during surgery because (a) It is potent and fast acting (b) It has no central action (c) It has antisecretory and vagolytic actions (d) All of the above
Description : Which term is used to describe the ability of the heart to initiate an electrical impulse? a) Automaticity Automaticity is the ability of specialized electrical cells of the cardiac conduction ... the specialized electrical cells of the cardiac conduction system to respond to an electrical impulse.
Last Answer : a) Automaticity Automaticity is the ability of specialized electrical cells of the cardiac conduction system to initiate an electrical impulse.
Description : Which of the following drugs used for the treatment of angina by inhalation has a very rapid onset and a brief duration of effect ? (a) Amyl nitrite (b) Hydralazine (c) Isosorbide mononitrate (d) Nifedipine (e) Nimodipine
Description : A patient receiving a class I antiarrhythmic agent on a chronic basis complains of fatigue, low-grade fever, and joint pain suggestive of systemic lupus erythematosus (SLE). The patient is most likely receiving (a) Lidocaine (b) Procainamide (c) Quinidine (d) Flecainide (e) Propranolol
Description : Choose the antiarrhythmic drug which prolongs action potential, can aggravate atrioventricular block but not heart failure, and has broad spectrum utility in acute as well as chronic, and ventricular as well as supraventricular arrhythmias: A. Quinidine B. Amiodarone C. Mexiletine D. Diltiazem
Last Answer : B. Amiodarone
Description : Procainamide differs from quinidine in the following respect (a) It does not cause paradoxical tachycardia (b) It has no alfa adrenergic blocking activity (c) It has little antivagal action (d) Both (b ... a) Pacemaker function (b) Resting potential (c) Action potential duration (d) All of the above
Description : The electrophysiological effects of digitalis on Purkinje fibres include the following except: A. Enhancement of resting membrane potential B. Decrease in the slope of phase-0 depolarization C. Increase in the rate of phase-4 depolarization D. Abbreviation of action potential duration
Last Answer : A. Enhancement of resting membrane potential
Description : In parkinsonian patients levodopa exerts the following effects except: A. Reduces skeletal muscle contractility B. Decreases muscle tone C. Increases locomotor activity D. Inhibits muscle tremor
Last Answer : A. Reduces skeletal muscle contractility
Description : A 70-year-old man has severe urinary hesitancy associated with benign prostatic hyperplasia. He has tried alpha blockers with little relief. His physician recommends a drug that blocks 5a - reductase in ... prescription for (a) Atropine (b) Clonidine (c) Hydralazine (d) Neostigmine (e) Propranolol
Description : A drug that is useful in glaucoma and high-altitude sickness is (a) Acetazolamide (b) Amiloride (c) Demeclocycline (d) Desmopressin (e) Ethacrynic acid
Description : A 55-year-old patient with severe posthepatitis cirrhosis is started on a diuretic for another condition. Two days later he is found in a coma. The drug most likely to cause coma in a patient with cirrhosis is (a) Acetazolamide (b) Amiloride (c) Furosemide (d) Hydrochlorothiazide (e) Spironolactone
Description : Which of the following is a vasodilator drug used for hypertension that lacks a direct effect on autonomic receptors but may provoke anginal attacks? (a) Amyl nitrite (b) Hydralazine (c) Isosorbide mononitrate (d) Nifedipine (e) Nimodipine
Description : A friend has very severe hypertension and asks about a drug her doctor wishes to prescribe. Her physician has explained that this drug is associated with tachycardia and fluid retention (which may be marked ... has described? (a) Captopril (b) Guanethidine (c) Minoxidil (d) Prazosin (e) Propranolol
Description : Which of the following drugs is the drug of choice in anaphylaxis associated with bronchospasm and hypotension ? (a) Cortisone (b) Epinephrine (c) Isoproterenol (d) Norepinephrine (e) Phenylephrine
Description : Your patient is to receive a selective ß2 stimulant drug ß2 selective stimulant are often effective in (a) Angina due to coronary insufficiency (b) Asthma (c) Chronic heart failure (d) Delayed or insufficiently strong labor (e) All of the above
Description : Characteristics of Vitamin D and its metabolites include which one of the following? (a) Act to decrease serum levels of calcium (b) Activation of their Vitamin D receptors increases cellular CAMP ... Vitamin D increase renal excretion of calcium (e) Vitamin D deficiency results in Pager's disease
Description : Which one of the following is characteristic of captopril and enalapril ? (a) Competitively blocks angiotensim II at its receptor (b) Decreases angiotensin II concentration in the blood (c) Decreases ... and decreases potassium in the blood (e) Decreases sodium and increases potassium in the urine
Description : Cromolyn has as its major action (a) Block of calcium channels in lymphocytes (b) Block of mediator release from mast cells (c) Block of phosphodiesterase in mast cells and basophils (d) Smooth muscle relaxation in the bronchi (e) Stimulation of cortisol release by the adrenals
Description : The biochemical mechanism of action of digitalis is associated with (a) A decrease in calcium uptake by the sarcoplasmic reticulum (b) An increase in ATP synthesis (c) A modification of the actin molecule (d) An increase in systolic intracellular calcium levels (e) A block of sodium/calcium exchange
Description : Which of the following best describes the mechanism of action of scopolamine ? (a) Irreversible antagonist at nicotinic receptors (b) Irreversible antagonist at muscarinic receptors (c) ... receptors (d) Reversible antagonist at muscarinic receptors (e) Reversible antagonist at nicotinic receptors
Description : At rest, the interior of the typical mammalian neuronal axon potential is approximately ________ mV (a) 0 (b) –70 (c) –100 (d) –20
Description : The drug which produces vasoconstriction despite being an a adrenergic blocker is (a) Phenoxybenzamine (b) Ergotamine (c) Dihydroergotoxine (d) Tolazoline
Description : Choose the incorrect statement from the following (a) Sympathetic system increases rate of SA node (b) Sympathetic system causes constriction of coronary arteries (c) Sympathetic system causes increased motility of GIT smooth muscles (d) Sympathetic system causes constriction of sphincter in GIT
Description : Propranolol does not block the following action of adrenaline (a) Bronchodilation (b) Lipolysis (c) Muscle tremor (d) Mydriasis
Description : Which of the following mydriatics has the fastest and briefest action ? (a) Atropine (b) Homatropine (c) Tropicamide (d) Cyclopentolate
Description : Action of norepinephrine and epinephrine are terminated by (a) Reuptake into nerve terminal (b) Dilution by diffusion and uptake at extraneuronal site (c) Metabolic transformation (d) All of the above
Description : Consider the following statements: 1. When a nerve fibre is stimulated, a profound change is produced in the electrical properties of surface membrane and in steady potential. 2. Upon excitation, the resting potentialis suddenly changed. 3. It is due ... 1, 2, 3 (b) 2, 3 (c) 1, 2, 3, 4 (d) 1, 2, 4
Last Answer : Ans:(d)
Description : Following statement is true about lidocaine (a) Reduce the slope of Phase 4 (b) Threshold excitability is not altered (c) Action potential is not affected (d) All of the above
Description : The following antiarrhythmic drug has the most prominent anticholinergic action: A. Disopyramide B. Quinidine C. Procainamide D. Lignocaine
Last Answer : A. Disopyramide
Description : Mechanism by which adrenaline can prolong the duration of local anesthesia a) Decreased permeability of the vascular endothelium b) Precipitation of lidocaine c) Changing the pH of the solution d) Local Vasoconstriction
Last Answer : d) Local Vasoconstriction
Description : Once the project is approved and moves into the planning stage, what happens in the next phase of the project life cycle? Select one: a. Agreements for risk sharing need to be concluded. ... activities. e. A risk response plan can be used to identify increasing levels of detailed risk analysis
Last Answer : d. Risks are identified with each major group of activities.
Description : Drugs that block the a receptor on effector cells at adrenergic nerve endings (a) Antagonize the effects of isoproterenol on the heart rate (b) Antagonize some of the effects of epinephrine on ... the effects of epinephrine on adenylyl cyclase (d) Cause mydriasis (e) Decreases blood glucose levels
Description : A patient is admitted to the emergency room with orthostatic hypotension and evidence of marked GI bleeding. Which of the following most accurately describes the probable autonomic response to this ... constricted pupils, increased bowel sounds (e) Rapid heart rate, constricted pupils, warm skin