The chief metabolite of catecholamines is (A) Metanephrine (B) Normetanephrine (C) 3, 4-Dihydroxymandelic acid (D) Vanillylmandelic acid

The chief metabolite of catecholamines is (A) Metanephrine (B) Normetanephrine (C) 3, 4-Dihydroxymandelic acid (D) Vanillylmandelic acid
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Immediate precursor of epinephrine is (A) Metanephrine (B) Norepinephrine (C) Dopa (D) Dopamine

Description : Immediate precursor of epinephrine is (A) Metanephrine (B) Norepinephrine (C) Dopa (D) Dopamine

Last Answer : Answer : B

Dopamine is synthesised from (A) Dihydroxyphenylalanine (B) Epinephrine (C) Norepinephrine (D) Metanephrine

Description : Dopamine is synthesised from (A) Dihydroxyphenylalanine (B) Epinephrine (C) Norepinephrine (D) Metanephrine

Last Answer : Answer : A

Tyrosine hydroxylase is inhibited by (A) Catecholamines (B) α−Methyldopa (C) Phenylalanine (D) Vanillyl mandelic acid

Description : Tyrosine hydroxylase is inhibited by (A) Catecholamines (B) α−Methyldopa (C) Phenylalanine (D) Vanillyl mandelic acid

Last Answer : Answer : A

An enzyme involved in catabolism of catecholamines is (A) Dopa decarboxylase (B) Aromatic amino acid decarboxylase (C) Monoamine oxidase (D) Catechol oxidas

Description : An enzyme involved in catabolism of catecholamines is (A) Dopa decarboxylase (B) Aromatic amino acid decarboxylase (C) Monoamine oxidase (D) Catechol oxidas

Last Answer : Answer : C

This abnormal metabolite may be responsible for the neurological manifestation of pernicious anemia. (A) Taurine (B) Methyl malonic acid (C) Xanthurenic acid (D) Phenyl pyruvic acid

Description : This abnormal metabolite may be responsible for the neurological manifestation of pernicious anemia. (A) Taurine (B) Methyl malonic acid (C) Xanthurenic acid (D) Phenyl pyruvic acid

Last Answer : Answer : B

This abnormal metabolite may be responsible for the neurological manifestation of pernicious anemia: (A) Taurine (B) Methyl malonic acid (C) Xantherunic acid (D) Phenyl pyruvic acid

Description : This abnormal metabolite may be responsible for the neurological manifestation of pernicious anemia: (A) Taurine (B) Methyl malonic acid (C) Xantherunic acid (D) Phenyl pyruvic acid

Last Answer : Answer : A

Xanthuric acid is an abnormal metabolite of (A) Xanthine (B) Uric acid (C) Tyrosine (D) Tryptophan

Description : Xanthuric acid is an abnormal metabolite of (A) Xanthine (B) Uric acid (C) Tyrosine (D) Tryptophan

Last Answer : Answer : D

All the following statements about serotonin are true except (A) It causes vasolidatation (B) It causes bronchoconstriction (C) It is metabolized by monoamine oxidase (D) Its metabolite is 5-hydroxyindole acetic acid

Description : All the following statements about serotonin are true except (A) It causes vasolidatation (B) It causes bronchoconstriction (C) It is metabolized by monoamine oxidase (D) Its metabolite is 5-hydroxyindole acetic acid

Last Answer : Answer : A

Which of the following metabolite integrates glucose and fatty acid metabolism? (A) Acetyl CoA (B) Pyruvate (C) Citrate (D) Lactate

Description : Which of the following metabolite integrates glucose and fatty acid metabolism? (A) Acetyl CoA (B) Pyruvate (C) Citrate (D) Lactate

Last Answer : A

Secretion of catecholamines is increased in (A) Cushing’s syndrome (B) Addison’s disease (C) Phaeochromocytoma (D) Simmond’s disease

Description : Secretion of catecholamines is increased in (A) Cushing’s syndrome (B) Addison’s disease (C) Phaeochromocytoma (D) Simmond’s disease

Last Answer : Answer : C

Phosphoinositide cascade is activated on binding of catecholamines to (A) α1-Adrenergic receptors (B) α2-Adrenergic receptors (C) β1-Adrenergic receptors (D) β2-Adrenergic receptors

Description : Phosphoinositide cascade is activated on binding of catecholamines to (A) α1-Adrenergic receptors (B) α2-Adrenergic receptors (C) β1-Adrenergic receptors (D) β2-Adrenergic receptors

Last Answer : Answer : A

Binding of catecholamines to α2− adrenergic receptors (A) Increases the intracellular concentration of cAMP (B) Increases the intracellular concentration of cGMP (C) Decreases the intracellular concentration of cAMP (D) Decreases the intracellular concentration of cGMP

Description : Binding of catecholamines to α2− adrenergic receptors (A) Increases the intracellular concentration of cAMP (B) Increases the intracellular concentration of cGMP (C) Decreases the intracellular concentration of cAMP (D) Decreases the intracellular concentration of cGMP

Last Answer : Answer : C

Posterior pituitary gland secretes (A) Catecholamines (B) Oxytocin (C) Follicle stimulating hormone (D) Serotonin

Description : Posterior pituitary gland secretes (A) Catecholamines (B) Oxytocin (C) Follicle stimulating hormone (D) Serotonin

Last Answer : Answer : B

Methyl dopa decreases blood pressure by (A) Inhibiting the synthesis of catecholamines (B) Antagonising the action of aldosterone (C) Stimulating the release of renin (D) Inhibiting the breakdown of angiotensin

Description : Methyl dopa decreases blood pressure by (A) Inhibiting the synthesis of catecholamines (B) Antagonising the action of aldosterone (C) Stimulating the release of renin (D) Inhibiting the breakdown of angiotensin

Last Answer : Answer : A

DOPA is an intermediate in the synthesis of (A) Thyroid hormones (B) Catecholamines (C) Melanin (D) Catecholamines and melanin

Description : DOPA is an intermediate in the synthesis of (A) Thyroid hormones (B) Catecholamines (C) Melanin (D) Catecholamines and melanin

Last Answer : Answer : D

All the following statements about phenylketonuria are correct except (A) Phenylalanine cannot be converted into tyrosine (B) Urinary excretion of phenylpyruvate and phenyllactate is increased (C) It can be controlled by giving a lowphenylalanine diet (D) It leads to decreased synthesis of thyroid hormones, catecholamines and melanin

Description : All the following statements about phenylketonuria are correct except (A) Phenylalanine cannot be converted into tyrosine (B) Urinary excretion of phenylpyruvate and phenyllactate is increased (C) It ... diet (D) It leads to decreased synthesis of thyroid hormones, catecholamines and melanin

Last Answer : Answer : D

The rate limiting step in the biosynthesis of catecholamines is (A) Decarboxylation of dihydroxyphenylalanine (B) Hydroxylation of phenylalanine (C) Hydroxylation of tyrosine (D) Oxidation of dopamine

Description : The rate limiting step in the biosynthesis of catecholamines is (A) Decarboxylation of dihydroxyphenylalanine (B) Hydroxylation of phenylalanine (C) Hydroxylation of tyrosine (D) Oxidation of dopamine

Last Answer : Answer : C

Methylmalonyl CoA is a metabolite of (A) Valine (B) Leucine (C) Isoleucine (D) All of these

Description : Methylmalonyl CoA is a metabolite of (A) Valine (B) Leucine (C) Isoleucine (D) All of these

Last Answer : Answer : A

N-Formiminoglutamate is a metabolite of (A) Glutamate (B) Histidine (C) Tryptophan (D) Methionine

Description : N-Formiminoglutamate is a metabolite of (A) Glutamate (B) Histidine (C) Tryptophan (D) Methionine

Last Answer : Answer : B

The major metabolite of progesterone is (A) Pregnenolone (B) Pregnanediol (C) Estradiol (D) Norethindrone

Description : The major metabolite of progesterone is (A) Pregnenolone (B) Pregnanediol (C) Estradiol (D) Norethindrone

Last Answer : Answer : B

The most potent Vitamin D metabolite is (A) 25-Hydroxycholecalciferol (B) 1,25-Dihydroxycholecalciferol (C) 24, 25-Dihydroxycholecalciferol (D) 7-Dehydrocholesterol

Description : The most potent Vitamin D metabolite is (A) 25-Hydroxycholecalciferol (B) 1,25-Dihydroxycholecalciferol (C) 24, 25-Dihydroxycholecalciferol (D) 7-Dehydrocholesterol

Last Answer : Answer : B

A metabolite which is common to pathways of cholesterol biosynthesis from acetyl-CoA and cholecalciferol formation from cholesterol is (A) Zymosterol (B) Lumisterol (C) Ergosterol (D) 7 Dehydrocholesterol

Description : A metabolite which is common to pathways of cholesterol biosynthesis from acetyl-CoA and cholecalciferol formation from cholesterol is (A) Zymosterol (B) Lumisterol (C) Ergosterol (D) 7 Dehydrocholesterol

Last Answer : Answer : D

At normal levels of creatinine in the blood, this metabolite is (A) Filtered at the glomerulus but not secreted nor reabsorbed by the tubule (B) Secreted by the tubule (C) Reabsorbed by the tubule (D) Secreted and reabsorbed by tubule

Description : At normal levels of creatinine in the blood, this metabolite is (A) Filtered at the glomerulus but not secreted nor reabsorbed by the tubule (B) Secreted by the tubule (C) Reabsorbed by the tubule (D) Secreted and reabsorbed by tubule

Last Answer : Answer : A

The metabolite which sustains urea cycle is (A) Ornithine (B) Citrulline (C) Carbamoyl phosphate (D) n-acetyl glutamate

Description : The metabolite which sustains urea cycle is (A) Ornithine (B) Citrulline (C) Carbamoyl phosphate (D) n-acetyl glutamate

Last Answer : Answer : C

Pentagastrin is a (A) Naturally occurring form of gastrin (B) Inactive metabolite of gastrin (C) Active metabolite of gastrin (D) Synthetic form of gastrin

Description : Pentagastrin is a (A) Naturally occurring form of gastrin (B) Inactive metabolite of gastrin (C) Active metabolite of gastrin (D) Synthetic form of gastrin

Last Answer : Answer : D

What is true of isonicotinic acid hydrazide (INH): A. An active transport mechanism concentrates INH inside sensitive mycobacteria B. Sensitive mycobacteria generate an active metabolite of INH through a catalaseperoxidase enzyme C. The most common mechanism of INH resistance is mutation i

Description : What is true of isonicotinic acid hydrazide (INH): A. An active transport mechanism concentrates INH inside sensitive mycobacteria B. Sensitive mycobacteria generate an active metabolite of INH through a catalaseperoxidase enzyme C. The most common mechanism of INH resistance is mutation i

Last Answer : D. Both 'A' and 'B' are correct

Catecholamines - blood?

Description : Catecholamines - blood?

Last Answer : DefinitionCatecholamines are hormones produced by the adrenal glands, which are found on top of the kidneys. They are released into the blood during times of physical or emotional stress. The major ... the hand. The site is cleaned with germ-killing medicine (antiseptic). The health care provider

Figure shows human urinary system with structures labelled A to D. Select option which correctly identifies them and gives their characteristic and/ or functions. (a) C - Medulla - inner zone of kidney and contains complete nephrons. (b) D - Cortex - outer part of kidney and do not contain any part of nephrons. (c) A - Adrenal gland - located at the anterior part of kidney. Secrete catecholamines which stimulate glycogen breakdown. (d) B - Pelvis - broad funnel shaped space inner to hilum, directly connected to loops of Henle

Description : Figure shows human urinary system with structures labelled A to D. Select option which correctly identifies them and gives their characteristic and/ or functions. (a) C - Medulla - inner zone of ... B - Pelvis - broad funnel shaped space inner to hilum, directly connected to loops of Henle

Last Answer : (c) A - Adrenal gland - located at the anterior part of kidney. Secrete catecholamines which stimulate glycogen breakdown.

The action of histamine that is not mediated through H1 receptors is: A. Release of EDRF from vascular endothelium resulting in vasodilatation B. Direct action on vascular smooth muscle causing vasodilatation C. Bronchoconstriction D. Release of catecholamines from adrenal medulla

Description : The action of histamine that is not mediated through H1 receptors is: A. Release of EDRF from vascular endothelium resulting in vasodilatation B. Direct action on vascular smooth muscle causing vasodilatation C. Bronchoconstriction D. Release of catecholamines from adrenal medulla

Last Answer : B. Direct action on vascular smooth muscle causing vasodilatation

The rate limiting enzyme in the synthesis of catecholamines is: A. Tyrosine hydroxylase B. Dopa decarboxylase C. Dopamine β-hydroxylase D. Noradrenaline N-methyl transferase

Description : The rate limiting enzyme in the synthesis of catecholamines is: A. Tyrosine hydroxylase B. Dopa decarboxylase C. Dopamine β-hydroxylase D. Noradrenaline N-methyl transferase

Last Answer : A. Tyrosine hydroxylase

The action of histamine that is not mediated through H1 receptors is: A. Release of EDRF from vascular endothelium resulting in vasodilatation B. Direct action on vascular smooth muscle causing vasodilatation C. Bronchoconstriction D. Release of catecholamines from adrenal medulla

Description : The action of histamine that is not mediated through H1 receptors is: A. Release of EDRF from vascular endothelium resulting in vasodilatation B. Direct action on vascular smooth muscle causing vasodilatation C. Bronchoconstriction D. Release of catecholamines from adrenal medulla

Last Answer : B. Direct action on vascular smooth muscle causing vasodilatation

The rate limiting enzyme in the synthesis of catecholamines is: A. Tyrosine hydroxylase B. Dopa decarboxylase C. Dopamine β-hydroxylase D. Noradrenaline N-methyl transferase

Description : The rate limiting enzyme in the synthesis of catecholamines is: A. Tyrosine hydroxylase B. Dopa decarboxylase C. Dopamine β-hydroxylase D. Noradrenaline N-methyl transferase

Last Answer : A. Tyrosine hydroxylase

Is rubber a primary metabolite or a secondary metabolite? -Biology

Description : Is rubber a primary metabolite or a secondary metabolite? -Biology

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Which of the following is not an attribute of amlodipine ? (a) High and consistent oral bioavailability (b) Large volume of distribution (c) Generation of an active metabolite (d) Long elimination half-life

Description : Which of the following is not an attribute of amlodipine ? (a) High and consistent oral bioavailability (b) Large volume of distribution (c) Generation of an active metabolite (d) Long elimination half-life

Last Answer : Ans: C

Cefotaxime has the following properties except (a) It is highly active against aerobic gram negative bacteria (b) It is the most active cephalosporin against Pseudomonas aeruginosa (c) It produces an active metabolite (d) It has achieved high cure rates in serious hospital acquired infections

Description : Cefotaxime has the following properties except (a) It is highly active against aerobic gram negative bacteria (b) It is the most active cephalosporin against Pseudomonas aeruginosa (c) It produces an active metabolite (d) It has achieved high cure rates in serious hospital acquired infections

Last Answer : Ans: B

Match the following. (A) Inhibitor of (i) Ricin catalytic activity (B) Possess peptide (ii) Malonate bonds (C) Cell wall material (iii)Chitin in fungi (D) Secondary (iv) Collagen metabolite Choose the correct option from the following: (A) (B) (C) (D) (a) (ii) (iv) (iii) (i) (b) (iii) (i) (iv) (ii) (c) (iii) (iv) (i) (ii) (d) (ii) (iii) (i) (iv)

Description : Match the following. (A) Inhibitor of (i) Ricin catalytic activity (B) Possess peptide (ii) Malonate bonds (C) Cell wall material (iii)Chitin in fungi (D) Secondary (iv) Collagen metabolite Choose the correct option from the following: (A) ... iv) (ii) (c) (iii) (iv) (i) (ii) (d) (ii) (iii) (i) (iv)

Last Answer : (A) Inhibitor of (i) Ricin catalytic activity

A metabolite obtained from Aspergillus terreus that can bind very tightly to HMG CoA reductase enzyme is (A) Fluvastatin (B) Cerivastatin (C) Lovastatin (D) Somatostatin

Description : A metabolite obtained from Aspergillus terreus that can bind very tightly to HMG CoA reductase enzyme is (A) Fluvastatin (B) Cerivastatin (C) Lovastatin (D) Somatostatin

Last Answer : (C) Lovastatin

The most potent Vitamin D metabolite is (A) 25-Hydroxycholecalciferol (B) 1,25-Dihydroxycholecalciferol (C) 24, 25-Dihydroxycholecalciferol (D) 7-Dehydrocholesterol

Description : The most potent Vitamin D metabolite is (A) 25-Hydroxycholecalciferol (B) 1,25-Dihydroxycholecalciferol (C) 24, 25-Dihydroxycholecalciferol (D) 7-Dehydrocholesterol

Last Answer : (B) 1,25-Dihydroxycholecalciferol

Choose the correct statement about famciclovir: A. It is active against acyclovir resistant strains of herpes simplex virus B. It does not need conversion to an active metabolite C. It is used orally to treat genital herpes simplex D. It is the drug of choice for cytomegalovirus retinitis

Description : Choose the correct statement about famciclovir: A. It is active against acyclovir resistant strains of herpes simplex virus B. It does not need conversion to an active metabolite C. It is used orally to treat genital herpes simplex D. It is the drug of choice for cytomegalovirus retinitis

Last Answer : C. It is used orally to treat genital herpes simplex

The high virus selectivity of acyclovir is due to: A. Its preferential uptake by virus infected cells B. Need of virus specific enzyme for its conversion to the active metabolite C. Its action on virus directed reverse transcriptase which does not occur in noninfected cells D. Both ‘A’ and ‘B’ are correct

Description : The high virus selectivity of acyclovir is due to: A. Its preferential uptake by virus infected cells B. Need of virus specific enzyme for its conversion to the active metabolite C. Its action on ... reverse transcriptase which does not occur in noninfected cells D. Both A' and B' are correct

Last Answer : D. Both ‘A’ and ‘B’ are correct

Cefotaxime has the following properties except: A. It is highly active against aerobic gram negative bacteria B. It is the most active cephalosporin against Pseudomonas aeruginosa C. It produces an active metabolite D. It has achieved high cure rates in serious hospital acquired infections

Description : Cefotaxime has the following properties except: A. It is highly active against aerobic gram negative bacteria B. It is the most active cephalosporin against Pseudomonas aeruginosa C. It produces an active metabolite D. It has achieved high cure rates in serious hospital acquired infections

Last Answer : B. It is the most active cephalosporin against Pseudomonas aeruginosa

Which of the following is not an attribute of amlodipine: A. Generation of an active metabolite B. Large volume of distribution C. High and consistent oral bioavailability D. Long elimination half life

Description : Which of the following is not an attribute of amlodipine: A. Generation of an active metabolite B. Large volume of distribution C. High and consistent oral bioavailability D. Long elimination half life

Last Answer : A. Generation of an active metabolit

The following is true of procainamide except: A. It generates an active metabolite in the body B. Its plasma half-life is longer than that of quinidine C. On long-term use, it can cause systemic lupus erythematosus like illness D. It is effective in many cases of ventricular extrasystoles, not responding to lignocaine

Description : The following is true of procainamide except: A. It generates an active metabolite in the body B. Its plasma half-life is longer than that of quinidine C. On long-term use, it ... erythematosus like illness D. It is effective in many cases of ventricular extrasystoles, not responding to lignocaine

Last Answer : A. Disopyramide

Norpethidine produced as a metabolite of pethidine is responsible for the following effect: A. Euphoria B. Excitement C. Analgesia D. Respiratory depression

Description : Norpethidine produced as a metabolite of pethidine is responsible for the following effect: A. Euphoria B. Excitement C. Analgesia D. Respiratory depression

Last Answer : B. Excitement

The following is not true of morphine: A. Its 2-glucuronide metabolite is an active analgesic B. Its active metabolite penetrates blood-brain barrier better than morphine C. Its oral: parenteral activity ratio is 1:4 D. It undergoes enterohepatic cycling

Description : The following is not true of morphine: A. Its 2-glucuronide metabolite is an active analgesic B. Its active metabolite penetrates blood-brain barrier better than morphine C. Its oral: parenteral activity ratio is 1:4 D. It undergoes enterohepatic cycling

Last Answer : B. Its active metabolite penetrates blood-brain barrier better than morphine

In the treatment of parkinsonism, bromocriptine differs from levodopa in the following respects except: A. It does not need conversion to an active metabolite B. It has a longer duration of action C. It activates dopamine D2 receptors, with little/antagonistic action on D1 receptors D. It does not produce behavioral/psychiatric side effect

Description : In the treatment of parkinsonism, bromocriptine differs from levodopa in the following respects except: A. It does not need conversion to an active metabolite B. It has a longer duration of ... with little/antagonistic action on D1 receptors D. It does not produce behavioral/psychiatric side effect

Last Answer : D. It does not produce behavioral/psychiatric side effects

The following statement is not true of carbamazepine: A. It generates an active metabolite B. Its plasma half life decreases to nearly half of the original value after chronic use C. It is being used in mania D. It is not effective in complex partial seizures

Description : The following statement is not true of carbamazepine: A. It generates an active metabolite B. Its plasma half life decreases to nearly half of the original value after chronic use C. It is being used in mania D. It is not effective in complex partial seizures

Last Answer : D. It is not effective in complex partial seizures

Ethanol is used in methanol poisoning because it: A. Antagonises the actions of methanol B. Stimulates the metabolism of methanol and reduces its blood level C. Inhibits the metabolism of methanol and generation of toxic metabolite D. Replenishes the folate stores depleted by methano

Description : Ethanol is used in methanol poisoning because it: A. Antagonises the actions of methanol B. Stimulates the metabolism of methanol and reduces its blood level C. Inhibits the metabolism of methanol and generation of toxic metabolite D. Replenishes the folate stores depleted by methano

Last Answer : C. Inhibits the metabolism of methanol and generation of toxic metabolite

Carbimazole differs from propylthiouracil in that: A. It is dose to dose less potent B. It has a shorter plasma half life C. It does not produce an active metabolite D. It does not inhibit peripheral conversion of thyroxine to triiodothyronine

Description : Carbimazole differs from propylthiouracil in that: A. It is dose to dose less potent B. It has a shorter plasma half life C. It does not produce an active metabolite D. It does not inhibit peripheral conversion of thyroxine to triiodothyronine

Last Answer : D. It does not inhibit peripheral conversion of thyroxine to triiodothyronine

Cells must constantly manage metabolic pathways, and this is often done by balancing specific biochemical reactions within a pathway. For example, the metabolic product of one pathway may block the formation of that specific metabolite at an earlier point in the pathway to prevent a buildup of that specific product. What is this process called?

Description : Cells must constantly manage metabolic pathways, and this is often done by balancing specific biochemical reactions within a pathway. For example, the metabolic product of one pathway may block the formation ... the pathway to prevent a buildup of that specific product. What is this process called?

Last Answer : Feedback inhibition