The following statement is not true of carbamazepine: A. It generates an active metabolite B. Its plasma half life decreases to nearly half of the original value after chronic use C. It is being used in mania D. It is not effective in complex partial seizures

The following statement is not true of carbamazepine:
A. It generates an active metabolite
B. Its plasma half life decreases to nearly half of
the original value after chronic use
C. It is being used in mania
D. It is not effective in complex partial seizures
by

1 Answer

Answer :

D. It is not effective in complex partial seizures
by

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The following is true of procainamide except: A. It generates an active metabolite in the body B. Its plasma half-life is longer than that of quinidine C. On long-term use, it can cause systemic lupus erythematosus like illness D. It is effective in many cases of ventricular extrasystoles, not responding to lignocaine

Description : The following is true of procainamide except: A. It generates an active metabolite in the body B. Its plasma half-life is longer than that of quinidine C. On long-term use, it ... erythematosus like illness D. It is effective in many cases of ventricular extrasystoles, not responding to lignocaine

Last Answer : A. Disopyramide

Carbamazepine possesses the following property not shared by phenytoin: A. Modification of maximal electroshock seizures B. Raising threshold for pentylenetetrazol convulsions C. Suppression of complex partial seizures D. Amelioration of trigeminal neuralgia

Description : Carbamazepine possesses the following property not shared by phenytoin: A. Modification of maximal electroshock seizures B. Raising threshold for pentylenetetrazol convulsions C. Suppression of complex partial seizures D. Amelioration of trigeminal neuralgia

Last Answer : B. Raising threshold for pentylenetetrazol convulsions

he antiepileptic drug which suppresses maximal electroshock as well as kindled seizures, raises pentylenetetrazol threshold and is effective in both generalized tonic-clonic as well as absence seizures is: A. Phenytoin B. Carbamazepine C. Sodium valproate D. Ethosuximide

Description : he antiepileptic drug which suppresses maximal electroshock as well as kindled seizures, raises pentylenetetrazol threshold and is effective in both generalized tonic-clonic as well as absence seizures is: A. Phenytoin B. Carbamazepine C. Sodium valproate D. Ethosuximide

Last Answer : C. Sodium valproate

Carbimazole differs from propylthiouracil in that: A. It is dose to dose less potent B. It has a shorter plasma half life C. It does not produce an active metabolite D. It does not inhibit peripheral conversion of thyroxine to triiodothyronine

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The following drug can be used as an alternative to lithium in mania and bipolar illness: A. Carbamazepine B. Carisoprodol C. Clomipramine D. Diethyl carbamazine

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The following is true of topiramate except: A. It is a broad spectrum antiepileptic drug B. It inhibits the enzyme carbonic anhydrase C. It is used as add-on therapy in refractory partial seizures D. It is not effective in generalized tonic-clonic seizures

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The following drug displaces plasma protein bound phenytoin as well as decreases its metabolism: A. Carbamazepine B. Sodium valproate C. Cimetidine D. Chloramphenicol

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Which of the following is the most suitable drug for a 6-year-old girl suffering from absence seizures with occasional generalized tonic-clonic seizures: A. Ethosuccimide B. Sodium valproate C. Carbamazepine D. Phenytoin

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The following antiepileptic drug raises pentylene tetrazol seizure threshold but does not modify maximal electroshock seizures: A. Ethosuximide B. Carbamazepine C. Primidone D. Phenobarbitone

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The following is not true of the cytochrome P450 isoenzyme CYP2D6: A. It generates the hepatotoxic metabolite N-acetyl benzoquinone immine from paracetamol B. It is involved in demethylation of codeine into morphine C. Its altered form is responsible for poor capacity to hydroxylate many drugs including metoprolol D. It is inhibited by quinidine

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Which of the following is not an attribute of amlodipine: A. Generation of an active metabolite B. Large volume of distribution C. High and consistent oral bioavailability D. Long elimination half life

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Select the factor which indicates that withdrawal of the successfully used antiepileptic medication is likely to result in recurrence of seizures: A. Childhood epilepsy B. Partial seizures C. Treatment started soon after seizure onset D. Absence of EEG abnormality

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Choose the correct statement about famciclovir: A. It is active against acyclovir resistant strains of herpes simplex virus B. It does not need conversion to an active metabolite C. It is used orally to treat genital herpes simplex D. It is the drug of choice for cytomegalovirus retinitis

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N-acetyl cysteine is beneficial in acute paracetamol poisoning because: A. It reacts with paracetamol to form a nontoxic complex B. It inhibits generation of the toxic metabolite of paracetamol C. It is a free radical scavenger D. It replenishes hepatic glutathione which in turn binds the toxic metabolite of paracetamol

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An epileptic woman controlled by phenytoin therapy conceives. Which of the following measures is most appropriate: A. Medical termination of pregnancy B. Withdraw phenytoin therapy C. Gradually reduce phenytoin dose to the lowest effective level D. Substitute phenytoin with a combination of carbamazepine and sodium valproate

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Select the antiepileptic drug that is effective in manicdepressive illness as well: A. Ethosuccimide B. Primidone C. Phenobarbitone D. Carbamazepine

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The high virus selectivity of acyclovir is due to: A. Its preferential uptake by virus infected cells B. Need of virus specific enzyme for its conversion to the active metabolite C. Its action on virus directed reverse transcriptase which does not occur in noninfected cells D. Both ‘A’ and ‘B’ are correct

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Cefotaxime has the following properties except: A. It is highly active against aerobic gram negative bacteria B. It is the most active cephalosporin against Pseudomonas aeruginosa C. It produces an active metabolite D. It has achieved high cure rates in serious hospital acquired infections

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In the treatment of parkinsonism, bromocriptine differs from levodopa in the following respects except: A. It does not need conversion to an active metabolite B. It has a longer duration of action C. It activates dopamine D2 receptors, with little/antagonistic action on D1 receptors D. It does not produce behavioral/psychiatric side effect

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Which of the following is a disease modifying antirheumatic drug whose active metabolite inhibits the enzyme dihydro-orotate dehydrogenase: A. Leflunomide B. Nimesulide C. Sulfasalazine D. Colchicine

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The following is not true of the cytochrome P450 isoenzyme CYP2D6: A. It generates the hepatotoxic metabolite N-acetyl benzoquinone immine from paracetamol B. It is involved in demethylation of codeine into morphine C. Its altered form is responsible for poor capacity to hydroxylate many drugs including metoprolol D. It is inhibited by quinidine

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Last Answer : A. It generates the hepatotoxic metabolite N-acetyl benzoquinone immine from paracetamo

The following statement about lithium is not correct: A. It has a sedative action in normal individuals B. It controls mania, but takes 1–2 weeks to produce the effect C. It has prophylactic effect in recurrent unipolar depression D. It can be combined with tricyclic antidepressants for refractory cases of major depression

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Last Answer : A. It has a sedative action in normal individuals

Roxithromycin has the following advantage(s) over erythromycin: A. It is more effective in whooping cough B. It causes less gastric irritation C. It has longer plasma half-life D. Both 'B' and 'C' are correct

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Last Answer : D. Both 'B' and 'C' are correct

Ceftriaxone has all the following attributes except: A. It has a long plasma half life of 8 hours B. It can cause bleeding by prolonging prothrombin time C. It has attained high cure rates in multiresistant typhoid infection D. It penetrates CSF poorly and therefore not effective in meningitis

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Last Answer : D. It penetrates CSF poorly and therefore not effective in meningitis

The following is true of bupropion except: A. It inhibits dopamine reuptake along with inhibiting noradrenaline reuptake B. It produces sedation as a side effect C. It is being used as an aid for smoking cessation D. It is likely to produce seizures in overdose

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Prazosin is an effective antihypertensive while nonselective α adrenergic blockers are not because: A. It is the only orally active α blocker B. It improves plasma lipid profile C. It does not concurrently enhance noradrenaline release D. It improves urine flow in males with prostatic hypertrophy

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Last Answer : C. It does not concurrently enhance noradrenaline release

Prazosin is an effective antihypertensive while nonselective α adrenergic blockers are not because: A. It is the only orally active α blocker B. It improves plasma lipid profile C. It does not concurrently enhance noradrenaline release D. It improves urine flow in males with prostatic hypertrophy

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Last Answer : C. It does not concurrently enhance noradrenaline release

The following is not true of naltrexone: A. It produces agonistic actions of its own in the absence of morphine B. It is active orally C. It has a long duration of action D. It can reduce craving for alcohol in chronic alcoholics

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Last Answer : A. It produces agonistic actions of its own in the absence of morphin

Which of the following is not an attribute of amlodipine ? (a) High and consistent oral bioavailability (b) Large volume of distribution (c) Generation of an active metabolite (d) Long elimination half-life

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Last Answer : Ans: C

Choose the correct statement about allopurinol: A. It is a purine antimetabolite with antineoplastic activity B. It is a competitive inhibitor of xanthine oxidase C. It is inactive itself, but its metabolite alloxanthine is a competitive inhibitor of xanthine oxidase D. Both allopurinol as well as its metabolite alloxanthine are noncompetitive inhibitors of xanthine oxidase

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Fibrinolytic therapy is based on activation of plasminogen, the inactive proteolytic enzyme of plasma that binds to fibrin during the formation of thrombosis. Activation of plasminogen to plasmin results in selective thrombolysis at the fibrin clot surface. Which of the following statement(s) is/are true concerning agents used in thrombolytic therapy? a. Streptokinase is a bacterial protein which is antigenic in humans, resulting in allergic reactions in up to l5% of cases b. Tissue plasminogen activator acts directly on plasmin without an intermediate drug–plasmin complex c. The half-life of urokinase, streptokinase, and TPA all exceed 30 minutes d. Streptokinase is significantly cheaper than urokinase or TPA

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Last Answer : Answer: a, b, d Streptokinase is a bacterial protein produced by group C b-hemolytic streptococci. It is therefore antigenic in humans and can be associated with allergic reaction in ... one agent over the other. Streptokinase however, is markedly less expensive than either urokinase or TPA

Choose the correct statement about lamotrigine: A. It is a dopaminergic agonist used in parkinsonism B. It acts by blocking NMDA-type of glutamate receptors C. It is a broad spectrum antiepileptic drug D. It suppresses tonic-clonic seizures, but worsens absence seizures

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Last Answer : C. It is a broad spectrum antiepileptic drug

Indications of tricyclic antidepressants include the following except: A. Attention deficit-hyperactive disorder in children B. Mania C. Prophylaxis of migraine D. Panic disorder

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Last Answer : B. Mania

The drug of choice for tropical eosinophilia is: A. Carbamazepine B. Diethyl carbamazine citrate C. Carbetapentane D. Clomiphene citrate

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Last Answer : B. Diethyl carbamazine citrate

Select the antiepileptic drug that in addition is a preferred treatment for post herpetic neuralgia and pain due to diabetic neuropathy: A. Carbamazepine B. Gabapentin C. Lamotrigine D. Primidone

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Last Answer : B. Gabapentin

The drug of choice for trigeminal neuralgia is: A. Aspirin B. Imipramine C. Carbamazepine D. Valproic acid

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Last Answer : C. Carbamazepine

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Last Answer : B. Carbamazepine

Aminoglycoside antibiotics have the following property common to all members: A. They are primarily active against aerobic gram negative bacilli B. They are more active in acidic medium C. They readily enter cells and are distributed in total body water D. They are nearly completely metabolized in liver

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Last Answer : A. They are primarily active against aerobic gram negative bacilli

The following is true of heparin except: A. Sudden stoppage of continuous heparin therapy causes rebound increase in blood coagulability B. High doses of heparin inhibit platelet aggregation C. Heparin is the physiologically active circulating anticoagulant D. Heparin clears lipemic plasma in vivo but not in vitro

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Last Answer : B. Anaemia during pregnancy

The following is an orally active lignocaine congener used for both acute as well as chronic ventricular arrhythmias: A. Mexiletine B. Flecainide C. Moricizine D. Propafenone

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Choose the correct statement about lovastatin: A. It markedly lowers plasma triglyceride with little effect on cholesterol level B. It is used as an adjuvant to gemfibrozil for type III hyperlipoproteinemia C. It is not effective in diabetes associated hypercholesterolemia D. It is a competitive inhibitor of the rate limiting step in cholesterol synthesis

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Last Answer : D. It has intermediate plasma half life so that dose adjustments are possible every 2-3 days and toxicity abates rather rapidly after discontinuatio

Choose the correct statement about the use of propranolol in anxiety: A. Being nonsedative, it is the drug of choice in chronic anxiety states B. It suppresses the psychological component of anxiety C. It suppresses the autonomic manifestations of acutely stressful situations D. Both ‘B’ and ‘C’ are correct

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Description : The following is true of quinine: A. It has a longer elimination half-life than chloroquine B. It is not to be used for prophylaxis of malaria C. It is not active against P. vivax D. It should not be used along with sulfa-pyrimethamine

Last Answer : B. It is not to be used for prophylaxis of malaria

Despite having anticonvulsant action, diazepam is not used in the treatment of epilepsy because: A. It is not effective orally B. It causes sedation C. Its anticonvulsant action wanes off with chronic use D. Both ‘B’ and ‘C’ are correct

Description : Despite having anticonvulsant action, diazepam is not used in the treatment of epilepsy because: A. It is not effective orally B. It causes sedation C. Its anticonvulsant action wanes off with chronic use D. Both ‘B’ and ‘C’ are correct

Last Answer : D. Both ‘B’ and ‘C’ are correct