Description : A very efficient inhibitor of steroid biosynthesis is (A) Aminoglutethimide (B) Aminoimidazole (C) Aminoimidazolesuccinyl carboxamine (D) Aminopterin
Last Answer : Answer : A
Description : Carbonic anhydrase is competitively inhibited by (A) Allopurinol (B) Acetazolamide (C) Aminopterin (D) Neostigmine
Last Answer : Answer : B
Description : A substrate for enzymes of pyrimidine nucleotide biosynthesis is (A) Allopurinol (B) Tetracylin (C) Chloramphenicol (D) Puromycin
Description : Mitochondrial protein synthesis is inhibited by (A) Cycloheximide (B) Chloramphenicol (C) Diptheria toxin (D) None of these
Description : Peptidyl transferase activity of 50 S ribosomal subunits is inhibited by (A) Rifampicin (B) Cycloheximide (C) Chloramphenicol (D) Erythromycin
Last Answer : Answer : C
Description : Binding of formylmehtionyl tRNA to 30 S ribosomal subunit of prokaryotes is inhibited by (A) Streptomycin (B) Chloramphenicol (C) Erythromycin (D) Mitomycin
Description : The enzyme aspartate transcarbamoylase of pyrimidine biosynthesis is inhibited by (A) ATP (B) ADP (C) AMP (D) CTP
Last Answer : Answer : D
Description : Pyrimidine and purine nucleoside biosynthesis share a common precursor: (A) PRPP (B) Glycine (C) Fumarate (D) Alanine
Description : In the biosynthesis of purine nucleotides the AMP feed back regulates (A) Adenylosuccinase (B) Adenylosuccinate synthetase (C) IMP dehydrogenase (D) HGPR Tase
Description : The major determinant of the overall rate of denovo purine nucleotide biosynthesis is the concentration of (A) 5-phosphoribosyl 1-pyrophosphate (B) 5-phospho β-D-ribosylamine (C) Glycinamide ribosyl-5-phosphate (D) Formylglycinamide ribosyl-5-phosphate
Description : In purine biosynthesis ring closure in the molecule formyl glycinamide ribosyl-5- phosphate requires the cofactors: (A) ADP (B) NAD (C) FAD (D) ATP and Mg++
Description : In purine biosynthesis carbon atoms at 4 and 5 position and N at 7 position are contributed by (A) Glycine (B) Glutamine (C) Alanine (D) Threonine
Description : PRPP glutamyl amidotransferase, the first enzyme uniquely committed to purine synthesis is feed back inhibited by (A) AMP (B) IMP (C) XMP (D) CMP
Description : The cyclooxygenase isoenzymes COX-1 and COX-2 differ from each other in that (a) They catalyse different pathways in prostanoid biosynthesis (b) COX–1 is inhibited by aspirin but not COX–2 (c) COX–2 is inhibited by ibuprofen but not COX–1 (d) COX–1 is constitutive while COX–2 is inducible
Last Answer : Ans: D
Description : The cyclooxygenase isoenzymes COX-1 and COX-2 differ from each other in that: A. They catalyse different pathways in prostanoid biosynthesis B. COX-1 is inhibited by aspirin but not COX-2 C. COX-2 is inhibited by ibuprofen but not COX-1 D. COX-1 is constitutive while COX-2 is largely
Last Answer : D. COX-1 is constitutive while COX-2 is largely
Description : pregnant woman with UTI which is the best antibiotics to be given if she has no allergy? nitrofurantoin ampicillin sulfatrimethoprim tetracyclin aminoglycoside
Last Answer : nitrofurantoin
Description : Hybridoma cells are selected by culturing them in a medium containing (A) Adenine, guanine, cytosine and thymine (B) Adenine, guanine, cytosine and uracil (C) Hypoxanthine, aminopterin and thymine (D) Hypoxanthine, aminopterin and thymidine
Description : Amethopterin and aminopterin decrease the synthesis of (A) TMP (B) UMP (C) CMP (D) All of these
Description : The anti-vitamin for para amino benzoic acid is (A) Aminopterin (B) Dicoumarol (C) INH (D) Sulphanomides
Description : An anti-vitamin for folic acid is (A) Aminopterin (B) Dicoumarol (C) Pyrithiamine (D) Isoniazid
Description : The anti-vitamin for para amino benzoic acid is (A) Aminopterin (B) Dicoumasol (C) Sulphanomides (D) Thiopamic acid
Description : The anti vitamin for para aminobenzoic acid is (A) Aminopterin (B) Dicoumarol (C) Sulphonamides (D) Thiopanic acid
Description : Methotrexate blocks the synthesis of thymidine monophosphate by inhibiting the activity of the enzyme: (A) Dihydrofolate reductase (B) Orotate phosphoribosyl transferase (C) Ribonucleotide reductase (D) Dihydroorotase
Description : 5 HIAA test is negative if patient is taking (A) Aspirin (B) Colchicine (C) Phenothiazone (D) Methotrexate
Description : In prokaryotes, chloramphenicol (A) Causes premature release of the polypeptide chain (B) Causes misreading of the mRNA (C) Depolymerises DNA (D) Inhibits peptidyl transferase activity
Description : Can i take aleve for pain when taking methotrexate?
Last Answer : Need answer
Description : Potential adverse effects associated with aspirin include all of the following except (a) Gastrointestinal ulceration (b) Renal dysfunction (c) Enhanced methotrexate toxicity (d) Cardiac arrhythmias (e) Hypersensitivity asthma
Last Answer : Ans: E
Description : Which one of the following drugs is prescribed for the treatment of Philadelphia chromosome positive patients with Chronic myeloid Leukemia? (A) Pentostatin (B) Methotrexate (C) Imatinib (D) L-Asparaginase
Last Answer : (C) Imatinib
Description : -ttt of pyoderma gangrenosum a- sys steroids b- methotrexate ________________
Last Answer : a- sys steroids
Description : Select the drug which is used exclusively in organ transplantation and autoimmune diseases, but not in cancers: A. Cyclophosphamide B. Cyclosporine C. Methotrexate D. 6-Mercaptopurine
Last Answer : B. Cyclosporine
Description : Select the cell cycle nonspecific antineoplastic drug: A. Vincristine B. Bleomycin C. Methotrexate
Last Answer : D. 5-Fluorouracil
Description : Methotrexate has the following attributes except: A. It is cell cycle specific and kills cells in the S phase B. Its toxicity primarily affects bone marrow and epithelial structures C. Folic acid reverses its toxic effects D. It is the drug of choice for choriocarcinoma
Last Answer : C. Folic acid reverses its toxic effects
Description : Among the disease modifying antirheumatic drugs, fastest symptom relief is obtained with: A. Auranofin B. Hydroxychloroquine C. Sulfasalazine D. Methotrexate
Last Answer : D. Methotrexate
Description : Which of the following is a reserve drug but not a disease modifying drug in rheumatoid arthritis: A. Chloroquine B. Sulfasalazine C. Prednisolone D. Methotrexate
Last Answer : C. Prednisolone
Description : Concurrent administration of aspirin interacts unfavourably with the following drugs except: A. Furosemide B. Spironolactone C. Codeine D. Methotrexate
Last Answer : C. Codeine
Description : ___________ drug is usually avoided with breastfeeding. a) Ibuprofen b) propranalol c) Methotrexate d) Naproxe
Last Answer : c) Methotrexate
Description : In the biosynthesis of c-DNA, the joining enzyme ligase requires (A) GTP (B) ATP (C) CTP (D) UTP
Description : A key substance in the committed step of pyrimidines biosynthesis is (A) Ribose-5-phosphate (B) Carbamoyl phosphate (C) ATP (D) Glutamine
Description : What is the subcellular site for the biosynthesis of proteins? (A) Chromosomes (B) Lymosomes (C) Ribosomes (D) Centrosomes
Description : In biosynthesis of proteins the chain terminating codons are (A) UAA, UAG and UGA (B) UGG, UGU and AGU (C) AAU, AAG and GAU (D) GCG, GCA and GCU
Description : An enzyme of pyrimidine nucleotides biosynthesis regulated at the genetic level by apparently coordinate repression and derepression is (A) Carbamoyl phosphate synthetase (B) Dihydroorotate dehydrogenase (C) Thymidine kinase (D) Deoxycytidine kinase
Description : An enzyme of pyrimidine nucleotide biosynthesis sensitive to allosteric regulation is (A) Aspartate transcarbamoylase (B) Dihydroorotase (C) Dihydroorotate dehydrogenase (D) Orotidylic acid decarboxylase
Description : Pyrimidine biosynthesis begins with the formation from glutamine, ATP and CO2, of (A) Carbamoyl aspartate (B) Orotate (C) Carbamoyl phosphate (D) Dihydroorotate
Description : In the biosynthesis of testosterone the rate limiting step is conversion of (A) Cholesterol to pregnenolone (B) Pregnenolone to progesterone (C) Progesterone to 17 α-hydroxy progesterone (D) 17 α-Hydroxy progesterone to androstenedione
Description : The biosynthesis of both Catecholamine and serotonin require (A) Tyrosine hydroxylase (B) N-methyl transferase (C) Aromatic amino acid decarboxylase (D) Tryptophan pyrrolase
Description : For Catecholamine biosynthesis the rate limiting enzyme is (A) DOPA decarboxylase (B) DOPAMINE β-hydroxylase (C) Tyrosine hydroxylase (D) Phenylalanine hydroxylase
Description : In the biosynthesis of cortiol, the sequence of enzymes involved is (A) Hydroxylase–dehydrogenase + isomerase – hydroxylase (B) Dehydrogenase–hydroxylase–isomerase (C) Hydroxylase–lyase–dehydrogenase isomerase (D) Isomerase–lyase–hydroxylase–dehydrogenase
Description : In mammalian liver the rate controlling enzyme in porphyrin biosynthesis is (A) ALA synthase (B) ALA hydratase (C) Uroporphyrinogen I synthase (D) Uroporphyrinogen III cosynthase
Description : In the biosynthesis of heme, condensation between succinyl CoA and glycine requires (A) NAD+ (B) FAD (C) NADH + H+ (D) B6-phosphate
Description : In the biosynthesis of the iron protoporphyrin, the product of the condensation between succinyl-CoA and glycine is (A) α-Amino β-ketoadipic acid (B) δ-Aminolevulinate (C) Hydroxymethylbilane (D) Uroporphyrinogen I