Description : Which of the following classes of antineoplastic agents is cell- cycle-specific? a) Antimetabolites (5-FU) Antimetabolites are cell-cycle-specific (S phase). b) Antitumor antibiotics ( ... agents are cell-cycle nonspecific. d) Nitrosureas (carmustine) Nitrosureas are cell-cycle nonspecific.
Last Answer : a) Antimetabolites (5-FU) Antimetabolites are cell–cycle-specific (S phase).
Description : The following antineoplastic drug is a mitotic inhibitor and causes metaphase arrest: A. Busulfan B. Vincristine C. Cytarabine D. Procarbazine
Last Answer : B. Vincristine
Description : Methotrexate has the following attributes except: A. It is cell cycle specific and kills cells in the S phase B. Its toxicity primarily affects bone marrow and epithelial structures C. Folic acid reverses its toxic effects D. It is the drug of choice for choriocarcinoma
Last Answer : C. Folic acid reverses its toxic effects
Description : An advantage of bleomycin over most antineoplastic drugs is its (a) Rapid onset of action (b) Lack of toxicity to all normal cells (c) Relative lack of bone marrow toxicity (d) Very broad spectrum of activity (e) Both (a) and (b)
Last Answer : Ans: C
Description : Select the drug which is used exclusively in organ transplantation and autoimmune diseases, but not in cancers: A. Cyclophosphamide B. Cyclosporine C. Methotrexate D. 6-Mercaptopurine
Last Answer : B. Cyclosporine
Description : The following anticancer drug has high emetogenic potential: A. Vincristine B. Chlorambucil C. 6-Mercaptopurine D. Cisplatin
Last Answer : D. Cisplatin
Description : Bleomycin is used in most effective drug combination regiment for the chemotherapy of testicular carcinoma. Which one of the following statements about the drug is accurate? (a) Acts mainly in the ... neuropathy occurs in more than 50% of patients (e) Pulmonary infiltrates and fibrosis may occur
Last Answer : Ans: E
Description : Select the antibiotic(s) that can be used to treat nonspecific urethritis due to Chlamydia trachomatis: A. Azithromycin B. Doxycycline C. Clindamycin D. Both 'A' and 'B' are correct
Last Answer : D. Both 'A' and 'B' are correct
Description : The drug, Interleukin-2, is an example of which type of biologic response modifier? a) Cytokine Other cytokines include interferon alfa and filgrastim. b) Monoclonal antibodies Monoclonal ... an example of a retinoid. d) Antimetabolites Antimetabolites are cell cycle-specific antineoplastic agents.
Last Answer : a) Cytokine Other cytokines include interferon alfa and filgrastim.
Description : Which of the following is a reserve drug but not a disease modifying drug in rheumatoid arthritis: A. Chloroquine B. Sulfasalazine C. Prednisolone D. Methotrexate
Last Answer : C. Prednisolone
Description : Vincristine differs from vinblastine in the following respect(s): A. Its prominent adverse effect is neuropathy B. It frequently produces alopecia C. It does not significantly depress bone marrow D. All of the above
Last Answer : D. All of the above
Description : Practically all antineoplastic drugs can produce the following toxic effects except: A. Depression of leucocyte count B. Mucositis C. Cardiomyopathy D. Oligozoospermia
Last Answer : C. Cardiomyopathy
Description : Choose the correct statement about allopurinol: A. It is a purine antimetabolite with antineoplastic activity B. It is a competitive inhibitor of xanthine oxidase C. It is inactive itself ... D. Both allopurinol as well as its metabolite alloxanthine are noncompetitive inhibitors of xanthine oxidase
Last Answer : B. It is a competitive inhibitor of xanthine oxidase
Description : A single oral dose of the following antibiotic is curative in most patients of nonspecific urethritis due to Chlamydia trachomatis: A. Doxycycline B. Azithromycin C. Erythromycin D. Cotrimoxazole
Last Answer : B. Azithromycin
Description : Among the disease modifying antirheumatic drugs, fastest symptom relief is obtained with: A. Auranofin B. Hydroxychloroquine C. Sulfasalazine D. Methotrexate
Last Answer : D. Methotrexate
Description : Concurrent administration of aspirin interacts unfavourably with the following drugs except: A. Furosemide B. Spironolactone C. Codeine D. Methotrexate
Last Answer : C. Codeine
Description : Select the drug that is neither bronchodilator nor antiinflammatory, but has antihistaminic and mast cell stabilizing activity: A. Sodium cromoglycate B. Ketotifen C. Beclomethasone dipropionate D. Chlorpheniramine
Last Answer : B. Ketotifen
Description : Choose the correct statement about topotecan: A. It is a DNA topoisomerase I inhibitor which causes single strand DNA breaks B. It is a cell cycle specific anticancer drug C. It is a COMT-inhibitor used in advanced parkinsonism D. Both 'A' and 'B' are correc
Description : ___________ drug is usually avoided with breastfeeding. a) Ibuprofen b) propranalol c) Methotrexate d) Naproxe
Last Answer : c) Methotrexate
Description : Select the drug that is used orally to treat scabies: A. Permethrin B. Ivermectin C. Praziquantel D. Crotamiton
Last Answer : B. Ivermectin
Description : Select the drug which is active against a variety of diarrhoea producing organisms like Giardia, Shigella, Salmonella as well as S. typhi and Trichomonas vaginalis, but is not a first line treatment for any of these: A. Metronidazole B. Mepacrine C. Cotrimoxazole D. Furazolidone
Last Answer : D. Furazolidone
Description : Select the drug which is used to treat antibiotic associated pseudomembranous enterocolitis and is a component of anti-H.pylori triple drug regimen: A. Amoxicillin B. Vancomycin C. Metronidazole D. Clotrimazole
Last Answer : C. Metronidazole
Description : Select the correct statement about primaquine: A. It has no role in falciparum malaria B. It is used as a gametocidal drug in falciparum malaria C. It is combined with chloroquine to treat resistant P. falciparum infection D. It is used to prevent recrudescence of falciparum malaria
Last Answer : B. It is used as a gametocidal drug in falciparum malaria
Description : An adult male living in nonmalarious area has to visit an area where chloroquine resistant P. falciparum is prevalent. He is intolerant to mefloquine and his G6PD status is unknown. Select the ... you will prescribe for prophylaxis of malaria: A. Primaquine B. Doxycycline C. Amodiaquine D. Quinine
Last Answer : B. Doxycycline
Description : Select the drug which is a causal prophylactic for both falciparum and vivax malaria but is not used as prophylactic on mass scale due to risk of severe reaction in some individuals: A. Mefloquine B. Amodiaquine C. Primaquine D. Pyrimethamine
Last Answer : C. Primaquine
Description : Select the drug which directly inhibits HIV-reverse transcriptase without the need for intracellular activation by phosphorylation: A. Nelfinavir B. Nevirapine C. Stavudine D. Didanosine
Last Answer : B. Nevirapine
Description : Select the drug that acts by inhibiting HIV protease enzyme: A. Zalcitabine B. Efavirenz C. Stavudine D. Nelfinavi
Last Answer : D. Nelfinavir
Description : Select the drug that is active against both HIV and hepatitis B virus: A. Lamivudine B. Indinavir C. Didanosine D. Efavirenz
Last Answer : A. Lamivudine
Description : Select the drug that is fungicidal and acts by inhibiting fungal squalene epoxidase enzyme: A. Ketoconazole B. Terbinafine C. Tolnaftate D. Hamycin
Last Answer : B. Terbinafine
Description : Select the antifungal drug which is administered only by the oral route: A. Amphotericin B B. Ketoconazole C. Griseofulvin D. Tolnaftate
Last Answer : C. Griseofulvin
Description : Select the antibiotic which inhibits drug metabolizing isoenzyme CYP3A4 resulting in potentially fatal drug interaction with terfenadine: A. Erythromycin B. Clindamycin C. Gentamicin D. Vancomycin
Last Answer : A. Erythromycin
Description : Select the antimicrobial drug which is used orally only for urinary tract infection or for bacterial diarrhoeas: A. Nalidixic acid B. Azithromycin C. Bacampicillin D. Pefloxacin
Last Answer : A. Nalidixic acid
Description : Select the sulfonamide drug which is active against Pseudomonas and is used by topical application for prophylaxis of infection in burn cases: A. Sulfadiazine B. Silver sulfadiazine C. Sulfadoxine D. Sulfamethoxazole
Last Answer : B. Silver sulfadiazine
Description : Select the drug combination which does not exhibit supraadditive synergism: A. Nalidixic acid + Nitrofurantoin B. Amoxicillin + Clavulanic acid C. Pyrimethamine + Sulfadoxine D. Sulfamethoxazole + Trimethoprim
Last Answer : A. Nalidixic acid + Nitrofurantoin
Description : Select the drug(s) which afford(s) relief in gastroesophageal reflux by increasing lower esophageal sphincter tone and promoting gastric emptying, but without affecting acidity of gastric contents: A. Sodium alginate B. Metoclopramide C. Cisapride D. Both ‘B’ and ‘C
Last Answer : D. Both ‘B’ and ‘C’
Description : Select the prokinetic-antiemetic drug which at relatively higher doses blocks both dopamine D2 as well as 5-HT3 receptors and enhances acetylcholine release from myenteric neurones: A. Cisapride B. Prochlorperazine C. Metoclopramide D. Domperidon
Last Answer : C. Metoclopramide
Description : Select the drug which is an inhibitor of gastric mucosal proton pump: A. Carbenoxolone sodium B. Sucralfate C. Famotidine D. Lansoprazole
Last Answer : D. Lansoprazole
Description : Select the first line hypolipidemic drug/drugs for treating hypertriglyceridemia in a subject with normal cholesterol level: A. Fibrates B. HMG-CoA reductase inhibitors C. Nicotinic acid D. Both 'A' and 'C' are correc
Last Answer : D. Both 'A' and 'C' are correct
Description : Select the hypolipidemic drug that enhances lipoprotein synthesis, fatty acid oxidation and LDLreceptor expression in liver through paroxisome proliferator-activated receptor α: A. Lovastatin B. Atorvastatin C. Bezafibrate D. Nicotinic acid
Last Answer : C. Bezafibrate
Description : Select the hypocholesterolemic drug which interferes with intestinal absorption of bile salts and cholesterol, and secondarily increases cholesterol turnover in the liver: A. Gemfibrozil B. Cholestyramine C. Lovastatin D. Bezafibrate
Last Answer : B. Cholestyramine
Description : Select the drug which reduces cholesterol synthesis in liver, increases expression of LDL receptors on hepatocytes and has been found to reduce mortality due to coronary artery disease: A. Simvastatin B. Nicotinic acid C. Gemfibrozil D. Colestipol (
Last Answer : A. Simvastatin
Description : Select the most appropriate hypolipidemic drug for a patient with raised LDL-cholesterol level but normal triglyceride level: A. A HMG-CoA reductase inhibitor B. A fibric acid derivative C. Gugulipid D. Nicotinic acid
Last Answer : A. A HMG-CoA reductase inhibitor
Description : Select the fibrinolytic drug(s) that is/are antigenic: A. Streptokinase B. Urokinase C. Alteplase D. Both ‘A’ and ‘B’
Last Answer : A. Streptokinase
Description : Select the correct statement about ethamsylate: A. It checks capillary bleeding B. It inhibits platelet aggregation C. It is an antifibrinolytic drug D. It is used to fibrose bleeding piles
Last Answer : ut ethamsylate: A
Description : A woman in the 28th week of pregnancy has developed pregnancy induced hypertension with a blood pressure reading of 150/100 mm Hg. Select the most appropriate antihypertensive drug for her: A. Furosemide B. Methyldopa C. Propranolol D. Captopril
Last Answer : B. Methyldopa
Description : Select the drug that may improve myocardial tolerance to ischaemia and reduce anginal attacks without altering heart rate, blood pressure or myocardial O2 consumption: A. Trimetazidine B. Nicorandil C. Dipyridamole D. Nicotinic acid
Last Answer : A. Trimetazidine
Description : Select the drug which is a potassium channel opener as well as nitric oxide donor: A. Diazoxide B. Sodium nitroprusside C. Minoxidil D. Nicorandil
Last Answer : D. Nicorandil
Description : Select the drug which can markedly potentiate the vasodilator action of organic nitrates: A. Propranolol B. Fluoxetine C. Hydrochlorothiazide D. Sildenafil
Last Answer : D. Sildenafil
Description : Select the drug which is used by intravenous infusion for emergency control of tachycardia and sudden rise in blood pressure: A. Amiodarone B. Lignocaine C. Esmolol D. Disopyramide
Last Answer : C. Esmolo
Description : Select the drug which is an ‘inodilator’ beneficial in refractory congestive heart failure: A. Nicorandil B. Amiodarone C. Amrinone D. Carvedilol
Last Answer : C. Amrinone