Methotrexate has the following attributes except: A. It is cell cycle specific and kills cells in the S phase B. Its toxicity primarily affects bone marrow and epithelial structures C. Folic acid reverses its toxic effects D. It is the drug of choice for choriocarcinoma

Methotrexate has the following attributes except:
A. It is cell cycle specific and kills cells in the
S phase
B. Its toxicity primarily affects bone marrow
and epithelial structures
C. Folic acid reverses its toxic effects
D. It is the drug of choice for choriocarcinoma
by

1 Answer

Answer :

C. Folic acid reverses its toxic effects
by

Related questions

Cyclosporine has the following attributes except: A. It selectively suppresses humoral immunity without affecting cell mediated immunity B. It is more active as immunosuppressant when administered before antigen exposure than after it C. It is not toxic to the bone marrow D. Its major toxicity is kidney damage

Description : Cyclosporine has the following attributes except: A. It selectively suppresses humoral immunity without affecting cell mediated immunity B. It is more active as immunosuppressant when administered before antigen exposure ... It is not toxic to the bone marrow D. Its major toxicity is kidney damage

Last Answer : A. It selectively suppresses humoral immunity without affecting cell mediated immunity

The most important toxicity of amphotericin B is: A. Nephrotoxicity B. Neurotoxicity C. Hepatotoxicity D. Bone marrow depression

Description : The most important toxicity of amphotericin B is: A. Nephrotoxicity B. Neurotoxicity C. Hepatotoxicity D. Bone marrow depression

Last Answer : A. Nephrotoxicity

Palliation refers to a) relief of symptoms associated with cancer. Palliation is the goal for care in terminal cancer patients. b) hair loss. Alopecia is the term that refers to hair loss. c) the spread of cancer cells from the primary tumor to distant sites. Metastasis is the term that refers to the spread of cancer cells from the primary tumor to distant sites. d) the lowest point of white blood cell depression after therapy that has toxic effects on the bone marrow. Nadir is the term that refers to the lowest point of white blood cell depression after therapy that has toxic effects on the bone marrow.

Description : Palliation refers to a) relief of symptoms associated with cancer. Palliation is the goal for care in terminal cancer patients. b) hair loss. Alopecia is the term that refers to hair loss. c) ... the lowest point of white blood cell depression after therapy that has toxic effects on the bone marrow.

Last Answer : a) relief of symptoms associated with cancer. Palliation is the goal for care in terminal cancer patients.

Potential adverse effects associated with aspirin include all of the following except (a) Gastrointestinal ulceration (b) Renal dysfunction (c) Enhanced methotrexate toxicity (d) Cardiac arrhythmias (e) Hypersensitivity asthma

Description : Potential adverse effects associated with aspirin include all of the following except (a) Gastrointestinal ulceration (b) Renal dysfunction (c) Enhanced methotrexate toxicity (d) Cardiac arrhythmias (e) Hypersensitivity asthma

Last Answer : Ans: E

Select the cell cycle nonspecific antineoplastic drug: A. Vincristine B. Bleomycin C. Methotrexate

Description : Select the cell cycle nonspecific antineoplastic drug: A. Vincristine B. Bleomycin C. Methotrexate

Last Answer : D. 5-Fluorouracil

An advantage of bleomycin over most antineoplastic drugs is its (a) Rapid onset of action (b) Lack of toxicity to all normal cells (c) Relative lack of bone marrow toxicity (d) Very broad spectrum of activity (e) Both (a) and (b)

Description : An advantage of bleomycin over most antineoplastic drugs is its (a) Rapid onset of action (b) Lack of toxicity to all normal cells (c) Relative lack of bone marrow toxicity (d) Very broad spectrum of activity (e) Both (a) and (b)

Last Answer : Ans: C

The following is true of vancomycin except: A. It is a bactericidal antibiotic active primarily against gram positive bacteria B. It acts by inhibiting bacterial protein synthesis C. It is an alternative to penicillin for enterococcal endocarditis D. It can cause deafness as a dose related toxicity

Description : The following is true of vancomycin except: A. It is a bactericidal antibiotic active primarily against gram positive bacteria B. It acts by inhibiting bacterial protein synthesis C. It is an alternative to penicillin for enterococcal endocarditis D. It can cause deafness as a dose related toxicity

Last Answer : B. It acts by inhibiting bacterial protein synthesis

For examination of diatoms sample should collect from (a). Bone marrow (b). Blood (c). Tissue (d). Epithelial cells

Description : For examination of diatoms sample should collect from (a). Bone marrow (b). Blood (c). Tissue (d). Epithelial cells 

Last Answer : Ans: (a). Bone marrow

A hypochromic microcytic anaemia which increases Fe, store in the bone marrow may be (A) Folic acid responsive (B) Vitamin B12 responsive (C) Pyridoxine responsive (D) Vitamin C responsive

Description : A hypochromic microcytic anaemia which increases Fe, store in the bone marrow may be (A) Folic acid responsive (B) Vitamin B12 responsive (C) Pyridoxine responsive (D) Vitamin C responsive

Last Answer : Answer : D

A hypochromic necrocytic anaemia with increase Fe stores in the bone marrow may be (A) Folic acid responsive (B) Vitamin B12 responsive (C) Pyridoxine responsive (D) Vitamin C responsive

Description : A hypochromic necrocytic anaemia with increase Fe stores in the bone marrow may be (A) Folic acid responsive (B) Vitamin B12 responsive (C) Pyridoxine responsive (D) Vitamin C responsive

Last Answer : Answer : C

The following statement is true in relation to ‘drug toxicity’ and ‘poisoning’: A. The two terms are synonymous B. When a toxic effect requires specific treatment, it is called poisoning C. A toxic effect which endangers life by markedly affecting vital functions is called poisoning D. Toxicity is caused by drugs while poisoning is caused by other harmful chemicals

Description : The following statement is true in relation to drug toxicity' and poisoning': A. The two terms are synonymous B. When a toxic effect requires specific treatment, it is called poisoning C. ... is called poisoning D. Toxicity is caused by drugs while poisoning is caused by other harmful chemicals

Last Answer : C. A toxic effect which endangers life by markedly affecting vital functions is called poisoning

The following statement is true in relation to ‘drug toxicity’ and ‘poisoning’: A. The two terms are synonymous B. When a toxic effect requires specific treatment, it is called poisoning C. A toxic effect which endangers life by markedly affecting vital functions is called poisoning D. Toxicity is caused by drugs while poisoning is caused by other harmful chemicals

Description : The following statement is true in relation to drug toxicity' and poisoning': A. The two terms are synonymous B. When a toxic effect requires specific treatment, it is called poisoning C. ... is called poisoning D. Toxicity is caused by drugs while poisoning is caused by other harmful chemicals

Last Answer : C. A toxic effect which endangers life by markedly affecting vital functions is called poisoning

Select the drug which is used exclusively in organ transplantation and autoimmune diseases, but not in cancers: A. Cyclophosphamide B. Cyclosporine C. Methotrexate D. 6-Mercaptopurine

Description : Select the drug which is used exclusively in organ transplantation and autoimmune diseases, but not in cancers: A. Cyclophosphamide B. Cyclosporine C. Methotrexate D. 6-Mercaptopurine

Last Answer : B. Cyclosporine

Which of the following is a reserve drug but not a disease modifying drug in rheumatoid arthritis: A. Chloroquine B. Sulfasalazine C. Prednisolone D. Methotrexate

Description : Which of the following is a reserve drug but not a disease modifying drug in rheumatoid arthritis: A. Chloroquine B. Sulfasalazine C. Prednisolone D. Methotrexate

Last Answer : C. Prednisolone

Concurrent administration of aspirin interacts unfavourably with the following drugs except: A. Furosemide B. Spironolactone C. Codeine D. Methotrexate

Description : Concurrent administration of aspirin interacts unfavourably with the following drugs except: A. Furosemide B. Spironolactone C. Codeine D. Methotrexate

Last Answer : C. Codeine

Vincristine differs from vinblastine in the following respect(s): A. Its prominent adverse effect is neuropathy B. It frequently produces alopecia C. It does not significantly depress bone marrow D. All of the above

Description : Vincristine differs from vinblastine in the following respect(s): A. Its prominent adverse effect is neuropathy B. It frequently produces alopecia C. It does not significantly depress bone marrow D. All of the above

Last Answer : D. All of the above

The following does not apply to cancer chemotherapy: A. Each treatment with a cytotoxic drug kills a constant number of malignant cells B. Drugs are generally used at maximum tolerated doses C. The same regimen which is palliative for a large solid tumour may be curative after surgical removal of the tumour D. Combination regimens using several drugs in succession are superior to single drug used continuously

Description : The following does not apply to cancer chemotherapy: A. Each treatment with a cytotoxic drug kills a constant number of malignant cells B. Drugs are generally used at maximum tolerated ... D. Combination regimens using several drugs in succession are superior to single drug used continuously

Last Answer : A. Each treatment with a cytotoxic drug kills a constant number of malignant cells

Neostigmine reverses the following actions of d-tubocurarine except: A. Motor weakness B. Ganglionic blockade C. Histamine release D. Respiratory paralysis

Description : Neostigmine reverses the following actions of d-tubocurarine except: A. Motor weakness B. Ganglionic blockade C. Histamine release D. Respiratory paralysis

Last Answer : C. Histamine release

A patient of chronic renal failure maintained on intermittent haemodialysis has anaemia not responding to iron therapy. Which of the following additional drug is indicated: A. Epoetin B. Cyanocobalamin C. Folic acid D. Pyridoxine

Description : A patient of chronic renal failure maintained on intermittent haemodialysis has anaemia not responding to iron therapy. Which of the following additional drug is indicated: A. Epoetin B. Cyanocobalamin C. Folic acid D. Pyridoxine

Last Answer : A. Epoetin

That sulfonamides act by inhibiting folate synthesis in bacteria is supported by the following findings except: A. Paraaminobenzoic acid antagonises the action of sulfonamides B. Methionine antagonises the action of sulfonamides C. Purines and thymidine present in pus antagonise the action of sulfonamides D. Bacteria that utilise folic acid taken up from the medium are insensitive to sulfonamides

Description : That sulfonamides act by inhibiting folate synthesis in bacteria is supported by the following findings except: A. Paraaminobenzoic acid antagonises the action of sulfonamides B. Methionine antagonises ... . Bacteria that utilise folic acid taken up from the medium are insensitive to sulfonamides

Last Answer : B. Methionine antagonises the action of sulfonamides

Which of the following neoplastic diseases is almost curable by chemotherapy: A. Bronchogenic carcinoma B. Choriocarcinoma C. Malignant melanoma D. Colorectal carcinoma

Description : Which of the following neoplastic diseases is almost curable by chemotherapy: A. Bronchogenic carcinoma B. Choriocarcinoma C. Malignant melanoma D. Colorectal carcinoma

Last Answer : B. Choriocarcinoma

Clavulanic acid is combined with amoxicillin because: A. It kills bacteria that are not killed by amoxicillin B. It retards renal excretion of amoxicillin C. It counteracts the adverse effects of amoxicillin D. It inhibits beta lactamases that destroy amoxicillin

Description : Clavulanic acid is combined with amoxicillin because: A. It kills bacteria that are not killed by amoxicillin B. It retards renal excretion of amoxicillin C. It counteracts the adverse effects of amoxicillin D. It inhibits beta lactamases that destroy amoxicillin

Last Answer : D. It inhibits beta lactamases that destroy amoxicillin

Practically all antineoplastic drugs can produce the following toxic effects except: A. Depression of leucocyte count B. Mucositis C. Cardiomyopathy D. Oligozoospermia

Description : Practically all antineoplastic drugs can produce the following toxic effects except: A. Depression of leucocyte count B. Mucositis C. Cardiomyopathy D. Oligozoospermia

Last Answer : C. Cardiomyopathy

Adverse effects of ciprofloxacin are referable primarily to the following except: A. Gastrointestinal tract B. Kidney C. Skin D. Nervous system

Description : Adverse effects of ciprofloxacin are referable primarily to the following except: A. Gastrointestinal tract B. Kidney C. Skin D. Nervous system

Last Answer : B. Kidney

What is the most important reason for the restricted use of systemic chloramphenicol: A. Emergence of chloramphenicol resistance B. Its potential to cause bone marrow depression C. Its potential to cause superinfections D. Its potential to inhibit the metabolism of many drugs

Description : What is the most important reason for the restricted use of systemic chloramphenicol: A. Emergence of chloramphenicol resistance B. Its potential to cause bone marrow depression C. Its potential to cause superinfections D. Its potential to inhibit the metabolism of many drugs

Last Answer : B. Its potential to cause bone marrow depression

A 60-year-old patient presented with anorexia, weakness, paresthesia and mental changes. His tongue was red, tendon reflexes were diminished, haemoglobin was 6 g% with large red cells and neutrophils had hypersegmented nuclei. Endoscopy revealed atrophic gastritis. Deficiency of which factor is likely to be responsible for his condition: A. Folic acid B. Vitamin B12 C. Pyridoxine D. Riboflavin

Description : A 60-year-old patient presented with anorexia, weakness, paresthesia and mental changes. His tongue was red, tendon reflexes were diminished, haemoglobin was 6 g% with large red cells and neutrophils had ... be responsible for his condition: A. Folic acid B. Vitamin B12 C. Pyridoxine D. Riboflavin

Last Answer : B. Vitamin B12

Which disease affects the bone marrow and tissues which produce blood corpuscles?

Description : Which disease affects the bone marrow and tissues which produce blood corpuscles?

Last Answer : Leukemia

The following is true of linezolid except: A. It inhibits bacterial protein synthesis at an early step B. It is active against vancomycin resistant enterococci C. It is the drug of choice for enterococcal endocarditis D. It can be administered orally as well as by i.v. infusion

Description : The following is true of linezolid except: A. It inhibits bacterial protein synthesis at an early step B. It is active against vancomycin resistant enterococci C. It is the drug of choice for enterococcal endocarditis D. It can be administered orally as well as by i.v. infusion

Last Answer : C. It is the drug of choice for enterococcal endocarditis

Choose the correct statement about topotecan: A. It is a DNA topoisomerase I inhibitor which causes single strand DNA breaks B. It is a cell cycle specific anticancer drug C. It is a COMT-inhibitor used in advanced parkinsonism D. Both 'A' and 'B' are correc

Description : Choose the correct statement about topotecan: A. It is a DNA topoisomerase I inhibitor which causes single strand DNA breaks B. It is a cell cycle specific anticancer drug C. It is a COMT-inhibitor used in advanced parkinsonism D. Both 'A' and 'B' are correc

Last Answer : D. Both 'A' and 'B' are correct

The use of antibiotics can be based on either the clinical course of a patient without the benefit of well-defined microbiologic data (empiric therapy), or targeted at specific identified pathogens once sensitivity reports are available (directed therapy). The following statement(s) is/are true concerning these therapies. a. The issue of toxic side effects of antibiotics is only important in dealing with emperic therapy b. Single agent therapy is generally inferior to specific multi-drug therapy (aminoglycoside plus an antianaerobic agent) for the treatment of secondary bacterial peritonitis due to appendicitis, diverticulitis, penetrating gastrointestinal injury, or anastomotic leak c. With the empiric use of antibiotics, a diligent search for the septic source should be undertaken and co

Description : The use of antibiotics can be based on either the clinical course of a patient without the benefit of well-defined microbiologic data (empiric therapy), or targeted at ... which polymicrobial infection is identified, specifically-directed treatment for the predominant organism is satisfactory

Last Answer : Answer: c The use of empiric therapy without the benefit of well-defined microbiologic data is appropriate when there is sufficient clinical evidence to support the diagnosis such that it would ... components of the infection if the body site is such that these microorganisms may be present

Thermal pollution of water increases its toxicity and oxidation of oxygen demanding waste besides favouring bacterial growth. A rise in water temperature by 10°C, doubles the toxic effects of __________ present in it. (A) Coal ash (B) Potassium cyanide (C) Ortho-xylene (D) None of these

Description : Thermal pollution of water increases its toxicity and oxidation of oxygen demanding waste besides favouring bacterial growth. A rise in water temperature by 10°C, doubles the toxic effects of __________ present in it. (A) Coal ash (B) Potassium cyanide (C) Ortho-xylene (D) None of these

Last Answer : (B) Potassium cyanide

Praziquantel is preferred over niclosamide for Taenia solium infestation because: A. It achieves higher cure rates B. It produces fewer side effects C. It does not lead to digestion of worm and kills encysted larvae, so that chances of cysticercosis are minimized D. Both ‘A’ and ‘B’ are correct

Description : Praziquantel is preferred over niclosamide for Taenia solium infestation because: A. It achieves higher cure rates B. It produces fewer side effects C. It does not lead to digestion of worm and kills encysted larvae, so that chances of cysticercosis are minimized D. Both ‘A’ and ‘B’ are correct

Last Answer : C. It does not lead to digestion of worm and kills encysted larvae, so that chances of cysticercosis are minimized

The following drug given concurrently can enhance toxicity of digoxin: A. Phenobarbitone B. Metoclopramide C. Quinidine D. Magnesium hydroxide

Description : The following drug given concurrently can enhance toxicity of digoxin: A. Phenobarbitone B. Metoclopramide C. Quinidine D. Magnesium hydroxide

Last Answer : C. Quinidine

Select the most suitable antiarrhythmic drug for counteracting ventricular extrasystoles due to digoxin toxicity: A. Lignocaine B. Quinidine C. Verapamil D. Amiodarone

Description : Select the most suitable antiarrhythmic drug for counteracting ventricular extrasystoles due to digoxin toxicity: A. Lignocaine B. Quinidine C. Verapamil D. Amiodarone

Last Answer : A. Lignocaine

The antipsychotic drug most likely to cause ocular toxicity on long-term use is: A. Thioridazine B. Haloperidol C. Flupenthixol D. Pimozide

Description : The antipsychotic drug most likely to cause ocular toxicity on long-term use is: A. Thioridazine B. Haloperidol C. Flupenthixol D. Pimozide

Last Answer : A. Thioridazine

Drug cumulation is the basis of organ toxicity of the following drug when used for prolonged periods: A. Prednisolone B. Chloroquine C. Aspirin D. Hydralazine

Description : Drug cumulation is the basis of organ toxicity of the following drug when used for prolonged periods: A. Prednisolone B. Chloroquine C. Aspirin D. Hydralazine

Last Answer : B. Chloroquine

Toxicity of local anaesthetics involves the following organs except: A. Heart B. Brain C. Kidney D. Skin and subcutaneous tissue

Description : Toxicity of local anaesthetics involves the following organs except: A. Heart B. Brain C. Kidney D. Skin and subcutaneous tissue (p. 324)

Last Answer : D. Dibucaine

Adrenaline added to local anaesthetic solution for infiltration anaesthesia affords the following except: A. Prolongs the duration of local anaesthesia B. Makes the injection less painful C. Provides a more bloodless field for surgery D. Reduces systemic toxicity of the local anaesthetic

Description : Adrenaline added to local anaesthetic solution for infiltration anaesthesia affords the following except: A. Prolongs the duration of local anaesthesia B. Makes the injection less painful C. Provides a more bloodless field for surgery D. Reduces systemic toxicity of the local anaesthetic

Last Answer : B. Makes the injection less painful

_____ is when an antimicrobial drug should harm the infectious agent but not the host. a. Selective toxicity b. Toxic dose c. Therapeutic dose d. Chemotherapeutic index

Description : _____ is when an antimicrobial drug should harm the infectious agent but not the host. a. Selective toxicity b. Toxic dose c. Therapeutic dose d. Chemotherapeutic index

Last Answer : a. Selective toxicity

The primary reason why chloramphenicol is not being used as the first line drug for typhoid fever in most areas is: A. Toxic potential of chloramphenicol B. Delayed defervescence with chloramphenicol C. Delayed bacteriological cure with chloramphenicol D. Spread of chloramphenicol resistance among S. typhi

Description : The primary reason why chloramphenicol is not being used as the first line drug for typhoid fever in most areas is: A. Toxic potential of chloramphenicol B. Delayed defervescence with ... C. Delayed bacteriological cure with chloramphenicol D. Spread of chloramphenicol resistance among S. typhi

Last Answer : D. Spread of chloramphenicol resistance among S. typhi

Among the disease modifying antirheumatic drugs, fastest symptom relief is obtained with: A. Auranofin B. Hydroxychloroquine C. Sulfasalazine D. Methotrexate

Description : Among the disease modifying antirheumatic drugs, fastest symptom relief is obtained with: A. Auranofin B. Hydroxychloroquine C. Sulfasalazine D. Methotrexate

Last Answer : D. Methotrexate

Olanzapine has the following features except: A. It is an antipsychotic drug with weak D2 receptor blocking action B. It has potent 5-HT2 blocking and antimuscarinic actions C. It lowers seizure threshold D. It produces prominent extrapyramidal side effects

Description : Olanzapine has the following features except: A. It is an antipsychotic drug with weak D2 receptor blocking action B. It has potent 5-HT2 blocking and antimuscarinic actions C. It lowers seizure threshold D. It produces prominent extrapyramidal side effects

Last Answer : D. It produces prominent extrapyramidal side effect

Which of the following statements reflect current stem cell research? a) The stem cell is known as a precursor cell that continually replenishes the body’s entire supply of both red and white cells. The stem cell is known as a precursor cell that continually replenishes the body’s entire supply of both red and white cells. Stem cells comprise only a small portion of all types of bone marrow cells.

Description : Which of the following statements reflect current stem cell research? a) The stem cell is known as a precursor cell that continually replenishes the body's entire supply of ... an autoimmune component including systemic lupus erythematosus, rheumatoid arthritis, scleroderma, and multiple sclerosis.

Last Answer : a) The stem cell is known as a precursor cell that continually replenishes the body's entire supply of both red and white cells. The stem cell is known as a precursor cell that continually replenishes ... and white cells. Stem cells comprise only a small portion of all types of bone marrow cells.

Paraaminosalicylic acid is a second line antitubercular drug because of the following feature(s): A. Low antitubercular efficacy B. Frequent side effects C. Bulky daily dose D. All of the above

Description : Paraaminosalicylic acid is a second line antitubercular drug because of the following feature(s): A. Low antitubercular efficacy B. Frequent side effects C. Bulky daily dose D. All of the above

Last Answer : D. All of the above

Digoxin affords the following benefit/benefits in CHF: A. Restores cardiac compensation and relieves symptoms B. Reverses the pathological changes of CHF C. Prolongs survival of CHF patients D. Both ‘A’ and ‘B’ are correc

Description : Digoxin affords the following benefit/benefits in CHF: A. Restores cardiac compensation and relieves symptoms B. Reverses the pathological changes of CHF C. Prolongs survival of CHF patients D. Both ‘A’ and ‘B’ are correc

Last Answer : A. Restores cardiac compensation and relieves symptoms

Addition of a progestin for 10-12 days each month to estrogen replacement therapy in menopausal women is recommended because the progestin: A. Blocks the increased risk of myocardial infarction due to estrogen B. Blocks the increased risk of endometrial carcinoma due to estrogen C. Reverses vulval atrophy occurring in postmenopausal women D. Enhances the metabolic benefits of estrogen treatment

Description : Addition of a progestin for 10-12 days each month to estrogen replacement therapy in menopausal women is recommended because the progestin: A. Blocks the increased risk of myocardial ... vulval atrophy occurring in postmenopausal women D. Enhances the metabolic benefits of estrogen treatment

Last Answer : The estrogen commonly used for hormone replacement therapy in menopausal women is: A. Ethinylestradiol B. Estradiol benzoate C. Diethylstilbestrol D. Conjugated estrogens

Adrenaline directly affects on (a) SA node (b) β-cells of Langerhans (c) dorsal root of spinal nerve (d) epithelial cells of stomach.

Description : Adrenaline directly affects on (a) SA node (b) β-cells of Langerhans (c) dorsal root of spinal nerve (d) epithelial cells of stomach.

Last Answer : (a) SA node

Antiretroviral therapy is not recommended in asymptomatic HIV infected subjects with CD4 cell count more than 350/µl because of the following reason(s): A. All antiretroviral drugs lose efficacy after some time B. Adverse effects of antiretroviral drugs compromise the quality of life of asymptomatic subjects C. The treated subjects may produce and transmit drug resistant virus D. All of the above

Description : Antiretroviral therapy is not recommended in asymptomatic HIV infected subjects with CD4 cell count more than 350/µl because of the following reason(s): A. All antiretroviral drugs lose efficacy after ... C. The treated subjects may produce and transmit drug resistant virus D. All of the above

Last Answer : D. All of the above