The medications most commonly prescribed for treating osteoporosis are called Bisphosphonates. We know them as Fosamax, Actonel, Boniva and Reclast. These medications have been shown to be safe and effective. Bisphosphonates work by slowing down the deterioration of the bones, thereby decreasing the risk of breaking a bone as a result of osteoporosis. Hormones, such as estrogen, are sometimes used in osteoporosis treatment, but they carry an increased risk for developing certain cancers, as well as heart disease, strokes and blood clots. Bisphosphonates only affect the bone and are generally well tolerated.. Boniva and Reclast are available as intravenous injections. Boniva is given once every three months, and Reclast is given once a year . In addition to medication, regular exercise is important, as well as a diet rich in calcium and vitamin D