Difference between fine powders and granules.
Fine powder
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Granules
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1. Fine powder does not have free flowing property, hence weight variation in tablet is produced.
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1.Granules flow easily and do not give weight variation in the tablet produced
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2. In mixed powder, segregation of different components is possible.
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2. Granules are of uniform composition and segregation is not a problem. But granules should contain 5-15%of fine
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3. Tablets formed are brittle.
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3. Granules packed down easily and produced hard tablets.
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4. Fine particles tend to blow out of die cavity during compression.
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4. Granules being heavier do not blow out of die cavity.
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