What is the difference between ‘Purified water’ and ‘Water for injection’? How will you prepare ‘ Water for injection’ in laboratory.

What is the difference between ‘Purified water’ and ‘Water for injection’? How will you prepare ‘ Water for injection’ in laboratory.
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1 Answer

Answer :

Purified Water
Water for injection
1) Water which is free from volatile and non-volatile impurities is called as purified water. 
1) Water which is free from volatile and non-volatile impurities, micro-organisms and pyrogens is called as water for injection. 
2) It may contain pyrogens.
2) It is free from pyrogens.
3) It can not be used in parenteral preparations.
3)It can be used in parenteral preparations.
4) pH is 4.5 to 7.0
4) pH is 5.0 to 7.0
5) It is supplied in large volume.
5) It is supplied in small volume.
6) It is used for long duration. 
6) It must be used within 24 hours for parenteral preparations.

Preparation of water for injection I.P.:  Water for injection is prepared in a distillation unit. It consists of a boiler made of cast iron. It is connected to condenser tubes through the baffles. The condenser tubes and baffles are made of stainless steel. Baffles are provided over the top of the condenser tubes to avoid water drops getting mixed with the vapours. It is done to avoid carry-over of pyrogen and other water-soluble materials in the droplets. The cooling water enters at the bottom of the condenser and is heated by the condensing vapours. The flow rate is adjusted in such a way that water gets heated at 90- 95 0 C before it enters the boiler. The top of the condenser jacket is open so that gases from the water can escape into the atmosphere. A constant level device is fitted in such a way that only the heated water free from gases enters the boiler.

Diagram:

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