Description : Which of the following is an idiosyncratic adverse drug reaction: A. Muscle dystonia caused by triflupromazine B. Insomnia after taking pentobarbitone C. Precipitation of asthma by morphine D. Gum hyperplasia caused by phenytoin
Last Answer : B. Insomnia after taking pentobarbitone
Description : Which adverse drug effect is more common in children than in adults: A. Isoniazid induced neuropathy B. Chlorpromazine induced muscle dystonia C. Digoxin induced cardiac arrhythmia D. Penicillin hypersensitivity
Last Answer : B. Chlorpromazine induced muscle dystonia
Description : Which of the following adverse drug reactions is due to a specific genetic abnormality: A. Tetracycline induced sunburn like skin lesions B. Quinidine induced thrombocytopenia C. Metoclopramide induced muscle dystonia D. Primaquine induced massive haemolysis
Last Answer : D. Primaquine induced massive haemolysis
Description : The following adverse effect(s) of phenytoin is/are related to high plasma drug concentration: A. Ataxia B. Hirsutism C. Gum hyperplasia D. All of the above
Last Answer : A. Ataxia
Description : Compared to the drug named within parenthesis, which of the following drugs has a higher potency but lower efficacy: A. Pethidine (morphine) B. Furosemide (hydrochlorothiazide) C. Diazepam (pentobarbitone) D. Enalapril (captopril)
Last Answer : C. Diazepam (pentobarbitone)
Description : The extrapyramidal adverse effect of antipsychotic drug therapy which does not respond to central anticholinergics is: A. Parkinsonism B. Acute muscle dystonia C. Rabbit syndrome D. Tardive dyskinesia
Last Answer : D. Tardive dyskinesia
Description : Which of the following is a weakly acidic drug: A. Atropine sulfate B. Chloroquine phosphate C. Ephedrine hydrochloride D. Phenytoin sodium
Last Answer : D. Phenytoin sodium
Description : A drug which produces qualitatively different actions when administered through different routes is: A. Phenytoin sodium B. Hydralazine C. Magnesium sulfate D. Nitroglycerine
Last Answer : C. Magnesium sulfate
Description : Which of the following is a type B (unpredictable) adverse drug reaction: A. Side effect B. Toxic effect C. Idiosyncrasy D. Physical dependence
Last Answer : A. Side effect
Last Answer : C. Idiosyncrasy
Description : Adverse consequences may follow sudden discontinuation of the following drug after chronic intake: A. Cocaine B. Cannabis C. Clonidine D. All of the above
Last Answer : C. Clonidine
Description : Which of the following constitutes ‘drug abuse’: A. Physician prescribed use of penicillin G for the cure of viral fever B. Self administration of aspirin to relieve headache C. Repeated self administration of morphine to derive euphoria D. All of the above
Last Answer : D. Differ from each other in the degree of attendant psychological dependence
Description : The following drug adverse effect is specially noted in men compared to women: A. Tardive dyskinesia due to neuroleptics B. Levodopa induced abnormal movements C. Ampicillin induced loose motions D. Ketoconazole induced loss of libido
Last Answer : D. Ketoconazole induced loss of libido
Description : The following allergic drug reaction is caused by circulating antibodies: A. Serum sickness B. Anaphylactic shock C. Systemic lupus erythematosus D. Angioedema
Last Answer : A. Serum sickness
Description : Which of the following drugs is most likely to be absorbed from the stomach: A. Morphine sulfate B. Diclofenac sodium C. Hyoscine hydrobromide D. Quinine dihydrochloride
Last Answer : B. Diclofenac sodium
Description : Significant tolerance does not develop to the following action of morphine: A. Analgesia B. Euphoria C. Sedation D. Miosis
Last Answer : D. Miosis
Description : The following is not true of the cytochrome P450 isoenzyme CYP2D6: A. It generates the hepatotoxic metabolite N-acetyl benzoquinone immine from paracetamol B. It is involved in demethylation of ... for poor capacity to hydroxylate many drugs including metoprolol D. It is inhibited by quinidine
Last Answer : A. It generates the hepatotoxic metabolite N-acetyl benzoquinone immine from paracetamo
Description : Which of the following patients are at the highest risk of suffering from an adverse drug reaction? a) An 8 month year old infant receiving a prescription for an antibiotic. b) A 22 year old patient ... ACE Inhibitor. d) A 68 year old patient who has oedema receiving a prescription for a diuretic.
Last Answer : d) A 68 year old patient who has oedema receiving a prescription for a diuretic.
Description : The following statement is true in relation to drug toxicity' and poisoning': A. The two terms are synonymous B. When a toxic effect requires specific treatment, it is called poisoning C. ... is called poisoning D. Toxicity is caused by drugs while poisoning is caused by other harmful chemicals
Last Answer : C. A toxic effect which endangers life by markedly affecting vital functions is called poisoning
Description : The side effect of a drug which has been used as a therapeutic effect in another condition is: A. Constipation caused by codeine B. Cough caused by captopril C. Uterine stimulation caused by quinine D. Diarrhoea caused by ampicillin
Last Answer : A. Constipation caused by codeine
Description : An undesirable effect of a drug that occurs at therapeutic doses and can be predicted from its pharmacological actions is called: A. Side effect B. Toxic effect C. Allergic reaction D. Idiosyncrasy
Description : An immunologically mediated reaction to a drug producing stereotyped symptoms unrelated to its pharmacodynamic actions is: A. Hypersensitivity B. Supersensitivity C. Intolerance D. Idiosyncrasy
Last Answer : A. Hypersensitivity
Description : The following drug metabolizing reaction is entirely nonmicrosomal: A. Glucuronide conjugation B. Acetylation C. Oxidation D. Reduction
Last Answer : B. Acetylation
Description : A 35 yr old pt she is on phenytoin since she was 29 due to partial epilipsy she didn’t have any attack since. She want to stop taking the drug due to facial hair growth: a. It is reasonable to stop it now b. Stop it after 6 months c. Stop after 10 years d. Don’t stop it
Last Answer : a. It is reasonable to stop it now
Description : A ‘toxic effect’ differs from a ‘side effect’ in that: A. It is not a pharmacological effect of the drug B. It is a more intense pharmacological effect that occurs at high dose or after prolonged medication C. It must involve drug induced cellular injury D. It involves host defence mechanisms
Last Answer : B. It is a more intense pharmacological effect that occurs at high dose or after prolonged medication
Description : When the same dose of a drug is repeated at half life intervals, the steady-state (plateau) plasma drug concentration is reached after: A. 2–3 half lives B. 4–5 half lives C. 6–7 half lives D. 8–10 half lives
Last Answer : B. 4–5 half lives
Description : The site of action of miotics for therapeutic effect in angle closure glaucoma is: A. Canal of Schlemm B. Ciliary body C. Ciliary muscle D. Sphincter pupillae muscle
Last Answer : D. Sphincter pupillae muscle
Description : Pilocarpine reduces intraocular tension in open angle glaucoma by: A. Contracting sphincter pupillae B. Increasing tone of ciliary muscle C. Reducing aqueous formation D. Enhancing uveo-scleral outflow
Last Answer : B. Increasing tone of ciliary muscle
Description : Edrophonium is more suitable for differentiating myasthenic crisis from cholinergic crisis because of its: A. Shorter duration of action B. Longer duration of action C. Direct action on muscle end-plate D. Selective inhibition of true cholinesterase
Last Answer : A. Shorter duration of action
Description : The mechanism by which neostigmine improves contraction of myasthenic muscle involves: A. Repetitive binding of the acetylcholine molecules to the same receptors at the muscle endplate B. Diffusion of ... Activation of motor end-plate receptors by neostigmine molecules themselves D. All of the above
Last Answer : D. All of the above
Description : Neostigmine is preferred over physostigmine for treating myasthenia gravis because: A. It is better absorbed orally B. It has longer duration of action C. It has additional direct agonistic action on nicotinic receptors at the muscle end plate D. It penetrates blood-brain barrier
Last Answer : C. It has additional direct agonistic action on nicotinic receptors at the muscle end plate
Description : The smooth muscle structure that is relaxed by cholinergic drugs is: A. Colon B. Gastric fundus C. Major bronchi D. Bladder trigone
Last Answer : D. Bladder trigone
Description : Which of the following is a high potency antipsychotic drug having minimal sedative and autonomic effects and no propensity to cause weight gain: A. Chlorpromazine B. Triflupromazine C. Haloperidol D. Olanzapine
Last Answer : C. Haloperido
Description : The following side effect of typical neuroleptics may respond to propranolol: A. Parkinsonism B. Acute muscle dystonia C. Tardive dyskinesia D. Akathisia (p. 397) 30.15 3 0 . 1 5 B 30.16 3 0 . 1 6 D
Last Answer : D. Akathisia (p. 397)
Description : Reflex bronchoconstriction is most likely to occur with the following form of inhaled antiasthma medication: A. Metered dose spray of drug in solution B. Dry powder rotacap C. Nebuliser D. Nebuliser with spacer
Last Answer : B. Dry powder rotacap
Description : Select the drug which has been found to be a strong human teratogen: A. Isoniazid B. Isotretinoin C. Hydralazine D. Propylthiouracil
Last Answer : B. Isotretinoin
Description : An addicting drug which produces little or no physical dependence is: A. Diazepam B. Phenobarbitone C. Amphetamine D. Methadone
Last Answer : C. Amphetamine
Description : Intradermal drug sensitivity tests can detect the presence of following type of hypersensitivity: A. Type I (anaphylactic) B. Type II (cytolytic) C. Type III (retarded) D. All of the above
Last Answer : A. Type I (anaphylactic)