Description : The following allergic drug reaction is caused by circulating antibodies: A. Serum sickness B. Anaphylactic shock C. Systemic lupus erythematosus D. Angioedema
Last Answer : A. Serum sickness
Description : Which type of hypersensitivity reaction involves immune complexes formed when antigens bind to antibodies? a) Type III Type III hypersensitivity is associated with systemic lupus erythematosus, rheumatoid ... , or delayed-type, hypersensitivity occurs 24-72 hours after exposure to an allergen.
Last Answer : a) Type III Type III hypersensitivity is associated with systemic lupus erythematosus, rheumatoid arthritis, serum sickness, certain types of nephritis, and some types of bacterial endocarditis.
Description : The most appropriate route of administration for adrenaline in a case of anaphylactic shock is: A. Intracardiac B. Intravenous C. Intramuscular D. Subcutaneous
Last Answer : A. Intracardiac
Description : Which of the following is the only life saving measure in case of anaphylactic shock: A. Intravenous hydrocortisone hemisuccinate B. Intravenous chlorpheniramine maleate C. Intramuscular adrenaline hydrochloride D. Intravenous glucose-saline
Last Answer : C. Intramuscular adrenaline hydrochloride
Description : Which of the following statements about septic shock are true? A. A circulating myocardial depressant factor may account for the cardiac dysfunction sometimes seen with shock due to sepsis or ... animal studies that demonstrate a significant improvement in survival with the use of such agents.
Last Answer : Answer: AB DISCUSSION: Shock due to sepsis or SIRS frequently manifests as a hyperdynamic cardiovascular response, consisting of an elevated CI and a decreased SVR or SVRI. Occasionally, ... been encouraging thus far in human clinical trials, despite the promising results from many animal studies
Description : SLE stands for_________________ and is an autoimmune disease. A. squamous laceration ecchymosis B. systemic lupus erythematosus C. septic lymphodic edema
Last Answer : Ans: B
Description : A patient receiving a class I antiarrhythmic agent on a chronic basis complains of fatigue, low-grade fever, and joint pain suggestive of systemic lupus erythematosus (SLE). The patient is most likely receiving (a) Lidocaine (b) Procainamide (c) Quinidine (d) Flecainide (e) Propranolol
Description : Which of the following is NOT an autoimmune disease? a. Myasthenia gravis b. Type i diabetes c. Systemic lupus erythematosus d. Rheumatoid arthritis e. All of the above are autoimmune disorders
Last Answer : e. All of the above are autoimmune disorders
Description : Which one of the following applies to the disease systemic lupus erythematosus (SLE)? a. It is a type of cytotoxic hypersensitivity. b. It is often accompanied by a butterfly rash. c. It is due to an overreaction of T lymphocytes. d. It is the result of a cellular hypersensitivity.
Last Answer : d. It is the result of a cellular hypersensitivity.
Description : A patient has painful lesions on her buccal mucosa. Biopsy report shows acantholysis and supra basilare, your diagnosis is: A. Pemphigus vulgaris B. Bulla lichen planus C. Erythema multiform D. Systemic lupus erythematosus
Last Answer : A. Pemphigus vulgaris
Description : The following is true of procainamide except: A. It generates an active metabolite in the body B. Its plasma half-life is longer than that of quinidine C. On long-term use, it ... erythematosus like illness D. It is effective in many cases of ventricular extrasystoles, not responding to lignocaine
Last Answer : A. Disopyramide
Description : Intradermal drug sensitivity tests can detect the presence of following type of hypersensitivity: A. Type I (anaphylactic) B. Type II (cytolytic) C. Type III (retarded) D. All of the above
Last Answer : A. Type I (anaphylactic)
Description : Drugs producing allergic reactions generally act as: A. Complete antigens B. Haptenes C. Antibodies D. Mediators
Last Answer : B. Haptenes
Description : Compared to subcutaneous injection, the intramuscular injection of drugs: A. Is more painful B. Produces faster response C. Is unsuitable for depot preparations D. Carries greater risk of anaphylactic reaction
Last Answer : B. Produces faster response
Description : An undesirable effect of a drug that occurs at therapeutic doses and can be predicted from its pharmacological actions is called: A. Side effect B. Toxic effect C. Allergic reaction D. Idiosyncrasy
Last Answer : A. Side effect
Description : H1 antihistaminics are beneficial in (a) All types of allergic disorders (b) Certain type I allergic reactions only (c) Anaphylactic shock(d) Bronchial asthma
Description : Chloroquine is indicated in the following disorders except: A. Rheumatic fever B. Discoid lupus erythematosus C. Photogenic skin reactions D. Lepra reaction
Last Answer : B. Discoid lupus erythematosus
Description : Tricyclic antidepressants can alter the oral absorption of many drugs by: A. Complexing with the other drug in the intestinal lumen B. Altering gut motility C. Altering gut flora D. Damaging gut mucosa
Last Answer : C. Altering gut flora
Description : Bioavailability of drug refers to: A. Percentage of administered dose that reaches systemic circulation in the unchanged form B. Ratio of oral to parenteral dose C. Ratio of orally administered drug to ... in the faeces D. Ratio of drug excreted unchanged in urine to that excreted as metabolites
Last Answer : A. Percentage of administered dose that reaches systemic circulation in the unchanged form
Description : To be used as a topically applied ocular beta blocker a drug should have the following properties except: A. Strong local anaesthetic activity B. High lipophilicity C. High ocular capture D. Low systemic activity
Last Answer : A. Strong local anaesthetic activity
Description : Which of the following statement(s) is/are true concerning septic shock? a. The clinical picture of gram negative septic shock is specifically different than shock associated with ... mechanisms of intrinsic expansion of the circulating blood volume, exogenous volume resuscitation is necessary
Last Answer : Answer: d The clinical findings in sepsis and septic shock represent the host response to infection. Gram-positive and gram-negative bacteria, viruses, fungi, rickettsiae, and ... intravascular volume, exogenous volume resuscitation must be provided to restore venous return and ventricular filling
Description : Recognized adverse effects of quinidine include which one of the following? (a) Cinchonism (b) Constipation (c) Lupus erythematosus (d) Increase in digoxin clearance (e) Precipitation of hyperthyroidism
Last Answer : Ans: A
Description : Long-term hydralazine therapy is likely to cause: A. Gynaecomastia B. Thrombocytopenia C. Haemolytic anaemia D. Lupus erythematosus
Last Answer : D. Lupus erythematosus
Description : Which of the following is an idiosyncratic adverse drug reaction: A. Muscle dystonia caused by triflupromazine B. Insomnia after taking pentobarbitone C. Precipitation of asthma by morphine D. Gum hyperplasia caused by phenytoin
Last Answer : B. Insomnia after taking pentobarbitone
Description : An intradermal penicillin sensitivity test has been performed on a patient and found to be negative. This indicates that: A. Penicillin antibodies are not present in his body B. He will ... He is unlikely to develop immediate type of hypersensitivity reaction when full dose of penicillin is injected
Last Answer : D. He is unlikely to develop immediate type of hypersensitivity reaction when full dose of penicillin is injected
Description : Which of the following statement(s) is/are true concerning metabolic derangements in sepsis and the systemic inflammatory response syndrome which may follow progressive shock? a. Alterations in glucose ... The serum aromatic amino acids fall rapidly as they are actively used in oxidative metabolism
Last Answer : Answer: b, c A broad spectrum of metabolic abnormalities become apparent in sepsis and the systemic inflammatory response syndrome following shock. Disruption of the normal cycles of carbohydrate, ... acetyl coenzyme A. This results in reduced serum level of leucine, isoleucine and valine
Description : Which of the following drugs is administered by intranasal spray/application for systemic action: A. Phenylephrine B. Desmopressin C. Azelastine D. Beclomethasone dipropionate
Last Answer : B. Desmopressin
Description : Which one of the following is a false statement about atopic eczema? a) It commonly begins by drug reaction. b) Super-added herpes simplex infection is a serious complication. c) The serum IgE ... . d) The skin lesions are typically itchy. e) Treatment with systemic steroids is often necessary.
Last Answer : Ans: E
Description : The following statement is true in relation to drug toxicity' and poisoning': A. The two terms are synonymous B. When a toxic effect requires specific treatment, it is called poisoning C. ... is called poisoning D. Toxicity is caused by drugs while poisoning is caused by other harmful chemicals
Last Answer : C. A toxic effect which endangers life by markedly affecting vital functions is called poisoning
Description : The side effect of a drug which has been used as a therapeutic effect in another condition is: A. Constipation caused by codeine B. Cough caused by captopril C. Uterine stimulation caused by quinine D. Diarrhoea caused by ampicillin
Last Answer : A. Constipation caused by codeine
Description : A 75-year-old man had been receiving gentamicin (an aminoglycoside antibiotic) to treat an urinary tract infection. After three months of therapy patient's serum creatinine levels were 10 mg/ ... Type II allergic reaction b)Type III allergic reaction c) Pseudo allergic reaction d) Overdose toxicity
Last Answer : d) Overdose toxicity
Description : Which of the following is a type B (unpredictable) adverse drug reaction: A. Side effect B. Toxic effect C. Idiosyncrasy D. Physical dependence
Description : An immunologically mediated reaction to a drug producing stereotyped symptoms unrelated to its pharmacodynamic actions is: A. Hypersensitivity B. Supersensitivity C. Intolerance D. Idiosyncrasy
Last Answer : A. Hypersensitivity
Last Answer : C. Idiosyncrasy
Description : The following drug metabolizing reaction is entirely nonmicrosomal: A. Glucuronide conjugation B. Acetylation C. Oxidation D. Reduction
Last Answer : B. Acetylation
Description : ___________ is an example of latent adverse drug reactions. a) Antibiotic-associated diarrhea b) Tardive dyskinesia c) Serum sickness d) Severe bronchoconstriction
Last Answer : D
Description : The nurse anticipates that the immunosuppressed patient is at greatest risk for which type of shock? a) Septic Septic shock is associated with immunosuppression, extremes of age, ... disease of the heart. d) Anaphylactic Anaphylactic shock is associated with hypersensitivity reactions.
Last Answer : a) Septic Septic shock is associated with immunosuppression, extremes of age, malnourishment, chronic illness, and invasive procedures.
Description : The presence of IgM antibodies in the blood indicates a. An early stage of an infection. b. A chronic infection. c. An allergic reaction is occurring. d. Humoral immunity has yet to start.
Last Answer : a. An early stage of an infection.
Description : Atopic allergic disorders are characterized by a) a hereditary predisposition. Atopic allergic disorders are characterized by a hereditary predisposition and production of a local reaction to IgE ... of a local reaction to IgE antibodies produced in response to common environmental allergens.
Last Answer : a) a hereditary predisposition. Atopic allergic disorders are characterized by a hereditary predisposition and production of a local reaction to IgE antibodies produced in response to common environmental allergens.
Description : 9 Which one of the following antibodies initiates an allergic reaction? a) Ig A b) Ig E c) Ig G d) Ig M
Last Answer : ANS: b Ig E
Description : Immunodeficiency: a) A localized protective reaction of tissue to irritation, injury, or infection, characterized by pain, redness, swelling, and sometimes a loss of function b) A disorder or deficiency ... effect and damage the liver. e) It is an immunity disorder which is genetically transferred.
Description : Reflex bronchoconstriction is most likely to occur with the following form of inhaled antiasthma medication: A. Metered dose spray of drug in solution B. Dry powder rotacap C. Nebuliser D. Nebuliser with spacer
Last Answer : B. Dry powder rotacap