Choose the correct statement about drotaverine: A. It is a smooth muscle antispasmodic acting by non-anticholinergic mechanisms B. It is a papaverine congener used in peripheral vascular diseases C. It is a synthetic atropine substitute used to control diarrhoea D. It is a M1/M3 selective antagonist used for spastic constipation

Choose the correct statement about drotaverine: A. It is a smooth muscle antispasmodic acting by non-anticholinergic mechanisms B. It is a papaverine congener used in peripheral vascular diseases C. It is a synthetic atropine substitute used to control diarrhoea D. It is a M1/M3 selective antagonist used for spastic constipation
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Answer :

A. It is a smooth muscle antispasmodic acting by non-anticholinergic mechanisms
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Choose the correct statement about drotaverine: A. It is a smooth muscle antispasmodic acting by non-anticholinergic mechanisms B. It is a papaverine congener used in peripheral vascular diseases C. It is a synthetic atropine substitute used to control diarrhoea D. It is a M1/M3 selective antagonist used for spastic constipation

Description : Choose the correct statement about drotaverine: A. It is a smooth muscle antispasmodic acting by non-anticholinergic mechanisms B. It is a papaverine congener used in peripheral vascular diseases C. It ... used to control diarrhoea D. It is a M1/M3 selective antagonist used for spastic constipation

Last Answer : A. It is a smooth muscle antispasmodic acting by non-anticholinergic mechanisms

Atropine does not exert relaxant/antispasmodic effect on the following muscle: A. Intestinal B. Ureteric C. Bronchial D. Laryngeal

Description : Atropine does not exert relaxant/antispasmodic effect on the following muscle: A. Intestinal B. Ureteric C. Bronchial D. Laryngeal

Last Answer : D. Laryngeal

Atropine does not exert relaxant/antispasmodic effect on the following muscle: A. Intestinal B. Ureteric C. Bronchial D. Laryngeal

Description : Atropine does not exert relaxant/antispasmodic effect on the following muscle: A. Intestinal B. Ureteric C. Bronchial D. Laryngeal

Last Answer : D. Laryngeal

Choose the selective estrogen receptor modulator that is useful in dysfunctional uterine bleeding by acting as estrogen antagonist in endometrium, but does not alter vaginal epithelium or cervical mucus: A. Ormeloxifene B. Tamoxifen C. Centchroman D. Danazol

Description : Choose the selective estrogen receptor modulator that is useful in dysfunctional uterine bleeding by acting as estrogen antagonist in endometrium, but does not alter vaginal epithelium or cervical mucus: A. Ormeloxifene B. Tamoxifen C. Centchroman D. Danazol

Last Answer : . Ormeloxifen

Choose the correct statement about nonopioid analgesics: A. All have antiinflammatory property B. All lack dependence producing liability C. All act exclusively at peripheral pain mechanisms D. All inhibit prostaglandin synthesis

Description : Choose the correct statement about nonopioid analgesics: A. All have antiinflammatory property B. All lack dependence producing liability C. All act exclusively at peripheral pain mechanisms D. All inhibit prostaglandin synthesis

Last Answer : B. All lack dependence producing liability

The quarternary analogues of belladonna alkaloids are preferred over the natural alkaloids for antisecretory/ antispasmodic indications because: A. They have additional nicotinic receptor blocking activity B. They are incompletely absorbed after oral administration C. They are devoid of CNS and ocular effects D. Dose to dose they are more potent than atropine

Description : The quarternary analogues of belladonna alkaloids are preferred over the natural alkaloids for antisecretory/ antispasmodic indications because: A. They have additional nicotinic receptor blocking activity B. They are ... of CNS and ocular effects D. Dose to dose they are more potent than atropine

Last Answer : C. They are devoid of CNS and ocular effects

Atropine does not exert relaxant/ antispasmodic effect on the following muscle (a) Intestinal (b) Ureteric (c) Bronchial (d) Layngeal

Description : Atropine does not exert relaxant/ antispasmodic effect on the following muscle (a) Intestinal (b) Ureteric (c) Bronchial (d) Layngeal

Last Answer : Ans: D

The most suitable laxative for a patient of irritable bowel disease with spastic constipation is: A. Dietary fibre B. Liquid paraffin C. Bisacodyl D. Senna

Description : The most suitable laxative for a patient of irritable bowel disease with spastic constipation is: A. Dietary fibre B. Liquid paraffin C. Bisacodyl D. Senna

Last Answer : A. Dietary fibre

Stimulant purgatives are contraindicated in the following: A. Bed ridden patients B. Before abdominal radiography C. Spastic constipation D. Atonic constipation

Description : Stimulant purgatives are contraindicated in the following: A. Bed ridden patients B. Before abdominal radiography C. Spastic constipation D. Atonic constipation

Last Answer : C. Spastic constipation

The antihypertensive action of calcium channel blockers is characterized by the following except: A. Delayed onset; blood pressure starts falling after 1–2 weeks therapy B. Lack of central side effects C. No compromise of male sexual function D. Safety in peripheral vascular diseases

Description : The antihypertensive action of calcium channel blockers is characterized by the following except: A. Delayed onset; blood pressure starts falling after 1–2 weeks therapy B. Lack of central side effects C. No compromise of male sexual function D. Safety in peripheral vascular diseases

Last Answer : A. Delayed onset; blood pressure starts falling after 1–2 weeks therapy

The following drug is believed to improve microcirculation in peripheral vascular diseases by promoting RBC flexibility: A. Cyclandelate B. Theophylline C. Pentoxiphylline D. Nicotinic acid

Description : The following drug is believed to improve microcirculation in peripheral vascular diseases by promoting RBC flexibility: A. Cyclandelate B. Theophylline C. Pentoxiphylline D. Nicotinic acid

Last Answer : C. Pentoxiphylline

Organic nitrates relax vascular smooth muscle by: A. Increasing intracellular cyclic GMP B. Increasing intracellular cyclic AMP C. Decreasing intracellular cyclic AMP D. Both ‘A’ and ‘C’ are correct

Description : Organic nitrates relax vascular smooth muscle by: A. Increasing intracellular cyclic GMP B. Increasing intracellular cyclic AMP C. Decreasing intracellular cyclic AMP D. Both ‘A’ and ‘C’ are correct

Last Answer : A. Increasing intracellular cyclic GMP

Oxytremorine is a selective agonist of muscarinic _______ receptors (a) M1 (b) M2 (c) M3 (d) M4

Description : Oxytremorine is a selective agonist of muscarinic _______ receptors (a) M1 (b) M2 (c) M3 (d) M4

Last Answer : Ans: A

The following is not a feature of second generation antihistaminics: A. Nonimpairment of psychomotor performance B. High antimotion sickness activity C. Absence of anticholinergic/anti5 -HTa ctions D. Additional mechanisms of antiallergic action

Description : The following is not a feature of second generation antihistaminics: A. Nonimpairment of psychomotor performance B. High antimotion sickness activity C. Absence of anticholinergic/anti5 -HTa ctions D. Additional mechanisms of antiallergic action

Last Answer : B. High antimotion sickness activity

4 Choose the correct statement about the role of opioid antimotility drugs in the management of diarrhoeas: A. They are used to control diarrhoea irrespective of its etiology B. They should be used only as a short-term measure after ensuring that enteroinvasive organisms are not involved C. They are used as adjuvants to antimicrobial therapy of diarrhoea D. They are the drugs of choice in irritable bowel syndrome diarrhoea

Description : 4 Choose the correct statement about the role of opioid antimotility drugs in the management of diarrhoeas: A. They are used to control diarrhoea irrespective of its etiology B. They should ... antimicrobial therapy of diarrhoea D. They are the drugs of choice in irritable bowel syndrome diarrhoea

Last Answer : B. They should be used only as a short-term measure after ensuring that enteroinvasive organisms are not involved

A. It is a clonidine congener used in spasticity due to stroke or spinal injury B. It reduces muscle tone by activating GABAB receptors C. It inhibits release of excitatory amino-acids in spinal interneurones D. It reduces muscle spasms without producing weaknes

Description : A. It is a clonidine congener used in spasticity due to stroke or spinal injury B. It reduces muscle tone by activating GABAB receptors C. It inhibits release of excitatory amino-acids in spinal interneurones D. It reduces muscle spasms without producing weaknes

Last Answer : B. It reduces muscle tone by activating GABAB receptors

The selective serotonin reuptake inhibitors have overcome the following limitation(s) of typical tricyclic antidepressants: A. Frequent anticholinergic, sedative and hypotensive side effects B. High risk of cardiac arrhythmias and seizures in overdose C. Delayed response

Description : The selective serotonin reuptake inhibitors have overcome the following limitation(s) of typical tricyclic antidepressants: A. Frequent anticholinergic, sedative and hypotensive side effects B. High risk of cardiac arrhythmias and seizures in overdose C. Delayed response

Last Answer : D. It does not block neuronal uptake of biogenic amines

The following tissue is most sensitive to vasopressin: A. Renal collecting ducts B. Intestinal smooth muscle C. Vascular smooth muscle D. Uterus

Description : The following tissue is most sensitive to vasopressin: A. Renal collecting ducts B. Intestinal smooth muscle C. Vascular smooth muscle D. Uterus

Last Answer : A. Renal collecting ducts

The following vasodilator(s) act(s) by opening K+ channels in the vascular smooth muscle: A. Dipyridamole B. Minoxidil C. Diazoxide D. Both ‘B’ and ‘C’

Description : The following vasodilator(s) act(s) by opening K+ channels in the vascular smooth muscle: A. Dipyridamole B. Minoxidil C. Diazoxide D. Both ‘B’ and ‘C’

Last Answer : D. Both ‘B’ and ‘C

Select the tissue that is most sensitive to oxytocin: A. Myometrium B. Myoepithelium of mammary alveoli C. Vascular smooth muscle D. Renal collecting ducts

Description : Select the tissue that is most sensitive to oxytocin: A. Myometrium B. Myoepithelium of mammary alveoli C. Vascular smooth muscle D. Renal collecting ducts

Last Answer : B. Myoepithelium of mammary alveoli

Choose the correct statement about moclobemide: A. It is a reversible inhibitor of MAO-A with short duration of action B. Patients taking it need to be cautioned not to consume tyramine rich food C. It is contraindicated in elderly patients D. It produces anticholinergic side effect

Description : Choose the correct statement about moclobemide: A. It is a reversible inhibitor of MAO-A with short duration of action B. Patients taking it need to be cautioned not to consume tyramine rich food C. It is contraindicated in elderly patients D. It produces anticholinergic side effect

Last Answer : A. It is a reversible inhibitor of MAO-A with short duration of action

Morphine induced constipation involves the following mechanisms except: A. Increase in tone and decrease in propulsive activity of intestinal muscles B. Antivagal action C. Spasm of gastrointestinal sphincters D. Reduction of gastrointestinal secretions

Description : Morphine induced constipation involves the following mechanisms except: A. Increase in tone and decrease in propulsive activity of intestinal muscles B. Antivagal action C. Spasm of gastrointestinal sphincters D. Reduction of gastrointestinal secretions

Last Answer : B. Antivagal action

Losartan is a: A. Selective AT1 receptor antagonist B. Selective AT2 receptor antagonist C. Nonselective AT1 + AT2 receptor antagonist D. AT1 receptor partial agonist

Description : Losartan is a: A. Selective AT1 receptor antagonist B. Selective AT2 receptor antagonist C. Nonselective AT1 + AT2 receptor antagonist D. AT1 receptor partial agonist

Last Answer : A. Selective AT1 receptor antagonist

The following is a selective α2 adrenoceptor antagonist: A. Prazosin B. Phentolamine C. Yohimbine D. Clonidine

Description : The following is a selective α2 adrenoceptor antagonist: A. Prazosin B. Phentolamine C. Yohimbine D. Clonidine

Last Answer : C. Yohimbine

The following is a selective α 2 adrenoceptor antagonist: A. Prazosin B. Phentolamine C. Yohimbine D. Clonidine

Description : The following is a selective α 2 adrenoceptor antagonist: A. Prazosin B. Phentolamine C. Yohimbine D. Clonidine

Last Answer : C. Yohimbine

Choose the correct statement about tetracyclines: A. Being broad spectrum antibioics they are dependable for empirical treatment of lifethreatening infections B. Currently, they are not the first choice antibiotic for any specific infection C. They reduce stool volume and duration of diarrhoea in cholera D. The are preferred for treatment of anaerobic bacterial infections

Description : Choose the correct statement about tetracyclines: A. Being broad spectrum antibioics they are dependable for empirical treatment of lifethreatening infections B. Currently, they are not the first ... of diarrhoea in cholera D. The are preferred for treatment of anaerobic bacterial infections

Last Answer : C. They reduce stool volume and duration of diarrhoea in cholera

Choose the correct statement about ondansetron: A. It is a dopamine D2 receptor antagonist B. It suppresses postoperative nausea and vomiting C. It is the most effective antiemetic for motion sickness D. It is not effective by oral route

Description : Choose the correct statement about ondansetron: A. It is a dopamine D2 receptor antagonist B. It suppresses postoperative nausea and vomiting C. It is the most effective antiemetic for motion sickness D. It is not effective by oral route

Last Answer : B. It suppresses postoperative nausea and vomitin

The quarternary analogues of belladonna alkaloids are preferred over the natural alkaloids for antisecretory/ antispasmodic indications because: A. They have additional nicotinic receptor blocking activity B. They are incompletely absorbed after oral administration C. They are devoid of CNS and ocular effects D. Dose to dose they are more potent than atropine

Description : The quarternary analogues of belladonna alkaloids are preferred over the natural alkaloids for antisecretory/ antispasmodic indications because: A. They have additional nicotinic receptor blocking activity B. They are ... of CNS and ocular effects D. Dose to dose they are more potent than atropine

Last Answer : C. They are devoid of CNS and ocular effects

Metoclopramide blocks apomorphine induced vomiting, produces muscle dystonias and increases prolactin release indicates that it has: A. Anticholinergic action B. Antihistaminic action C. Anti 5-HT3 action D. Antidopaminergic action

Description : Metoclopramide blocks apomorphine induced vomiting, produces muscle dystonias and increases prolactin release indicates that it has: A. Anticholinergic action B. Antihistaminic action C. Anti 5-HT3 action D. Antidopaminergic action

Last Answer : D. Antidopaminergic action

Choose the correct statement about trimetazidine: A. It is a novel calcium channel blocker B. It improves tissue perfusion by modifying rheological property of blood C. It is an antianginal drug which acts by nonhaemodynamic mechanisms D. Both 'A' and 'B' are correct

Description : Choose the correct statement about trimetazidine: A. It is a novel calcium channel blocker B. It improves tissue perfusion by modifying rheological property of blood C. It is an antianginal drug which acts by nonhaemodynamic mechanisms D. Both 'A' and 'B' are correct

Last Answer : C. It is an antianginal drug which acts by nonhaemodynamic mechanisms

Choose the drug that has been found to be more selective for the ω1 subtype of BZD receptor, and produces hypnotic action but little antianxiety, muscle relaxant or anticonvulsant actions: A. Zopiclone B. Zolpidem C. Flumazenil D. Melatonin

Description : Choose the drug that has been found to be more selective for the ω1 subtype of BZD receptor, and produces hypnotic action but little antianxiety, muscle relaxant or anticonvulsant actions: A. Zopiclone B. Zolpidem C. Flumazenil D. Melatonin

Last Answer : B. Zolpidem

Hyoscine differs from atropine in that it: A. Exerts depressant effects on the CNS at relatively low doses B. Exerts more potent effects on the heart than on the eye C. Is longer acting D. Has weaker antimotion sickness activity

Description : Hyoscine differs from atropine in that it: A. Exerts depressant effects on the CNS at relatively low doses B. Exerts more potent effects on the heart than on the eye C. Is longer acting D. Has weaker antimotion sickness activity

Last Answer : A. Exerts depressant effects on the CNS at relatively low doses

Entacapone differs from tolcapone in the following respect/respects: A. It is shorter acting B. It acts only by inhibiting peripheral metabolism of levodopa C. It is not hepatotoxic D. All of the above are correct

Description : Entacapone differs from tolcapone in the following respect/respects: A. It is shorter acting B. It acts only by inhibiting peripheral metabolism of levodopa C. It is not hepatotoxic D. All of the above are correct

Last Answer : D. All of the above are correct

The following is true of rivastigmine except: A. It is a relatively selective inhibitor of G1 isoform of acetylcholinesterase B. It has been found to retard disease progression in Alzheimer's disease C. It affords measurable improvement in Alzheimer's disease symptom score D. It enhances cerebral cholinergic transmission with only mild peripheral effect

Description : The following is true of rivastigmine except: A. It is a relatively selective inhibitor of G1 isoform of acetylcholinesterase B. It has been found to retard disease progression in ... 's disease symptom score D. It enhances cerebral cholinergic transmission with only mild peripheral effect

Last Answer : B. It has been found to retard disease progression in Alzheimer's disease

Choose the correct statement(s) about ipratropium bromide: A. It preferentially dilates peripheral bronchioles B. It produces additional bronchodilatation when added to nebulized salbutamol C. As metered dose inhaler it is used for terminating asthma attacks D. Both 'B' and 'C'

Description : Choose the correct statement(s) about ipratropium bromide: A. It preferentially dilates peripheral bronchioles B. It produces additional bronchodilatation when added to nebulized salbutamol C. As metered dose inhaler it is used for terminating asthma attacks D. Both 'B' and 'C'

Last Answer : B. It produces additional bronchodilatation when added to nebulized salbutamol

The following statement is correct about buspirone: A. It interacts with benzodiazepine receptor as an inverse agonist B. It is a rapidly acting anxiolytic, good for panic states C. It produces physical dependence and suppresses barbiturate withdrawal syndrome D. It has anxiolytic but no anticonvulsant or muscle relaxant propert

Description : The following statement is correct about buspirone: A. It interacts with benzodiazepine receptor as an inverse agonist B. It is a rapidly acting anxiolytic, good for panic states C. ... suppresses barbiturate withdrawal syndrome D. It has anxiolytic but no anticonvulsant or muscle relaxant propert

Last Answer : D. It has anxiolytic but no anticonvulsant or muscle relaxant property

Choose the correct statement about anabolic steroids: A. They are testosterone congeners having anabolic but no androgenic activity B. They are androgens with relatively selective anabolic activity C. They are suitable for long-term therapy in children D. Both ‘B’ and ‘C’ are correct

Description : Choose the correct statement about anabolic steroids: A. They are testosterone congeners having anabolic but no androgenic activity B. They are androgens with relatively selective anabolic activity C. They are suitable for long-term therapy in children D. Both ‘B’ and ‘C’ are correct

Last Answer : B. They are androgens with relatively selective anabolic activity

Choose the correct statement about latanoprost: A. It is a PGF2α derivative used in glaucoma B. It is a selective α1 blocker used in benign hypertrophy of prostate C. It is a 5-α-reductase inhibitor used to reduce the size of enlarged prostate gland D. It is a PGE2 analogue used intravaginally for cervical priming

Description : Choose the correct statement about latanoprost: A. It is a PGF2α derivative used in glaucoma B. It is a selective α1 blocker used in benign hypertrophy of prostate C. It is a 5-α- ... reduce the size of enlarged prostate gland D. It is a PGE2 analogue used intravaginally for cervical priming

Last Answer : A. It is a PGF2α derivative used in glaucoma

Choose the correct statement about latanoprost: A. It is a PGF2α derivative used in glaucoma B. It is a selective α1 blocker used in benign hypertrophy of prostate C. It is a 5-α-reductase inhibitor used to reduce the size of enlarged prostate gland D. It is a PGE2 analogue used intravaginally for cervical priming

Description : Choose the correct statement about latanoprost: A. It is a PGF2α derivative used in glaucoma B. It is a selective α1 blocker used in benign hypertrophy of prostate C. It is a 5-α- ... reduce the size of enlarged prostate gland D. It is a PGE2 analogue used intravaginally for cervical priming

Last Answer : A. It is a PGF2α derivative used in glaucoma

Atropine does not antagonise the following feature of anticholinesterase poisoning: A. Hypotension B. Central excitation C. Muscle paralysis D. Bronchoconstriction

Description : Atropine does not antagonise the following feature of anticholinesterase poisoning: A. Hypotension B. Central excitation C. Muscle paralysis D. Bronchoconstriction

Last Answer : C. Muscle paralysis

The organ most sensitive to actions of atropine is: A. Gastric glands B. Salivary glands C. Urinary bladder muscle D. Heart

Description : The organ most sensitive to actions of atropine is: A. Gastric glands B. Salivary glands C. Urinary bladder muscle D. Heart

Last Answer : B. Salivary glands

Atropine does not antagonise the following feature of anticholinesterase poisoning: A. Hypotension B. Central excitation C. Muscle paralysis D. Bronchoconstriction

Description : Atropine does not antagonise the following feature of anticholinesterase poisoning: A. Hypotension B. Central excitation C. Muscle paralysis D. Bronchoconstriction

Last Answer : C. Muscle paralysis

Of the following, choose the antidepressant having both high sedative and high anticholinergic activity: A. Imipramine B. Amitriptyline C. Fluoxetine D. Trazodone

Description : Of the following, choose the antidepressant having both high sedative and high anticholinergic activity: A. Imipramine B. Amitriptyline C. Fluoxetine D. Trazodone

Last Answer : B. Amitriptyline

Of the following, choose the antidepressant having both high sedative and high anticholinergic activity: A. Imipramine B. Amitriptyline C. Fluoxetine D. Trazodone

Description : Of the following, choose the antidepressant having both high sedative and high anticholinergic activity: A. Imipramine B. Amitriptyline C. Fluoxetine D. Trazodone

Last Answer : B. Amitriptyline

Choose the relatively vasicoselective anticholinergic drug used for urinary frequency and urge incontinence due to detrusor instability: A. Pirenzepine B. Oxybutynin C. Oxyphenonium D. Glycopyrolate

Description : Choose the relatively vasicoselective anticholinergic drug used for urinary frequency and urge incontinence due to detrusor instability: A. Pirenzepine B. Oxybutynin C. Oxyphenonium D. Glycopyrolate

Last Answer : B. Oxybutynin

Choose the relatively vasicoselective anticholinergic drug used for urinary frequency and urge incontinence due to detrusor instability: A. Pirenzepine B. Oxybutynin C. Oxyphenonium D. Glycopyrolate

Description : Choose the relatively vasicoselective anticholinergic drug used for urinary frequency and urge incontinence due to detrusor instability: A. Pirenzepine B. Oxybutynin C. Oxyphenonium D. Glycopyrolate

Last Answer : B. Oxybutynin

Atropine overdose may cause which one of the following (a) Gastrointestinal smooth muscle crampine (b) Increased cardiac rate (c) Increased gastric secretion (d) Pupillary constriction (e) Urinary frequency

Description : Atropine overdose may cause which one of the following (a) Gastrointestinal smooth muscle crampine (b) Increased cardiac rate (c) Increased gastric secretion (d) Pupillary constriction (e) Urinary frequency

Last Answer : Ans: B

Hydralazine is a directly acting vasodilator, but is not used alone as an antihypertensive because: A. By itself, it is a low efficacy antihypertensive B. Effective doses cause marked postural hypotension C. Tolerance to the antihypertensive action develops early due to counterregulatory mechanisms D. It primarily reduces systolic blood pressure with little effect on diastolic blood pressure

Description : Hydralazine is a directly acting vasodilator, but is not used alone as an antihypertensive because: A. By itself, it is a low efficacy antihypertensive B. Effective doses cause marked ... mechanisms D. It primarily reduces systolic blood pressure with little effect on diastolic blood pressure

Last Answer : C. Tolerance to the antihypertensive action develops early due to counterregulatory mechanisms

Methyldopa lowers BP by: A. Inhibiting dopa decarboxylase in adrenergic nerve endings B. Generating α-methyl noradrenaline in brain which reduces sympathetic tone C. Generating α-methyl noradrenaline which acts as a false transmitter in peripheral adrenergic nerve endings D. Activating vascular dopamine receptors

Description : Methyldopa lowers BP by: A. Inhibiting dopa decarboxylase in adrenergic nerve endings B. Generating α-methyl noradrenaline in brain which reduces sympathetic tone C. Generating α-methyl ... as a false transmitter in peripheral adrenergic nerve endings D. Activating vascular dopamine receptors

Last Answer : B. Generating α-methyl noradrenaline in brain which reduces sympathetic tone

The most likely mechanism of antihypertensive action of thiazide diuretics in the long-term is: A. Reduction of circulating blood volume B. Reduction in cardiac output C. Decreased sympathetic tone D. Reduction in total peripheral vascular resistance and improved compliance of resistance vessels

Description : The most likely mechanism of antihypertensive action of thiazide diuretics in the long-term is: A. Reduction of circulating blood volume B. Reduction in cardiac output C. Decreased sympathetic tone D. Reduction in total peripheral vascular resistance and improved compliance of resistance vessels

Last Answer : D. Reduction in total peripheral vascular resistance and improved compliance of resistance vessels