Description : What is true of nimesulide: A. It exerts antiinflammatory action by several mechanisms in addition to cyclooxygenase inhibition B. It is preferred for long-term use in rheumatoid arthritis C. It is contraindicated in aspirin intolerant asthma patients D. All of the above
Last Answer : A. It exerts antiinflammatory action by several mechanisms in addition to cyclooxygenase inhibition
Description : Of the following classifications of medications, which is known to inhibit prostaglandin synthesis or release? a) Nonsteroidal anti-inflammatory drugs (NSAIDs) in large doses NSAIDs ... to cause immunosuppression. d) Antineoplastic agents Antineoplastic agents are known to cause immunosuppression.
Last Answer : a) Nonsteroidal anti-inflammatory drugs (NSAIDs) in large doses NSAIDs include aspirin and ibuprofen.
Description : Choose the correct statement about nefopam: A. It is a nonopioid analgesic which does not inhibit prostaglandin synthesis B. It is an orally active opioid analgesic C. It is an analgesic with potent antiinflammatory activity D. It is a preferential COX-2 inhibitor
Last Answer : A. It is a nonopioid analgesic which does not inhibit prostaglandin synthesis
Description : Choose the correct statement about nonopioid analgesics: A. All have antiinflammatory property B. All lack dependence producing liability C. All act exclusively at peripheral pain mechanisms D. All inhibit prostaglandin synthesis
Last Answer : B. All lack dependence producing liability
Description : Roxithromycin has the following advantage(s) over erythromycin: A. It is more effective in whooping cough B. It causes less gastric irritation C. It has longer plasma half-life D. Both 'B' and 'C' are correct
Last Answer : D. Both 'B' and 'C' are correct
Description : The distinctive feature of the isoenzyme cyclooxygenase-2 is: A. It is not inhibited by indomethacin B. It is inducible C. It generates cytoprotective prostagladins in gastric mucosa D. It is found only in foetal tissues
Last Answer : B. It is inducible
Description : The limitations of quinidine in the treatment of cardiac arrhythmias include the following except: A. It has narrow spectrum antiarrhythmic activity B. It is not tolerated by many patients C. It can precipitate myocardial decompensation D. It can cause marked hypotension
Last Answer : A. It has narrow spectrum antiarrhythmic activity
Description : The distinctive feature(s) of methadone compared to morphine is/are: A. High oral bioavailability B. High plasma protein and tissue binding C. Delayed and milder withdrawal symptoms in dependent subjects D. All of the above
Last Answer : D. All of the above
Description : The following is true of clarithromycin except: A. It produces less gastric irritation and pain than erythromycin B. It is the most active macrolide antibiotic against Helicobacter pylori ... terfenadine or cisapride to cause cardiac arrhythmias D. It exhibits dose dependent elimination kinetics
Last Answer : C. It does not interact with terfenadine or cisapride to cause cardiac arrhythmias
Description : Weakly acidic drugs: A. Are bound primarily to α1 acid glycoprotein in plasma B. Are excreted faster in alkaline urine C. Are highly ionized in the gastric juice D. Do not cross blood-brain barrier
Last Answer : B. Are excreted faster in alkaline urine
Description : Bradykinin and angiotensin II have the following feature common to both: A. They both cause fall in BP B. They both are degraded by Kininase II C. Their precursor proteins are plasma α2 globulins D. They both release aldosterone from adrenal cortex
Last Answer : C. Their precursor proteins are plasma α2 globulins
Description : Histamine H2 blockers attenuate the gastric secretory response to acetylcholine and pentagastrin as well because: A. H2 blockers block gastric mucosal cholinergic and gastrin receptors as well B. H2 ... acetylcholine and gastrin all act through the phospholipase C-IP3:DAG pathway in gastric mucosa
Last Answer : C. Acetylcholine and gastrin act partly by releasing histamine in gastric mucosa
Description : The distinctive feature of secnidazole is: A. It is not absorbed after oral ingestion B. It is recommended for single dose treatment of intestinal amoebiasis C. It is effective in intestinal but not in hepatic amoebiasis D. It is effective in both trichomonas as well as monilial vaginitis
Last Answer : B. It is recommended for single dose treatment of intestinal amoebiasis
Description : The distinctive feature of terbinafine is: A. It is highly effective in histoplasmosis B. It can be used topically as well as orally for dermatophytosis C. It inhibits Mucor and Aspergillus as well D. Applied intravaginally it cures both candida as well as trichomonas vaginitis
Last Answer : B. It can be used topically as well as orally for dermatophytosis
Description : riiodothyronine differs from thyroxine in that: A. It is more avidly bound to plasma proteins B. It has a shorter plasma half life C. It is less potent D. It has a longer latency of action
Last Answer : B. It has a shorter plasma half life
Description : 17.2 Triiodothyronine differs from thyroxine in that: A. It is more avidly bound to plasma proteins B. It has a shorter plasma half life C. It is less potent D. It has a longer latency of action (
Description : The following is true of proton pump inhibitors except: A. They are the most effective drugs for Zolinger Ellison syndrome B. Their prolonged use can cause atrophy of gastric mucosa C. They inhibit growth of H. pylori in stomach D. They have no effect on gastric motilit
Last Answer : B. Their prolonged use can cause atrophy of gastric mucosa
Description : n the treatment of hyperthyroidism, carbimazole has the following advantage over radioactive iodine: A. Cost of treatment is lower B. It is preferable in uncooperative patient C. It is better tolerated by the patients D. Hypothyroidism when induced is reversible
Last Answer : Hypothyroidism when induced is reversible
Description : In addition to their ability to decrease inflammatory prostaglandin synthesis, some non-steroidal anti-inflammatory drugs (NSAIDs) may owe part of their effects to their ability to (a) Inhibit leukocyte migration (b ... (c) Stabilize lysosmal membranes (d) All of the above (e) None of the above
Last Answer : Ans: D
Description : Choose the drug which alters surface receptors on platelet membrane to inhibit aggregation, release reaction and to improve platelet survival in extracorporeal circulation: A. Dipyridamole B. Ticlopidine C. Aspirin D. Heparin
Last Answer : B. Ticlopidine
Description : A patient who has been taking quantities of aspirin might show increased post operative bleeding because aspirin inhibits:** A. Synthesis of thromboxane A2 and prevents platelet aggregation B. ... network E. Increase the absorption of vitamin K and prevents synthesis of blood clotting factors
Last Answer : A. Synthesis of thromboxane A2 and prevents platelet aggregation
Description : Inhibition of prostaglandin synthesis does not underlie the following action of aspirin: A. Analgesia B. Closure of patent ductus arteriosus C. Hyperventilation D. Bleeding tendency
Last Answer : C. Hyperventilation
Description : The constellation of adverse effects associated with nonsteroidal antiinflammatory drugs include the following except: A. Sedation B. Gastric irritation C. Fluid retention D. Rashes
Last Answer : A. Sedation
Description : The following drug displaces plasma protein bound phenytoin as well as decreases its metabolism: A. Carbamazepine B. Sodium valproate C. Cimetidine D. Chloramphenicol
Last Answer : B. Sodium valproate
Description : The distinctive features of fluoxetine compared to the typical tricyclic antidepressants include the following except: A. It is less likely to produce cardiac arrhythmias in overdose B. It infrequently ... suffering from chronic somatic illness D. It does not block neuronal uptake of biogenic amines
Last Answer : D. It does not block neuronal uptake of biogenic amines
Description : The distinctive action of chlorpromazine like drugs not possessed by any other class of drugs is: A. Relief of anxiety without producing sedation B. Suppression of agressive behaviour C. Mood elevation in depressed patients D. Correction of distortions of thoug
Last Answer : D. Correction of distortions of thought and perception occurring in psy
Description : Aldosterone enhances Na+ reabsorption in renal tubules by: A. Stimulating carbonic anhydrase B. Activating Na+ K+ ATPase C. Inducing the synthesis of Na+ K+ ATPase D. Inducing renal prostaglandin synthesis
Last Answer : C. Inducing the synthesis of Na+ K+ ATPase
Description : Tachyphylaxis to many actions on repeated injection is a feature of the following autacoid: A. Histamine B. 5-Hydroxytryptamine C. Bradykinin D. Prostaglandin E2
Last Answer : B. 5-Hydroxytryptamine
Description : The distinctive feature(s) of sparfloxacin compared to ciprofloxacin is/are: A. Enhanced activity against gram positive bacteria B. Lack of pharmacokinetic interaction with theophylline and warfarin C. Higher incidence of phototoxic reaction D. All of the above
Description : Agonist induced autophosphorylation, internalization and down regulation is a distinctive feature of: A. G-protein coupled receptors B. Intrinsic ion channel containing receptors C. Tyrosine protein kinase receptors D. Receptors regulating gene expression
Last Answer : C. Tyrosine protein kinase receptors
Description : Blockade of both dopamine D2 and serotonin 5-HT2A/2C receptors is a distinctive feature of: A. Pimozide B. Haloperidol C. Ketanserin D. Clozapine
Last Answer : D. Clozapine
Description : Roxithromycin has the following advantages over erythromycin except (a) It is more effective in whooping cough (b) It causes less gastric irritation (c) It has longer plasma half-life (d) It is unlikely to precipitate theophylline toxicity
Last Answer : Ans: A
Description : As an anthelmintic mebendazole has the following advantages except: A. It is active against most intestinal helminths B. It is very well tolerated C. Single dose cures roundworm and hookworm infestation D. It does not require predrug fasting or postdrug purging
Last Answer : C. Single dose cures roundworm and hookworm infestatio
Description : Inhibitors of prostaglandin synthesis share the following features except: A. Prolongation of bleeding time B. Prolongation of prothrombin time C. Prolongation of labour D. Gastric mucosal damage
Last Answer : B. Prolongation of prothrombin time
Description : The following is true of heparin except: A. Sudden stoppage of continuous heparin therapy causes rebound increase in blood coagulability B. High doses of heparin inhibit platelet aggregation ... active circulating anticoagulant D. Heparin clears lipemic plasma in vivo but not in vitro
Last Answer : C. Heparin is the physiologically active circulating anticoagulant
Description : Carbimazole differs from propylthiouracil in that: A. It is dose to dose less potent B. It has a shorter plasma half life C. It does not produce an active metabolite D. It does not inhibit peripheral conversion of thyroxine to triiodothyronine
Last Answer : D. It does not inhibit peripheral conversion of thyroxine to triiodothyronine
Description : Aspirin is contraindicated in children suffering from influenza or similar viral infection because of increased risk of: A. Gastric bleeding B. Thrombocytopenia C. Fancony syndrome D. Reye’s syndrome
Last Answer : D. Reye’s syndrome
Description : The distinctive feature of the isoenzyme cyclooxygenase-2 is (a) It is not inhibited by indomethacin (b) It is inducible (c) It generates cytoprotective prostagladins in gastric mucosa (d) It is found only in foetal tissues
Last Answer : Ans: B
Description : The following is applicable to itraconazole except: A. It has largely replaced ketoconazole for treatment of systemic mycosis B. It does not inhibit human steroid hormone synthesis C. It is ... the treatment of fungal meningitis D. It can interact with terfenadine to produce ventricular arrhythmias
Last Answer : C. It is preferred for the treatment of fungal meningitis
Description : The most important mechanism by which tetracycline antibiotics exert antimicrobial action is: A. They chelate Ca2+ ions and alter permeability of bacterial cell membrane B. They bind to 30S ribosomes ... peptide chain in the bacteria D. They interfere with DNA mediated RNA synthesis in bacteria
Last Answer : B. They bind to 30S ribosomes and inhibit bacterial protein synthesis
Description : Transdermal estradiol differs from oral estrogen therapy in that it: A. Causes less induction of hepatic synthesis of clotting factors B. Does not inhibit FSH secretion C. Does not affect vaginal cytology D. All of the above are correct
Last Answer : A. Causes less induction of hepatic synthesis of clotting factors
Description : ntithyroid drugs exert the following action: A. Inhibit thyroxine synthesis B. Block the action of thyroxine on pituitary C. Block the action of TSH on thyroid D. Block the action of thyroxine on peripheral tissues
Last Answer : A. Inhibit thyroxine synthesis
Description : Antithyroid drugs exert the following action: A. Inhibit thyroxine synthesis B. Block the action of thyroxine on pituitary C. Block the action of TSH on thyroid D. Block the action of thyroxine on peripheral tissues
Last Answer : . Inhibit thyroxine synthesis
Description : The most effective drug for prevention of stroke in atrial fibrillation patients is: A. Aspirin B. Warfarin C. Low dose subcutaneous heparin D. Digoxin
Last Answer : B. Warfarin
Description : Which of the following is a disease modifying antirheumatic drug whose active metabolite inhibits the enzyme dihydro-orotate dehydrogenase: A. Leflunomide B. Nimesulide C. Sulfasalazine D. Colchicine
Last Answer : A. Leflunomide
Description : Select the drug which inhibits cyclooxygenase in the brain but not at peripheral sites of inflammation: A. Nimesulide B. Paracetamol C. Ketorolac D. Mephenamic acid
Last Answer : B. Paracetamol
Description : Which of the following is an efficacious antiinflammatory drug but a relatively weak inhibitor of cyclooxygenase: A. Nimesulide B. Paracetamol C. Ketoprofen D. Indomethacin
Last Answer : A. Nimesulide
Description : Which analgesic-antiinflammatory drug is more appropriate in musculo-skeletal disorder where pain is more prominent than inflammation: A. Ibuprofen B. Piroxicam C. Indomethacin D. Nimesulide
Last Answer : A. Ibuprofen
Description : The following is not a feature of thiazide diuretics used as antihypertensive: A. They do not cause symptomatic postural hypotension B. The dose has to be titrated over a wide range ... has developed D. They decrease renal calcium excretion which may improve calcium balance in elderly patients
Last Answer : B. The dose has to be titrated over a wide range according to the response
Description : The plasma half life of aspirin (along with salicylic acid released from it): A. Remains constant irrespective of dose B. Is longer for antiinflammatory doses compared to that for analgesic ... for antiinflammatory doses compared to that for analgesic dose D. Can be shortened by acidifying urine
Last Answer : B. Is longer for antiinflammatory doses compared to that for analgesic dose