6.9 For therapeutic use, growth hormone is obtained
from:
A. Recombinant DNA technique
B. Human cadaver pituitaries
C. Porcine pituitaries
D. Chemical synthesis

1 Answer

Answer :

A. Recombinant DNA technique

Related questions

Description : Human insulins are obtained by the following sources/methods except: A. Cadaver pancreas B. Proinsulin recombinant bacterial C. Precursor yeast recombinant D. Enzyme modification of pork insulin

Last Answer : . Cadaver pancreas

Description : The first protein synthesized by recombinant DNA technology was (A) Streptokinase (B) Human growth hormone (C) Tissue plasminogen activator (D) Human insulin

Last Answer : Answer : D

Description : 16.3 Actions of growth hormone include the following except: A. Increased protein synthesis B. Increased fat utilization C. Increased carbohydrate utilization D. Glucose intolerance

Last Answer : C. Increased carbohydrate utilization

Description : The first human hormone produced by recombinant DNA technology is (a) insulin (b) estrogen (c) thyroxin (d) progesterone

Last Answer : (a) insulin

Description : The following is applicable to itraconazole except: A. It has largely replaced ketoconazole for treatment of systemic mycosis B. It does not inhibit human steroid hormone synthesis C. It is ... the treatment of fungal meningitis D. It can interact with terfenadine to produce ventricular arrhythmias

Last Answer : C. It is preferred for the treatment of fungal meningitis

Description : Recombinant human erythropoietin is indicated for: A. Megaloblastic anaemia B. Haemolytic anaemia C. Anaemia in patients of thalassemia D. Anaemia in chronic renal failure patients

Last Answer : D. Anaemia in chronic renal failure patients

Description : 16.6 Somatostatin inhibits the release of: A. Growth hormone B. Insulin C. Thyrotropin D. All of the above

Last Answer : D. All of the above

Description : 6.4 Several actions of growth hormone are exerted through the elaboration of: A. Cyclic AMP B. Cyclic GMP C. Somatostatin D. Insulin like growth factor-1

Last Answer : D. Insulin like growth factor-1

Description : The sequence of amino acids in human growth hormone and the synthesis were done by (A) Sanger (B) Krebs (C) Chah Holi (D) Molisch

Last Answer : Answer : C

Description : Vinca alkaloids exert antitumor activity by: A. Activating topoisomerase II to cause breaks in DNA strands B. Crosslinking DNA strands C. Inhibiting DNA mediated RNA synthesis D. Inhibiting polymerization of tubulin to form intracellular microtubules

Last Answer : D. Inhibiting polymerization of tubulin to form intracellular microtubules

Description : The polyene antibiotics act by: A. Inhibiting fungal cytochrome P450 enzyme B. Binding to ergosterol and creating micropores in fungal cell membrane C. Inhibiting fungal DNA synthesis D. Disorienting microtubules in fungal cells

Last Answer : B. Binding to ergosterol and creating micropores in fungal cell membrane

Description : Rifampin kills tubercle bacilli by: A. Binding to mycobacterial DNA dependent RNA polymerase B. Inhibiting mycobacterial DNA synthesis C. Inhibiting synthesis of mycolic acids in mycobacteria D. Damaging mycobacterial mitochondria

Last Answer : A. Binding to mycobacterial DNA dependent RNA polymerase

Description : The most important mechanism by which tetracycline antibiotics exert antimicrobial action is: A. They chelate Ca2+ ions and alter permeability of bacterial cell membrane B. They bind to 30S ribosomes ... peptide chain in the bacteria D. They interfere with DNA mediated RNA synthesis in bacteria

Last Answer : B. They bind to 30S ribosomes and inhibit bacterial protein synthesis

Description : 16.8 Drugs that suppress growth hormone release in acromegaly include the following except: A. Bromocriptine B. Somatostatin C. Octreotide D. Nafarelin

Last Answer : D. Nafarelin

Description : 16.5 Octreotide is a long acting synthetic analogue of: A. Prolactin B. Growth hormone C. Somatostatin D. Gonadotropin releasing hormone

Last Answer : D. All of the above

Description : The following hypothalamic regulatory hormone is not a peptide: A. Growth hormone release inhibitory hormone B. Prolactin release inhibitory hormone C. Gonadotropin releasing hormone D. Corticotropin releasing hormone (

Last Answer : B. Prolactin release inhibitory hormone

Description : Indicate the drug which attains therapeutic antibacterial concentration in the urinary tract but not in other tissues: A. Pefloxacin B. Amikacin C. Nitrofurantoin D. Cephalexin

Last Answer : C. Nitrofurantoin

Description : Select the antibiotic that has a high therapeutic index: A. Streptomycin B. Doxycycline C. Cephalexin D. Vancomycin

Last Answer : C. Cephalexin

Description : Mesalazine (coated 5-amino salicylic acid) differs from sulfasalazine in that: A. It is more effective in ulcerative colitis B. It produces less adverse effect C. It has no therapeutic effect in rheumatoid arthritis D. Both ‘B’ and ‘C’ are correc

Last Answer : D. Both ‘B’ and ‘C’ are correct

Description : The therapeutic effect of sulfasalazine in ulcerative colitis is exerted by: A. Inhibitory action of the unabsorbed drug on the abnormal colonic flora B. Breakdown of the drug in ... locally C. Release of sulfapyridine having antibacterial property D. Systemic immunomodulatory action of the drug

Last Answer : B. Breakdown of the drug in colon to release 5-aminosalicylic acid which suppresses inflammation locally

Description : You are treating a patient of deep vein thrombosis with warfarin. What value of International normalized ratio (INR) will you attempt by adjusting dose of the anticoagulant for an adequate therapeutic effect: A. 1.2 – 1.5 B. 1.3 – 1.7 C. 1.5 – 2.0 D. 2.0 – 3.0

Last Answer : D. 2.0 – 3.0

Description : he current therapeutic indication of acetazolamide is: A. Congestive heart failure B. Renal insufficiency C. Cirrhosis of liver D. Glaucoma

Last Answer : D. Glaucoma

Description : n a failing heart therapeutic dose of digoxin has no effect on the following parameter: A. Cardiac output B. Heart rate C. Tone of ventricular fibres D. Cardiac vagal tone

Last Answer : C. Tone of ventricular fibres

Description : Angiotensin converting enzyme inhibitors afford maximum protection against progression of heart failure when used: A. At the higher therapeutic dose range over long term B. At the maximum tolerated dose only till ... restored C. At low doses over long term D. At low doses along with diuretics/digoxi

Last Answer : A. At the higher therapeutic dose range over long term

Description : The following drug claimed to have a therapeutic effect in senile dementia has α adrenergic blocking activity: A. Piracetam B. Pyritinol C. Codergocrine D. Methylphenidate

Last Answer : C. Codergocrine

Description : For therapeutic effect in manic depressive illness, steady-state serum lithium concentration should be maintained between: A. 0.2–0.4 mEq/L B. 0.5–0.8 mEq/L C. 1.0–1.3 mEq/L D. 1.5–2.5 mEq/L

Last Answer : B. 0.5–0.8 mEq/L

Description : A patient of endogenous depression was put on imipramine therapy. After what interval the therapeutic effect is likely to manifest: A. Three days B. One week C. Three weeks D. Three months

Last Answer : C. Three weeks

Description : The antiparkinsonian action of central anticholinergics has the following features except: A. They control tremor more than rigidity B. They produce a low ceiling therapeutic effect C. They are effective in neuroleptic drug induced parkinsonism D. They are the preferred drugs in advanced case

Last Answer : D. They are the preferred drugs in advanced cases

Description : The following is true about entacapone except: A. It acts by inhibiting degradation of dopamine in the brain B. If prolongs the therapeutic effect of levodopacarbidopa in parkinsonism C. It can accentuate levodopa induced dyskinesias D. It can cause diarrhoea as a side effec

Last Answer : A. It acts by inhibiting degradation of dopamine in the brain

Description : The primary action by which entacapone and tolcapone enhance the therapeutic effect of levodopa-carbidopa in parkinsonism is: A. Inhibition of levodopa methylation in the liver B. Inhibition of ... of dopamine in the brain D. Facilitation of active transport of levodopa across brain capillaries

Last Answer : A. Inhibition of levodopa methylation in the liver

Description : Though bromocriptine acts directly on dopamine receptors, it is used in parkinsonism only as a supplement to levodopa because: A. It has low efficacy B. It produces marked dyskinesias C. ... its effective doses produce intolerable side effects D. Its therapeutic effect takes long time to develop

Last Answer : C. Used alone, its effective doses produce intolerable side effect

Description : The drug which abolishes the therapeutic effect of levodopa in parkinsonism, but not that of levodopacarbidopa combination is: A. Metoclopramide B. Pyridoxine C. Chlorpromazine D. Isoniazid

Last Answer : B. Pyridoxine

Description : The following drug/drugs does/do not produce any overt CNS effect in normal individuals but exert(s) clear cut therapeutic effect at the same dose in the presence of a specific neurological/psychiatric disorder: A. Chlorpromazine B. Levodopa C. Imipramine D. All of the above

Last Answer : B. Levodopa

Description : The characteristic feature of phenytoin pharmacokinetics is: A. High first pass metabolism B. Nonsaturation kinetics of metabolism C. Capacity limited metabolism saturating at higher therapeutic concentration range D. Extrahepatic metabolism

Last Answer : C. Capacity limited metabolism saturating at higher therapeutic concentration range

Description : Benzodiazepines differ from barbiturates in the following aspects except: A. They have a steeper dose response curve B. They have higher therapeutic index C. They have lower abuse liability D. They do not induce microsomal drug metabolizing enzymes

Last Answer : A. They have a steeper dose response curve

Description : he minimal alveolar concentration of an inhalational anaesthetic is a measure of its: A. Potency B. Therapeutic index C. Diffusibility D. Oil: water partition coefficient

Last Answer : A. Potency

Description : At therapeutic doses, actions of amphetamine include the following except: A. Prolongation of attention span B. Wakefulness C. Lowering of seizure threshold D. Delaying fatigue

Last Answer : C. Lowering of seizure threshold

Description : At therapeutic doses, actions of amphetamine include the following except: A. Prolongation of attention span B. Wakefulness C. Lowering of seizure threshold D. Delaying fatigue

Last Answer : C. Lowering of seizure threshold

Description : The site of action of miotics for therapeutic effect in angle closure glaucoma is: A. Canal of Schlemm B. Ciliary body C. Ciliary muscle D. Sphincter pupillae muscle

Last Answer : D. Sphincter pupillae muscle

Description : Which of the following drugs exhibits ‘therapeutic window’ phenomenon: A. Captopril B. Furosemide C. Diazepam D. Imipramine

Last Answer : D. Imipramine

Description : When therapeutic effects decline both below and above a narrow range of doses, a drug is said to exhibit: A. Ceiling effect B. Desensitization C. Therapeutic window phenomenon D. Nonreceptor mediated action

Last Answer : C. Therapeutic window phenomenon

Description : Relatively higher dose of theophylline is required to attain therapeutic plasma concentration in: A. Smokers B. Congestive heart failure patients C. Those receiving erythromycin D. Those receiving cimetidine

Last Answer : A. Smokers

Description : Which component of sulfasalazine is responsible for the therapeutic effect in rheumatoid arthritis: A. Intact sulfasalazine molecule B. Sulfapyridine C. 5–aminosalicylic acid D. Both ‘B’ and ‘C’

Last Answer : B. Sulfapyridine

Description : At therapeutic doses, actions of amphetamine include the following except: A. Prolongation of attention span B. Wakefulness C. Lowering of seizure threshold D. Delaying fatigue

Last Answer : C. Lowering of seizure threshold

Description : Some contemporary products already obtained by plasmid technology include a. interferon b. insulin c. human growth hormone d. A-C above are correct

Last Answer : d. A-C above are correct

Description : Assetion: In recombinant DNA technology, human genes are often transferred into bacteria (prokaryotes) or yeast (eukaryote) Reason : Both bacteria and

Last Answer : Assetion: In recombinant DNA technology, human genes are often transferred into bacteria (prokaryotes) or ... . If both assertion and reason are false

Description : Which of the following features of genetic code does allow bacteria to produce human insulin by recombinant DNA technology? (a) Genetic code is specific. (b) Genetic code is not ambiguous. (c) Genetic code is redundant. (d) Genetic code is nearly universal

Last Answer : (c) Genetic code is redundant.

Description : Which of the following features of genetic code does allow bacteria to produce human insulin by recombinant DNA technology? (a) Genetic code is specific. (b) Genetic code is not ambiguous. (c) Genetic code is redundant. (d) Genetic code is nearly universal.

Last Answer : (d) Genetic code is nearly universal

Description : Which of the following statement(s) is/are true concerning pharmacologic agents used to accelerate wound healing? a. A number of these agents are now currently approved for use in ... healing in chronic wounds d. Growth hormone functions by promoting fibroblast proliferation and collagen synthesis

Last Answer : Answer: b, c Currently there are no approved clinical agents that accelerate normal healing. Although a number of clinical trials are in progress, no agents are currently ... hormone administration significantly accelerates donor site healing, presumably due to its effects in minimizing catabolism

Description : Most hormone receptors are localized on the cell membrane and transduce hormone binding into altered levels of intracellular messengers. A limited number of intracellular receptors do exist. Which of ... protein serves as an inhibitor protein blocking the DNA-binding domain of the steroid receptor

Last Answer : Answer: a, d Although most hormone and other messenger receptors are extracellular, intracellular receptors have been identified. The hormone messengers involved for these receptors are primarily ... DNA-binding domain of the receptor. Activation involves the dissociation of the inhibitor protein