Description : Which of the following is true of acarbose: A. It reduces absorption of glucose from intestines B. It produces hypoglycaemia in normal as well as diabetic subjects C. It limits postprandial hyperglycaemia in diabetics D. It raises circulating insulin levels
Last Answer : C. It limits postprandial hyperglycaemia in diabetics
Description : Which of the following is not a sulfonylurea but acts by analogous mechanism to bring about quick and brief insulin release that is useful for normalizing meal time glycaemic excursions in type 2 diabetes mellitus: A. Glimepiride B. Miglitol C. Repaglinide D. Rosiglitazone
Last Answer : C. Repaglinide
Description : Select the drug for which the following instructions must be given to the patient "To be taken on empty stomach in the morning with a full glass of water (not milk, tea or coffee), to remain ... not take any food or medicine for 30 min": A. Alfacalcidol B. Alendronate C. Glibenclamide D. Raloxifene
Last Answer : B. Alendronate
Description : In a patient of diabetes mellitus maintained on insulin therapy, administration of the following drug can vitiate glycaemia control: A. Prednisolone B. Prazosin C. Paracetamol D. Phenytoin
Last Answer : A. Prednisolone
Description : A drug which is generally administered in standard doses without the need for dose individualization is: A. Insulin B. Mebendazole C. Prednisolone D. Digoxin
Last Answer : B. Mebendazole
Description : Which of the following glucose transporters is insulin-dependent? (a) GLUT IV (b) GLUT I (c) GLUT II (d) GLUT III
Last Answer : (a) GLUT IV
Description : The 1st phase of insulin release from pancreatic β cells is augmented by: A. Glibenclamide B. Metformin C. Nateglinide D. Both 'A' and 'C'
Last Answer : C. Nateglinide
Description : he following antidiabetic drug inhibits intestinal brush border α-glucosidase enzymes: A. Acarbose B. Pioglitazone C. Metformin D. Guargum
Last Answer : A. Acarbose
Description : Choose the most suitable antihypertensive drug for a 45-year-old male company executive who has a travelling job. His blood pressure is 160/100 mm Hg, and he is a diabetic ... → rebound hypertension. Hydrochlorothiazide: May worsen diabetes; more likely to produce weakness, fatigue and impotenc
Last Answer : B. Enalapril
Description : Long-term thiazide therapy can cause hyperglycaemia by: A. Reducing insulin release B. Interfering with glucose utilization in tissues C. Increasing sympathetic activity D. Increasing corticosteroid secretion
Last Answer : A. Reducing insulin release
Description : Sulfonylurea hypoglycaemics act by: A. Reducing intestinal absorption of glucose B. Increasing insulin secretion from pancreas C. Reversing down-regulation of insulin receptors D. Both ‘B’ and ‘C’ are correct
Last Answer : D. Both ‘B’ and ‘C’ are correct
Description : The preferred drug for controlling an acute exacerbation of ulcerative colitis is: A. Prednisolone B. Sulfasalazine C. Mesalazine D. Vancomycin
Last Answer : . Prednisolone
Description : Drug cumulation is the basis of organ toxicity of the following drug when used for prolonged periods: A. Prednisolone B. Chloroquine C. Aspirin D. Hydralazine
Last Answer : B. Chloroquine
Description : The following antirheumatic drug affords symptomatic relief but does not bring about remission in rheumatoid arthritis: A. Gold sodium thiomalate B. Prednisolone C. Hydroxychloroquine D. Leflunomide
Last Answer : B. Prednisolone
Description : Which of the following is a reserve drug but not a disease modifying drug in rheumatoid arthritis: A. Chloroquine B. Sulfasalazine C. Prednisolone D. Methotrexate
Last Answer : C. Prednisolone
Description : Select the compound that is preferred for high dose intravenous corticosteroid pulse therapy: A. Cortisone B. Hydrocortisone C. Triamcinolone D. Methyl prednisolone
Last Answer : D. Methyl prednisolone
Description : Select the corticosteroid with the lowest oral: parenteral activity ratio: A. Prednisolone B. Methyl prednisolone C. Hydrocortisone D. Dexamethasone
Last Answer : C. Hydrocortisone
Description : The most important mechanism of bacterial resistance to an aminoglycoside antibiotic is: A. Plasmid mediated acquisition of aminoglycoside conjugating enzyme B. Mutational acquisition of aminoglycoside ... affinity of ribosomal protein for the antibiotic D. Mutational loss of porin channels
Last Answer : A. Plasmid mediated acquisition of aminoglycoside conjugating enzyme
Description : The most likely mechanism of antihypertensive action of thiazide diuretics in the long-term is: A. Reduction of circulating blood volume B. Reduction in cardiac output C. Decreased sympathetic tone D. Reduction in total peripheral vascular resistance and improved compliance of resistance vessels
Last Answer : D. Reduction in total peripheral vascular resistance and improved compliance of resistance vessels
Description : Select the drug which directly inhibits HIV-reverse transcriptase without the need for intracellular activation by phosphorylation: A. Nelfinavir B. Nevirapine C. Stavudine D. Didanosine
Last Answer : B. Nevirapine
Description : Which of the following drugs is a potassium channel opener: A. Nicorandil B. Hydralazine C. Glibenclamide D. Amiloride
Last Answer : D. Amiloride
Description : Select the drug(s) which afford(s) relief in gastroesophageal reflux by increasing lower esophageal sphincter tone and promoting gastric emptying, but without affecting acidity of gastric contents: A. Sodium alginate B. Metoclopramide C. Cisapride D. Both ‘B’ and ‘C
Last Answer : D. Both ‘B’ and ‘C’
Description : Select the drug that improves some symptoms in Alzheimer’s dementia by increasing brain acetylcholine levels: A. Pemoline B. Donepezil C. Nicergoline D. Piribedi
Last Answer : B. Donepezi
Description : Select the drug which is neither analgesic, nor antiinflammatory, nor uricosuric, but is highly efficacious in acute gout: A. Prednisolone B. Colchicine C. Naproxen D. Sulfinpyrazone
Last Answer : B. Colchicine
Description : Gemfibrozil has the following features except: A. It lowers plasma LDL cholesterol to a greater extent than triglycerides B. It tends to raise plasma HDL-cholesterol level C. It is a first ... type III, type IV and type V hyperlipoproteinemia D. It reduces the incidence of myocardial infarctio
Last Answer : A. It lowers plasma LDL cholesterol to a greater extent than triglycerides
Description : The following antihypertensive drug tends to lower plasma renin activity: A. Clonidine B. Hydralazine C. Nifedipine D. Captopril
Last Answer : A. Clonidine
Description : Used alone the following antihypertensive drug tends to increase cardiac work and can precipitate angina: A. Clonidine B. Hydralazine C. Captopril D. Prazosin
Last Answer : B. Hydralazine
Description : The following is true about use of prednisolone in malignant diseases except: A. It is curative in acute childhood leukaemia B. It is used in Hodgkin’s disease C. It controls hypercalcaemia in patients with bony metastasis D. It affords symptomatic relief in most cancer patients
Last Answer : A. It is curative in acute childhood leukaemia
Description : The following measure can minimise pituitary-adrenal suppression during long-term corticosteroid therapy: A. Use of betamethasone in place of prednisolone B. Use of prednisolone on alternate days C. Division of ... in three equal 8 hourly doses D. Administration of the total daily dose at bed time
Last Answer : B. Use of prednisolone on alternate days
Description : A patient of chronic bronchial asthma maintained on oral prednisolone 20 mg daily and inhaled salbutamol as required develops chest infection. Which of the following measures is recommended: A. ... mg/day C. No change/increase in prednisolone dose D. Substitute prednisolone with inhaled budesonid
Last Answer : C. No change/increase in prednisolone dose
Description : A patient being treated with 20 mg prednisolone daily has to be shifted on to dexamethasone. What should be his daily dose of dexamethasone: A. 0.75 mg B. 3 mg C. 10 mg D. 40 mg
Last Answer : B. 3 mg
Description : Dexamethasone differs from prednisolone in that it is: A. Longer acting B. More potent C. More selective D. All of the above
Last Answer : D. All of the above
Description : 6 A patient of chronic bronchial asthma was maintained on oral prednisolone 20 mg/day for 3 months. It was decided to switch him over to inhaled beclomethasone dipropionate 200 μg 4 times a day. What should ... week and then tapered D. Its dose should be doubled for one week and then tapered (p. 2
Last Answer : C. It should be given at the same dose for one week and then tapered
Description : Choose the correct statement about nonsteroidal antiinflammatory drugs (NSAIDs): A. NSAIDs attenuate hypoglycaemic action of sulfonylureas B. NSAIDs potentiate antihypertensive action of ACE inhibitors C. ... D. Combined therapy with prednisolone and NSAIDs carries higher risk of gastric bleeding
Last Answer : D. Combined therapy with prednisolone and NSAIDs carries higher risk of gastric bleeding
Description : ___________ drug can cause lactic acidosis. a) Metformin b) Pioglitazone c) Repaglinide d) Glibenclamide
Last Answer : a) Metformin
Description : Diazoxide is an effective hypotensive, but is not used in the long-term treatment of hypertension because: A. It impairs glucose tolerance by inhibiting insulin release B. It inhibits uric acid ... causes marked Na+ and water retention leading to development of tolerance D. All of the above
Description : Glucocorticoids impair carbohydrate tolerance by: A. Promoting gluconeogenesis in liver B. Depressing glucose uptake into skeletal muscles C. Inhibiting insulin secretion D. Both A and B are correct
Last Answer : D. Both A and B are correct
Description : Glucagon release from pancreas is stimulated by: A. High blood glucose level B. Insulin C. Somatostatin D. Adrenaline
Last Answer : D. Adrenaline
Description : Metformin acts by: A. Releasing insulin from pancreas B. Suppressing gluconeogenesis and glucose output from liver
Last Answer : B. Suppressing gluconeogenesis and glucose output from liver
Description : Choose the correct statement(s) about actions of insulin: A. It favours translocation of glucose transporters from intracellular site to the plasma membrane B. It enhances transcription of lipoprotein ... vascular endothelium C. It increases production of the enzyme glucokinase D. All of the above
Description : Glucose entry into the cells of the following organ/ tissue is highly dependent on the presence of insulin: A. Brain B. Liver C. Adipose tissue D. Kidney tubules
Last Answer : C. Adipose tissue
Description : Action of Insulin does not include the following: A. Facilitation of glucose transport into cells B. Facilitation of glycogen synthesis by liver C. Facilitation of neoglucogenesis by liver D. Inhibition of lipolysis in adipose tissue
Last Answer : . Facilitation of neoglucogenesis by liver
Description : Adrenaline raises blood glucose level by the following actions except: A. Inducing hepatic glycogenolysis B. Inhibiting insulin secretion from pancreatic β cells C. Augmenting glucagon secretion from pancreatic α cells D. Inhibiting peripheral glucose utilization
Last Answer : D. Inhibiting peripheral glucose utilization
Description : Choose the correct statement about paracetamol: A. It increases uric acid excretion B. It is the most common drug implicated in causing analgesic nephropathy C. In equianalgesic doses it is safer than aspirin D. It stimulates cellular metabolism
Last Answer : C. In equianalgesic doses it is safer than aspirin
Description : Which of the following represents the action of insulin? (a) Increases blood glucose level by stimulating glucagon production. (b) Decreases blood glucose levels by forming glycogen. (c) ... promoting cellular uptake of glucose. (d) Increases blood glucose levels by hydrolysis of glycogen.
Last Answer : (b) Decreases blood glucose levels by forming glycogen
Description : Name a peptide hormone which acts mainly on hepatocytes, adipocytes and enhances cellular glucose uptake and utilisation. (a) Insulin (b) Glucagon (c) Secretin (d) Gastrin
Last Answer : (a) Insulin
Description : The present status of oral hypoglycaemics in diabetes mellitus is: A. They are the first choice drug in all cases B. They should be prescribed only if the patient refuses insulin injections C. ... I diabetes mellitus D. They are used first in most uncomplicated mild to moderate type 2 diabetics
Last Answer : D. They are used first in most uncomplicated mild to moderate type 2 diabetics
Description : The thiazolidinediones are mainly used as: A. Sole drug in type 1 diabetes mellitus B. Sole drug in type 2 diabetes mellitus C. Addon drug to a sulfonylurea and/or a biguanide in type 2 diabetes mellitus D. Addon drug to insulin in type 1 ... 18.34 1 8 . 3 4 B 18.35 1 8 . 3 5 D 18.36 1 8 . 3 6 C
Last Answer : C. Addon drug to a sulfonylurea and/or a biguanide in type 2 diabetes mellitus