The following is not true of local anaesthetics: A. The local anaesthetic is required in the unionized form for penetrating the neuronal membrane B. The local anaesthetic approaches its receptor only from the intraneuronal face of the Na+ channel C. The local anaesthetic binds to its receptor mainly when the Na+ channel is in the resting state D. The local anaesthetic combines with its receptor in the ionized cationic form

The following is not true of local anaesthetics:
A. The local anaesthetic is required in the
unionized form for penetrating the neuronal
membrane
B. The local anaesthetic approaches its
receptor only from the intraneuronal face of
the Na+ channel
C. The local anaesthetic binds to its receptor
mainly when the Na+ channel is in the
resting state
D. The local anaesthetic combines with its
receptor in the ionized cationic form
by

1 Answer

Answer :

C. The local anaesthetic binds to its receptor
mainly when the Na+ channel is in the
resting state
by

Related questions

Local anaesthetics block nerve conduction by: A. Blocking all cation channels in the neuronal membrane B. Hyperpolarizing the neuronal membrane C. Interfering with depolarization of the neuronal membrane D. Both ‘B’ and ‘C’ are correct

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e primary mechanism by which general anaesthetics produce their action is: A. Affecting receptor operated ion channels in cerebral neurones B. Blocking voltage sensitive Na+ channels in neuronal membrane C. Depressing metabolic activity of cerebral neurones D. Blocking production of high energy phosphates in the brain

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Last Answer : A. Affecting receptor operated ion channels in cerebral neurones

A resting nerve is relatively resistant to blockade by lignocaine compared to one which is repeatedly stimulated because: A. Lignocaine penetrates resting nerve membrane poorly B. Lignocaine binds more avidly to the inactivated Na+ channel C. Nerve impulse promotes ionization of lignocaine D. Nodes of Ranvier are inaccessible in the resting state

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The local anaesthetics having amide linkage differ from those having ester linkage in that the amidelinked local anaesthetics: A. Are not surface anaesthetics B. Have a shorter duration of action C. Are degraded in the plasma D. Do not show cross-sensitivity with esterlinked local anaesthetic

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Oxethazaine is used for anaesthetizing gastric mucosa because: A. It is not absorbed from the gastrointestinal tract B. It remains largely unionized in acidic medium C. It is highly ionized in acidic medium D. It produces no systemic effects even at high doses

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The GABAB receptor: A. Is an intrinsic ion channel containing receptor B. Mediates neuronal depolarization C. Is insensitive to blockade by bicuculline D. Regulates intracellular cAMP

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Sodium valproate has been shown to: A. Prolong neuronal Na+ channel inactivation B. Attenuate ‘T’ type Ca2+ current in neurones C. Inhibit degradation of GABA by GABA-transaminase D. All of the above

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The most probable mechanism of anticonvulsant action of phenytoin is: A. Facilitation of GABAergic inhibitory transmission B. Hyperpolarization of neurones C. Interaction with Ca2+ channels to promote Ca2+ influx D. Prolongation of voltage sensitive neuronal Na+ channel inactivation

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Select the correct statement about nitrous oxide: A. It irritates the respiratory mucosa B. It has poor analgesic action C. It is primarily used as a carrier and adjuvant to other anaesthetics D. It frequently induces post anaesthetic nausea and retching

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The neuronal resting membrane of the human brain is : a. maintained by the sodium pump b. around -70mV c. maintained by using ATP for energy d. all above

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The following receptor type has 7 helical membrane spanning amino acid segments with 3 extracellular and 3 intracellular loops: A. Tyrosine protein kinase receptor B. Gene expression regulating receptor C. Intrinsic ion channel containing receptor D. G protein coupled receptor

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Toxicity of local anaesthetics involves the following organs except: A. Heart B. Brain C. Kidney D. Skin and subcutaneous tissue

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Which of the following is not the reason for greater susceptibility of smaller sensory fibres to blockade by local anaesthetics than larger motor fibres: A. Sensory fibres are inherently more sensitive than motor fibres B. More slender fibres have shorter internodal distances C. Small sensory fibres generate higher frequency longer lasting action potential D. Smaller fibres have shorter critical lengths for blockade

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The clinically used local anaesthetics have the following common features except: A. They are amphiphilic weak bases B. They are used for surgery in non-cooperative patients C. In their use, care of vital functions is generally not needed D. They are safer than general anaesthetics in patients with respiratory and cardiovascular disease

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Which of the following statements is true for lignocaine: A. It is an ester-linked local anaesthetic B. It is not likely to exhibit cross-sensitivity with procaine C. It has a shorter duration of action than procaine D. It is not a surface anaesthetic

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Omeprazole exerts practically no other action except inhibition of gastric acid secretion because: A. It transforms into the active cationic forms only in the acidic pH of the gastric juice B. Its active forms have selective affinity for the H+K+ATPase located in the apical canaliculi of gastric parietal cells C. Its cationic forms are unable to diffuse out from the gastric parietal cell canaliculi D. All of the above

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In the resting state of the neural membrane, diffusion due to concentration gradients, if allowed, would drive (a) K+ into the cell (b) K+ and Na+ out of the cell (c) Na+ into the cell (d) Na+ out of the cell.

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When a neuron is in resting state i.e., not conducting any impulse, the axonal membrane is (a) comparatively more permeable to Na+ ions and nearly impermeable to K+ ions (b) equally permeable to both Na+ and K+ ions (c) impermeable to both Na+ and K+ ions (d) comparatively more permeable to K+ ions and nearly impermeable to Na+ ions.

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Epidural anaesthesia differs from spinal anaesthesia in that: A. Epidural anaesthesia produces less cardiovascular complications B. Headache is more common after epidural anaesthesia C. Blood concentrations of the local anaesthetic are lower after epidural anaesthesia D. Greater separation between sensory and motor blockade can be obtained with epidural anaesthes

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The duration of spinal anaesthesia depends on each of the following except: A. Which local anaesthetic is used B. Concentration of the local anaesthetic used C. Posture of the patient D. Whether adrenaline has been added to the local anaesthetic

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The segmental level of spinal anaesthesia depends on: A. Volume of the local anaesthetic injected B. Specific gravity of the local anaesthetic solution C. Posture of the patient D. All of the above factors

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n which of the following techniques the concentration of the local anaesthetic used is the lowest: A. Infiltration anaesthesia B. Nerve block anaesthesia C. Spinal anaesthesia D. Epidural anaesthesia

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Choose the local anaesthetic that is specifically used to produce corneal anaesthesia for tonometry: A. Tetracaine B. Oxethazaine C. Ropivacaine D. Benoxinate

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The following local anaesthetic is poorly water soluble, PABA derivative and primarily used for anorectal lesions, wounds and ulcers: A. Benzocaine B. Dibucaine C. Procaine D. Benoxinate

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The local anaesthetic having high cardiotoxic and arrhythmogenic potential is: A. Lignocaine B. Procaine C. Bupivacaine D. Ropivacaine

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The following local anaesthetic raises BP instead of tending to cause a fall: A. Cocaine B. Dibucaine C. Lignocaine D. Procaine

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Adrenaline added to local anaesthetic solution for infiltration anaesthesia affords the following except: A. Prolongs the duration of local anaesthesia B. Makes the injection less painful C. Provides a more bloodless field for surgery D. Reduces systemic toxicity of the local anaesthetic

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Injection of adrenaline along with a local anaesthetic serves the following purpose: A. Lowers the concentration of the local anaesthetic to produce nerve block B. Prolongs the duration of local anaesthesia C. Increases the anaesthetised area D. Reduces the local toxicity of the local anaesthetic

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Which sensation is blocked first by low concentrations of a local anaesthetic: A. Pain B. Temperature C. Touch D. Deep pressure

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The electrophysiological effects of digitalis on Purkinje fibres include the following except: A. Enhancement of resting membrane potential B. Decrease in the slope of phase-0 depolarization C. Increase in the rate of phase-4 depolarization D. Abbreviation of action potential duration

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At resting stage permeability of `K^(+)` ion is more comparatively `Na^(+)` ion through axonal membrane

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Which of the following is not true of the blood-brain barrier: A. It is constituted by tight junctions between the endothelial cells of brain capillaries and the glial tissue B. It allows passage of lipid soluble drugs into the brain C. It limits entry of highly ionized drugs into the brain D. It regulates passage of substances from brain into blood

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The glucocorticoid receptor is located: A. On the outer surface of the cell membrane B. On the inner surface of the cell membrane C. In the cytoplasm D. Inside the nucleus

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A striking feature of living cells is a marked difference between the composition of the cytosol and the extracellular milieu. Which of the following statement(s) concerning the mechanisms of maintenance of these differences is/are true? a. The cell membrane is able to maintain a 10,000 fold gradient between the extracellular concentration of ionized calcium and the intracellular concentration b. The key to these differences is the fact that the plasma membrane is normally impermeable to sodium, potassium and calcium c. The selectivity of biologic membranes is highly consistent and seldom changes d. The selectivity of cell membranes relates only to ions and not organic compounds

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Cell regulation can be thought of as the effector side of cell communication. Most commonly cell regulation occurs by means of extracellular chemical messengers. Which of the following statement(s) is/are true concerning these messengers? a. Paracrine regulation involves a messenger which is produced and acts systemically b. The extracellular signal or stimulus is received by a receptor on or in the target cell c. Neurocrine regulation depends on a physical connection between the neuron and the target cell d. Most hormones, local mediators, and neurotransmitters readily cross the cell plasma membrane

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