The mechanism of action of barbiturates differs
from that of benzodiazepines in that they:
A. Do not affect the GABA-benzodiazepine
receptor-chloride channel complex
B. Act as inverse agonists at the benzodiazepine receptor
C. Increase the frequency of chloride channel
opening without affecting its life time
D. Have both GABA-facilitatory as well as
GABA-mimetic actions

1 Answer

Answer :

D. Have both GABA-facilitatory as well as
GABA-mimetic actions

Related questions

Description : Select the correct statement about flumazenil: A. It is a CNS stimulant used as an antidote for benzodiazepine poisoning B. It is a CNS depressant but blocks the action of diazepam C. It has ... of its own but blocks the depressant effect of diazepam as well as stimulant effect of beta carbolines

Last Answer : D. It has no CNS effect of its own but blocks the depressant effect of diazepam as well as stimulant effect of beta carbolines

Description : Select the correct statement about benzodiazepines (BZDs): A. All BZDs facilitate GABA mediated Cl¯ influx into neurones B. Different BZDs exert the same degrees of hypnotic, anxiolytic and anticonvulsant ... at all neuronal sites D. The muscle relaxant action of BZDs is not blocked by flumazenil

Last Answer : A. All BZDs facilitate GABA mediated Cl¯ influx into neurones

Description : Which of the following statements is not true of zopiclone: A. It is a nonbenzodiazepine hypnotic with efficacy and safety similar to benzodiazepines B. It does not produce rebound sleep disturbances ... act by potentiating GABA D. It is used to wean off insomniacs from regular benzodiazepine use

Last Answer : C. It does not act by potentiating GABA

Description : The following receptor has an intrinsic ion channel: A. Histamine H1 receptor B. Histamine H2 receptor C. Adrenergic alfa receptor D. GABA-benzodiazepine receptor

Last Answer : D. GABA-benzodiazepine receptor

Description : The primary mechanism of action of benzodiazepines is: A. Dopamine antagonism B. Adenosine antagonism C. Opening of neuronal chloride channels D. Facilitation of GABA-mediated chloride influx

Last Answer : D. Facilitation of GABA-mediated chloride influx

Description : The following receptor has an intrinsic ion channel: A. Histamine H1 receptor B. Histamine H2 receptor C. Adrenergic alfa receptor D. GABA-benzodiazepine receptor

Last Answer : D. GABA-benzodiazepine receptor

Description : The following statement is correct about buspirone: A. It interacts with benzodiazepine receptor as an inverse agonist B. It is a rapidly acting anxiolytic, good for panic states C. ... suppresses barbiturate withdrawal syndrome D. It has anxiolytic but no anticonvulsant or muscle relaxant propert

Last Answer : D. It has anxiolytic but no anticonvulsant or muscle relaxant property

Description : The following drugs exert their action through the GABAA-benzodiazepine–receptor Cl¯ channel complex except: A. Baclofen B. Zolpidem C. Bicuculline D. Phenobarbitone

Last Answer : A. Baclofen

Description : Benzodiazepines differ from barbiturates in the following aspects except: A. They have a steeper dose response curve B. They have higher therapeutic index C. They have lower abuse liability D. They do not induce microsomal drug metabolizing enzymes

Last Answer : A. They have a steeper dose response curve

Description : e primary mechanism by which general anaesthetics produce their action is: A. Affecting receptor operated ion channels in cerebral neurones B. Blocking voltage sensitive Na+ channels in neuronal ... activity of cerebral neurones D. Blocking production of high energy phosphates in the brain

Last Answer : A. Affecting receptor operated ion channels in cerebral neurones

Description : Agonists affect the receptor molecule in the following manner: A. Alter its amino acid sequence B. Denature the receptor protein C. Alter its folding or alignment of subunits D. Induce covalent bond formation

Last Answer : C. Alter its folding or alignment of subunits

Description : elect the drug which relieves anxiety but neither reacts with benzodiazepine receptor nor produces any overt CNS effect: A. Oxazepam B. Thioproperazine C. Buspirone D. Chlordiazepoxide

Last Answer : C. Buspirone

Description : Barbiturates exert the following actions except: A. Anticonvulsant B. Analgesic C. Antianxiety D. Respiratory depressant

Last Answer : B. Analgesic

Description : Gabapentin acts: A. As GABAA agonist B. As precursor of GABA C. By enhancing GABA release D. By GABA independent mechanism

Last Answer : C. By enhancing GABA release

Description : Olanzapine has the following features except: A. It is an antipsychotic drug with weak D2 receptor blocking action B. It has potent 5-HT2 blocking and antimuscarinic actions C. It lowers seizure threshold D. It produces prominent extrapyramidal side effects

Last Answer : D. It produces prominent extrapyramidal side effect

Description : Choose the drug that has been found to be more selective for the ω1 subtype of BZD receptor, and produces hypnotic action but little antianxiety, muscle relaxant or anticonvulsant actions: A. Zopiclone B. Zolpidem C. Flumazenil D. Melatonin

Last Answer : B. Zolpidem

Description : Sodium valproate has been shown to: A. Prolong neuronal Na+ channel inactivation B. Attenuate ‘T’ type Ca2+ current in neurones C. Inhibit degradation of GABA by GABA-transaminase D. All of the above

Last Answer : D. All of the above

Description : The major constraint in the long term use of benzodiazepines for treatment of generalized anxiety disorder is: A. Development of tolerance to antianxiety action of the benzodiazepines B. Possibility of drug dependence C. Cardiovascular depression D. Likelyhood of overdose toxicit

Last Answer : B. Possibility of drug dependence

Description : Hypnotic benzodiazepines increase the period of time spent in the following stage of sleep: A. Stage II B. Stage III C. Stage IV D. REM stage

Last Answer : A. Stage II

Description : Choose the correct statement about the action of nitrates on coronary vessels: A. They mitigate angina pectoris by increasing total coronary flow B. They preferentially dilate conducting ... the larger arteries D. They increase subepicardial blood flow without affecting subendocardial blood flow

Last Answer : B. They preferentially dilate conducting arteries without affecting resistance arterioles

Description : Agonists affect the receptor molecule in the following manner: A. Alter its amino acid sequence B. Denature the receptor protein C. Alter its folding or alignment of subunits D. Induce covalent bond formation

Last Answer : C. Alter its folding or alignment of subunits

Description : Identify A, B and C in the diagramatic representation of the mechanism of hormone action. B A Response 1 C Physiological Responses Select the correct option from the following. (a) A-Steroid Hormone; B- ... ; C - Second Messenger (d) A-Protein Hormone; B-Cyclic AMP; C-Hormone-receptor Complex

Last Answer : (b) A-Protein Hormone; B-Receptor; C-Cyclic AMP

Description : Anthelmintic action of piperazine is due to: A. Interference with ATP generation in the worm B. Blockade of glucose uptake by the worm C. Hyperpolarization of nematode muscle by GABA agonistic action D. Depolarization of nematode muscle by activating nicotinic receptors

Last Answer : C. Hyperpolarization of nematode muscle by GABA agonistic action

Description : The β3 adrenoceptor differs from the other subtypes of β receptor in that it: A. Is not blocked by the conventional doses of propranolol B. Is located primarily in the heart C. Regulates blood sugar level D. Is not coupled to G proteins

Last Answer : A. Is not blocked by the conventional doses of propranolol

Description : The β 3 adrenoceptor differs from the other subtypes of β receptor in that it: A. Is not blocked by the conventional doses of propranolol B. Is located primarily in the heart C. Regulates blood sugar level D. Is not coupled to G proteins

Last Answer : A. Is not blocked by the conventional doses of propranolol

Description : What is true in relation to drug receptors: A. All drugs act through specific receptors B. All drug receptors are located on the surface of the target cells C. Agonists induce a conformational change in the receptor D. Partial agonists have low affinity for the receptor

Last Answer : C. Agonists induce a conformational change in the receptoR

Description : What is true in relation to drug receptors: A. All drugs act through specific receptors B. All drug receptors are located on the surface of the target cells C. Agonists induce a conformational change in the receptor D. Partial agonists have low affinity for the receptor

Last Answer : C. Agonists induce a conformational change in the receptor

Description : The most probable mechanism of anticonvulsant action of phenytoin is: A. Facilitation of GABAergic inhibitory transmission B. Hyperpolarization of neurones C. Interaction with Ca2+ channels to promote Ca2+ influx D. Prolongation of voltage sensitive neuronal Na+ channel inactivation

Last Answer : D. Prolongation of voltage sensitive neuronal Na+ channel inactivation

Description : Methyldopa differs from clonidine in the following respect: A. It is less likely to cause rebound hypertension on sudden discontinuation B. It does not reduce plasma renin activity C. It has a central as well as peripheral site of antihypertensive action D. It does not produce central side effect

Last Answer : A. It is less likely to cause rebound hypertension on sudden discontinuation

Description : The principal action common to all class I antiarrhythmic drugs is: A. Na+ channel blockade B. K+ channel opening C. Depression of impulse conduction D. Prolongation of effective refractory period

Last Answer : A. Na+ channel blockade

Description : At the muscle end-plate, d-tubocurarine reduces the: A. Number of Na+ channels B. Duration for which the Na+ channels remain open C. Ion conductance of the open Na+ channel D. Frequency of Na+ channel opening

Last Answer : D. Frequency of Na+ channel opening

Description : Superactive GnRH agonists cause: A. Initial as well as sustained release of gonadotropins B. Initial inhibition followed by stimulation of gonadotropin release after 1-2 weeks C. Initial stimulation ... release after 1-2 weeks D. Initial as well as sustained inhibition of gonadotropin release

Last Answer : C. Initial stimulation followed by inhibition of gonadotropin release after 1-2 weeks

Description : 16.17 Superactive GnRH agonists cause: A. Initial as well as sustained release of gonadotropins B. Initial inhibition followed by stimulation of gonadotropin release after 1-2 weeks C. Initial ... release after 1-2 weeks D. Initial as well as sustained inhibition of gonadotropin release

Last Answer : C. Initial stimulation followed by inhibition of gonadotropin release after 1-2 weeks

Description : Digitalis in creases the force of contraction of ventricles by: A. Increasing the duration of systole B. Increasing the rate of contraction without affecting the duration of systole C. Increasing the rate ... of systole D. Increasing both the rate of contraction as well as the duration of systole

Last Answer : C. Increasing the rate of contraction, but reducing the duration of systole

Description : The characteristic feature(s) of dihydropyridine calcium channel blockers is/are: A. They have minimal negative inotropic action on the heart B. They have no effect on A-V conduction C. They do not affect the activation-inactivation kinetics of the calcium channels D. All of the above

Last Answer : D. All of the above

Description : Triamterene differs from spironolactone in that: A. It has greater natriuretic action B. Its K+ retaining action is not dependent on presence of aldosterone C. It acts from the luminal membrane side of the distal tubular cells D. Both ‘B’ and ‘C’ are correct

Last Answer : D. Both ‘B’ and ‘C’ are correct

Description : The following is not true of local anaesthetics: A. The local anaesthetic is required in the unionized form for penetrating the neuronal membrane B. The local anaesthetic approaches its receptor ... the resting state D. The local anaesthetic combines with its receptor in the ionized cationic form

Last Answer : C. The local anaesthetic binds to its receptor mainly when the Na+ channel is in the resting state

Description : riiodothyronine differs from thyroxine in that: A. It is more avidly bound to plasma proteins B. It has a shorter plasma half life C. It is less potent D. It has a longer latency of action

Last Answer : B. It has a shorter plasma half life

Description : 17.2 Triiodothyronine differs from thyroxine in that: A. It is more avidly bound to plasma proteins B. It has a shorter plasma half life C. It is less potent D. It has a longer latency of action (

Last Answer : B. It has a shorter plasma half life

Description : Procainamide differs from quinidine in the following respect(s): A. It does not cause paradoxical tachycardia B. It has no α adrenergic blocking activity C. It has little antivagal action D. Both ‘B’ and ‘C’ are corre

Last Answer : D. Both ‘B’ and ‘C’ are correct

Description : Procainamide differs from quinidine in the following respect(s): A. It does not cause paradoxical tachycardia B. It has no α adrenergic blocking activity C. It has little antivagal action D. Both ‘B’ and ‘C’ are correct

Last Answer : D. Both ‘B’ and ‘C’ are correct

Description : The GABAB receptor: A. Is an intrinsic ion channel containing receptor B. Mediates neuronal depolarization C. Is insensitive to blockade by bicuculline D. Regulates intracellular cAMP

Last Answer : C. Is insensitive to blockade by bicuculline

Description : The insulin receptor is a: A. Ion channel regulating receptor B. Tyrosine protein kinase receptor C. G-protein coupled receptor D. None of the above

Last Answer : B. Tyrosine protein kinase receptor

Description : Receptors perform the following function/functions: A. Ligand recognition B. Signal transduction C. Both ligand recognition and signal transduction D. Disposal of agonists and antagonists

Last Answer : D. Disposal of agonists and antagonists

Description : The following has been found to act as a male contraceptive without affecting libido or potency: A. Cyproterone acetate B. Goserelin C. Centchroman D. Gossypol

Last Answer : D. Gossypol

Description : Clobazam is a benzodiazepine used as: A. Hypnotic B. Muscle relaxant C. Anxiolytic D. Antiepileptic

Last Answer : D. Antiepileptic

Description : The following is a very potent and short acting benzodiazepine whose use as hypnotic has been noted to cause psychiatric disturbances in some cases: A. Flurazepam B. Nitrazepam C. Temazepam D. Triazolam

Last Answer : D. Triazolam

Description : Trimethoprim inhibits bacteria without affecting mammalian cells because: A. It does not penetrate mammalian cells B. It has high affinity for bacterial but low affinity for mammalian dihydrofolate ... bacterial folate synthetase as well as dihydrofolate reductase enzymes D. All of the above

Last Answer : B. It has high affinity for bacterial but low affinity for mammalian dihydrofolate reductase enzyme

Description : Choose the drug which blocks basal as well as stimulated gastric acid secretion without affecting cholinergic, histaminergic or gastrin receptors: A. Famotidine B. Loxatidine C. Omeprazole D. Pirenzepine

Last Answer : C. Omeprazole

Description : Piperacillin differs from carbenicillin in the following respect(s): A. It is more active against Pseudomonas aeruginosa B. It is active against Klebsiella as well C. It is acid resistant D. Both ‘A’ and ‘B’ are correct

Last Answer : D. Both ‘A’ and ‘B’ are correct