Which filler can NOT be used for the preparation of tablets for amine containing basic drugs to avoid discoloration of the tablets? (A) Dicalcium phosphate (B) Microcrystalline cellulose (C) Starch (D) Lactose

Which filler can NOT be used for the preparation of tablets for amine containing basic drugs to avoid discoloration of the tablets? (A) Dicalcium phosphate (B) Microcrystalline cellulose (C) Starch (D) Lactose
by

1 Answer

Answer :

(D) Lactose
by

Related questions

Bloom strength is used to check the quality of (A) Lactose (B) Ampoules (C) Hardness of tablets (D)Gelatin

Description : Bloom strength is used to check the quality of (A) Lactose (B) Ampoules (C) Hardness of tablets (D)Gelatin

Last Answer : (D)Gelatin

Chemical nomenclature of procaine is (A) 2-Diethylaminoethyl 4-aminobenzoate (B) N,N-Diethyl 4-aminobenzoate (C) 4-Aminobenzamidoethyl amine (D) 4-Amino-2-diethylaminoethyl benzoate

Description : Chemical nomenclature of procaine is (A) 2-Diethylaminoethyl 4-aminobenzoate (B) N,N-Diethyl 4-aminobenzoate (C) 4-Aminobenzamidoethyl amine (D) 4-Amino-2-diethylaminoethyl benzoate

Last Answer : Ans. A & D

In nail polish, following polymer is used as a film-former : (A) Nitrocellulose (B) Polylactic acid (C) Hydroxypropyl methylcellulose (D) Cellulose acetate phthalate

Description : In nail polish, following polymer is used as a film-former : (A) Nitrocellulose (B) Polylactic acid (C) Hydroxypropyl methylcellulose (D) Cellulose acetate phthalate

Last Answer : (A) Nitrocellulose

Which one of the following is the commonly used bulking agent in the formulation of freeze dried low dose drug products? (A) Sodium chloride (B) Mannitol (C) Starch (D) HPMC

Description : Which one of the following is the commonly used bulking agent in the formulation of freeze dried low dose drug products? (A) Sodium chloride (B) Mannitol (C) Starch (D) HPMC

Last Answer : (B) Mannitol

Aminotransferases usually require the following for their activity : (A) Niacinamide (B)Vitamin B12 (C) Pyridoxal phosphate (D) Thiamine

Description : Aminotransferases usually require the following for their activity : (A) Niacinamide (B)Vitamin B12 (C) Pyridoxal phosphate (D) Thiamine

Last Answer : (C) Pyridoxal phosphate

Is microcrystalline cellulose an inorganic compound?

Description : Is microcrystalline cellulose an inorganic compound?

Last Answer : No. It is an organic compound.

The most abundant carbohydrate present in blood is (a) glucose (b) lactose (c) starch (d) cellulose

Description : The most abundant carbohydrate present in blood is (a) glucose (b) lactose (c) starch (d) cellulose

Last Answer : Ans:(a)

A person who is eating boiled potato, his food contains the component (a) cellulose which is digested by cellulase (b) starch which is digested (c) lactose which is not digested (d) DNA which can be digested by pancreatic DNase.

Description : A person who is eating boiled potato, his food contains the component (a) cellulose which is digested by cellulase (b) starch which is digested (c) lactose which is not digested (d) DNA which can be digested by pancreatic DNase.

Last Answer : (b) starch which is digested

In which of the following groups are all polysaccharides? (a) Sucrose, glucose and fructose (b) Maltose, lactose and fructose (c) Glycogen, sucrose and maltose (d) Glycogen, cellulose and starch

Description : In which of the following groups are all polysaccharides? (a) Sucrose, glucose and fructose (b) Maltose, lactose and fructose (c) Glycogen, sucrose and maltose (d) Glycogen, cellulose and starch

Last Answer : (d) Glycogen, cellulose and starch

Which one of the following is NOT an ex-officio member of Pharmacy Council of India? (A) The Director General of Health Services (B) The Director of Central Drugs Laboratory (C) The Drugs Controller General of India (D) The Director of Pharmacopoeia Laboratory

Description : Which one of the following is NOT an ex-officio member of Pharmacy Council of India? (A) The Director General of Health Services (B) The Director of Central Drugs Laboratory (C) The Drugs Controller General of India (D) The Director of Pharmacopoeia Laboratory

Last Answer : (D) The Director of Pharmacopoeia Laboratory

Drugs in suspensions and semi-solid formulations always degrade by (A) first order kinetics (B)second order kinetics (C) zero order kinetics (D) non-linear kinetics

Description : Drugs in suspensions and semi-solid formulations always degrade by (A) first order kinetics (B)second order kinetics (C) zero order kinetics (D) non-linear kinetics

Last Answer : (C) zero order kinetics

Drugs following one compartment open model pharmacokinetics eliminate (A) bi-exponentially (B) tri-exponentially (C) non-exponentially (D) mono-exponentially

Description : Drugs following one compartment open model pharmacokinetics eliminate (A) bi-exponentially (B) tri-exponentially (C) non-exponentially (D) mono-exponentially

Last Answer : (D) mono-exponentially

The common structural feature amongst the three categories of anticonvulsant drugs barbiturates, succinimides and hydantoins is (A) ureide (B) imidazolidinone (C) dihydropyrimidine (D) tetrahydropyrimidine

Description : The common structural feature amongst the three categories of anticonvulsant drugs barbiturates, succinimides and hydantoins is (A) ureide (B) imidazolidinone (C) dihydropyrimidine (D) tetrahydropyrimidine

Last Answer : (A) ureide

Stevens Johnson sjmdrome is the most common adverse effect associated with one of the following category of drugs : (A) Sulphonamides (B) Macrolides (C) Penicillins (D) Tetracyclines

Description : Stevens Johnson sjmdrome is the most common adverse effect associated with one of the following category of drugs : (A) Sulphonamides (B) Macrolides (C) Penicillins (D) Tetracyclines

Last Answer : (A) Sulphonamides

Which one of the following drugs is withdrawn from the market due to torsade de pointes? (A) Chlorpromazine (B) Astemizole (C) Haloperidol (D) Domperidone

Description : Which one of the following drugs is withdrawn from the market due to torsade de pointes? (A) Chlorpromazine (B) Astemizole (C) Haloperidol (D) Domperidone

Last Answer : (B) Astemizole

Select the correc: combination of drugs for the treatment of patients suffering from Hepatitis C : (A) Interferon with Ribavirin (B) Interferon with Zidovudine (C) Interferon with Stavudine (D) Interferon with Lamivudine

Description : Select the correc: combination of drugs for the treatment of patients suffering from Hepatitis C : (A) Interferon with Ribavirin (B) Interferon with Zidovudine (C) Interferon with Stavudine (D) Interferon with Lamivudine

Last Answer : (B) Interferon with Zidovudine

In the Drugs and Cosmetics Act and Rules, the Schedule relating to GMP is ( A) Schedule M (B) Schedule C (C) Schedule Y (D) Schedule H

Description : In the Drugs and Cosmetics Act and Rules, the Schedule relating to GMP is ( A) Schedule M (B) Schedule C (C) Schedule Y (D) Schedule H

Last Answer : ( A) Schedule M

Which one of the following drugs specifically inhibits calcineurin in the activated T lymphocytes? (A) Daclizumab (B) Prednisone (C) Sirolimus (D) Tacrolimus

Description : Which one of the following drugs specifically inhibits calcineurin in the activated T lymphocytes? (A) Daclizumab (B) Prednisone (C) Sirolimus (D) Tacrolimus

Last Answer : (D) Tacrolimus

Which one of the following drugs is NOT a typical anti-psychotic agent? (A) Chlorpromazine (B) Haloperidol (C) Risperidone (D) Flupentixol

Description : Which one of the following drugs is NOT a typical anti-psychotic agent? (A) Chlorpromazine (B) Haloperidol (C) Risperidone (D) Flupentixol

Last Answer : (C) Risperidone

Improvement of memory in Alzheimer's disease is brought about by drugs which increase transmission in (A) cholinergic receptors (B) dopaminergic receptors (C) GABAergic receptors (D) adrenergic receptors

Description : Improvement of memory in Alzheimer's disease is brought about by drugs which increase transmission in (A) cholinergic receptors (B) dopaminergic receptors (C) GABAergic receptors (D) adrenergic receptors

Last Answer : (A) cholinergic receptors

Which one of the following drugs is most effective in preventing transmission of HIV virus from the mother to the foetus? (A) Lamivudine (B) Zidovudine (C) Indinavir (D) Ribavirin

Description : Which one of the following drugs is most effective in preventing transmission of HIV virus from the mother to the foetus? (A) Lamivudine (B) Zidovudine (C) Indinavir (D) Ribavirin

Last Answer : (B) Zidovudine

Which one of the following drugs does NOT act through G-Protein coupled receptors? (A) Epinephrine (B) Insulin (C) Dopamine (D) TSH

Description : Which one of the following drugs does NOT act through G-Protein coupled receptors? (A) Epinephrine (B) Insulin (C) Dopamine (D) TSH

Last Answer : (B) Insulin

Which one of the following drugs is prescribed for the treatment of Philadelphia chromosome positive patients with Chronic myeloid Leukemia? (A) Pentostatin (B) Methotrexate (C) Imatinib (D) L-Asparaginase

Description : Which one of the following drugs is prescribed for the treatment of Philadelphia chromosome positive patients with Chronic myeloid Leukemia? (A) Pentostatin (B) Methotrexate (C) Imatinib (D) L-Asparaginase

Last Answer : (C) Imatinib

The chemical behaviour of morphine alkaloid is (A) acidic (B)Basic (C) neutral (D) amphoteric

Description : The chemical behaviour of morphine alkaloid is (A) acidic (B)Basic (C) neutral (D) amphoteric

Last Answer : (B)Basic

Has anyone had any problems with talc as a filler in tablets?

Description : Has anyone had any problems with talc as a filler in tablets?

Last Answer : Interesting. I am allergic to synthroid, but not other thyroid medications, and I think it must be some sort of inert ingredient.

A FDA – approved ingredient for protection against painful sensitivity of the teeth due to cold, heat, acids, sweets or contact is (a) Dicalcium phosphate (b) Sodium lauryl sulfate (c) 5% potassium nitrate (d) Zinc chloride (e) Calcium carbonate

Description : A FDA – approved ingredient for protection against painful sensitivity of the teeth due to cold, heat, acids, sweets or contact is (a) Dicalcium phosphate (b) Sodium lauryl sulfate (c) 5% potassium nitrate (d) Zinc chloride (e) Calcium carbonate

Last Answer : Ans: C

A phosphatic fertiliser contains 16% P2O5 . It could be (A) Dicalcium phosphate (B) Superphosphate(C) Triple superphosphate(D) None of these

Description : A phosphatic fertiliser contains 16% P2O5 . It could be (A) Dicalcium phosphate (B) Superphosphate (C) Triple superphosphate (D) None of these

Last Answer : (B) Superphosphate

In which of the following techniques the sample is kept below triple point? (A) Lyophilization (B) Spray drying (C) Spray congealing (D) Centrifugation

Description : In which of the following techniques the sample is kept below triple point? (A) Lyophilization (B) Spray drying (C) Spray congealing (D) Centrifugation

Last Answer : (A) Lyophilization

It is required to maintain a therapeutic concentration of 10 microgram/mL for 12 hours of a drug having half life of 1.386 hr and Vd of 5 L. The dose required in a sustained release product will be (A) 600 mg (B) 300 mg (C) 30 mg (D) 60 mg

Description : It is required to maintain a therapeutic concentration of 10 microgram/mL for 12 hours of a drug having half life of 1.386 hr and Vd of 5 L. The dose required in a sustained release product will be (A) 600 mg (B) 300 mg (C) 30 mg (D) 60 mg

Last Answer : (B) 300 mg

The Volume of distribution of a drug administered at a dose of 300 mg and exhibiting 30 microgram/mL instantaneous concentration in plasma shall be (A)10 L (B) 100 L (C) 1.0 L (D) 0.10 L

Description : The Volume of distribution of a drug administered at a dose of 300 mg and exhibiting 30 microgram/mL instantaneous concentration in plasma shall be (A)10 L (B) 100 L (C) 1.0 L (D) 0.10 L

Last Answer : (A)10 L

How many mL of a 1:500 w/v stock solution should be used to make 5 liters of 1:2000 w/v solution? (A) 750 mL (B) 1000 mL (c) 1250 mL (D) 1500 mL

Description : How many mL of a 1:500 w/v stock solution should be used to make 5 liters of 1:2000 w/v solution? (A) 750 mL (B) 1000 mL (c) 1250 mL (D) 1500 mL

Last Answer : (c) 1250 mL

Class 100 area is referred to (A) Manufacturing area (B) Aseptic area (C) Clean room (D) Ware house

Description : Class 100 area is referred to (A) Manufacturing area (B) Aseptic area (C) Clean room (D) Ware house

Last Answer : (B) Aseptic area

Geriatric population should be included in the following Phase of clinical trials (A) Phase I (B) Phase II (C) Phase III (D) Phase

Description : Geriatric population should be included in the following Phase of clinical trials (A) Phase I (B) Phase II (C) Phase III (D) Phase

Last Answer : (B) Phase II

A drug (200 mg dose) administered in tablet form and as intravenous injection (50 mg dose) showed AUG of 100 and 200 microgram hr/mL, respectively. The absolute availability of the drug through oral administration is : (A) 125% (B) 250 % (C) 12.5% (D) 1.25%

Description : A drug (200 mg dose) administered in tablet form and as intravenous injection (50 mg dose) showed AUG of 100 and 200 microgram hr/mL, respectively. The absolute availability of the drug through oral administration is : (A) 125% (B) 250 % (C) 12.5% (D) 1.25%

Last Answer : (C) 12.5%

Rabies vaccine (living) is prepared using (A) Sheep blood (B) Mice lymph (C) Horse plasma (D) Fertile eggs

Description : Rabies vaccine (living) is prepared using (A) Sheep blood (B) Mice lymph (C) Horse plasma (D) Fertile eggs

Last Answer : (D) Fertile eggs

The following protein/polypeptide has a quaternary structure : (A) cc-Chymotrypsin (B) Hemoglobin (C) Insulin (D) Myoglobin

Description : The following protein/polypeptide has a quaternary structure : (A) cc-Chymotrypsin (B) Hemoglobin (C) Insulin (D) Myoglobin

Last Answer : (B) Hemoglobin

Many xenobiotics are oxidized by cytochrome P450 in order to (A) increase their biological activity (B) increase their disposition in lipophilic compartments of the body (C) increase their aqueous solubility (D) all of the above

Description : Many xenobiotics are oxidized by cytochrome P450 in order to (A) increase their biological activity (B) increase their disposition in lipophilic compartments of the body (C) increase their aqueous solubility (D) all of the above

Last Answer : (D) all of the above

The temperature condition for storage of drug products under cold temperature is given as : (A) temperature between 8°C and 25°C (B) temperature below 20 C (C) temperature at 0°C (D) temperature between 2c C and S: C

Description : The temperature condition for storage of drug products under cold temperature is given as : (A) temperature between 8°C and 25°C (B) temperature below 20 C (C) temperature at 0°C (D) temperature between 2c C and S: C

Last Answer : (D) temperature between 2c C and S: C

Coulter counter is used in determination of (A) particle surface area (B) particle size (C) particle volume (D)all of A, B, C

Description : Coulter counter is used in determination of (A) particle surface area (B) particle size (C) particle volume (D)all of A, B, C

Last Answer : (D)all of A, B, C

Oxidative phosphorylation involves (A) Electron transport system (B) Substrate level phosphorylation (C) Reaction catalyzed by succinic thiokinase in TCA cycle (D) None of the above

Description : Oxidative phosphorylation involves (A) Electron transport system (B) Substrate level phosphorylation (C) Reaction catalyzed by succinic thiokinase in TCA cycle (D) None of the above

Last Answer : (A) Electron transport system

In Gas-Liquid Chromatography, some of the samples need to be derivatized in order to increase their (A) volatility (B) solubility (C)thermal conductivity (D) polarizability

Description : In Gas-Liquid Chromatography, some of the samples need to be derivatized in order to increase their (A) volatility (B) solubility (C)thermal conductivity (D) polarizability

Last Answer : (D) polarizability

Glass transition temperature is detected through (A) X-Ray diffractometery (B) Solution calorimetery (C) Differential scanning calorimetery (D) Thermogravimetric analysis

Description : Glass transition temperature is detected through (A) X-Ray diffractometery (B) Solution calorimetery (C) Differential scanning calorimetery (D) Thermogravimetric analysis

Last Answer : (C) Differential scanning calorimetery

In organic molecules, fluorescence seldom results from absorption of UV radiation of wavelengths lower than (A) 350 nm (B) 200 nm (C) 300 nm (D) 250 nm

Description : In organic molecules, fluorescence seldom results from absorption of UV radiation of wavelengths lower than (A) 350 nm (B) 200 nm (C) 300 nm (D) 250 nm

Last Answer : (A) 350 nm

Streptomycin can NOT be given orally for treatment of tuberculosis because (A) it gets degraded in the GIT (B) it causes severe diarrhoea (C) it causes metallic taste in the mouth (D) it is not absorbed from the GIT

Description : Streptomycin can NOT be given orally for treatment of tuberculosis because (A) it gets degraded in the GIT (B) it causes severe diarrhoea (C) it causes metallic taste in the mouth (D) it is not absorbed from the GIT

Last Answer : (D) it is not absorbed from the GIT

In thiazides following substituent is essential for diuretic activity : (A) Chloro group at position 6 (B) Methyl group at position 2 (C) Sulphamoyl group at position 7 (D) Hydrophobic group at position 3

Description : In thiazides following substituent is essential for diuretic activity : (A) Chloro group at position 6 (B) Methyl group at position 2 (C) Sulphamoyl group at position 7 (D) Hydrophobic group at position 3

Last Answer : (C) Sulphamoyl group at position 7

One of the following statements is NOT true : (A) Accuracy expresses the correctness of measurement (B) Precision represents reproducibility of measurement (C) High degree of precision implies high degree of accuracy also (D) High degree of accuracy implies high degree of precesion also

Description : One of the following statements is NOT true : (A) Accuracy expresses the correctness of measurement (B) Precision represents reproducibility of measurement (C) High degree of precision implies high degree of accuracy also (D) High degree of accuracy implies high degree of precesion also

Last Answer : (C) High degree of precision implies high degree of accuracy also

Indicate the HPLC detector that is most sensitive to change in temperature : (A) PDA detector (B) Refractive Index detector (C) Electrochemical detector (D) Fluorescence detector

Description : Indicate the HPLC detector that is most sensitive to change in temperature : (A) PDA detector (B) Refractive Index detector (C) Electrochemical detector (D) Fluorescence detector

Last Answer : (B) Refractive Index detector

Artemisinin contains the following group in its structure : (A) an endoperoxide (B) an exoperoxide (C) an epoxide (D) an acid hydrazide

Description : Artemisinin contains the following group in its structure : (A) an endoperoxide (B) an exoperoxide (C) an epoxide (D) an acid hydrazide

Last Answer : (A) an endoperoxide

Cyclophosphamide as anticancer agent acts as (A) alkylating agent before metabolism (B)alkylating agent after metabolism (C) phosphorylating agent after metabolism (D) DNA intercalating agent

Description : Cyclophosphamide as anticancer agent acts as (A) alkylating agent before metabolism (B)alkylating agent after metabolism (C) phosphorylating agent after metabolism (D) DNA intercalating agent

Last Answer : (B)alkylating agent after metabolism

A metabolite obtained from Aspergillus terreus that can bind very tightly to HMG CoA reductase enzyme is (A) Fluvastatin (B) Cerivastatin (C) Lovastatin (D) Somatostatin

Description : A metabolite obtained from Aspergillus terreus that can bind very tightly to HMG CoA reductase enzyme is (A) Fluvastatin (B) Cerivastatin (C) Lovastatin (D) Somatostatin

Last Answer : (C) Lovastatin