Sulfamethoxypyridazine and other related long acting sulfonamides have now gone into disuse because (a) They have produced serious cutaneous reactions (b) They have produced high incidence of crystalluria (c) They interact with many drugs (d) They do not penetrate blood-brain barrier

Sulfamethoxypyridazine and other related long acting sulfonamides have now gone into disuse because (a) They have produced serious cutaneous reactions (b) They have produced high incidence of crystalluria (c) They interact with many drugs (d) They do not penetrate blood-brain barrier
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Which of the following is not true of sulfonamides ? (a) They are primarily metabolized by acetylation (b) They are more likely to produce crystalluria in alkaline urine in which they are less soluble (c) They may exert bactericidal action in the urinary tract (d) Used alone, they have become therapeutically unreliable for serious infections

Description : Which of the following is not true of sulfonamides ? (a) They are primarily metabolized by acetylation (b) They are more likely to produce crystalluria in alkaline urine in which they are ... in the urinary tract (d) Used alone, they have become therapeutically unreliable for serious infections

Last Answer : Ans: B

The following is true of sulfonamides except: A. They are more likely to produce crystalluria in alkaline urine in which they are less soluble B. They are primarily metabolized by acetylation C. They may exert bactericidal action in the urinary tract D. Used alone, they have become therapeutically unreliable for serious infections

Description : The following is true of sulfonamides except: A. They are more likely to produce crystalluria in alkaline urine in which they are less soluble B. They are primarily metabolized by acetylation ... in the urinary tract D. Used alone, they have become therapeutically unreliable for serious infections

Last Answer : A. They are more likely to produce crystalluria in alkaline urine in which they are less soluble

The drug of choice for scarlet fever is (a) Tetracycline (b) Sulfonamides (c) Penicillin (d) Chloromycetin (e) Novobiocin

Description : The drug of choice for scarlet fever is (a) Tetracycline (b) Sulfonamides (c) Penicillin (d) Chloromycetin (e) Novobiocin

Last Answer : Ans: C

Gram negative organisms are largely insensitive to benzyl penicillin because (a) They produce large quantities of penicillinase (b) They do not utilize D-alanine whose incorporation in the cell wall is inhibited by benzyl penicillin (c) Benzyl penicillin is not able to penetrate deeper into the lipoprotein-peptidoglycan multiplayer cell wall of gram-negative bacteria (d) Both (a) and (b)

Description : Gram negative organisms are largely insensitive to benzyl penicillin because (a) They produce large quantities of penicillinase (b) They do not utilize D-alanine whose incorporation in the cell wall is ... lipoprotein-peptidoglycan multiplayer cell wall of gram-negative bacteria (d) Both (a) and (b)

Last Answer : Ans: C

Methicillin resistant staphylococci do not respond to ß-lactam antibiotics because (a) They produce a ß-lactamase which destroys methicillin and related drugs (b) They elaborate an amidase which destroys methicillin and related drugs (c) They have acquired a penicillin binding protein which has low affinity for ß-lactam antibiotics (d) They are less permeable to ß-lactam antibiotics

Description : Methicillin resistant staphylococci do not respond to ß-lactam antibiotics because (a) They produce a ß-lactamase which destroys methicillin and related drugs (b) They elaborate an amidase which destroys ... low affinity for ß-lactam antibiotics (d) They are less permeable to ß-lactam antibiotics

Last Answer : Ans: C

The capacity of an antihistaminic to produce sedation depends on the following except (a) Relative affinity for central versus peripheral H1 receptors (b) Ability to penetrate blood-brain barrier (c) Individual susceptibility (d) Ratio of H1 : H2 blockade produced by the drug

Description : The capacity of an antihistaminic to produce sedation depends on the following except (a) Relative affinity for central versus peripheral H1 receptors (b) Ability to penetrate blood-brain barrier (c) Individual susceptibility (d) Ratio of H1 : H2 blockade produced by the drug

Last Answer : Ans: D

The capacity of an antihistaminic to produce sedation depends on the following except: A. Relative affinity for central versus peripheral H1 receptors B. Ability to penetrate blood-brain barrier C. Individual susceptibility D. Ratio of H1:H2 blockade produced by the drug

Description : The capacity of an antihistaminic to produce sedation depends on the following except: A. Relative affinity for central versus peripheral H1 receptors B. Ability to penetrate blood-brain barrier C. Individual susceptibility D. Ratio of H1:H2 blockade produced by the drug

Last Answer : D. Ratio of H1:H2 blockade produced by the drug

The capacity of an antihistaminic to produce sedation depends on the following except: A. Relative affinity for central versus peripheral H1 receptors B. Ability to penetrate blood-brain barrier C. Individual susceptibility D. Ratio of H1:H2 blockade produced by the drug

Description : The capacity of an antihistaminic to produce sedation depends on the following except: A. Relative affinity for central versus peripheral H1 receptors B. Ability to penetrate blood-brain barrier C. Individual susceptibility D. Ratio of H1:H2 blockade produced by the drug

Last Answer : D. Ratio of H1:H2 blockade produced by the drug

Compared to older tetracyclines, doxycycline produces a lower incidence of superinfection diarrhoea because (a) It is completely absorbed in the small intestines so that drug concentration in the colonic contents is low (b) It is inactivated by the gut microflora (c) It is not active against the microbes of the normal gut flora (d) It is a potent tetracycline and inhibits the superinfection causing microbes as well

Description : Compared to older tetracyclines, doxycycline produces a lower incidence of superinfection diarrhoea because (a) It is completely absorbed in the small intestines so that drug concentration in the colonic ... (d) It is a potent tetracycline and inhibits the superinfection causing microbes as well

Last Answer : Ans: A

Which out of the following antibiotics penetrates blood-CSF barrier the best (a) Erythromycin (b) Gentamicin (c) Tetracycline (d) Chloramphenicol

Description : Which out of the following antibiotics penetrates blood-CSF barrier the best (a) Erythromycin (b) Gentamicin (c) Tetracycline (d) Chloramphenicol

Last Answer : Ans: D

Highest incidence of antibiotic associated pseudo membranous enterocolitis has been noted with the use of (a) Ampicillin (b) Chloramphenicol (c) Vancomycin (d) Clindamycin

Description : Highest incidence of antibiotic associated pseudo membranous enterocolitis has been noted with the use of (a) Ampicillin (b) Chloramphenicol (c) Vancomycin (d) Clindamycin

Last Answer : Ans: D

06. A hydrophilic medicinal agent has the following property: a) Low ability to penetrate through the cell membrane lipids b) Penetrate through membranes by means of endocytosis c) Easy permeation through the blood-brain barrier d) High reabsorption in renal tubules

Description : 06. A hydrophilic medicinal agent has the following property: a) Low ability to penetrate through the cell membrane lipids b) Penetrate through membranes by means of endocytosis c) Easy permeation through the blood-brain barrier d) High reabsorption in renal tubules

Last Answer : a) Low ability to penetrate through the cell membrane lipids

A woman has an upper respiratory infection. Six years ago, she experienced an episode of bronchospasm follwing penicillin V therapy. The cultures now reveal a strain of streptococcus pneumoniae that is sensitive to all of the following drugs. Which of these drugs would be the best choice for this patient? (a) Amoxicillin/clavulanate (b) Erythromycin (c) Ampicillin (d) cefaclor (e) Cyclacillin

Description : A woman has an upper respiratory infection. Six years ago, she experienced an episode of bronchospasm follwing penicillin V therapy. The cultures now reveal a strain of streptococcus pneumoniae that is ... ? (a) Amoxicillin/clavulanate (b) Erythromycin (c) Ampicillin (d) cefaclor (e) Cyclacillin

Last Answer : Ans: B

Ephedrine is similar to adrenaline in the following feature (a) Potency (b) Inability to penetrate blood-brain barrier (c) Duration of action (d) Producing both a and ß adrenergic effects

Description : Ephedrine is similar to adrenaline in the following feature (a) Potency (b) Inability to penetrate blood-brain barrier (c) Duration of action (d) Producing both a and ß adrenergic effects

Last Answer : Ans: D

Compared to ****/beef insulins, the human insulins: A. Are more potent B. Have a faster kinetics of absorption and elimination C. Have longer biological action half life D. Penetrate blood-brain barrier more efficiently

Description : Compared to pork/beef insulins, the human insulins: A. Are more potent B. Have a faster kinetics of absorption and elimination C. Have longer biological action half life D. Penetrate blood-brain barrier more efficiently

Last Answer : B. Have a faster kinetics of absorption and elimination

Ephedrine is similar to adrenaline in the following feature: A. Potency B. Inability to penetrate blood-brain barrier C. Duration of action D. Producing both α and β adrenergic effects

Description : Ephedrine is similar to adrenaline in the following feature: A. Potency B. Inability to penetrate blood-brain barrier C. Duration of action D. Producing both α and β adrenergic effects

Last Answer : D. Producing both α and β adrenergic effects

Ephedrine is similar to adrenaline in the following feature: A. Potency B. Inability to penetrate blood-brain barrier C. Duration of action D. Producing both α and β adrenergic effects

Description : Ephedrine is similar to adrenaline in the following feature: A. Potency B. Inability to penetrate blood-brain barrier C. Duration of action D. Producing both α and β adrenergic effects

Last Answer : D. Producing both α and β adrenergic effects

Cefotaxime has the following properties except (a) It is highly active against aerobic gram negative bacteria (b) It is the most active cephalosporin against Pseudomonas aeruginosa (c) It produces an active metabolite (d) It has achieved high cure rates in serious hospital acquired infections

Description : Cefotaxime has the following properties except (a) It is highly active against aerobic gram negative bacteria (b) It is the most active cephalosporin against Pseudomonas aeruginosa (c) It produces an active metabolite (d) It has achieved high cure rates in serious hospital acquired infections

Last Answer : Ans: B

In which of the following groups do all four drugs warrant careful monitoring for drugrelated seizures in high-risk patients? (a) Penicillin G, imipenem, amphotericin B, metronidazol (b) Penicillin G, chlormphenicol, tetracycline, vancomycin (c) Imipenem, tetracycline, vancomycin, sulfadiazine (d) Cycloserine, metronidazole, vancomycin, sulfadiazine (e) Metronidazole, imipenem, doxycycline, erythromycin

Description : In which of the following groups do all four drugs warrant careful monitoring for drugrelated seizures in high-risk patients? (a) Penicillin G, imipenem, amphotericin B, metronidazol ... (d) Cycloserine, metronidazole, vancomycin, sulfadiazine (e) Metronidazole, imipenem, doxycycline, erythromycin

Last Answer : Ans: A

Choose the correct statement about the role of opioid antimotility drugs in the management of diarrhoeas (a) They are used to control diarrhoea irrespective of its etiology (b) They should be used only as a short-term measure after ensuring that enteroinvasive organisms are not involved (c) They are used as adjuvants to antimicrobial therapy of diarrhoea (d) They are the drugs of choice in irritable bowel syndrome diarrhoea

Description : Choose the correct statement about the role of opioid antimotility drugs in the management of diarrhoeas (a) They are used to control diarrhoea irrespective of its etiology (b) They should be ... therapy of diarrhoea (d) They are the drugs of choice in irritable bowel syndrome diarrhoea

Last Answer : Ans: B

Which of the following drugs has demonstrated in vitro activity against Mycobacterium avium-intracellular(MAI)? (a) Vancomycin (b) Clarithromycin (c) Erythromycin base (d) Troleandomycin (e) Erythromycin estolate

Description : Which of the following drugs has demonstrated in vitro activity against Mycobacterium avium-intracellular(MAI)? (a) Vancomycin (b) Clarithromycin (c) Erythromycin base (d) Troleandomycin (e) Erythromycin estolate

Last Answer : Ans: B

Tetracyclines are still the first choice drugs for the following disease. (a) Granuloma linguinale (b) Chancroid (c) Syphilis (d) Gonorrhoea in patients allergic to penicillin

Description : Tetracyclines are still the first choice drugs for the following disease. (a) Granuloma linguinale (b) Chancroid (c) Syphilis (d) Gonorrhoea in patients allergic to penicillin

Last Answer : Ans: A

All of the following drugs are suitable oral therapy for a lower urinary tract infection due to Pseudomonas aeruginosa except (a) Norfloxacin (b) Trimethoprim-sulfamethxazole (c) Ciprofloxacin (d) Carbenicillin (e) Methenamine mandelate

Description : All of the following drugs are suitable oral therapy for a lower urinary tract infection due to Pseudomonas aeruginosa except (a) Norfloxacin (b) Trimethoprim-sulfamethxazole (c) Ciprofloxacin (d) Carbenicillin (e) Methenamine mandelate

Last Answer : Ans: B

An advantage of bleomycin over most antineoplastic drugs is its (a) Rapid onset of action (b) Lack of toxicity to all normal cells (c) Relative lack of bone marrow toxicity (d) Very broad spectrum of activity (e) Both (a) and (b)

Description : An advantage of bleomycin over most antineoplastic drugs is its (a) Rapid onset of action (b) Lack of toxicity to all normal cells (c) Relative lack of bone marrow toxicity (d) Very broad spectrum of activity (e) Both (a) and (b)

Last Answer : Ans: C

The persistent suppression of bacterial growth that may occur following limited exposure to some antimicrobial drugs is called (a) Time-dependent killing (b) The post antibiotic effect (c) Clinical synergy (d) Concentration – dependent killing (e) Sequential blockade

Description : The persistent suppression of bacterial growth that may occur following limited exposure to some antimicrobial drugs is called (a) Time-dependent killing (b) The post antibiotic effect (c) Clinical synergy (d) Concentration – dependent killing (e) Sequential blockade

Last Answer : Ans: B

Which one of the following antimicrobial drugs does not require supplementation of dosage following hemodialysis? (a) Ampicillin (b) Cefazolin (c) Ganciclovir (d) Tobramycin (e) Vancomycin

Description : Which one of the following antimicrobial drugs does not require supplementation of dosage following hemodialysis? (a) Ampicillin (b) Cefazolin (c) Ganciclovir (d) Tobramycin (e) Vancomycin

Last Answer : Ans: E

Which one of the following drugs is most likely to be effective against multidrug – resistant strains of M tuberculosis, including those resistant to streptomycin? (a) Amikacin (b) Clarithromycin (c) Gentamicin (d) Meropenem (e) Spectinomycin

Description : Which one of the following drugs is most likely to be effective against multidrug – resistant strains of M tuberculosis, including those resistant to streptomycin? (a) Amikacin (b) Clarithromycin (c) Gentamicin (d) Meropenem (e) Spectinomycin

Last Answer : Ans: A

Anyone else scared of taking antibiotics due to reactions?

Description : Anyone else scared of taking antibiotics due to reactions?

Last Answer : Every single freaking thing you put in your mouth can have side effects. No, I’m not going to beat myself up over something so unlikely to happen.

Antibiotic query ... about reactions?

Description : Antibiotic query ... about reactions?

Last Answer : i dont blame you…penicillin almost killed me once. anaphalaxis. I rarely take antibiotics now. Just be aware.

An advantge of betamethasone acetate over betamethasone sodium phosphate is (a) Fewer allergic reactions (b) Prompter action (c) More sustained action (d) Greater solubility (e) There is no advantage

Description : An advantge of betamethasone acetate over betamethasone sodium phosphate is (a) Fewer allergic reactions (b) Prompter action (c) More sustained action (d) Greater solubility (e) There is no advantage

Last Answer : Ans: C

Neuromuscular blocking drugs do not produce central actions because: A. They do not cross the blood-brain barrier B. Nicotinic receptors are not present in the brain C. They are sequestrated in the periphery by tight binding to the skeletal muscles D. They do not ionise at the brain pH

Description : Neuromuscular blocking drugs do not produce central actions because: A. They do not cross the blood-brain barrier B. Nicotinic receptors are not present in the brain C. They are sequestrated in the periphery by tight binding to the skeletal muscles D. They do not ionise at the brain pH

Last Answer : A. They do not cross the blood-brain barrier

Which of the following is not true of the blood-brain barrier: A. It is constituted by tight junctions between the endothelial cells of brain capillaries and the glial tissue B. It allows passage of lipid soluble drugs into the brain C. It limits entry of highly ionized drugs into the brain D. It regulates passage of substances from brain into blood

Description : Which of the following is not true of the blood-brain barrier: A. It is constituted by tight junctions between the endothelial cells of brain capillaries and the glial tissue B. It allows passage ... of highly ionized drugs into the brain D. It regulates passage of substances from brain into blood

Last Answer : D. It regulates passage of substances from brain into blood

6 The blood-brain barrier, which restricts entry of many drugs into brain, is constituted by: A. P-glycoprotein efflux carriers in brain capillary cells B. Tight junctions between endothelial cells of brain capillaries C. Enzymes present in brain capillary walls D. All of the above

Description : 6 The blood-brain barrier, which restricts entry of many drugs into brain, is constituted by: A. P-glycoprotein efflux carriers in brain capillary cells B. Tight junctions between endothelial cells of brain capillaries C. Enzymes present in brain capillary walls D. All of the above

Last Answer : D. All of the above

Which of the following is not true of the blood-brain barrier: A. It is constituted by tight junctions between the endothelial cells of brain capillaries and the glial tissue B. It allows passage of lipid soluble drugs into the brain C. It limits entry of highly ionized drugs into the brain D. It regulates passage of substances from brain into blood

Description : Which of the following is not true of the blood-brain barrier: A. It is constituted by tight junctions between the endothelial cells of brain capillaries and the glial tissue B. It allows passage ... of highly ionized drugs into the brain D. It regulates passage of substances from brain into blood

Last Answer : D. It regulates passage of substances from brain into blood

The blood-brain barrier, which restricts entry of many drugs into brain, is constituted by: A. P-glycoprotein efflux carriers in brain capillary cells B. Tight junctions between endothelial cells of brain capillaries C. Enzymes present in brain capillary walls D. All of the above

Description : The blood-brain barrier, which restricts entry of many drugs into brain, is constituted by: A. P-glycoprotein efflux carriers in brain capillary cells B. Tight junctions between endothelial cells of brain capillaries C. Enzymes present in brain capillary walls D. All of the above

Last Answer : D. All of the above

Which of the following is not true of the blood-brain barrier: A. It is constituted by tight junctions between the endothelial cells of brain capillaries and the glial tissue B. It allows passage of lipid soluble drugs into the brain C. It limits entry of highly ionized drugs into the brain D. It regulates passage of substances from brain into blood

Description : Which of the following is not true of the blood-brain barrier: A. It is constituted by tight junctions between the endothelial cells of brain capillaries and the glial tissue B. It allows passage ... of highly ionized drugs into the brain D. It regulates passage of substances from brain into blood

Last Answer : D. It regulates passage of substances from brain into blood

The blood-brain barrier, which restricts entry of many drugs into brain, is constituted by: A. P-glycoprotein efflux carriers in brain capillary cells B. Tight junctions between endothelial cells of brain capillaries C. Enzymes present in brain capillary walls D. All of the above

Description : The blood-brain barrier, which restricts entry of many drugs into brain, is constituted by: A. P-glycoprotein efflux carriers in brain capillary cells B. Tight junctions between endothelial cells of brain capillaries C. Enzymes present in brain capillary walls D. All of the above

Last Answer : D. All of the above

Weakly acidic drugs: A. Are bound primarily to α1 acid glycoprotein in plasma B. Are excreted faster in alkaline urine C. Are highly ionized in the gastric juice D. Do not cross blood-brain barrier

Description : Weakly acidic drugs: A. Are bound primarily to α1 acid glycoprotein in plasma B. Are excreted faster in alkaline urine C. Are highly ionized in the gastric juice D. Do not cross blood-brain barrier

Last Answer : B. Are excreted faster in alkaline urine

Weakly acidic drugs: A. Are bound primarily to α1 acid glycoprotein in plasma B. Are excreted faster in alkaline urine C. Are highly ionized in the gastric juice D. Do not cross blood-brain barrier

Description : Weakly acidic drugs: A. Are bound primarily to α1 acid glycoprotein in plasma B. Are excreted faster in alkaline urine C. Are highly ionized in the gastric juice D. Do not cross blood-brain barrier

Last Answer : B. Are excreted faster in alkaline urine

Weakly acidic drugs: A. Are bound primarily to α1 acid glycoprotein in plasma B. Are excreted faster in alkaline urine C. Are highly ionized in the gastric juice D. Do not cross blood-brain barrier

Description : Weakly acidic drugs: A. Are bound primarily to α1 acid glycoprotein in plasma B. Are excreted faster in alkaline urine C. Are highly ionized in the gastric juice D. Do not cross blood-brain barrier

Last Answer : B. Are excreted faster in alkaline urine

Streptomycin sulfate is not absorbed orally because it is (a) Degraded by gastrointestinal enzymes (b) Destroyed by gastric acid (c) Highly ionized at a wide range of pH values (d) Insoluble in water

Description : Streptomycin sulfate is not absorbed orally because it is (a) Degraded by gastrointestinal enzymes (b) Destroyed by gastric acid (c) Highly ionized at a wide range of pH values (d) Insoluble in water

Last Answer : Ans: C

Clavulanic acid is combined with amoxicillin because (a) It kills bacteria that are not killed by-moxicillin (b) It reduces renal clearance of amoxicillin (c) It counteracts the adverse effects of amoxicillin (d) It inhibits beta lactamases that destroy amoxicillin

Description : Clavulanic acid is combined with amoxicillin because (a) It kills bacteria that are not killed by-moxicillin (b) It reduces renal clearance of amoxicillin (c) It counteracts the adverse effects of amoxicillin (d) It inhibits beta lactamases that destroy amoxicillin

Last Answer : Ans: D

Widespread and prolonged used of an antibiotic leads to emergence of drug resistant strains because antibiotics (a) Induce mutation in the bacteria (b) Promote conjugation among bacteria (c) Allow resistant strains to propagate preferentially (d) All of the above

Description : Widespread and prolonged used of an antibiotic leads to emergence of drug resistant strains because antibiotics (a) Induce mutation in the bacteria (b) Promote conjugation among bacteria (c) Allow resistant strains to propagate preferentially (d) All of the above

Last Answer : Ans: C

The plasma half life of pencillin-G is longer in the new born because their (a) Plasma protein level is low (b) Drug metabolizing enzymes are immature (c) Glomerular filtration rate is low (d) Tubular transport mechanisms are not well developed

Description : The plasma half life of pencillin-G is longer in the new born because their (a) Plasma protein level is low (b) Drug metabolizing enzymes are immature (c) Glomerular filtration rate is low (d) Tubular transport mechanisms are not well developed

Last Answer : Ans: D

In a patient with culture-positive enterococcal endocarditis who has failed to respond to vancomycin because of resistance, the treatment most likely to be effective is (a) Clarithromycin (b) Erythromycin (c) Linezolid (d) Minocycline (e) Ticarcillin

Description : In a patient with culture-positive enterococcal endocarditis who has failed to respond to vancomycin because of resistance, the treatment most likely to be effective is (a) Clarithromycin (b) Erythromycin (c) Linezolid (d) Minocycline (e) Ticarcillin

Last Answer : Ans: D

Select the antibiotic with a high therapeutic index (a) Streptomycin (b) Doxy (c) Cephalexin (d) Polymyxin B

Description : Select the antibiotic with a high therapeutic index (a) Streptomycin (b) Doxy (c) Cephalexin (d) Polymyxin B

Last Answer : Ans: C

A high school student presents with headache, fever, and cough of 2 day’s duration. Sputum is scant and nonpurulent and a Gram stain reveals many white cells but no organisms. Since this patient appears to have atypical pneumonia. You should initiate treatment with (a) Cefazolin (b) Clindamycin (c) Erythromycin (d) Gentamicin (e) Trovafloxacin

Description : A high school student presents with headache, fever, and cough of 2 day's duration. Sputum is scant and nonpurulent and a Gram stain reveals many white cells but no organisms. Since this ... initiate treatment with (a) Cefazolin (b) Clindamycin (c) Erythromycin (d) Gentamicin (e) Trovafloxacin

Last Answer : Ans: C