Description : Ephedrine is similar to adrenaline in the following feature: A. Potency B. Inability to penetrate blood-brain barrier C. Duration of action D. Producing both α and β adrenergic effects
Last Answer : D. Producing both α and β adrenergic effects
Description : Dobutamine differs from dopamine in that (a) It does not activate peripheral dopaminergic receptors (b) It does not activate adrenergic ß receptors (c) It causes pronounced tachycardia (d) It has good blood-brain barrier penetrability
Last Answer : Ans: A
Description : Adrenaline raises blood glucose level by the following actions except (a) Inducing hepatic glycogenolysis (b) Inhibiting insulin secretion from pancreatic ß cells (c) Augmenting glucagons secretion from pancreatic a cells (d) Inhibiting peripheral glucose utilization
Last Answer : Ans: D
Description : The ß-adrenergic blocker which possesses both ß1 selectivity as well as intrinsic sympathomimetic activity is (a) Alprenolol (b) Atenolol (c) Acebutolol (d) Metoprolol
Last Answer : Ans: C
Description : Drugs that block the a receptor on effector cells at adrenergic nerve endings (a) Antagonize the effects of isoproterenol on the heart rate (b) Antagonize some of the effects of epinephrine on ... the effects of epinephrine on adenylyl cyclase (d) Cause mydriasis (e) Decreases blood glucose levels
Last Answer : Ans: B
Description : Postural hypotension is a common adverse effect of which one of the following types of drugs ? (a) ACE inhibitors (b) Alpha-receptor blockers (c) Arteriolar dilators (d) ß1 – selective receptor blockers (e) Nonselective ß - blockers
Description : Propranolol does not block the following action of adrenaline (a) Bronchodilation (b) Lipolysis (c) Muscle tremor (d) Mydriasis
Description : A sympathomimetic amine that acts almost exclusively by releasing noradrenaline from the nerve endings is (a) Ephedrine (b) Dopamine (c) Isoprenaline (d) Tyramine
Description : A 7-years-old boy has a significant bedwetting problem. A long-acting indirect sympathomimetic agent sometimes used by the oral route for this and other indications is (a) Dobutamine (b) Ephedrine (c) Epinephrine (d) Isoproterenol (e) Phenylephrine
Description : Which of the following is an orally active drug that blocks sodium channels and decreases action potential duration? (a) Adenosine (b) Amiodarone (c) Disopyramide (d) Esmolol (e) Mexiletine
Last Answer : Ans: E
Description : When used as an antiarrhythmic drug, Lidocaine typically (a) Increases action potential duration (b) Increases contractility (c) Increses PR interval (d) Reduces abnormal automaticity (e) Reduces resting potential
Description : Compared to pork/beef insulins, the human insulins: A. Are more potent B. Have a faster kinetics of absorption and elimination C. Have longer biological action half life D. Penetrate blood-brain barrier more efficiently
Last Answer : B. Have a faster kinetics of absorption and elimination
Description : Low doses of adrenaline dilate the following vascular bed (a) Cutaneous (b) Mucosal (c) Renal (d) Skeletal muscle
Description : Adrenergic neurone blocking drugs: A. Block the action of adrenaline on neuronal α2 adrenoceptors B. Block both α and β adrenoceptor mediated effects of injected adrenaline C. Do not block any effect of injected adrenaline D. Do not block the effects of sympathetic nerve
Last Answer : C. Do not block any effect of injected adrenaline
Description : Adrenergic neurone blocking drugs: A. Block the action of adrenaline on neuronal α2 adrenoceptors B. Block both α and β adrenoceptor mediated effects of injected adrenaline C. Do not block any effect of injected adrenaline D. Do not block the effects of sympathetic nerve stimulation
Description : Prazosin is an effective antihypertensive while nonselective a adrenergic blockers are not because (a) It is the only orally active a blocker (b) It improves plasma lipid profile (c) It does not concurrently enhance noradrenaline release (d) It improves urine flow in males with prostatic hypertrophy
Description : The drug which produces vasoconstriction despite being an a adrenergic blocker is (a) Phenoxybenzamine (b) Ergotamine (c) Dihydroergotoxine (d) Tolazoline
Description : Continuous exposure of ctecholaminesensitive cells and tissues to adrenergic agonists causes a progressive diminition in their capacity to respond, this phenomenon is called as (a) Refractoriness (b) Desensitization (c) Tachyphylaxis (d) All of the above
Description : a2–adrenergic receptors are associated with following except (a) Increase in phospholipase C activity (b) Increase in potassium channel conductance (c) Decrease in calcium channel conductance (d) Increase in adenylyl cyclase activity
Description : Choose the correct statement from the following about a1 – adrenergic receptor agonists (a) Norepinephrine > isoproterenol > epinephrine (b) Norepinephrine < epinephrine > isoproterenol (c) Epinephrine = norepinephrine >> isoproterenol (d) Epinephrine > isoproterenol > norepinephrine
Description : Tyramine induces release of noradrenaline from adrenergic nerve endings (a) By depolarizing the axonal membrane (b) By mobilizing Ca2+ (c) By a nonexocytotic process (d) Only in the presence of MAO inhibitors
Description : Select the correct statement from the following about a1 – adrenergic receptor agonists (a) Isoproterenol > epinephrine = norepinephrine (b) Epinephrine > isoproterenol > norepinephrine (c) Isoproterenol = epinephrine = norepinephrine (d) Epinephrine = norepinephrine > isoproterenol
Description : Neostigmine is preferred over physostigmine for treating myasthenia gravis because: A. It is better absorbed orally B. It has longer duration of action C. It has additional direct agonistic action on nicotinic receptors at the muscle end plate D. It penetrates blood-brain barrier
Last Answer : C. It has additional direct agonistic action on nicotinic receptors at the muscle end plate
Description : Which of the following drugs used for the treatment of angina by inhalation has a very rapid onset and a brief duration of effect ? (a) Amyl nitrite (b) Hydralazine (c) Isosorbide mononitrate (d) Nifedipine (e) Nimodipine
Description : The capacity of an antihistaminic to produce sedation depends on the following except (a) Relative affinity for central versus peripheral H1 receptors (b) Ability to penetrate blood-brain barrier (c) Individual susceptibility (d) Ratio of H1 : H2 blockade produced by the drug
Description : Sulfamethoxypyridazine and other related long acting sulfonamides have now gone into disuse because (a) They have produced serious cutaneous reactions (b) They have produced high incidence of crystalluria (c) They interact with many drugs (d) They do not penetrate blood-brain barrier
Description : The capacity of an antihistaminic to produce sedation depends on the following except: A. Relative affinity for central versus peripheral H1 receptors B. Ability to penetrate blood-brain barrier C. Individual susceptibility D. Ratio of H1:H2 blockade produced by the drug
Last Answer : D. Ratio of H1:H2 blockade produced by the drug
Description : 06. A hydrophilic medicinal agent has the following property: a) Low ability to penetrate through the cell membrane lipids b) Penetrate through membranes by means of endocytosis c) Easy permeation through the blood-brain barrier d) High reabsorption in renal tubules
Last Answer : a) Low ability to penetrate through the cell membrane lipids
Description : Dobutamine differs from dopamine in that: A. It does not activate peripheral dopaminergic receptors B. It does not activate adrenergic β receptors C. It causes pronounced tachycardia D. It has good blood-brain barrier penetrability
Last Answer : A. It does not activate peripheral dopaminergic receptors
Description : Hyoscine differs from atropine in that it (a) Exerts depressant effects on the CNS at relatively low doses (b) Exerts more potent effects on the heart than on the eye (c) Is longer acting (d) Has weaker antimotion sickness activity
Description : Recognized adverse effects of quinidine include which one of the following? (a) Cinchonism (b) Constipation (c) Lupus erythematosus (d) Increase in digoxin clearance (e) Precipitation of hyperthyroidism
Description : In a patient given a cardiac glycoside, important effects of the drug on the heart include which of the following? (a) Decreased atrioventricular conduction velocity (b) Decreased ejection time (c) Increased ectopic automaticity (d) Increased ectopic automaticity (e) All of the above
Description : Nitroglycerin, either directly or through reflexes, results in which one of the following effects (a) Decreased heart rate (b) Decreased venous capacitance (c) Increased afterload (d) Increased cardiac force (e) Increased diastolic intramyocardial fiber tension
Description : Reserprine, an alkaloid derived from the root of Rauwolfia serpentina (a) Can be used to control hyperglycemia (b) Can cause severe depression of mood (c) Can decrease gastrointestinal secretion and motility (d) Has no cardiac effects (e) A spare receptor agonist
Description : A friend has very severe hypertension and asks about a drug her doctor wishes to prescribe. Her physician has explained that this drug is associated with tachycardia and fluid retention (which may be marked ... has described? (a) Captopril (b) Guanethidine (c) Minoxidil (d) Prazosin (e) Propranolol
Description : Which of the following effects of epinephrine would be blocked by phentolamine but not by metoprolol ? (a) Cardiac stimulation (b) Contractionof radial smooth muscle in the iris (c) Increase of camp in fat (d) Relaxation of bronchial smooth muscle (e) Relaxation of the uterus
Description : Several children at a summer camp were hospitalized with symptoms thought to be due to ingestion of food containing botulinum toxins. The effects of botulinum toxin are likely to include (a) Bronchospasm (b) Cycloplegia (c) Diarrhea (d) Skeletal muscle spasms (e) Hyperventilation
Description : Which of the following mydriatics has the fastest and briefest action ? (a) Atropine (b) Homatropine (c) Tropicamide (d) Cyclopentolate
Description : Glycopyrrolate is the preferred antimuscannic drug for use before and during surgery because (a) It is potent and fast acting (b) It has no central action (c) It has antisecretory and vagolytic actions (d) All of the above
Description : Action of norepinephrine and epinephrine are terminated by (a) Reuptake into nerve terminal (b) Dilution by diffusion and uptake at extraneuronal site (c) Metabolic transformation (d) All of the above
Description : Cromolyn has as its major action (a) Block of calcium channels in lymphocytes (b) Block of mediator release from mast cells (c) Block of phosphodiesterase in mast cells and basophils (d) Smooth muscle relaxation in the bronchi (e) Stimulation of cortisol release by the adrenals
Description : The biochemical mechanism of action of digitalis is associated with (a) A decrease in calcium uptake by the sarcoplasmic reticulum (b) An increase in ATP synthesis (c) A modification of the actin molecule (d) An increase in systolic intracellular calcium levels (e) A block of sodium/calcium exchange
Description : Which of the following best describes the mechanism of action of scopolamine ? (a) Irreversible antagonist at nicotinic receptors (b) Irreversible antagonist at muscarinic receptors (c) ... receptors (d) Reversible antagonist at muscarinic receptors (e) Reversible antagonist at nicotinic receptors
Description : Enhanced automaticity in cardiac cells may occur because of (a) ß-adrenergic stimulation (b) Hypokalemia (c) Mechanical stretch of cardiac muscles (d) All of the above
Description : According to Hahnemann, which scale of potency is capable of producing medicines of highest development of power and mildest action Options: 1) Straight Potency 2) Jumping Potency 3) Decimal Stale of Potency 4) Fifty Millesimal Scale of Potency
Last Answer : Correct Answer: 4) Fifty Millesimal Scale of Potency
Description : Which of the following is a noncatecholamine sympathomimetic: A. Adrenaline B. Ephedrine C. Dopamine D. Isoprenaline
Last Answer : B. Ephedrine