Description : Which one of the following antibiotics is likely to be most effective agent in the treatment of an infection due to enterococci if used in conjuction with penicillin G? (a) Amikacin (b) Gentamicin (c) Netilmicin (d) Streptomycin (e) Tobramycin
Last Answer : Ans: D
Description : Beta - lactamase production by strains of Haemophilus influenzae, Moraxella catarrhalis, and Neissera gonorrhoeae confers resistance against penicillin G.which one of the following antibiotics is most likely to be ... ? (a) Ampicillin (b) Ceftriaxone (c) Clindamycin (d) Gentamicin (e) Piperacillin
Last Answer : Ans: B
Description : Clarithromycin and erythromycin have very similar spectrums of antimicrobial activity. The major advantage of clarithromytcin is that it (a) Eradicates mycoplasmal infections in a single dose (b ... not inhibit live drug-metabolizing enzymes (e) Acts on methicillin-resistant strains of staphylococci
Last Answer : Ans: C
Description : Clarithromycin is used for the following: A. Multidrug resistant M.tuberculosis infection B. M.avium complex infection in AIDS patient C. M.tuberculosis infection in a patient who develops jaundice due to first line antitubercular drugs D. Both ‘A’ and ‘B’ are correct
Last Answer : B. M.avium complex infection in AIDS patient
Description : Spectinomycin is an aminoglycoside-like antibiotic indicated for the treatment of (a) Gram-negative bacillary septicemia (b) Tuberculosis (c) Penicillin-resistant gonococcal infections (d) Syphilis (e) Gram-negative meningitis due to susceptible organisms
Description : Which of the following drugs has demonstrated in vitro activity against Mycobacterium avium-intracellular(MAI)? (a) Vancomycin (b) Clarithromycin (c) Erythromycin base (d) Troleandomycin (e) Erythromycin estolate
Description : Which aminoglycoside antibiotic causes more hearing loss than vestibular disturabance as toxic effect ? (a) Streptomycin (b) Gentamicin (c) Kanamycin (d) Sisomicin
Description : In a patient with culture-positive enterococcal endocarditis who has failed to respond to vancomycin because of resistance, the treatment most likely to be effective is (a) Clarithromycin (b) Erythromycin (c) Linezolid (d) Minocycline (e) Ticarcillin
Description : The drug of choice for treatment of methicillin resistant Staphylococcus aureus infection is (a) Cloxacillin (b) Vancomycin (c) Erythromycin (d) Amikacin
Description : Widespread and prolonged used of an antibiotic leads to emergence of drug resistant strains because antibiotics (a) Induce mutation in the bacteria (b) Promote conjugation among bacteria (c) Allow resistant strains to propagate preferentially (d) All of the above
Description : A patient needs antibiotic treatment for native valve, culture-positive infective enterococcal endocarditis. His medical history includes a severe anaphylactic reaction to penicillin G during the past year. ... /clavulanate (b) Aztreonam (c) Cefazolin plus genatamicin (d) Meropenem (e) Vancomycin
Last Answer : Ans: E
Description : Gentamicin differs from streptomycin in that: A. It is less nephrotoxic B. It is used for pseudomonas infections C. It is not effective in tuberculosis D. Both ‘B’ and ‘C’ are correct
Last Answer : D. Both ‘B’ and ‘C’ are correct
Description : Use of artemisinin derivatives is restricted to treatment of multidrug resistant falciparum malaria because: A. Wide spread use for all cases of malaria may foster development of resistant strains B. They are not ... P.vivax C. They are more toxic than quinine D. All of the above are correct
Last Answer : A. Wide spread use for all cases of malaria may foster development of resistant strain
Description : Multidrug resistant (MDR) tuberculosis is defined as resistance to: A. Any two or more antitubercular drugs B. Isoniazid + any other antitubercular drug C. Isoniazid + Rifampin + any one or more antitubercular drugs D. All five first line antitubercular drugs
Last Answer : C. Isoniazid + Rifampin + any one or more antitubercular drugs
Description : Your 23-year-old female patient is pregnant and has gonorrhea. The past medical history includes anaphylaxis following exposure to amoxicillin. Worried about compliance, you would like to treat this patient ... chose (a) Cefixime (b) Ceftriaxone (c) Ciprofloxacin (d) Spectinomycin (e) Tetracycline
Description : A single oral dose of the following drug can cure most cases of uncomplicated gonorrhoea (a) Ciprofloxacin (b) Cotrimoxazole (c) Spectinomycin (d) Doxycycline
Last Answer : Ans: A
Description : This drug has activity against many strains of Pseudomomas aeruginosa. However, when it is used alone, resistance has emerged during the course of treatment. The drug should not be used in ... with tazobactam (a) Amoxicillin (b) Aztreonam (c) Imipenem (d) Piperacillin (e) Vancomycin
Description : Which one of the following statements about cefotetan is accurate? (a) It is active against MRSA strains (b) It is the drug of choice in community-acquired pneumonia (c) ... fourth-generation cephalosporin (d) It decreases prothrombin time (e) Its antibacterial spectrum include Bacteroides fragilis
Description : The aminoglycoside antibiotic which is distinguished by its resistance to bacterial aminoglycoside inactivating enzymes is (a) Kanamycin (b) Sisomicin (c) Amikacin (d) Tobramycin
Description : A 19-year-old woman with recurrent sinusitis has been treated with different antibiotics on several occasions. During the course of one such treatment she developed a severe diarrhea and was hospitalized. ... difficile? (a) Ampicillin (b) Cefazolin (c) Clindamycin (d) Metonidazole (e) Tetracycline
Description : Chloramphenicol is particularly effective in the treatment of (a) Diphtheria (b) Tuberculosis (c) Emphysema (d) Rickettsial diseases (e) Streptomyces pyogenes infections
Description : Of the following which is the most important mechanism of concurrent acquisition of multidrug resistance among bacteria ? (a) Mutation (b) Conjugation (c) Transduction (d) Transformation
Description : The following antibiotic is a first line drug for treatment of Mycobacterium avium complex infection in AIDS patients (a) Clindamycin (b) Clarithromycin (c) Roxithromycin (d) Erythromycin
Description : Methicillin resistant staphylococci do not respond to ß-lactam antibiotics because (a) They produce a ß-lactamase which destroys methicillin and related drugs (b) They elaborate an amidase which destroys ... low affinity for ß-lactam antibiotics (d) They are less permeable to ß-lactam antibiotics
Description : A high school student presents with headache, fever, and cough of 2 day's duration. Sputum is scant and nonpurulent and a Gram stain reveals many white cells but no organisms. Since this ... initiate treatment with (a) Cefazolin (b) Clindamycin (c) Erythromycin (d) Gentamicin (e) Trovafloxacin
Description : Regarding the antibacterial action of gentamicin, which one of the following statements is most accurate? (a) Efficacy is directly proportionate to the time that the plasma level of the drug is ... an inhibitor of cell wall synthesis (e) The antibacterial action of gentamicin is time - dependent
Description : All of the following factors may increase the risk of nephrotoxicity from gentamicin therapy except (a) age over 70 years (b) prolonged courses of gentamicin therapy (c) concurrent amphotericin B therapy (d) trough gentamicin levels below 2 mg/ml (e) concurrent cisplatin therapy
Description : Which out of the following antibiotics penetrates blood-CSF barrier the best (a) Erythromycin (b) Gentamicin (c) Tetracycline (d) Chloramphenicol
Description : Which one of the following statements about ampicillin is false? (a) Its activity is enhanced by sulbactam (b) It causes maculopapular rashes (c) It is the drug of choice for Listeria monocytogenes infection (d) It eradicates most strains of MRSA (e) Pseudomembranous colitis may occur with its use
Description : Amoxicillin + Clavulanic acid is active against the following organism except (a) Methicillin resistant Staph. aureus (b) Penicillinase producing Staph. aureus (c) Penicillinase producing n. gonorrhoeae (d) ß-lactamase producing E. coli
Description : Piperacillin differs from carbenicillin in the following respect(s) (a) It is more active against pseudomonas aeruginosa (b) It is active against Klebsiella also (c) It is acid resistant (d) Both (a) and (b)
Description : Streptomycin sulfate is not absorbed orally because it is (a) Degraded by gastrointestinal enzymes (b) Destroyed by gastric acid (c) Highly ionized at a wide range of pH values (d) Insoluble in water
Description : Select the antibiotic with a high therapeutic index (a) Streptomycin (b) Doxy (c) Cephalexin (d) Polymyxin B
Description : Mycobact. tuberculosis infection in a HIV infected patient is treated with: A. The same antitubercular regimen as HIV negative patient B. Four first line antitubercular drugs for 2 months followed ... line antitubercular drugs for 9 months D. Clarithromycin + Ciprofloxacin + Rifabutin for 12 months
Last Answer : B. Four first line antitubercular drugs for 2 months followed by a longer continuation phase of 7 months with rifampin + isoniazid
Description : Sterptomycin has no useful activity in the treatment of (a) Bubonic plague (b) Brucellosis (c) Lyme disease (d) Tuberculosis (e) Tularemia
Description : Which of the following is effective against tuberculosis? (1) Penicillin (2) Chloromycetin (3) Terramycin (4) Streptomycin
Last Answer : (4) Streptomycin Explanation: Streptomycin is an antibiotic drug, the first of a class of drugs called amino glycosides to be discovered, and it was the first antibiotic remedy for ... antibiotic. Streptomycin cannot be given orally, but must be administered by regular intramuscular injections.
Description : Which of the following is effective against tuberculosis ? (1) Penicillin (2) Chloromycetin (3) Terramycin (4) Streptomycin
Last Answer : Streptomycin
Description : If a multibacillary leprosy patient treated with standard fixed duration multidrug therapy relapses, he should be treated with: A. The same rifampin + dapsone + clofazimine regimen B. ... + minocycline C. Clofazimine + ofloxacin + clarithromycin D. Ofloxacin + minocycline + clarithromycin
Last Answer : . The same rifampin + dapsone + clofazimine regimen
Description : In the treatment of typhoid fever, ciprofloxacin has the following advantage(s) (a) It is effective in nearly all cases (b) Early abetment of fever and other symptoms (c) Development of carrier state is less likely (d) All of the above
Description : Bleomycin is used in most effective drug combination regiment for the chemotherapy of testicular carcinoma. Which one of the following statements about the drug is accurate? (a) Acts mainly in the ... neuropathy occurs in more than 50% of patients (e) Pulmonary infiltrates and fibrosis may occur
Description : What is break point concentration of an antibiotic ? (a) Concentration at which the antibiotic lyses the bacteria (b) Concentration of the antibiotic which demarks between sensitive ... which overcomes bacterial resistance (d) Concentration at which a bacteriostatic antibiotic becomes bactericidal
Description : All of the following drugs are suitable oral therapy for a lower urinary tract infection due to Pseudomonas aeruginosa except (a) Norfloxacin (b) Trimethoprim-sulfamethxazole (c) Ciprofloxacin (d) Carbenicillin (e) Methenamine mandelate
Description : A woman has an upper respiratory infection. Six years ago, she experienced an episode of bronchospasm follwing penicillin V therapy. The cultures now reveal a strain of streptococcus pneumoniae that is ... ? (a) Amoxicillin/clavulanate (b) Erythromycin (c) Ampicillin (d) cefaclor (e) Cyclacillin
Description : An advantage of bleomycin over most antineoplastic drugs is its (a) Rapid onset of action (b) Lack of toxicity to all normal cells (c) Relative lack of bone marrow toxicity (d) Very broad spectrum of activity (e) Both (a) and (b)
Description : In which of the following groups do all four drugs warrant careful monitoring for drugrelated seizures in high-risk patients? (a) Penicillin G, imipenem, amphotericin B, metronidazol ... (d) Cycloserine, metronidazole, vancomycin, sulfadiazine (e) Metronidazole, imipenem, doxycycline, erythromycin
Description : The persistent suppression of bacterial growth that may occur following limited exposure to some antimicrobial drugs is called (a) Time-dependent killing (b) The post antibiotic effect (c) Clinical synergy (d) Concentration – dependent killing (e) Sequential blockade
Description : Which one of the following antimicrobial drugs does not require supplementation of dosage following hemodialysis? (a) Ampicillin (b) Cefazolin (c) Ganciclovir (d) Tobramycin (e) Vancomycin
Description : Which of the following drugs is effective against Trichomonas vaginalis C A. Penicillin B. Streptomycin C. Metronidazole D. Pentamidine
Last Answer : Metronidazole
Description : Tetracyclines are still the first choice drugs for the following disease. (a) Granuloma linguinale (b) Chancroid (c) Syphilis (d) Gonorrhoea in patients allergic to penicillin
Description : Sulfamethoxypyridazine and other related long acting sulfonamides have now gone into disuse because (a) They have produced serious cutaneous reactions (b) They have produced high incidence of crystalluria (c) They interact with many drugs (d) They do not penetrate blood-brain barrier