Description : Tachyphylaxis to many actions on repeated injection is a feature of the following autacoid: A. Histamine B. 5-Hydroxytryptamine C. Bradykinin D. Prostaglandin E2
Last Answer : B. 5-Hydroxytryptamine
Description : In an anaesthetized dog, repeated intravenous injection of ephedrine shows the phenomenon of: A. Anaphylaxis B. Tachyphylaxis C. Idiosyncrasy D. Drug resistance
Last Answer : B. Tachyphylaxis
Description : The most important receptor involved in cytotoxic drug induced vomiting is (a) Histamine H1 receptor (b) Serotonin 5-HT3 receptor (c) Dopamine D2 receptor (d) Opioid µ receptor
Last Answer : Ans: B
Description : Smooth muscle relaxation is due to stimulation of which type of histamine receptors (a) H1 (b) H2 (c) H3 (d) All of the above
Description : Histamine (a) May be released from mast cells by a number of therapeutic agents (b) Causes sedation (c) Decreases the force of contraction of ventricular muscle (d) Can cause strong contractions of the gravid human uterus
Last Answer : Ans: D
Description : Histamine is involved as a mediator in the following pathological conditon (a) Cocaine (b) Dibucaine (c) Lidocaine (d) Procaine
Description : Fall in blood pressure caused by larger doses of histamine is blocked by (a) H1 antihistaminics alone (b) H2 ANTAgonists alone (c) Combination of H1 and H2 antagonists (d) None of the above
Last Answer : Ans: C
Description : Which of the following is a selective H1 receptor agoinist ? (a) 4-methyl histamine (b) Impromidine (c) 2-Thiazolyl ethylamine (d) Mepyramine
Description : Bradykinin and angiotensin II have the following feature common to both: A. They both cause fall in BP B. They both are degraded by Kininase II C. Their precursor proteins are plasma α2 globulins D. They both release aldosterone from adrenal cortex
Last Answer : C. Their precursor proteins are plasma α2 globulins
Description : Dysmenorrhoea is often associated with excess production of the following autacoid by the endometrium: A. Bradykinin B. Prostaglandin C. Platelet activating factor D. 5-Hydroxytryptamine
Last Answer : B. Prostaglandin
Description : Select the nonapeptide which can be generated from plasma globulin by snake venom enzymes, causes fall in BP and intense pain when applied to blister base: A. Kallidin B. Bradykinin C. Angiotensin II D. Angiotensin III
Last Answer : B. Bradykinin
Description : Potentiation of bradykinin appears to play a role in the following effects of angiotensin converting enzyme inhibitors except: A. Fall in BP in the short term B. Fall in BP in the long term C. Cough in susceptible individuals D. Angioedema in susceptible individuals
Last Answer : B. Fall in BP in the long term
Description : Ventricular remodeling after myocardial infarction involves the mediation of: A. Angiotensin II B. Prostaglandin C. Bradykinin D. Thromboxane A2
Last Answer : A. Angiotensin II
Description : The following is a pressor peptide that can be generated both in circulation as well as locally in certain tissues: A. Bradykinin B. Angiotensin C. Kallidin D. Plasmin
Last Answer : B. Angiotensin
Description : Following mediators are involved in acute inflammation except (a) Histamine (b) Leukotrienes (c) Interferons (d) Bradykinin
Description : Prolonged airway hyperreactivity is characteristically caused by: A. Histamine B. Prostaglandin E2 C. Platelet activating factor D. Bradykinin
Last Answer : C. Platelet activating factor
Description : The 5-HT antagonist that has antihypertensive property is (a) Methysergide (b) Cyproheptadine (c) Ketanserin (d) Ondansetron
Description : The smooth muscle stimulating action of 5-HT is most marked in the (a) Bronchi (b) Intestines (c) Ureter (d) Billary tract
Description : The action of 5-Hydroxy tryptamine mediated by the 5-HT3 receptor is (a) Vasoconstriction (b) Bradycardia (c) EDRF release (d) Platelet aggregation
Description : Acute exacerbations of asthma can be triggered by all of the following except (a) Bacterial or viral pneumonia (b) Hypersensitivity reaction to penicillin (c) Discontinuation of asthma medication (d) Hot, dry weather (e) Stressful emotional events
Description : The symptoms of allergen-mediated asthma result from which of the following? (a) Increased release of mediators from mast cells (b) Increased adrenergic responsiveness of the airways (c) ... bronchial tissue (d) Decreased calcium influx into the mast cell (e) Decreased prostaglandin production
Last Answer : Ans: A
Description : Bacteria that make either a fementative or respiratory set of enzymes are known as (a) Obligate anacerobes (b) Obligate aerobes (c) Microacerophiles (d) Facultative organisms
Description : Relative to fexofenadine, diphenhydramine is more likely to (a) Be used for treatment of asthma (b) Be used for treatment of gastroesophageal reflux disease (c) Cause cardiac arrhythmias in ... ) Have efficacy in the prevention of motion sickness (e) Increase the serum concentration of warfarin
Description : A drug useful in the treatment of asthma but lacking bronchodilator action, is (a) Cromolyn (b) Ephedrine (c) Isoproterenol (d) Metaproterenol (e) Metoprolol
Description : Which one of the following drugs is most suitable for management of essential tremor in a patient who has pulmonary disease? (a) Diazepam (b) Levodopa (c) Metoprolol (d) Propranolol (e) Terbutaline
Description : Which of the following is a very longacting ß2 – selective agonist that is used for asthma prophylaxis? (a) Aminophyline (b) Cromolyn (c) Epinephrine (d) Ipratropium (e) Salmeterol
Last Answer : Ans: E
Description : Which of the following has overdose toxicity that includes insomnia, arrhythmias, and convulsions? (a) Aminophyline (b) Cromolyn (c) Epinephrine (d) Ipratropium (e) Metaproterenol
Description : Acute exacerbations of asthma can be triggered by all of the following except (a) Bacterial of viral pneumonia (b) Hypertsensitivity reaction to penicillin (c) Discontinuation of asthma medication (d) Hot, dry weather (e) Stressful emotional events
Description : Which of the following is a direct bronchodilator that is most often used in asthma by the oral route? (a) Aminophyline (b) Cromolyn (c) Epinephrine (d) Ipratropium (e) Metaproterenol
Description : Pyridostigmine differs from neostigmine in that (a) More potent orally (b) Longer acting (c) Less muscarinic side effects (d) All of the above
Description : What is symport ? (a) Counter transport (b) Contransport (c) Carrier mediated diffusion (d) Solvent drug
Description : Which xanthine derivative has no function in asthma ? (a) Theophylline (b) Pentoxyphyllin (c) Enprofylin (d) None of the above
Description : All the following are employed in inhalation therapy of asthma except (a) Beclomethasone (b) Budesonide (c) Dexamethasone (d) Triamcinolone
Description : Chronic Bronchitis is characterized by I. the distruction of central and peripheral portions of the acinus II. an increased number of mucous glands and goblet cells III. edema and inflammation of the bronchioles (a) only ... II are correct (d) II and III are correct (e) I, II and III are correct
Description : To be a useful inhaled glucocorticoid the drug should have (a) High oral bioavailability (b) Low oral bioavailability (c) Additional bronchodilator activity (d) Prodrug character
Description : In an asthma patient treated with systemic corticosteroids, bronchodilator drugs (a) Are not needed (b) Are contraindicated (c) May be used on ‘as and when required’ basis (d) Are ineffective
Description : Budesonide is a (a) Nonsteroidal anti-inflammatory drug (b) High ceiling diuretic (c) Inhaled corticosteroid for asthma (d) Contraceptive
Description : In patients of bronchial asthma inhaled corticosteroids achieve the following except (a) Reduce the need for bronchodilator medication (b) Control an attack of refractory asthma (c) Reduce bronchial hyperreactivity (d) Reverse diminished responsiveness to sympathomimetic bronchodilators
Description : Intransasal spray of budesonide is indicated in (a) Common cold (b) Acute vasomotor rhinitis (c) Perennial vasomotor rhinitis (d) Epistaxis
Description : The most consistent, pronounced and sustained relief of symptoms in chronic bronchial asthma is afforded by (a) ß2 sympathomimetics (b) Anticholinergics (c) Sodium cromoglycate (d) Corticosteroids
Description : Which of the following drugs is neither bronchodilator nor anti-inflammatory, but has antihistaminic and mast cell stabilizing activity ? (a) Sodium cromoglycate (b) Ketotifen (c) Beclomethasone dipropionate (d) Mepyramine maleate
Description : A 10 year old child suffers from exercise induced asthma: Which is the most suitable first line drug for regular prophylactic therapy ? (a) Oral salbutamol (b) Oral theophylline (c) Inhaled sodium cromoglycate (d) Inhaled beclomethasone dipropionate
Description : The antiasthma drug which cannot be administered by inhalation is (a) Theophylline (b) Ipratropium bromide (c) Budesonide (d) Terbutaline
Description : Relatively higher dose of theophylline is required to attain therapeutics plasma concentration in (a) Smokers (b) Congestive heart failure patients (c) Those receiving erythromycin (d) Those receiving cimetidine
Description : Methylxanthines exert the following action (s) at cellular/molecular level (a) Intracellular release of Ca2+ (b) Antagonism of adenosine (c) Inhibition of phosphodiesterase (d) All of the above
Description : Caffeine is more powerful than theophylline in exerting the following action (a) Bronchodilatation (b) Cardiac stimulation (c) Diuresis (d) Augmentation of skeletal muscle contractility
Description : Select the correct statement about salmeterol. (a) It is a long acting selective ß2 agonist bronchodilator (b) It is a bronchodilator with anti-inflammatory property (c) It is a ß blocker that can be safely given to asthmatics (d) It is an antihistaminic with mast cells stabilizing property
Description : In a patient of bronchial asthma, inhaled salbutamol produces the following effect(s). (a) Inhibits antigen-antibody reaction in the lungs (b) Causes bronchodilatation (c) Reduces bronchial hyperreactivity (d) Both (b) and (c)
Description : Which of the following tests is used at home to assess therapy and determine if a patient with asthma should seek emergency care? (a) Forced expiratory volume in one second (FEV1) (b) Forced vital capacity ... ) Total lung capacity (TLC) (d) Peak expiratory flow rate (PEFR) (e) Residual volume (RV)