Description : 15.45 To be a useful inhaled glucocorticoid the drug should have: A. High oral bioavailability B. Low oral bioavailability C. Additional bronchodilator activity
Last Answer : B. Low oral bioavailability
Description : In patients of bronchial asthma inhaled corticosteroids achieve the following except (a) Reduce the need for bronchodilator medication (b) Control an attack of refractory asthma (c) Reduce bronchial hyperreactivity (d) Reverse diminished responsiveness to sympathomimetic bronchodilators
Last Answer : Ans: B
Description : A 10 year old child suffers from exercise induced asthma: Which is the most suitable first line drug for regular prophylactic therapy ? (a) Oral salbutamol (b) Oral theophylline (c) Inhaled sodium cromoglycate (d) Inhaled beclomethasone dipropionate
Last Answer : Ans: C
Description : A drug useful in the treatment of asthma but lacking bronchodilator action, is (a) Cromolyn (b) Ephedrine (c) Isoproterenol (d) Metaproterenol (e) Metoprolol
Last Answer : Ans: A
Description : Which of the following is a direct bronchodilator that is most often used in asthma by the oral route? (a) Aminophyline (b) Cromolyn (c) Epinephrine (d) Ipratropium (e) Metaproterenol
Description : Which of the following drugs is neither bronchodilator nor anti-inflammatory, but has antihistaminic and mast cell stabilizing activity ? (a) Sodium cromoglycate (b) Ketotifen (c) Beclomethasone dipropionate (d) Mepyramine maleate
Description : Budesonide is a (a) Nonsteroidal anti-inflammatory drug (b) High ceiling diuretic (c) Inhaled corticosteroid for asthma (d) Contraceptive
Description : In an asthma patient treated with systemic corticosteroids, bronchodilator drugs (a) Are not needed (b) Are contraindicated (c) May be used on ‘as and when required’ basis (d) Are ineffective
Description : Select the correct statement about salmeterol. (a) It is a long acting selective ß2 agonist bronchodilator (b) It is a bronchodilator with anti-inflammatory property (c) It is a ß blocker that can be safely given to asthmatics (d) It is an antihistaminic with mast cells stabilizing property
Description : In a patient of bronchial asthma, inhaled salbutamol produces the following effect(s). (a) Inhibits antigen-antibody reaction in the lungs (b) Causes bronchodilatation (c) Reduces bronchial hyperreactivity (d) Both (b) and (c)
Description : The National Institutes of Health (NIH) guidelines for the treatment of asthma recommended institution of routine inhaled corticosteroids when patients are classified as having greater than or equal to which ... (a) Mild intermittent (b) Mild persistent (c) Moderate persistent (d) Severe persistent
Description : Which of the following is a nonselective but very potent and efficacious bonchodilator that is not active by the oral route? (a) Aminophyline (b) Cromolyn (c) Epinephrine (d) Ipratropium (e) Metaproterenol
Description : Choose the correct statement about bambuterol: A. It is an orally acting bronchodilator B. It is a prodrug C. It inhibits the enzyme pseudocholinesterase D. All of the above
Last Answer : D. All of the above
Description : Bronchodilators are useful in cough (a) Only when cough is non-productive (b) Only when cough is associated with thick sticky secretions (c) Only when reflex bronchoconstriction is associated (d) ... Rise in blood pressure (b) Muscle tremor (c) Hyperglycaemia (d) Central nervous system stimulation
Description : Which of the following is most useful in the treatment of hyperprolactinemia ? (a) Bromocriptine (b) Cimetidine (c) Ergotamine (d) Ketanserin (e) LSD
Description : The primary goals of asthma therapy include all of the following except (a) maintain normal activity levels (b) maintain control of symptoms (c) avoid adverse effects of asthma medications (d) prevent acute exacerbations and chronic symptoms (e) prevent destruction of lung tissue
Last Answer : Ans: E
Description : What is symport ? (a) Counter transport (b) Contransport (c) Carrier mediated diffusion (d) Solvent drug
Description : The antiasthma drug which cannot be administered by inhalation is (a) Theophylline (b) Ipratropium bromide (c) Budesonide (d) Terbutaline
Description : The most important receptor involved in cytotoxic drug induced vomiting is (a) Histamine H1 receptor (b) Serotonin 5-HT3 receptor (c) Dopamine D2 receptor (d) Opioid µ receptor
Description : The capacity of an antihistaminic to produce sedation depends on the following except (a) Relative affinity for central versus peripheral H1 receptors (b) Ability to penetrate blood-brain barrier (c) Individual susceptibility (d) Ratio of H1 : H2 blockade produced by the drug
Last Answer : Ans: D
Description : A drug administered by inhalation of powder as a prophylactic for asthma is (a) Ephedrine (b) Disodium cromolyn (c) Isoproterenol (d) Ocytriphylline (e) Epinephrine
Description : A patient undergoing cancer chemotherapy is vomiting frequently. A drug that might help in this situation is (a) Bromocriptine (b) Cimetidine (c) Ketanserin (d) Loratadine (e) Ondansetron
Description : If therapy with multiple drugs causes induction of drug metabolism in your asthma patient, it will (a) Result in increased smooth endoplasmic reticulum (b) Result in increased rough endoplasmic reticulum ... soluble cytoplasmic fraction (d) Require 3-4 months to reach completion (e) Be irreversible
Description : Inhaled ipratropium bromide has the following advantages except: A. It does not alter respiratory secretions B. It does not depress airway mucociliary clearance C. It has faster onset of bronchodilator action than inhaled salbutamol D. It only rarely produces systemic side effects
Last Answer : C. It has faster onset of bronchodilator action than inhaled salbutamol
Description : In patients of bronchial asthma inhaled corticosteroids achieve the following except: A. Reduce the need for bronchodilator medication B. Control an attack of refractory asthma C. Reduce bronchial hyperreactivity D. Reverse diminished responsiveness to sympathomimetic bronchodilators
Last Answer : B. Control an attack of refractory asthma
Description : Select the fastest acting inhaled bronchodilator: A. Ipratropium bromide B. Formoterol C. Salbutamol D. Salmeterol
Last Answer : C. Salbutamol
Description : Bioavailability differences among oral formulations of a drug are most likely to occur if the drug: A. Is freely water soluble B. Is completely absorbed C. Is incompletely absorbed D. Undergoes little first-pass metabolism
Last Answer : C. Is incompletely absorbed
Description : Tricyclic antidepressants can alter the oral absorption of many drugs by: A. Complexing with the other drug in the intestinal lumen B. Altering gut motility C. Altering gut flora D. Damaging gut mucosa
Last Answer : C. Altering gut flora
Description : Bioavailability of drug refers to: A. Percentage of administered dose that reaches systemic circulation in the unchanged form B. Ratio of oral to parenteral dose C. Ratio of orally administered drug to ... in the faeces D. Ratio of drug excreted unchanged in urine to that excreted as metabolites
Last Answer : A. Percentage of administered dose that reaches systemic circulation in the unchanged form
Description : Select the most appropriate drug for regular prophylactic therapy in a 10 year old child who suffers from exercise induced asthma: A. Oral salbutamol B. Oral theophylline C. Inhaled sodium cromoglycate D. Inhaled salmeterol
Last Answer : C. Inhaled sodium cromoglycate
Description : he dominant pharmacokinetic feature of penicillin G is: A. It is equally distributed extra- and intracellularly B. It is rapidly secreted by proximal renal tubules C. It has low oral bioavailability ... pass metabolism in liver D. It does not cross blood-CSF barrier even when meninges are inflamed
Last Answer : B. It is rapidly secreted by proximal renal tubules
Description : Drugs which undergo high degree of first-pass metabolism in liver: A. Have low oral bioavailability B. Are excreted primarily in bile C. Are contraindicated in liver disease D. Exhibit zero order kinetics of elimination
Last Answer : A. Have low oral bioavailability
Description : Select the drug that is neither bronchodilator nor antiinflammatory, but has antihistaminic and mast cell stabilizing activity: A. Sodium cromoglycate B. Ketotifen C. Beclomethasone dipropionate D. Chlorpheniramine
Last Answer : B. Ketotifen
Description : Limitations of typical tricyclic antidepressants include the following except: A. Narrow safety margin B. Low oral bioavailability C. Frequent side effects D. Long latent period for response
Description : The distinctive features of desogestrel include the following except: A. It is a prodrug B. It has both strong progestational and strong antiovulatory activities C. It has additional androgenic acitivity D. It does not counteract the beneficial effect of estrogen on lipid profile
Last Answer : C. It has additional androgenic acitivity
Description : he distinctive features of desogestrel include the following except: A. It is a prodrug B. It has both strong progestational and strong antiovulatory activities C. It has additional androgenic acitivity D. It does not counteract the beneficial effect of estrogen on lipid profile
Description : Which of the following is not an attribute of amlodipine ? (a) High and consistent oral bioavailability (b) Large volume of distribution (c) Generation of an active metabolite (d) Long elimination half-life
Description : Which of the following is not an attribute of amlodipine: A. Generation of an active metabolite B. Large volume of distribution C. High and consistent oral bioavailability D. Long elimination half life
Last Answer : A. Generation of an active metabolit
Description : The distinctive feature(s) of methadone compared to morphine is/are: A. High oral bioavailability B. High plasma protein and tissue binding C. Delayed and milder withdrawal symptoms in dependent subjects D. All of the above
Description : The ‘amine’ ergot alkaloid differs from ‘amino acid’ ergot alkaloid in that it has: A. High oral bioavailability B. Better CNS penetrability C. Weaker oxytocic action D. Strong anti-5-HT action
Last Answer : A. High oral bioavailability
Description : Dihydroergotamine (DHE) differs from ergotamine in the following respect: A. It is a more potent oxytocic B. It has antiemetic property C. It has high oral bioavailability D. It is a more potent α adrenergic blocker and less potent vasoconstrictor
Last Answer : D. It is a more potent α adrenergic blocker and less potent vasoconstrictor
Description : Acute exacerbations of asthma can be triggered by all of the following except (a) Bacterial or viral pneumonia (b) Hypersensitivity reaction to penicillin (c) Discontinuation of asthma medication (d) Hot, dry weather (e) Stressful emotional events
Description : The symptoms of allergen-mediated asthma result from which of the following? (a) Increased release of mediators from mast cells (b) Increased adrenergic responsiveness of the airways (c) ... bronchial tissue (d) Decreased calcium influx into the mast cell (e) Decreased prostaglandin production
Description : Bacteria that make either a fementative or respiratory set of enzymes are known as (a) Obligate anacerobes (b) Obligate aerobes (c) Microacerophiles (d) Facultative organisms
Description : Relative to fexofenadine, diphenhydramine is more likely to (a) Be used for treatment of asthma (b) Be used for treatment of gastroesophageal reflux disease (c) Cause cardiac arrhythmias in ... ) Have efficacy in the prevention of motion sickness (e) Increase the serum concentration of warfarin
Description : Which one of the following drugs is most suitable for management of essential tremor in a patient who has pulmonary disease? (a) Diazepam (b) Levodopa (c) Metoprolol (d) Propranolol (e) Terbutaline