Description : In an anaesthetized dog, repeated intravenous injection of ephedrine shows the phenomenon of: A. Anaphylaxis B. Tachyphylaxis C. Idiosyncrasy D. Drug resistance
Last Answer : B. Tachyphylaxis
Description : Tachyphylaxis to many actions on repeated injection is a feature of the following autacoid: A. Histamine B. 5-Hydroxytryptamine C. Bradykinin D. Prostaglandin E2
Last Answer : B. 5-Hydroxytryptamine
Description : Tachyphylaxis to many actions on repeated injection is a feature of the following autocoid (a) Histamine (b) 5-Hydroxytryptamine (c) Bradykinin (d) Angiotensin
Last Answer : Ans: B
Description : Which of the following terms does not describe an Adverse Drug Reaction? a) Idiosyncrasy b) Anaphylaxis c) Teratogenic effect d) Placebo effect
Last Answer : d) Placebo effect
Description : 5 A nonvolatile, highly lipid soluble drug is metabolized at a rate of 15% per hour. On intravenous injection it produces general anaesthesia for 10 min. Which process is responsible for termination ... : A. Metabolism in liver B. Plasma protein binding C. Excretion by kidney D. Redistribution
Last Answer : D. Redistribution
Description : Intravenous injection of quinine produces: A. Rise in blood pressure B. Neuromuscular block C. Hyperglycaemia D. Hypoglycaemia
Last Answer : D. Hypoglycaemia
Description : ‘Red man syndrome’ has been associated with rapid intravenous injection of the following antibiotic: A. Vancomycin B. Clindamycin C. Cefoperazone D. Piperacillin
Last Answer : A. Vancomycin
Description : A semiconscious patient of haemorrhagic cerebral stroke has been brought to the emergency. His blood pressure is 240/120 mmHg. Select the procedure to lower his blood pressure as ... injection of hydralazine C. Intravenous infusion of sodium nitroprusside D. Intravenous injection of clonidin
Last Answer : C. Intravenous infusion of sodium nitroprussid
Description : The following procedure for rapid lowering of BP in hypertensive urgency/emergency has been abandoned: A. Sublingual/oral nifedipine B. Intravenous glyceryl trinitrate infusion C. Intravenous sodium nitroprusside infusion D. Intravenous esmolol injection
Last Answer : A. Sublingual/oral nifedipine
Description : Rapid intravenous injection of clonidine causes rise in BP due to: A. Stimulation of vasomotor centre B. Release of noradrenaline from adrenergic nerve endings C. Agonistic action on vascular α2 adrenergic receptors D. Cardiac stimulation
Last Answer : C. Agonistic action on vascular α2 adrenergic receptors
Description : A patient of acute myocardial infarction being treated in intensive care unit developed left ventricular failure with raised central venous pressure. It was decided to use glyceryl trinitrate. Which route ... suitable: A. Sublingual B. Oral C. Intravenous bolus injection D. Slow intravenous infusion
Last Answer : D. Slow intravenous infusion
Description : Use of adenosine for terminating an episode of paroxysmal supraventricular tachycardia has the following advantages except: A. It does not produce any side effect B. It can be given to patients ... 1 min after bolus intravenous injection D. It is effective in patients not responding to verapamil
Last Answer : A. It does not produce any side effect
Description : The typical response to intravenous injection of 5-HT in an anaesthetised animal is: A. Rise in BP B. Fall in BP C. Rise followed by brief fall in BP D. Transient fall, followed by brief rise, followed by prolonged fall in BP
Last Answer : D. Transient fall, followed by brief rise, followed by prolonged fall in BP
Description : An immunologically mediated reaction to a drug producing stereotyped symptoms unrelated to its pharmacodynamic actions is: A. Hypersensitivity B. Supersensitivity C. Intolerance D. Idiosyncrasy
Last Answer : A. Hypersensitivity
Description : The primary reason for not using ethionamide as a first line antitubercular drug is: A. It produces gastrointestinal intolerance and hepatitis B. It is only tuberculostatic and not tuberculocidal C. Ethionamide resistance has become widespread D. It has to be given by injection
Last Answer : A. It produces gastrointestinal intolerance and hepatitis
Description : A drug (200 mg dose) administered in tablet form and as intravenous injection (50 mg dose) showed AUG of 100 and 200 microgram hr/mL, respectively. The absolute availability of the drug through oral administration is : (A) 125% (B) 250 % (C) 12.5% (D) 1.25%
Last Answer : (C) 12.5%
Description : A nonvolatile, highly lipid soluble drug is metabolized at a rate of 15% per hour. On intravenous injection it produces general anaesthesia for 10 min. Which process is responsible for termination of ... : A. Metabolism in liver B. Plasma protein binding C. Excretion by kidney D. Redistribution
Description : Continuous exposure of ctecholaminesensitive cells and tissues to adrenergic agonists causes a progressive diminition in their capacity to respond, this phenomenon is called as (a) Refractoriness (b) Desensitization (c) Tachyphylaxis (d) All of the above
Last Answer : Ans: D
Description : Select the drug which is used by intravenous infusion for emergency control of tachycardia and sudden rise in blood pressure: A. Amiodarone B. Lignocaine C. Esmolol D. Disopyramide
Last Answer : C. Esmolo
Description : The preferred drug for status epilepticus is: A. Intravenous diazepam B. Intravenous phenytoin sodium C. Intramuscular phenobarbitone D. Rectal diazepam
Last Answer : A. Intravenous diazepam
Description : The preferred drug for suppressing febrile convulsions is: A. Intramuscular phenobarbitone B. Intravenous phenytoin C. Rectal diazepam D. Oral sodium valproate
Last Answer : C. Rectal diazepam
Description : The drug used for controlling tetany is: A. Intravenous diazepam B. Intramuscular vitamin D C. Intravenous calcium gluconate D. Intravenous calcitonin
Last Answer : C. Intravenous calcium gluconate
Description : Which of the following interventions is the single most important aspect for the patient at risk for anaphylaxis? a) Prevention People who have experienced food, medication, idiopathic, or ... alert bracelet will assist those rendering aid to the patient who has experienced an anaphylactic reaction
Last Answer : a) Prevention People who have experienced food, medication, idiopathic, or exerciseinduced anaphylactic reactions should always carry an emergency kit containing epinephrine for injection to prevent the onset of the reaction upon exposure.
Description : Zolpidem differs from diazepam in that: A. It is safer in overdose than diazepam B. Its hypnotic action shows little fading on repeated nightly use C. It causes more marked suppression of REM sleep D. It has more potent muscle relaxant action
Last Answer : B. Its hypnotic action shows little fading on repeated nightly use
Description : Select the vasodilator that is administered only by slow intravenous infusion and dilates both resistance as well as capacitance vessels: A. Minoxidil B. Diazoxide C. Sodium nitroprusside D. Glyceryl trinitrate
Last Answer : C. Sodium nitroprusside
Description : Which of the following constitutes ‘drug abuse’: A. Physician prescribed use of penicillin G for the cure of viral fever B. Self administration of aspirin to relieve headache C. Repeated self administration of morphine to derive euphoria D. All of the above
Last Answer : C. Repeated self administration of morphine to derive euphoria
Description : Adaptive neurophysiological changes produced by repeated administration of a drug, which result in the appearance of characteristic withdrawal syndrome on discontinuation of the drug is called: A. Drug addiction B. Drug abuse C. Psychological dependence D. Physical dependence
Last Answer : D. Physical dependence
Description : Microsomal enzyme induction can be a cause of: A. Tolerance B. Physical dependence C. Psychological dependence D. Idiosyncrasy
Last Answer : A. Tolerance
Description : Which of the following is a noncatecholamine sympathomimetic: A. Adrenaline B. Ephedrine C. Dopamine D. Isoprenaline
Last Answer : B. Ephedrine
Description : The most important risk in the use of primaquine is the occurrence of the following reaction in certain recipients: A. Ventricular arrhythmia B. Agranulocytosis C. Haemolysis D. Anaphylaxis
Last Answer : C. Haemolysis
Description : The most important complication of streptokinase therapy is: A. Hypotension B. Bleeding C. Fever D. Anaphylaxis
Last Answer : B. Bleeding
Description : A drug which preferentially dilates autoregulatory coronary arterioles with little effect on large conducting vessels is likely to: A. Evoke coronary steal phenomenon B. Mitigate classical angina but not ... . Decrease total coronary blood flow in healthy subjects D. Avert ECG changes of ischaemia
Last Answer : A. Evoke coronary steal phenomenon
Description : When therapeutic effects decline both below and above a narrow range of doses, a drug is said to exhibit: A. Ceiling effect B. Desensitization C. Therapeutic window phenomenon D. Nonreceptor mediated action
Last Answer : C. Therapeutic window phenomenon
Description : Noradrenaline is administered by (a) Subcutaneous injection (b) Intramuscular injection (c) Slow intravenous infusion (d) All of the above routes
Last Answer : Ans: C
Description : A patient of acute myocardial infarction being treated in intensive care unit developed left ventricular failure with raised central venous pressure. It was decided to use glyceryl trinitrate. Which route/ ... (a) Sublingual (b) Oral (c) Intravenous bolus injection (d) Slow intravenous infusion
Description : Which of the following is the LEAST to cause toxicity from local anaesthetic injection: A. Injecting in supine position B. Injecting in vascular area C. Injecting without a vasoconstrictor D. Intravenous injections
Last Answer : A. Injecting in supine position
Description : Toxicity as a result of anaesthetic solution can be seen more when: A. Injection in supine position B. Injection into vascular area C. Injection without vasoconstrictors D. Intravenous injection
Last Answer : D. Intravenous injection
Description : Noradrenaline is administered by: A. Subcutaneous injection B. Intramuscular injection C. Slow intravenous infusion D. All of the above routes
Last Answer : C. Slow intravenous infusion
Description : Select the route of administration which carries the highest risk of adversely affecting vital functions: A. Intra arterial injection B. Intrathecal injection C. Intravenous injection D. Intramuscular injection
Last Answer : C. Intravenous injection
Description : Which of the following is a type B (unpredictable) adverse drug reaction: A. Side effect B. Toxic effect C. Idiosyncrasy D. Physical dependence
Last Answer : A. Side effect
Description : An undesirable effect of a drug that occurs at therapeutic doses and can be predicted from its pharmacological actions is called: A. Side effect B. Toxic effect C. Allergic reaction D. Idiosyncrasy
Last Answer : C. Idiosyncrasy
Description : The preferred route of administration of streptokinase in acute myocardial infarction is: A. Intravenous B. Subcutaneous C. Intracoronary
Last Answer : A. Intravenous
Description : Intravenous saline infusion is the treatment of choice for the following complication(s) of vigorous furosemide therapy: A. Dilutional hyponatremia B. Acute saline depletion C. Hypokalemia D. All of the above
Last Answer : B. Acute saline depletion