Description : Fall in blood pressure caused by larger doses of histamine is blocked by: A. H1 antihistaminics alone B. H2 antagonists alone C. Combination of H1 and H2 antagonists D. None of the above
Last Answer : C. Combination of H1 and H2 antagonists
Description : Smooth muscle relaxation is due to stimulation of which type of histamine receptors (a) H1 (b) H2 (c) H3 (d) All of the above
Last Answer : Ans: B
Description : H1 antihistaminics are beneficial in (a) All types of allergic disorders (b) Certain type I allergic reactions only (c) Anaphylactic shock(d) Bronchial asthma
Description : While prescribing the conventional H1 antihistaminics the patient should be advised to avoid (a) Driving motor vehicles (b) Consuming processed cheese (c) Strenuous physical exertion (d) All of the above
Last Answer : Ans: A
Description : The capacity of an antihistaminic to produce sedation depends on the following except (a) Relative affinity for central versus peripheral H1 receptors (b) Ability to penetrate blood-brain barrier (c) Individual susceptibility (d) Ratio of H1 : H2 blockade produced by the drug
Last Answer : Ans: D
Description : The most important receptor involved in cytotoxic drug induced vomiting is (a) Histamine H1 receptor (b) Serotonin 5-HT3 receptor (c) Dopamine D2 receptor (d) Opioid µ receptor
Description : Which of the following is a selective H1 receptor agoinist ? (a) 4-methyl histamine (b) Impromidine (c) 2-Thiazolyl ethylamine (d) Mepyramine
Last Answer : Ans: C
Description : In the intact animal H2 receptor antagonists potentiate the following action of histamine: A. Cardiac stimulation B. Fall in blood pressure C. Uterine relaxation D. Bronchospasm
Last Answer : D. Bronchospasm
Description : Benefit afforded by certain H1 antihistaminics in the following condition is not based on antagonism of histamine: A. Dermographism B. Insect bite C. Common cold D. Seasonal hay fever
Last Answer : C. Common cold
Description : The following class(es) of drugs are clinically beneficial in bronchial asthma: A. Histamine H1 receptor antagonists B. Platelet activating factor (PAF) antagonists C. Leukotriene ( cys LT1) receptor antagonists D. All of the above
Last Answer : C. Leukotriene ( cys LT1) receptor antagonists
Description : Select the H1 antihistaminic which is used topically in the nose for allergic rhinitis (a) Deep intra-abdominal operation (b) Trachial intubation (c) Tetanus (d) Diagonosis of myasthenia gravis
Description : Histamine (a) May be released from mast cells by a number of therapeutic agents (b) Causes sedation (c) Decreases the force of contraction of ventricular muscle (d) Can cause strong contractions of the gravid human uterus
Description : Tachyphylaxis to many actions on repeated injection is a feature of the following autocoid (a) Histamine (b) 5-Hydroxytryptamine (c) Bradykinin (d) Angiotensin
Description : Histamine is involved as a mediator in the following pathological conditon (a) Cocaine (b) Dibucaine (c) Lidocaine (d) Procaine
Description : Toxicities of H2 antihistamines include which one of the following? (a) Blurred vision (b) Diarrhea (c) Orthostatic hypotension (d) P450 inhibition (e) Sleepiness
Description : Which of the following will result from blockade of H2 receptors? (a) Decreased camp in cardiac muscle (b) Increased camp in cardiac muscle (c) Decreased IP3 in gastric mucosa (d) Increased IP3 in gastric mucosa (e) Increased IP3 in smooth muscle
Description : Of the following categories of medications, which is used in combination with bismuth salts to eradicate Helicobacter pylori? a) Antibiotics Antibiotics and bismuth salts are given to eradicate ... antagonists Histamine-2 receptor antagonists are given to decrease the acid secretion in the stomach.
Last Answer : a) Antibiotics Antibiotics and bismuth salts are given to eradicate H. pylori.
Description : The following receptor has an intrinsic ion channel: A. Histamine H1 receptor B. Histamine H2 receptor C. Adrenergic alfa receptor D. GABA-benzodiazepine receptor
Last Answer : D. GABA-benzodiazepine receptor
Description : Bronchodilators are useful in cough (a) Only when cough is non-productive (b) Only when cough is associated with thick sticky secretions (c) Only when reflex bronchoconstriction is associated (d) ... Rise in blood pressure (b) Muscle tremor (c) Hyperglycaemia (d) Central nervous system stimulation
Description : The conventional H1 antihistaminics possess the following additional properties except: A. Local anaesthetic B. Vasopressor C. Antiarrhythmic D. Catecholamine potentiating
Last Answer : B. Vasopressor
Description : H1 antihistaminics are beneficial in: A. All types of allergic disorders B. Certain type I allergic reactions only C. Certain type IV allergic reactions only D. Bronchial asthma
Last Answer : B. Certain type I allergic reactions only
Description : The second generation H1 antihistaminics have the following advantages except: A. Lack of anticholinergic side effects B. Lack of alcohol potentiating potential C. Recipient can drive motor vehicles D. Good antipruritic action
Last Answer : D. Good antipruritic action
Description : A ball is allowed to fall freely from a height of 3 metres on to a fixed plate. If the successive rebound heights are h1, h2, h3 a.5 metres b.4.25 metre c.0.5 metre d.1 metre e.Zero
Last Answer : a. 5 metres
Description : The fall in blood pressure caused by d-tubocurarine is due to: A. Reduced venous return B. Ganglionic blockade C. Histamine release D. All of the above
Last Answer : D. All of the above
Description : The β3 adrenoceptor differs from the other subtypes of β receptor in that it: A. Is not blocked by the conventional doses of propranolol B. Is located primarily in the heart C. Regulates blood sugar level D. Is not coupled to G proteins
Last Answer : A. Is not blocked by the conventional doses of propranolol
Description : The β 3 adrenoceptor differs from the other subtypes of β receptor in that it: A. Is not blocked by the conventional doses of propranolol B. Is located primarily in the heart C. Regulates blood sugar level D. Is not coupled to G proteins
Description : A 1-kg steam-water mixture at 1.0 MPa is contained in an inflexible tank. Heat is added until the pressure rises to 3.5 MPa and the temperature to 400°. Determine the heat added. a) 1378.7 kJ b) 1348.5 kJ c) 1278,7 kJ d) 1246,5 kJ Formula: Q = (h2 – p2v2) –(h1 –p1v1)
Last Answer : 1378.7 kJ
Description : Acute exacerbations of asthma can be triggered by all of the following except (a) Bacterial or viral pneumonia (b) Hypersensitivity reaction to penicillin (c) Discontinuation of asthma medication (d) Hot, dry weather (e) Stressful emotional events
Description : The symptoms of allergen-mediated asthma result from which of the following? (a) Increased release of mediators from mast cells (b) Increased adrenergic responsiveness of the airways (c) ... bronchial tissue (d) Decreased calcium influx into the mast cell (e) Decreased prostaglandin production
Description : Bacteria that make either a fementative or respiratory set of enzymes are known as (a) Obligate anacerobes (b) Obligate aerobes (c) Microacerophiles (d) Facultative organisms
Description : Relative to fexofenadine, diphenhydramine is more likely to (a) Be used for treatment of asthma (b) Be used for treatment of gastroesophageal reflux disease (c) Cause cardiac arrhythmias in ... ) Have efficacy in the prevention of motion sickness (e) Increase the serum concentration of warfarin
Description : A drug useful in the treatment of asthma but lacking bronchodilator action, is (a) Cromolyn (b) Ephedrine (c) Isoproterenol (d) Metaproterenol (e) Metoprolol
Description : Which one of the following drugs is most suitable for management of essential tremor in a patient who has pulmonary disease? (a) Diazepam (b) Levodopa (c) Metoprolol (d) Propranolol (e) Terbutaline
Description : Which of the following is a very longacting ß2 – selective agonist that is used for asthma prophylaxis? (a) Aminophyline (b) Cromolyn (c) Epinephrine (d) Ipratropium (e) Salmeterol
Last Answer : Ans: E
Description : Which of the following has overdose toxicity that includes insomnia, arrhythmias, and convulsions? (a) Aminophyline (b) Cromolyn (c) Epinephrine (d) Ipratropium (e) Metaproterenol
Description : Acute exacerbations of asthma can be triggered by all of the following except (a) Bacterial of viral pneumonia (b) Hypertsensitivity reaction to penicillin (c) Discontinuation of asthma medication (d) Hot, dry weather (e) Stressful emotional events
Description : Which of the following is a direct bronchodilator that is most often used in asthma by the oral route? (a) Aminophyline (b) Cromolyn (c) Epinephrine (d) Ipratropium (e) Metaproterenol
Description : Pyridostigmine differs from neostigmine in that (a) More potent orally (b) Longer acting (c) Less muscarinic side effects (d) All of the above
Description : What is symport ? (a) Counter transport (b) Contransport (c) Carrier mediated diffusion (d) Solvent drug
Description : Which xanthine derivative has no function in asthma ? (a) Theophylline (b) Pentoxyphyllin (c) Enprofylin (d) None of the above
Description : All the following are employed in inhalation therapy of asthma except (a) Beclomethasone (b) Budesonide (c) Dexamethasone (d) Triamcinolone
Description : Chronic Bronchitis is characterized by I. the distruction of central and peripheral portions of the acinus II. an increased number of mucous glands and goblet cells III. edema and inflammation of the bronchioles (a) only ... II are correct (d) II and III are correct (e) I, II and III are correct
Description : To be a useful inhaled glucocorticoid the drug should have (a) High oral bioavailability (b) Low oral bioavailability (c) Additional bronchodilator activity (d) Prodrug character
Description : In an asthma patient treated with systemic corticosteroids, bronchodilator drugs (a) Are not needed (b) Are contraindicated (c) May be used on ‘as and when required’ basis (d) Are ineffective
Description : Budesonide is a (a) Nonsteroidal anti-inflammatory drug (b) High ceiling diuretic (c) Inhaled corticosteroid for asthma (d) Contraceptive
Description : In patients of bronchial asthma inhaled corticosteroids achieve the following except (a) Reduce the need for bronchodilator medication (b) Control an attack of refractory asthma (c) Reduce bronchial hyperreactivity (d) Reverse diminished responsiveness to sympathomimetic bronchodilators
Description : Intransasal spray of budesonide is indicated in (a) Common cold (b) Acute vasomotor rhinitis (c) Perennial vasomotor rhinitis (d) Epistaxis