Description : In a patient receiving digoxin for congestive heart failure, condition that may facilitate the appearance of toxicity include (a) Hyperkalemia (b) Hypernatremia (c) Hypocalcemia (d) Hypomagnesemia (e) All of the above
Last Answer : Ans: D
Description : Situations that predispose a digitalistreated patient to toxicity include (a) Hypercalcemia (b) Hyperkalemia (c) Hypermagnesemia
Last Answer : Ans: A
Description : Recognized adverse effects of quinidine include which one of the following? (a) Cinchonism (b) Constipation (c) Lupus erythematosus (d) Increase in digoxin clearance (e) Precipitation of hyperthyroidism
Description : Which of the following is the drug of choice in treating suicidal overdose of digitoxin ? (a) Digoxin antibodies (b) Lidocaine (c) Magnesium (d) Potassium (e) Quinidine
Description : Which one of the following drugs increase digoxin plasma concentration by a pharmacokinetic mechanism? (a) Captopril (b) Hydrochorothiazide (c) Lidocaine (d) Quinidine (e) Sulfasalazine
Description : The following drug given concurrently can enhance toxicity of digoxin: A. Phenobarbitone B. Metoclopramide C. Quinidine D. Magnesium hydroxide
Last Answer : C. Quinidine
Description : Select the most suitable antiarrhythmic drug for counteracting ventricular extrasystoles due to digoxin toxicity: A. Lignocaine B. Quinidine C. Verapamil D. Amiodarone
Last Answer : A. Lignocaine
Description : Which one of the following is characteristic of captopril and enalapril ? (a) Competitively blocks angiotensim II at its receptor (b) Decreases angiotensin II concentration in the blood (c) Decreases ... and decreases potassium in the blood (e) Decreases sodium and increases potassium in the urine
Last Answer : Ans: B
Description : A friend has very severe hypertension and asks about a drug her doctor wishes to prescribe. Her physician has explained that this drug is associated with tachycardia and fluid retention (which may be marked ... has described? (a) Captopril (b) Guanethidine (c) Minoxidil (d) Prazosin (e) Propranolol
Last Answer : Ans: C
Description : A 16-year-old-girl is found to have paroxysmal attacks of rapid heart rate. The antiarrhythmic of choice in most cases of acute AV nodal tachycardia is (a) Adenosine (b) Amiodarone (c) Flecainide (d) Propranolol (e) Quinidine
Description : Which of the following has been shown to prolong life in patient with chronic congestive failure but has a negative inotropic effect on cardiac contractility? (a) Carvedilol (b) Digitoxin (c) Digoxin (d) Dobutamine (e) Enalapril
Description : A patient has been taking digoxin for several years for chronic heart failure is about to receive atropine for another condition. A common effect of digoxin (at therapeutic blood levels) that can ... Increased atrial contractility (c) Increased PR interval on the ECG (d) Headaches (e) Tachycardia
Description : In hyperparathyroidism there is (A) Hypocalcemia (B) Hypophophatemia (C) Hypokalemia (D) Hyperkalemia
Last Answer : Answer : B
Description : Raised plasma aldosterone level in CHF contributes to disease progression by exerting the following effects except: A. Fibrotic remodeling of myocardium B. Hyperkalemia and hypermagnesemia C. ... cardiac preload by Na+ and water retention D. Enhancing cardiotoxicity of sympathetic overactivity
Last Answer : B. Hyperkalemia and hypermagnesemia
Description : Digitalis toxicity is enhanced by co-administration of (A) Potassium (B) Quinidine (C) Diuretics (D) Antacids
Last Answer : Ans. B & C
Description : Which one of the following drugs predictably prolongs the PR interval and increases cardiac contractility? (a) Digoxin (b) Lidocaine (c) Propranolol (d) Quinidine (e) Verapamil
Description : The following drug increases cardiac output in congestive heart failure without having any direct myocardial action: A. Captopril B. Digoxin C. Amrinone D. Dobutamine
Last Answer : A. Captopril
Description : Which of the following drugs is preferred for termination of paroxysmal supraventricular tachycardia (a) Digoxin (b) Quinidine (c) Propranolol (d) Verapamil
Description : The following drug is preferred for termination as well as prophylaxis of paroxysmal supraventricular tachycardia: A. Digoxin B. Verapamil C. Propranolol D. Quinidine
Last Answer : B. Verapami
Description : The following drug/drugs should not be used to treat tricyclic antidepressant drug poisoning: A. Quinidine B. Digoxin C. Atropine D. All of the above
Last Answer : D. All of the above
Description : Infusion of potassium chloride is indicated in digitalis toxicity when the manifestation(s) is/are: A. Vomiting, hyperapnoea and visual disturbance B. Pulsus bigeminus with heart rate 110/min ... accidentally ingested 10 digoxin tablets D. 2:1 A-V block with occasional ventricular extrasystoles
Last Answer : B. Pulsus bigeminus with heart rate 110/min in a patient on maintenance digoxin therapy
Description : Among all cardiac glycosides, digoxin is the most commonly used, because: A. It is the most potent and fastest acting glycoside B. It has the highest and most consistent oral ... so that dose adjustments are possible every 2-3 days and toxicity abates rather rapidly after discontinuatio
Last Answer : D. It has intermediate plasma half life so that dose adjustments are possible every 2-3 days and toxicity abates rather rapidly after discontinuatio
Description : Drugs that block the a receptor on effector cells at adrenergic nerve endings (a) Antagonize the effects of isoproterenol on the heart rate (b) Antagonize some of the effects of epinephrine on ... the effects of epinephrine on adenylyl cyclase (d) Cause mydriasis (e) Decreases blood glucose levels
Description : A patient is admitted to the emergency room with orthostatic hypotension and evidence of marked GI bleeding. Which of the following most accurately describes the probable autonomic response to this ... constricted pupils, increased bowel sounds (e) Rapid heart rate, constricted pupils, warm skin
Description : Typical results of beta-receptor activation include which one of the following? (a) Hypoglycemia (b) Lipolysis (c) Glycogen synthesis (d) Decreased skeletal muscle tremor (e) Decreased rennin secretion
Description : A 70-year-old man has severe urinary hesitancy associated with benign prostatic hyperplasia. He has tried alpha blockers with little relief. His physician recommends a drug that blocks 5a - reductase in ... prescription for (a) Atropine (b) Clonidine (c) Hydralazine (d) Neostigmine (e) Propranolol
Description : Which one of the following drugs, when used chronically, is associated with the development of bone pain and mineralization defects such as osteomalacia? (a) Calcitonin (b) Dihydrotachysterol (c) Ergocalciferol (d) Etidronate (e) Norgestrel
Description : Clinical uses of Vitamin D do not include (a) Chronic renal failure (b) Hyperparathyroidism (c) Intestinal osteodystrophy (d) Nutritional rickets (e) Osteoporosis
Description : Which of the following conditions is an indication for the use of calcitonin? (a) Chronic renal failure (b) Hypoparathyroidism (c) Intestinal osteodystrophy (d) Pager’s disease (e) Rickets
Description : Characteristics of Vitamin D and its metabolites include which one of the following? (a) Act to decrease serum levels of calcium (b) Activation of their Vitamin D receptors increases cellular CAMP ... Vitamin D increase renal excretion of calcium (e) Vitamin D deficiency results in Pager's disease
Description : Which one of the following is lest likely to be useful in the therapy of hypercalcemia? (a) Calcitonin (b) Glucocorticoids (c) Plicamycin (d) Parenteral infusion of phosphate (e) Thiazide diuretics
Last Answer : Ans: E
Description : Cromolyn has as its major action (a) Block of calcium channels in lymphocytes (b) Block of mediator release from mast cells (c) Block of phosphodiesterase in mast cells and basophils (d) Smooth muscle relaxation in the bronchi (e) Stimulation of cortisol release by the adrenals
Description : A drug that is useful in glaucoma and high-altitude sickness is (a) Acetazolamide (b) Amiloride (c) Demeclocycline (d) Desmopressin (e) Ethacrynic acid
Description : A 55-year-old patient with severe posthepatitis cirrhosis is started on a diuretic for another condition. Two days later he is found in a coma. The drug most likely to cause coma in a patient with cirrhosis is (a) Acetazolamide (b) Amiloride (c) Furosemide (d) Hydrochlorothiazide (e) Spironolactone
Description : Which of the following therapies would be most useful in the management of severe hypercalcemia? (a) Amiloride plus saline infusion (b) Furosemide plus saline infusion (c) Hydrochlorothiazide plus saline infusion (d) Mannitol plus saline infusion (e) Spironolactone plus saline infusion
Description : Which of the following diuretics would be most useful in a patient with cerebral edema? (a) Acetazolamide (b) Amiloride (c) Ethacrynic acid (d) Furosemide (e) Mannitol
Description : Which of the following has the longest half-life of all antiarrhythmic drugs? (a) Adenosine (b) Amiodarone (c) Disopyramide (d) Esmolol (e) Flecainide
Description : Which of the following is an orally active drug that blocks sodium channels and decreases action potential duration? (a) Adenosine (b) Amiodarone (c) Disopyramide (d) Esmolol (e) Mexiletine
Description : When used as an antiarrhythmic drug, Lidocaine typically (a) Increases action potential duration (b) Increases contractility (c) Increses PR interval (d) Reduces abnormal automaticity (e) Reduces resting potential
Description : In a patient given a cardiac glycoside, important effects of the drug on the heart include which of the following? (a) Decreased atrioventricular conduction velocity (b) Decreased ejection time (c) Increased ectopic automaticity (d) Increased ectopic automaticity (e) All of the above
Description : The biochemical mechanism of action of digitalis is associated with (a) A decrease in calcium uptake by the sarcoplasmic reticulum (b) An increase in ATP synthesis (c) A modification of the actin molecule (d) An increase in systolic intracellular calcium levels (e) A block of sodium/calcium exchange
Description : Which of the following is a vasodilator drug used for hypertension that lacks a direct effect on autonomic receptors but may provoke anginal attacks? (a) Amyl nitrite (b) Hydralazine (c) Isosorbide mononitrate (d) Nifedipine (e) Nimodipine
Description : Which of the following drugs used for the treatment of angina by inhalation has a very rapid onset and a brief duration of effect ? (a) Amyl nitrite (b) Hydralazine (c) Isosorbide mononitrate (d) Nifedipine (e) Nimodipine
Description : Which of the following is approved for the treatment of hemorrhagic stroke ? (a) Amyl nitrite (b) Hydralazine (c) Isosorbide moninitrate (d) Nifedipine (e) Nimodipine
Description : The major common determinant of myocardial oxygen consumption is (a) Blood volume (b) Cardiac output (c) Diastolic blood pressure (d) Heart rate (e) Myocardial fiber tension
Description : The antianginal effect of propranolol may be attributed to which one of the following (a) Block of exercise – induced tachycardia (b) Decreased end – diastolic ventricular volume (c) Dilation of consticted coronary vessels (d) Increased cardiac force (e) Increased resting heart rate
Description : Nitroglycerin, either directly or through reflexes, results in which one of the following effects (a) Decreased heart rate (b) Decreased venous capacitance (c) Increased afterload (d) Increased cardiac force (e) Increased diastolic intramyocardial fiber tension
Description : Reserprine, an alkaloid derived from the root of Rauwolfia serpentina (a) Can be used to control hyperglycemia (b) Can cause severe depression of mood (c) Can decrease gastrointestinal secretion and motility (d) Has no cardiac effects (e) A spare receptor agonist
Description : A visitor from another city comes to your office complaining of incessant cough. He has diabetes and hypertension and has recently started taking a different antihypertensive medication. The most likely cause of his cough is (a) Enalapril (b) Losartan (c) Minoxidil (d) Propranolol (e) Verapamil
Description : Postural hypotension is a common adverse effect of which one of the following types of drugs ? (a) ACE inhibitors (b) Alpha-receptor blockers (c) Arteriolar dilators (d) ß1 – selective receptor blockers (e) Nonselective ß - blockers