Description : Which of the following drugs used for the treatment of angina by inhalation has a very rapid onset and a brief duration of effect ? (a) Amyl nitrite (b) Hydralazine (c) Isosorbide mononitrate (d) Nifedipine (e) Nimodipine
Last Answer : Ans: A
Description : Which of the following is approved for the treatment of hemorrhagic stroke ? (a) Amyl nitrite (b) Hydralazine (c) Isosorbide moninitrate (d) Nifedipine (e) Nimodipine
Last Answer : Ans: E
Description : A drug lacking vasodilator properties that is useful in angina is (a) Isosorbide dinitrate (b) Metoprolol (c) NIfedipine (d) Nitroglycerin (e) Verapamil
Last Answer : Ans: B
Description : Which of the following agents used in prinzmetal’s angina has spasmolytic actions, which increase coronary blood supply? (a) Nitroglycerin (b) Nifedipine (c) Timolol (d) Isosorbide mononitrate (e) Propranolol
Description : Propranolol should not be prescribed for a patient of angina pectoris who is already receiving (a) Nifedipine (b) Felodipine (c) Verapamil (d) Isosorbide mononitrate
Last Answer : Ans: C
Description : Propranolol should not be prescribed for a patient of angina pectoris who is already receiving: A. Nifedipine B. Felodipine C. Verapamil D. Isosorbide mononitrate
Last Answer : C. Verapami
Description : Muscarinic cholinergic receptors (a) Are located only on parasympathetically innervated effector cells (b) Mediate responses by opening an instrinsic Na+ ion channel (c) Are present on vascular endothelium which has no cholinergic nerve supply (d) Predominate in the autonomic ganglia
Description : Which vasodilator is most suitable for a patient of CHF who is symptomatic even at rest and has a central venous pressure of 25 mm Hg and cardiac index 1.8 L/min/m2 : A. Glyceryl trinitrate B. Enalapril C. Hydralazine D. Nifedipine
Last Answer : B. Enalapril
Description : A 70-year-old man has severe urinary hesitancy associated with benign prostatic hyperplasia. He has tried alpha blockers with little relief. His physician recommends a drug that blocks 5a - reductase in ... prescription for (a) Atropine (b) Clonidine (c) Hydralazine (d) Neostigmine (e) Propranolol
Description : In the autonomic regulation of blood pressure (a) Cardiac output is maintained constant at the expense of other hemodynamic variables (b) Elevation of blood pressure results in elevated ... the sensitivity of the sensory baroreceptor nerve endings might cause an increase in sympathetic discharge
Last Answer : Ans: D
Description : A friend has very severe hypertension and asks about a drug her doctor wishes to prescribe. Her physician has explained that this drug is associated with tachycardia and fluid retention (which may be marked ... has described? (a) Captopril (b) Guanethidine (c) Minoxidil (d) Prazosin (e) Propranolol
Description : A treatment of angina that consistently decreases the heart rate and can prevent vasospastic angina attacks is (a) Isosorbide dinitrate (b) NIFedipine (c) Nitroglycerin (d) Propranolol (e) Verapamil
Description : A patient is admitted to the emergency room with orthostatic hypotension and evidence of marked GI bleeding. Which of the following most accurately describes the probable autonomic response to this ... constricted pupils, increased bowel sounds (e) Rapid heart rate, constricted pupils, warm skin
Description : Select the drug that may improve myocardial tolerance to ischaemia and reduce anginal attacks without altering heart rate, blood pressure or myocardial O2 consumption: A. Trimetazidine B. Nicorandil C. Dipyridamole D. Nicotinic acid
Last Answer : A. Trimetazidine
Description : The autonomic nervous system is also known as (a) Visceral (b) Vegetative (c) Involuntary nervous system (d) All of the above
Description : Which of the following drug can result in result in cyanide poisoning? A. Amyl nitrite B. Hydroxycobalamine C. Sodium nitroprusside D. Sodium thiosulphate
Last Answer : C. Sodium nitroprusside
Description : Hydralazine is a directly acting vasodilator, but is not used alone as an antihypertensive because: A. By itself, it is a low efficacy antihypertensive B. Effective doses cause marked ... mechanisms D. It primarily reduces systolic blood pressure with little effect on diastolic blood pressure
Last Answer : C. Tolerance to the antihypertensive action develops early due to counterregulatory mechanisms
Description : A visitor from another city comes to your office complaining of incessant cough. He has diabetes and hypertension and has recently started taking a different antihypertensive medication. The most likely cause of his cough is (a) Enalapril (b) Losartan (c) Minoxidil (d) Propranolol (e) Verapamil
Description : Propranolol is useful in all of the following except (a) Angina (b) Familial tremor (c) Hypertension (d) Idiopathic hypertrophic subaortic cardiomyopathy (e) Partial atrioverntricular heart block
Description : Accepted therapeutic indications for the use of antimuscarinic drugs include all of the following except (a) Hypertension (b) Motion sickness (c) Parkinson’s disease (d) Postoperative bladder spasm (e) Traveler’s diarrhea
Description : The following antihypertensive drug tends to lower plasma renin activity: A. Clonidine B. Hydralazine C. Nifedipine D. Captopril
Last Answer : A. Clonidine
Description : Select the organic nitrate which undergoes minimal first-pass metabolism in the liver (a) Glyceryl trinitrate (b) Isosorbide dinitrate (c) Isosorbide mononitrate (d) Erythrityl tetranitrate
Description : Select the organic nitrate which undergoes minimal first-pass metabolism in the liver: A. Glyceryl trinitrate B. Isosorbide dinitrate C. Isosorbide mononitrate D. Erythrityl tetranitrate
Last Answer : C. Isosorbide mononitrate
Description : A 16-year-old-girl is found to have paroxysmal attacks of rapid heart rate. The antiarrhythmic of choice in most cases of acute AV nodal tachycardia is (a) Adenosine (b) Amiodarone (c) Flecainide (d) Propranolol (e) Quinidine
Description : Characteristics of Vitamin D and its metabolites include which one of the following? (a) Act to decrease serum levels of calcium (b) Activation of their Vitamin D receptors increases cellular CAMP ... Vitamin D increase renal excretion of calcium (e) Vitamin D deficiency results in Pager's disease
Description : Which of the following best describes the mechanism of action of scopolamine ? (a) Irreversible antagonist at nicotinic receptors (b) Irreversible antagonist at muscarinic receptors (c) ... receptors (d) Reversible antagonist at muscarinic receptors (e) Reversible antagonist at nicotinic receptors
Description : Phenylephrine (a) Mimics the transmitter at post-synaptic receptors (b) Displaces transmitter from axonal terminal (c) Inhibits synthesis of transmitter (d) None of the above
Description : Dobutamine differs from dopamine in that (a) It does not activate peripheral dopaminergic receptors (b) It does not activate adrenergic ß receptors (c) It causes pronounced tachycardia (d) It has good blood-brain barrier penetrability
Description : a2–adrenergic receptors are associated with following except (a) Increase in phospholipase C activity (b) Increase in potassium channel conductance (c) Decrease in calcium channel conductance (d) Increase in adenylyl cyclase activity
Description : a1 – receptors are coupled with _______ G protein. (a) Gs (b) Gi (c) Gq (d) Go
Description : The cardiac muscarinic receptors (a) Are of the M1 subtype (b) Are of the M2 subtype (c) Are selectively blocked by pirenzepine (d) Function through the PIP2 ? IP3/DAG pathway
Description : Yohimbine is an antagonist of ______ receptors. (a) a1 (b) a2 (c) both (a) and (b) (d) None of the above
Description : Oxytremorine is a selective agonist of muscarinic _______ receptors (a) M1 (b) M2 (c) M3 (d) M4
Description : Following is an antagonist of ganglion type nicotinic receptors (a) Tubercurarine (b) a-bungarotoxin (c) Trimethaphan (d) All of the above
Description : Denervation super-sensitivity includes (a) Proliferation of receptors (b) Loss of mechanism for transmitter removal (c) Increased post-junctional responsiveness (d) All of the above
Description : Which of the following combinations of drugs, when used together, reduce both preload and afterload? (a) Nitroglycerin and isosorbide dinitrate (b) Hydralazine and isosorbide dinitrate (c) Captopril and methyldopa (d) Prazosin and angiotension II (e) Hydralazine and methyldopa
Description : Which drug is used to cure Hypertension? (1) Risedronate (2) Diazepam (3) Folic Acid (4) Hydralazine
Last Answer : (4) Hydralazine Explanation: Hydralazine, sold under the brand name Apresoline among others, is a medication used to treat high blood pressure and heart failure.
Description : The agent given sublingually in an acute attack of angina pectoris is (a) Glyceryl trinitrate (b) Amyl nitrite (c) Erythrital tetranitrate (d) Pentaerythritol tetranitrate
Description : Maximal medical therapy for treating angina pectoris is represented by which of the following choices? (a) Diltiazem, verapamil, nitroglycerin (b) Atenolol, isoproterenol, diltiazem (c) Verapamil, nifedipine, propranolol (d) Isosorbide, atenolol, diltiazem (e) Nitroglycerin, isosorbide, atenolol
Description : The antianginal effect of propranolol may be attributed to which one of the following (a) Block of exercise – induced tachycardia (b) Decreased end – diastolic ventricular volume (c) Dilation of consticted coronary vessels (d) Increased cardiac force (e) Increased resting heart rate
Description : Six months after beginning atorvastatin, the patient's total and LDL cholesterol concentrations remained above normal and he continued to have anginal attacks despite good adherence to his antianginal ... Increased endocytosis of HDL by the liver (e) Increased lipid hydrolysis by lipoprotein lipase
Description : The following type of vasodilator is not beneficial in CHF due to systolic dysfunction: A. Calcium channel blocker B. Angiotensin converting enzyme inhibitor C. Nitrate D. Hydralazine
Last Answer : A. Calcium channel blocker
Description : A direct-acting cholinomimetic that is lipid-soluble and often used in the treatment of glaucoma is (a) Acetylcholine (b) Bethanechol (c) Physostigmine (d) Pilocarpine (e) Neostigmine
Description : Antianginal drugs afford the following benefit/benefits (a) Terminate anginal attacks (b) Decrease the frequency of anginal attacks (c) Retard the progression of coronary artery disease (d) Both (a) and (b)
Description : Antianginal drugs afford the following benefit/benefits: A. Terminate anginal attacks B. Decrease the frequency of anginal attacks C. Retard the progression of coronary artery disease D. Both ‘A’ and ‘B’ are correct
Last Answer : D. Both ‘A’ and ‘B’ are correct
Description : A drug that is useful in glaucoma and high-altitude sickness is (a) Acetazolamide (b) Amiloride (c) Demeclocycline (d) Desmopressin (e) Ethacrynic acid
Description : A 55-year-old patient with severe posthepatitis cirrhosis is started on a diuretic for another condition. Two days later he is found in a coma. The drug most likely to cause coma in a patient with cirrhosis is (a) Acetazolamide (b) Amiloride (c) Furosemide (d) Hydrochlorothiazide (e) Spironolactone
Description : Which of the following is an orally active drug that blocks sodium channels and decreases action potential duration? (a) Adenosine (b) Amiodarone (c) Disopyramide (d) Esmolol (e) Mexiletine
Description : When used as an antiarrhythmic drug, Lidocaine typically (a) Increases action potential duration (b) Increases contractility (c) Increses PR interval (d) Reduces abnormal automaticity (e) Reduces resting potential
Description : Which of the following is the drug of choice in treating suicidal overdose of digitoxin ? (a) Digoxin antibodies (b) Lidocaine (c) Magnesium (d) Potassium (e) Quinidine