Description : Haemophilia is a genetic disorder which leads to - (1) decrease in haemoglobin level (2) rheumatic heart disease (3) decrease in WBOC (4) non-clotting of blood
Last Answer : (4) non-clotting of blood Explanation: Haemophilia is a mostly inherited genetic disorder that impairs the body's ability to make blood clots, a process needed to stop bleeding.
Description : Haemophilia is a genetic disorder which lead to – (1) decrease in haemoglobin level (2) rheumatic heart disease (3) decrease in WBC (4) non-clotting of blood
Description : Select the incorrect statement with regard to haemophilia. (a) It is a dominant disease. (b) A single protein involved in the clotting of blood is affected. (c) It is a sex-linked disease. (d) It is a recessive disease.
Last Answer : (a) It is a dominant disease.
Description : Tests of coagulation are used to monitor anticoagulation treatment and detect intrinsic abnormalities in coagulation. Which of the following statement(s) is/are true concerning ... is used to monitor heparin levels intraoperatively during cardiovascular and peripheral vascular operations
Last Answer : Answer: a, c, d Coagulation tests include prothrombin time (PT), which measures the intrinsic and extrinsic pathways of fibrinogen production and is the most common method for ... more while for peripheral vascular applications, values of 250 seconds or greater are considered appropriate
Description : Which one of the following is a condition of delayed blood clotting? (1) Heaemorrhage (2) Hematuria (3) Haemophilia (4) Anaemia
Last Answer : (3) Haemophilia Explanation: Haemophilia is a group of hereditary genetic disorders that impair the body's ability to control blood clotting or coagulation, which is used to stop bleeding when a blood vessel is broken.
Last Answer : Haemophilia
Description : Patient with haemophilia presents which of the following findings:** A. Increased prothrombin time B. Increased bleeding time C. Increased clotting time
Last Answer : A. Increased prothrombin time
Description : .Christmas disease is another name for (a) haemophilia B (b) hepatitis B (c) Down’s syndrome (d) sleeping sickness.
Last Answer : a) haemophilia B
Description : Which one of the following statements is correct regarding sexually transmitted diseases (STDs)? (a) A person may contract syphilis by sharing milk with one already suffering from the disease. (b) Haemophilia is ... both STDs. (d) The chances of a 5-years boy contracting a STD are very little.
Last Answer : (d) The chances of a 5-years boy contracting a STD are very little.
Description : Which of the following statement(s) is/are true concerning hypoadrenal shock? a. In the United States, idiopathic adrenal atrophy (Addison's disease) is the most common cause b. Laboratory ... hypoadrenal shock d. ACTH stimulation test is the diagnostic test of choice to confirm hypoadrenal shock
Last Answer : Answer: b, c, d Shock of a dramatic nature, poorly responsive to resuscitation, may develop as a consequence of adrenal insufficiency. In this country, adrenal insufficiency most ... of an ACTH stimulation test. A significant major cortisol response should be elicited by ACTH administration
Description : Which of the following is the most important risk factor for development of Chronic Obstructive Pulmonary Disease? a) Cigarette smoking Pipe, cigar and other types of tobacco smoking are also risk factors. b) ... is a risk factor for development of COPD, but it is not the most important risk factor.
Last Answer : a) Cigarette smoking Pipe, cigar and other types of tobacco smoking are also risk factors.
Description : Ehlers-Danlos syndrome characterized by hypermobile joints and skin abnormalities is due to (A) Abnormality in gene for procollagen (B) Deficiency of lysyl oxidase (C) Deficiency of prolyl hydroxylase (D) Deficiency of lysyl hydroxylase
Last Answer : Answer : A
Description : The following metabolic abnormalities occur in Diabetes mellitus except (A) Increased plasma FFA (B) Increased pyruvate carboxylase activate (C) Decreased lipogenesis (D) Decreased gluconeogenesis
Last Answer : B
Description : Which of the following suggests a diagnosis of Hurler's Syndrome rather than Hunter's Syndrome? 1) X-linked inheritance 2) Mental retardation 3) Skeletal abnormalities 4) Cloudy cornea 5) Cardiomyopathy
Last Answer : Answers-4 Hunter's Syndrome (MPS-2) is of X-linked inheritance. The cornea are clear. The skeletal involvement tends to be mild with no gibbous present, though scoliosis is ... and gibbous deformation of the spine is characteristic. There is the characteristic coarse facies with hepatosplenomegaly.
Description : Which of the following statements concerning abnormalities of the haemoglobin molecule is true? 1) Alpha thalassaemia is due to a deficiency of beta-chain production 2) HbS is caused by a ... is an adverse prognostic sign 5) oliguneoclitide probes may assist in the diagnosis of haemoglobinopathies
Last Answer : Answers-2 Alpha Thalassaemia is due to abnormalities of the alpha chain. Persistence of HbF has survival advnatages in severely affected subjects. C-alpha 16, beta 11. e-Hb electrophoresis(Dr Shu Ho)
Description : $ Haemophilia is a sex linked disease ! Haemophilia is due to a recessive gene.
Last Answer : $ Haemophilia is a sex linked disease ! Haemophilia is due to a recessive gene. A. If both As and R are ... R is wrong D. If both As and R are wrong.
Description : Haemophilia is a kind of disease which is (1) viral (2) bacterial (3) hereditary (4) fungal
Last Answer : (3) hereditary Explanation: Hemophilia A and hemophilia B are inherited in an X-linked recessive pattern. The genes associated with these conditions are located on the X chromosome, which is one of the two sex chromosomes.
Description : Which one of the following is a hereditary disease? (1) Haemophilia (2) Myopia (3) Anaemia (4) Leukemia
Last Answer : (1) Haemophilia Explanation: Hemophilia is a group of hereditary genetic disorders that impair the body's ability to control blood clotting or coagulation, which is used to stop bleeding when a ... been associated with royal families due to inbreeding, and is sometimes called the 'Royal Disease.'
Description : Which one of the following is a hereditary disease? (1) Cataract (2) Haemophilia (3) Pellagra (4) Osteoporosis
Last Answer : (2) Haemophilia Explanation: In this instance, a specific gene from one or both parents leads to an abnormality. Examples of such a condition would be sickle cell anemia, cystic fibrosis, or hemophilia.
Last Answer : (2) Haemophilia Explanation: Haemophilia is a mostly inherited genetic disorder that impairs the body's ability to make blood clots, a process needed to stop bleeding.
Description : Which of the following is a correct match? (a) Down’s syndrome - 21st chromosome (b) Sickle cell anaemia - X-chromosome (c) Haemophilia - Y-chromosome (d) Parkinson’s disease - X and Y chromosome
Last Answer : a) Down’s syndrome - 21st chromosome
Description : .Which of the following is not a hereditary disease? (a) Cystic fibrosis (b) Thalassaemia (c) Haemophilia (d) Cretinism
Last Answer : (d) Cretinism
Description : Haemophilia is more commonly seen in human males than in human females because (a) a greater proportion of girls die in infancy (b) this disease is due to a Y-linked recessive mutation (c) this ... to an X-linked recessive mutation (d) this disease is due to an X-linked dominant mutation.
Last Answer : this disease is due to an X-linked recessive mutation
Description : Study the pedigree chart given below. What does it show? (a) Inheritance of a condition like phenylketonuria as an autosomal recessive trait. (b) The pedigree chart is wrong as this is ... disease like haemophilia. (d) Inheritance of a sex-linked inborn error of metabolism like phenylketonuria
Last Answer : (a) Inheritance of a condition like phenylketonuria as an autosomal recessive trait.
Description : Pick out the correct statements. (1) Haemophilia is a sex-linked recessive disease. (2) Down's syndrome is due to aneuploidy. (3) Phenylketonuria is an autosomal recessive gene disorder. (4) Sickle cell anaemia is an X- ... are correct. (c) (1) and (4) are correct. (d) (2) and (4) are correct.
Last Answer : (b) (1), (2) and (3) are correct.
Description : Which one of the following is a hereditary disease ? (1) Haemophilia (2) Myopia (3) Anaemia (4) Leukemia
Description : Vitamin K regulates the synthesis of blood clotting factors. (A) VII (B) IX (C) X (D) All of these
Last Answer : Answer : D
Description : Vitamin K regulates the synthesis of blood clotting factors: (A) VII (B) IX (C) X (D) All of these
Description : Vitamin K is involved in posttranslational modification of the blood clotting factors by acting as cofactor for the enzyme: (A) Carboxylase (B) Decarboxylase (C) Hydroxylase (D) Oxidase
Description : A protein reacts with biuret reagent which indicates 2 or more (A) Blood clotting (B) Peptide bond (C) Disulphide bonds (D) Hydrophobic bonds
Last Answer : Answer : B
Description : Platelets contain an enzyme which has important role in clotting in blood. This enzyme is known as (A) Cholinesterase (B) Transaminase (C) Decarboxylase (D) Thrombokinase
Description : Insulin is a protein which controls (A) Blood clotting (B) Metabolic pathway (C) Digestion (D) Kreb’s cycle
Description : Which of the following statement(s) is/are true concerning septic shock? a. The clinical picture of gram negative septic shock is specifically different than shock associated with ... mechanisms of intrinsic expansion of the circulating blood volume, exogenous volume resuscitation is necessary
Last Answer : Answer: d The clinical findings in sepsis and septic shock represent the host response to infection. Gram-positive and gram-negative bacteria, viruses, fungi, rickettsiae, and ... intravascular volume, exogenous volume resuscitation must be provided to restore venous return and ventricular filling
Description : Blood cancer is commonly known as – (1) Leucoderma (2) Leukaemia (3) Haemophilia (4) Sickle-cell. anaemia
Last Answer : (2) Leukaemia Explanation: Leukemia is a cancer of blood and bone marrow. When a person has leukemia, the body makes too many white blood cells (leukocytes). The causes of most types of leukemia are not known. In general, all cancers have a breakdown in the normal way cell division is controlled.
Description : Increased RBC's in the blood leads to a condition called - (1) Anemia (2) Haemophilia (3) Polycythemia (4) Leukaemia
Last Answer : (3) Polycythemia Explanation: Polycythemia is an abnormally high concentration of hemoglobin in the blood through an increase in red cell numbers. People with this condition have thicker blood, which ... in the circulation by increasing or decreasing the rate of production by the bone marrow.
Description : The blood cancer is known as (a) haemolysis (b) haemophilia (c) leukaemia (d) thrombosis.
Last Answer : (c) leukaemia
Description : Increased RBC’s in the blood leads to a condition called (1) Anemia (2) Haemophilia (3) Polycythemia (4) Leukaemia
Last Answer : Polycythemia
Description : The action of Vitamin K in formation of clotting factor is through (A) Post transcription (B) Post translation (C) Golgi complex (D) Endoplasmic reticulum
Description : Mammals other than higher primates do not suffer from gout because they (A) Lack xanthine oxidase (B) Lack adenosine deaminase (C) Lack purine nucleoside phosphorylase (D) Possess uricase
Description : Inherited deficiency of purine nucleoside phosphorylase causes (A) Dwarfism (B) Mental retardation (C) Immunodeficiency (D) Gout
Last Answer : Answer : C
Description : Complete absence of hypoxanthine guanine phospharibosyl transferase causes (A) Primary gout (B) Immunodeficiency (C) Uric acid stones (D) Lesh-Nyhan syndrome
Description : Inherited deficiency of adenosine deaminase causes (A) Hyperuricaemia and gout (B) Mental retardation (C) Immunodeficiency (D) Dwarfism
Description : All of the following statements about primary gout are true except (A) Uric acid stones may be formed in kidneys (B) Arthritis of small joints occurs commonly (C) Urinary excretion of uric acid is decreased (D) It occurs predominantly in males
Description : All the following statements about primary gout are true except (A) Its inheritance is X-linked recessive (B) It can be due to increased activity of PRPP synthetase (C) It can be ... activity of hypoxanthine guanine phosphoribosyl transferase (D) De novo synthesis of purines is increased in it
Description : The following abnormality in PRPP synthetase can cause primary gout: (A) High Vmax (B) Low Km (C) Resistance to allosteric inihbition. (D) All of these
Description : Inheritance of primary gout is (A) Autosomal recessive (B) Autosomal dominant (C) X-linked recessive (D) X-linked dominant
Description : Gout is characterized by increased plasma levels of (A) Urea (B) Uric acid (C) Creatine (D) Creatinine
Description : Gout is a metabolic disorder of catabolism of (A) Pyrimidine (B) Purine (C) Alanine (D) Phenylalanine
Description : A synthetic nucleotide analogue, 4-hydroxypyrazolopyrimidine is used in the treatment of (A) Acute nephritis (B) Gout (C) Cystic fibrosis of lung (D) Multiple myeloma
Description : A 73 year old male presented with an acute attack of gout in his left knee. What is the most likely underlying metabolic cause? 1) decreased renal excretion of uric acid 2) endogenous overproduction of uric acid 3) excessive dietary purine intake 4) lactic acidosis 5) starvation
Last Answer : Answers-1 The aetiology of gout can broadly be divided into cases where there is underexcretion of urate via the kidney (90%) or endogenous overproduction of uric acid (10%) although in practical ... diuretic use. Excessive dietary intake of purines is unlikely to be the main cause in this case.