Description : Non-protein nitrogenous substances in blood include all of the following except (A) Urea (B) Uric acid (C) Creatinine (D) Inositol
Last Answer : Answer : C
Description : Lesch-Nyhan syndrome, the sex linked, recessive absence of HGPRTase, may lead to (A) Compulsive self destructive behaviour with elevated levels of urate in serum (B) Hypouricemia due to liver damage (C) Failure to thrive and megaloblastic anemia (D) Protein intolerance and hepatic encephalopathy
Last Answer : Answer : A
Description : A 73 year old male presented with an acute attack of gout in his left knee. What is the most likely underlying metabolic cause? 1) decreased renal excretion of uric acid 2) endogenous overproduction of uric acid 3) excessive dietary purine intake 4) lactic acidosis 5) starvation
Last Answer : Answers-1 The aetiology of gout can broadly be divided into cases where there is underexcretion of urate via the kidney (90%) or endogenous overproduction of uric acid (10%) although in practical ... diuretic use. Excessive dietary intake of purines is unlikely to be the main cause in this case.
Description : B.M.R. is raised in (A) Polycythemia (B) Starvation (C) Lipid nephrosis (D) Hypothyroidism
Description : Answer: b, c The body contains fuel reserves which it can mobilize and utilize during times of starvation or stress. By far the greatest energy component is fat, which is calorically dense since it ... liver and free glucose have a trivial caloric value of less than 1000 kcal for a 70 kg male
Last Answer : Which of the following statement(s) is/are true concerning the indications and administration of nutritional support to cancer patients? a. Preoperative nutritional support should be provided to all ... total parenteral nutrition solutions maintain integrity of the small bowel e. None of the above
Description : If a fibrinolytic drug is used for treatment of acute myocardial infarction, the adverse drug effect that is most likely to occur is (a) Acute renal failure (b) Development of antiplatelet antibodies (c) Encephalitis secondary to liver dysfunction (d) Hemorrhagic stroke (e) Neutropenia
Last Answer : Ans: D
Description : he current therapeutic indication of acetazolamide is: A. Congestive heart failure B. Renal insufficiency C. Cirrhosis of liver D. Glaucoma
Last Answer : D. Glaucoma
Description : All the following statements correctly describe ketone bodies except (A) They may result from starvation (B) They are present at high levels in uncontrolled diabetes (C) They include—OH β-butyrate and acetone (D) They are utilized by the liver during long term starvation
Last Answer : Answer : D
Description : During starvation, ketone bodies are used as a fuel by (A) Erythrocytes (B) Brain (C) Liver (D) All of these
Last Answer : B
Description : Target tissue of insulin is (A) Red blood cells (B) Renal tubular cells (C) GI tract epithelial cells (D) Liver
Description : A 59-year-old trauma patient has suffered multiple septic complications including severe pneumonia, intraabdominal abscess, and major wound infection. He has now developed signs of multisystem organ ... the same extent d. In patients with hepatic failure, carbohydrate load should be increased
Last Answer : Answer: a, b The most severe complication of sepsis is multiple system organ dysfunction syndrome, which may result in death. The development of organ failure requires changes in the ... should be provided as fat emulsion. If encephalopathy develops, protein load should also be reduced0
Description : Blood glucose level can be raised by gluconeogenesis only by liver, why?
Last Answer : Glucose-6-phosphatase is present only in liver.
Description : When nitrogenous waste accumulates in the blood which organ is not functioning? (1) Liver (2) Lungs (3) Kidneys (4) Heart
Last Answer : (3) Kidneys Explanation: Acute kidney failure (AKF) occurs when there is a sudden reduction in kidney function that results in nitrogenous wastes accumulating in the blood (azotemia). The ... nitrogenous wastes is known as uremia. If untreated, uremia can cause coma and eventually death.
Description : When nitrogenous waste accumulates in the blood which organ is not functioning ? (1) Liver (2) Lungs (3) Kidneys (4) Heart
Last Answer : Kidneys
Description : Which one of the following correctly explains the function of a specific part of the human nephron? (a) Podocytes : create minute spaces (slit pores) for the filtration of blood into the ... blood capillaries (d) Afferent arteriole : carries the blood away from the glomerulus towards renal vein.
Last Answer : (a) Podocytes : create minute spaces (slit pores) for the filtration of blood into the Bowman’s capsule
Description : The Tm for PAH i.e the maximal secretory capacity of the tubule for PAH can be used to gavge the (A) Extent of tubular damage FATS AND FATTY ACID METABOLISM 81 (B) Impairment of the capacity of the tubule to perform osmotic work (C) Impairment of renal plasma flow (D) Glomerular filtration rate
Description : Metabolic alkalosis can occur in (A) Severe diarrhoea (B) Renal failure (C) Recurrent vomiting (D) Excessive use of carbonic anhydrase inhibitors
Description : Hypokalemia occurs in (A) Cushing’s syndrome (B) Addison’s disease (C) Renal failure (D) Advanced dehydration
Description : Deficiency of magnesium may occur with (A) Alcoholism (B) Diabetes mellitus (C) Hypothyroidism (D) Advanced renal failure
Description : An important cause of water intoxication is (A) Nephrogenic diabetes insipidus (B) Renal failure (C) Gastroenteritis (D) Fanconi syndrome
Last Answer : Answer : B
Description : Inborn errors of urea cycle can cause all the following except (A) Vomiting (B) Ataxia (C) Renal failure (D) Mental retardation
Description : Serum potassium level decreases in (A) Familial periodic paralysis (B) Addison’s disease (C) Renal failure (D) All of these
Description : Hyponatraemia occurs in the following condition: (A) Addison’s disease (B) Chronic renal failure (C) Severe diarrhoea (D) All of these
Description : Serum sodium level rises in all of the following except (A) Renal failure (B) Prolonged steroid therapy (C) Aldosteronism (D) Dehydration
Description : Serum inorganic phosphorous decreases in all the following conditions except (A) Hyperparathyroidism (B) Intestinal malabsorption (C) Osteomalacia (D) Chronic renal failure
Description : Serum inorganic phosphorous rises in all the following conditions except (A) Hypoparathyroidism (B) Hypervitaminosis D (C) Chronic renal failure (D) After a carbohydrate-rich meal MINERAL METABOLISM 197
Description : The product of serum calcium concentration (mg/dl) and serum inorganic phosphorous concentration (mg/dl) is decreased in (A) Rickets (B) Hypoparathyroidism (C) Hyperparathyroidism (D) Renal failure
Description : An important finding in Tay-sach’s disease is (A) Renal failure (B) Accumulation of gangliosides in brain and spleen (C) Cardiac failure (D) Anemia
Description : Character ist ic f ind ing in Gaucher ’s disease is (A) Night blindness (B) Renal failure (C) Hepatosplenomegaly (D) Deafness
Description : Primary hyperparathyroidism may occur in association with the following conditions 1) Chronic renal failure 2) Vitamin D deficiency 3) Gastrinoma 4) Autoimmune polyendocrine syndrome 5) Sjogren's syndrome
Last Answer : Answers-3 The association of primary hyperparathyroidism and a gastrinoma would suggest a diagnosis of multiple endocrine neoplasia type 1. CRF causes secondary or tertiary hyperparathyroidism, with vit D deficiency causing secondary hyperparathyroidism. Ther is no association with Sjogren's.
Description : Which of the following is associated with Hyperuricaemia? 1) is usually due to an excess purine consumption 2) occurs in association with acute lymphoblastic leukaemia 3) in primary gout is inherited in ... with low dose aspirin therapy 5) can be treated with uricosuric drugs even in renal failure
Last Answer : Answers-2 Hyperuricaemia may be due to increased purine intake, urate production or reduced urate clearance, and is most commonly due to the latter. Therefore it can occur in association with enhanced ... . Many of the uricosuric drugs may be detrimental in renal failure and may not be effective.
Description : Serum biochemistry of a 60 year old man revealed calcium of 1.98 mmol/l and phosphate of 0.55 mmol/l with an alkaline phosphatase of 450 IU/l.Which among the following mosts suits ... biochemistry? 1) Osteoporosis 2) Osteomalacia 3) Pagets Disease 4) Secondary Hyperparathyroidism 5) Renal failure
Last Answer : Answers-2 Osteomalacia is associated with low calcium and phosphate with raised alkaline phosphatase. Serum biochemistry is normal in osteoporosis. Pagets disease is associated with normal ... renal failure when tertiary hyperparathyroidism sets in there is low calcium with raised phosphate.
Description : Insulin is required for the active uptake of glucose by most of the cells except (A) Muscle cells (B) Renal tubular cells (C) Adipocytes (D) Liver cells
Description : Impaired galactose tolerance test suggests (A) Defect in glucose utilisation (B) Liver cell injury (C) Renal defect (D) Muscle injury
Description : Essential amino acids have been advocated as standard therapy for renal failure. Which of the following statements are true? A. Increased survival from acute renal failure has been reported ... BUN and creatinine to the same degree as solutions containing excessive nonessential amino acids.
Last Answer : Answer: BC DISCUSSION: Essential amino acids and hypertonic dextrose, as opposed to hypertonic dextrose alone, was reported by Abel and co-workers to be associated with a decreased mortality rate ... renal failure have not been carried out in sufficient numbers to yield answers to this question
Description : Sodium depletion occurs in excessive sweating, and cannot be corrected by drinking water alone. When uncorrected, it may lead to A. Increase of urea in blood B. Swelling of ankles and feet C. Muscle cramps, loss of energy, fatigue and faintness D. Renal failure
Last Answer : ANSWER: C
Description : The following conditions give rise to red blood cells with increased mean cell volume: a. anaemia of chronic disease. b. pernicious anaemia. c. anaemia due to renal failure. d. haemolytic anaemi
Last Answer : pernicious anaemia.
Description : All the following statements about obstructive jaundice are true except (A) Prothrombin time may be prolonged due to impaired absorption of vitamin K (B) Serum alkaline phosphatase may be raised ... systemic circulation due to biliary obstruction (D) There is no defect in conjugation of bilirubin
Description : he dominant pharmacokinetic feature of penicillin G is: A. It is equally distributed extra- and intracellularly B. It is rapidly secreted by proximal renal tubules C. It has low oral bioavailability ... pass metabolism in liver D. It does not cross blood-CSF barrier even when meninges are inflamed
Last Answer : B. It is rapidly secreted by proximal renal tubules
Description : Which of the following statement(s) is/are true concerning protein/amino acid metabolism in man? a. The major source of amino acids is breakdown of circulating proteins b. The recommended daily ... balance refers to a decrease in nitrogen taken into the body versus the amount of nitrogen lost
Last Answer : Answer: b, d About 15% of the total body weight is made up of proteins, about half of which are intracellular and half extracellular. In man and other animals, dietary protein is the source of ... is exceeded by the amount of nitrogen lost in the urine, stool, skin, wounds, and fistula drainage
Description : During starvation of cell, the amount of following may decrease a. RNA b. Protein c. Both d. None of them
Last Answer : Both
Description : Starvation starts with (a) Utilization of glucose by cells (b) Utilization of glycogen by cells (c) Utilization of fat & protein by cells (d) None of the above
Last Answer : (c) Utilization of fat & protein by cells
Description : Urine specific gravity of 1.054 indicates (A) Excellent renal function (B) Inappropriate secretion of ADH (C) Extreme dehydration (D) Presence of glucose or protein
Description : A 60-year-old man was diagnosed last year with adenocarcinoma of the lung, and a 4 cm mass lesion was treated with a right lower lobectomy. He now has an ... 2) Membranous glomerulonephritis 3) Minimal change glomerulonephritis 4) Nodular glomerulosclerosis 5) Rapidly progressive glomerulonephritis
Last Answer : Answers-2 Most cases of membranous GN are idiopathic, but in some patients there is a history of an infection or a malignancy (usually lung) with antigenemia.
Description : What substances will prevent fatty liver?
Last Answer : Choline, methionine, lecithin.
Description : The antibodies raised against a pure protein will show only one sharp spike on this technique: (A) Solubility curve (B) Solvent precipitation (C) Molecular weight determination (D) Immuno electrophoresis
Description : The principal nitrogenous excretory compound in humans is synthesised (a) in kidneys but eliminated mostly through liver (b) in kidneys as well as eliminated by kidneys (c) in liver and also eliminated by the same through bile (d) in the liver, but eliminated mostly through kidneys.
Last Answer : (d) in the liver, but eliminated mostly through kidneys.
Description : All of the following statements about bronzed diabetes are true except (A) It is caused by excessive intake of copper (B) Skin becomes pigmented (C) There is damage to β cells of Islets of Langerhans (D) Liver is damaged
Description : Pre- hepatic jaundice occurs because of (A) Increased haemolysis (B) Liver damage (C) Biliary obstruction (D) None of these
Description : Prothrombin time is prolonged in (A) Vitamin K deficiency (B) Liver damage (C) Both (A) and (B) (D) None of these