Which of the following is a microsomal enzyme inducer? (A) Indomethacin (B) Clofibrate (C) Tolbutamide (D) Glutethamide

Which of the following is a microsomal enzyme inducer? (A) Indomethacin (B) Clofibrate (C) Tolbutamide (D) Glutethamide
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In which of the following types of enzymes an inducer is not required? (A) Inhibited enzyme (B) Cooperative enzyme (C) Allosteric enzyme (D) Constitutive enzyme

Description : In which of the following types of enzymes an inducer is not required? (A) Inhibited enzyme (B) Cooperative enzyme (C) Allosteric enzyme (D) Constitutive enzyme

Last Answer : Answer : D

A demonstrable inducer is absent in (A) Allosteric enzyme (B) Constitutive enzyme (C) Inhibited enzyme (D) Co-operative enzyme ENZYMES 141

Description : A demonstrable inducer is absent in (A) Allosteric enzyme (B) Constitutive enzyme (C) Inhibited enzyme (D) Co-operative enzyme ENZYMES 141

Last Answer : Answer : B

An inducer is absent in the type of enzyme: (A) Allosteric enzyme (B) Constitutive enzyme (C) Co-operative enzyme (D) Isoenzymic enzyme

Description : An inducer is absent in the type of enzyme: (A) Allosteric enzyme (B) Constitutive enzyme (C) Co-operative enzyme (D) Isoenzymic enzyme

Last Answer : Answer : B

Which histamine H2 blocker has most marked inhibitory effect on microsomal cytochrome P-450 enzyme: A. Cimetidine B. Ranitidine C. Roxatidine D. Famotidine

Description : Which histamine H2 blocker has most marked inhibitory effect on microsomal cytochrome P-450 enzyme: A. Cimetidine B. Ranitidine C. Roxatidine D. Famotidine

Last Answer : A. Cimetidine

Microsomal enzyme induction has one of the following features: A. Takes about one week to develop B. Results in increased affinity of the enzyme for the substrate C. It is irreversible D. Can be used to treat acute drug poisonings

Description : Microsomal enzyme induction has one of the following features: A. Takes about one week to develop B. Results in increased affinity of the enzyme for the substrate C. It is irreversible D. Can be used to treat acute drug poisonings

Last Answer : A. Takes about one week to develop

Microsomal enzyme induction can be a cause of: A. Tolerance B. Physical dependence C. Psychological dependence D. Idiosyncrasy

Description : Microsomal enzyme induction can be a cause of: A. Tolerance B. Physical dependence C. Psychological dependence D. Idiosyncrasy

Last Answer : A. Tolerance

Microsomal enzyme induction can be a cause of: A. Tolerance B. Physical dependence C. Psychological dependence D. Idiosyncrasy

Description : Microsomal enzyme induction can be a cause of: A. Tolerance B. Physical dependence C. Psychological dependence D. Idiosyncrasy

Last Answer : A. Tolerance

Hypolipidemic drugs reduce serum cholesterol and triacylglycerol. The effect of clofibrate is attributed to (A) Block in absorption from G.I.T. (B) Decrease in secretion of triacylglycerol and cholesterol containing VLDL by liver (C) Block in the reabsorption of bile acids (D) Decreased synthesis of cholesterol

Description : Hypolipidemic drugs reduce serum cholesterol and triacylglycerol. The effect of clofibrate is attributed to (A) Block in absorption from G.I.T. (B) Decrease in secretion of triacylglycerol and cholesterol ... by liver (C) Block in the reabsorption of bile acids (D) Decreased synthesis of cholesterol

Last Answer : Answer : B

The activity of HMG-CoA reductase is inhibited by (A) A fungal inhibitor mevastatin (B) Probucol (C) Nicotinic acid (D) Clofibrate

Description : The activity of HMG-CoA reductase is inhibited by (A) A fungal inhibitor mevastatin (B) Probucol (C) Nicotinic acid (D) Clofibrate

Last Answer : Answer : A

Which of the following features would be expected on lipid analysis in a 57 year old female with two year history of primary biliary cirrhosis? 1) A lipaemic appearance of the serum would be expected. 2) is treated with clofibrate therapy 3) is characteristically associated with tendon xanthomas 4) is characteristically associated with palmar xanthomas 5) No evidence of a dyslipidaemia would be expected with this short a duration of disease

Description : Which of the following features would be expected on lipid analysis in a 57 year old female with two year history of primary biliary cirrhosis? 1) A lipaemic appearance of the serum would be ... xanthomas 5) No evidence of a dyslipidaemia would be expected with this short a duration of disease

Last Answer : Answers-4 In prolonged cholestasis features include: increased serum cholesterol, a moderate increase in triglyceride, the serum is not lipaemic, and reduced HDL levels. Clinical features include: ... persisted for more than 3 months sometimes fat deposits may involve bone and peripheral nerves.

Cimetidine interacts with more drugs than ranitidine because; a) It is subjected to greater first pass metabolism b) It is a more potent enzyme inducer c) It is a more potent enzyme inhibitor d) It has better oral absorption

Description : Cimetidine interacts with more drugs than ranitidine because; a) It is subjected to greater first pass metabolism b) It is a more potent enzyme inducer c) It is a more potent enzyme inhibitor d) It has better oral absorption

Last Answer : c) It is a more potent enzyme inhibitor  

How is Tolbutamide used to increase body weight?

Description : How is Tolbutamide used to increase body weight?

Last Answer : Insulin has been used in the past to stimulate appetite and in the treatment of malnutrition. Because of the hypoglycemic property of tolbutamide, the effect of this drug on this drug on the ... on body weight, the fasting blood sugar level, or the total and fractionated serum protein values.

Insulin resistance can be minimised by the use of: A. Corticosteroids B. Tolbutamide C. Protamine D. Monocomponent/human insulin

Description : Insulin resistance can be minimised by the use of: A. Corticosteroids B. Tolbutamide C. Protamine D. Monocomponent/human insulin

Last Answer : D. Monocomponent/human insulin

Conversion of a procarcinogen into a carcinogen often requires (A) Proteolysis (B) Microsomal hydroxylation (C) Exposure to ultraviolet radiation (D) Exposure to X-rays

Description : Conversion of a procarcinogen into a carcinogen often requires (A) Proteolysis (B) Microsomal hydroxylation (C) Exposure to ultraviolet radiation (D) Exposure to X-rays

Last Answer : Answer : B

Epinephrine increases the concentration of free fatty acids in plasma by increasing (A) Extramitochondrial fatty acid synthesis (B) Mitochondrial fatty acid chain elongation (C) Microsomal fatty acid chain elongation (D) Lipolysis in adipose tissue

Description : Epinephrine increases the concentration of free fatty acids in plasma by increasing (A) Extramitochondrial fatty acid synthesis (B) Mitochondrial fatty acid chain elongation (C) Microsomal fatty acid chain elongation (D) Lipolysis in adipose tissue

Last Answer : Answer : D

Microsomal hydroxylase system contains a (A) Di-oxygenase (B) Mono-oxygenase (C) Both (A) and (B) (D) None of thse

Description : Microsomal hydroxylase system contains a (A) Di-oxygenase (B) Mono-oxygenase (C) Both (A) and (B) (D) None of thse

Last Answer : Answer : B

All the following statements about acetyl CoA carboxylase are true except (A) It is required for de novo synthesis of fatty acids (B) It is required for mitochondrial elongation of fatty acids (C) It is required for microsomal elongation of fatty acids (D) Insulin converts its inactive form into its active form

Description : All the following statements about acetyl CoA carboxylase are true except (A) It is required for de novo synthesis of fatty acids (B) It is required for mitochondrial elongation of fatty acids ( ... for microsomal elongation of fatty acids (D) Insulin converts its inactive form into its active form

Last Answer : Answer : B

C22 and C24, fatty acids required for the synthesis of sphingolipids in brain are formed by (A) De novo synthesis (B) Microsomal chain elongation (C) Mitochondrial chain elongation (D) All of these

Description : C22 and C24, fatty acids required for the synthesis of sphingolipids in brain are formed by (A) De novo synthesis (B) Microsomal chain elongation (C) Mitochondrial chain elongation (D) All of these

Last Answer : Answer : B

The components of complement system are activated by (A) Microsomal hydroxylation (B) Phosphorylation (C) Glycosylation (D) Proteloysis

Description : The components of complement system are activated by (A) Microsomal hydroxylation (B) Phosphorylation (C) Glycosylation (D) Proteloysis

Last Answer : Answer : D

Which of the following is used to lower blood lipid levels? (a) Trimethadione (b) Clofibrate (c) Flucytosine (d) Coumarin (e) Propranolol

Description : Which of the following is used to lower blood lipid levels? (a) Trimethadione (b) Clofibrate (c) Flucytosine (d) Coumarin (e) Propranolol

Last Answer : Ans: B

Which hypolipidemic drug has been used to control and prevent pancreatitis in familial hypertriglyceridemia: A. Lovastatin B. Nicotinic acid C. Cholestyramine D. Clofibrate

Description : Which hypolipidemic drug has been used to control and prevent pancreatitis in familial hypertriglyceridemia: A. Lovastatin B. Nicotinic acid C. Cholestyramine D. Clofibrate

Last Answer : B. Nicotinic acid

Which one of the following binds to specific nucleotide sequences that are upstream and most distant from the start site? (A) RNA polymerase (B) Repressor (C) Inducer (D) Restriction

Description : Which one of the following binds to specific nucleotide sequences that are upstream and most distant from the start site? (A) RNA polymerase (B) Repressor (C) Inducer (D) Restriction

Last Answer : Answer : A

In the ’lac operon’ concept, which of the following is a protein? (A) Operator (B) Repressor (C) Inducer (D) Vector

Description : In the ’lac operon’ concept, which of the following is a protein? (A) Operator (B) Repressor (C) Inducer (D) Vector

Last Answer : Answer : B

Which one of the following binds to specific nucleotide sequences? (A) RNA polymerase (B) Repressor (C) Inducer (D) Restriction

Description : Which one of the following binds to specific nucleotide sequences? (A) RNA polymerase (B) Repressor (C) Inducer (D) Restriction

Last Answer : Answer : A

The enzymes encoded by z, y and a genes of lac operon are inducible, and their inducer is (A) Lactose (B) Allo-lactose (C) Catabolite gene activator protein (D) All of these

Description : The enzymes encoded by z, y and a genes of lac operon are inducible, and their inducer is (A) Lactose (B) Allo-lactose (C) Catabolite gene activator protein (D) All of these

Last Answer : Answer : B

Positive control of induction is best described as a control system in which an operon functions (A) Unless it is switched off by a derepressed repressor protein (B) Only after a repressor protein is inactivated by an inducer (C) Only after an inducer protein, which can be inactivated by a corepressor, switches it on (D) Only after an inducer protein, which is activated by an inducer, switch it on

Description : Positive control of induction is best described as a control system in which an operon functions (A) Unless it is switched off by a derepressed repressor protein (B) Only after a repressor protein is ... on (D) Only after an inducer protein, which is activated by an inducer, switch it on

Last Answer : Answer : D

In the lac operon concept, a protein molecule is (A) Operator (B) Inducer (C) Promoter (D) Repressor

Description : In the lac operon concept, a protein molecule is (A) Operator (B) Inducer (C) Promoter (D) Repressor

Last Answer : Answer : D

Phenylbutazone and indomethacin inhibit (A) Phospholipase A1 (B) Phospholipase A2 (C) Cyclo-oxygenase (D) Lipo-oxygenase

Description : Phenylbutazone and indomethacin inhibit (A) Phospholipase A1 (B) Phospholipase A2 (C) Cyclo-oxygenase (D) Lipo-oxygenase

Last Answer : Answer : C

Synthesis of prostaglandins is inhibited by (A) Glucocorticoids (B) Aspirin (C) Indomethacin (D) All of these

Description : Synthesis of prostaglandins is inhibited by (A) Glucocorticoids (B) Aspirin (C) Indomethacin (D) All of these

Last Answer : Answer : D

Benzodiazepines differ from barbiturates in the following aspects except: A. They have a steeper dose response curve B. They have higher therapeutic index C. They have lower abuse liability D. They do not induce microsomal drug metabolizing enzymes

Description : Benzodiazepines differ from barbiturates in the following aspects except: A. They have a steeper dose response curve B. They have higher therapeutic index C. They have lower abuse liability D. They do not induce microsomal drug metabolizing enzymes

Last Answer : A. They have a steeper dose response curve

Which of the following types of drug metabolizing enzymes are inducible: A. Microsomal enzymes B. Nonmicrosomal enzymes C. Both microsomal and nonmicrosomal enzymes D. Mitochondrial enzymes

Description : Which of the following types of drug metabolizing enzymes are inducible: A. Microsomal enzymes B. Nonmicrosomal enzymes C. Both microsomal and nonmicrosomal enzymes D. Mitochondrial enzymes

Last Answer : A. Microsomal enzymes

Which of the following types of drug metabolizing enzymes are inducible: A. Microsomal enzymes B. Nonmicrosomal enzymes C. Both microsomal and nonmicrosomal enzymes D. Mitochondrial enzymes

Description : Which of the following types of drug metabolizing enzymes are inducible: A. Microsomal enzymes B. Nonmicrosomal enzymes C. Both microsomal and nonmicrosomal enzymes D. Mitochondrial enzymes

Last Answer : A. Microsomal enzymes

The distinctive feature of the isoenzyme cyclooxygenase-2 is (a) It is not inhibited by indomethacin (b) It is inducible (c) It generates cytoprotective prostagladins in gastric mucosa (d) It is found only in foetal tissues

Description : The distinctive feature of the isoenzyme cyclooxygenase-2 is (a) It is not inhibited by indomethacin (b) It is inducible (c) It generates cytoprotective prostagladins in gastric mucosa (d) It is found only in foetal tissues

Last Answer : Ans: B

Instead of being effective in hyperuricaemia following drug is contradictred in the treatment of gout (a) Indomethacin (b) Diclofenac (c) Piroxicam (d) Aspirin

Description : Instead of being effective in hyperuricaemia following drug is contradictred in the treatment of gout (a) Indomethacin (b) Diclofenac (c) Piroxicam (d) Aspirin

Last Answer : Ans: D

The following prostanoid is a potent inducer of platelet aggregation (a) Prostacyclin (b) Prostaglandin E2 (c) Prostaglandin D2 (d) Thromboxane A2

Description : The following prostanoid is a potent inducer of platelet aggregation (a) Prostacyclin (b) Prostaglandin E2 (c) Prostaglandin D2 (d) Thromboxane A2

Last Answer : Ans: D

Which of the following is an irreversible inhibitor of cyclooxygenase ? (a) Aspirin (b) Phenylbutazone (c) Indomethacin (d) Piroxicam

Description : Which of the following is an irreversible inhibitor of cyclooxygenase ? (a) Aspirin (b) Phenylbutazone (c) Indomethacin (d) Piroxicam

Last Answer : Ans: A

Which of the following drugs may be effective in the treatment of gouty arthritis by acting by two separate and distinct mechanisms? (a) Allopurinol (b) Probenecid (c) Colchicine (d) Indomethacin (e) Sulfinpyrazone

Description : Which of the following drugs may be effective in the treatment of gouty arthritis by acting by two separate and distinct mechanisms? (a) Allopurinol (b) Probenecid (c) Colchicine (d) Indomethacin (e) Sulfinpyrazone

Last Answer : Ans: D

A newborn was diagnosed as having a congenital abnormality that resulted in transposition of her great arteries. While preparing the infant for surgery, the medical team needed to keep the ductus arteriosus open. They did this by infusing (a) Cortisol (b) Indomethacin (c) Ketorolac (d) Misoprostol (e) Tacrolimus

Description : A newborn was diagnosed as having a congenital abnormality that resulted in transposition of her great arteries. While preparing the infant for surgery, the medical team needed to keep the ductus arteriosus ... by infusing (a) Cortisol (b) Indomethacin (c) Ketorolac (d) Misoprostol (e) Tacrolimus

Last Answer : Ans: D

A 45-year-old surgeon has developed symmetric early morning stiffness in her hands. She wishes to take a nonsteroidal anti-inflammatory drug to relieve these symptoms and wants to avoid gastrointestinal side effects. Which one of the following drugs is most appropriate? (a) Aspirin (b) Celecoxib (c) Ibuprofen (d) Indomethacin (e) Piroxicam

Description : A 45-year-old surgeon has developed symmetric early morning stiffness in her hands. She wishes to take a nonsteroidal anti-inflammatory drug to relieve these symptoms and wants to avoid gastrointestinal side ... appropriate? (a) Aspirin (b) Celecoxib (c) Ibuprofen (d) Indomethacin (e) Piroxicam

Last Answer : Ans: B

Which one of the following antibiotics is a potent inducer of hepatic drug-metabolizing enzymes? (a) Ciprofloxacin (b) Cyclosporine (c) Erythromycin (d) Rifampin (e) Tetracycline

Description : Which one of the following antibiotics is a potent inducer of hepatic drug-metabolizing enzymes? (a) Ciprofloxacin (b) Cyclosporine (c) Erythromycin (d) Rifampin (e) Tetracycline

Last Answer : Ans: D

Which of the following is required as inducer(s) for the expression of Lac operon? (a) Lactose (b) Lactose and galactose (c) Glucose (d) Galactose

Description : Which of the following is required as inducer(s) for the expression of Lac operon? (a) Lactose (b) Lactose and galactose (c) Glucose (d) Galactose

Last Answer : (c) Glucose

Which one of the following is not a part of a transcription unit in DNA? (a) The inducer (b) A terminator (c) A promoter (d) The structural gene

Description : Which one of the following is not a part of a transcription unit in DNA? (a) The inducer (b) A terminator (c) A promoter (d) The structural gene

Last Answer : (c) A promoter

.An environmental agent, which triggers transcription from an operon, is a (a) depressor (b) controlling element (c) regulator (d) inducer.

Description : .An environmental agent, which triggers transcription from an operon, is a (a) depressor (b) controlling element (c) regulator (d) inducer.

Last Answer : (d) inducer.

.In negative operon, (a) co-repressor binds with repressor (b) co-repressor does not bind with repressor (c) co-repressor binds with inducer (d) cAMP have negative effect on lac operon. (

Description : .In negative operon, (a) co-repressor binds with repressor (b) co-repressor does not bind with repressor (c) co-repressor binds with inducer (d) cAMP have negative effect on lac operon. (

Last Answer : co-repressor binds with repressor

Which of the following is required as inducer(s) for the expression of Lac operon? (a) Lactose (b) Lactose and galactose (c) Glucose (d) Galactose

Description : Which of the following is required as inducer(s) for the expression of Lac operon? (a) Lactose (b) Lactose and galactose (c) Glucose (d) Galactose

Last Answer : Lactose

Which one of the following is not a part of a transcription unit in DNA? (a) The inducer (b) A terminator (c) A promoter (d) The structural gene

Description : Which one of the following is not a part of a transcription unit in DNA? (a) The inducer (b) A terminator (c) A promoter (d) The structural gene

Last Answer : (a) The inducer

Select the incorrect statement out of the five given below about lac operon when Lactose is present in the medium. a) Gene – A gets transcribed into mRNA which produces β-galactoside permease b) Inducer-Repressor complex is formed c) Lactose inactivates repressor protein d) RNA polymerase transcribe Z-gene, Y-gene and A-gene e) Allolactose is the inducer of lac operon

Description : Select the incorrect statement out of the five given below about lac operon when Lactose is present in the medium. a) Gene - A gets transcribed into mRNA which produces β-galactoside permease b) ... polymerase transcribe Z-gene, Y-gene and A-gene e) Allolactose is the inducer of lac operon

Last Answer : Gene – A gets transcribed into mRNA which produces β-galactoside permease b) Inducer-Repressor complex is formed

Renal excretion of lithium is reduced by: A. Furosemide B. Hydrochlorothiazide C. Indomethacin D. All of the above

Description : Renal excretion of lithium is reduced by: A. Furosemide B. Hydrochlorothiazide C. Indomethacin D. All of the above

Last Answer : D. All of the above

Which one of the following is not a part of a transcription unit in DNA ? (1) The structural gene (2) The inducer (3) A terminator (4) A promoter

Description : Which one of the following is not a part of a transcription unit in DNA ? (1) The structural gene (2) The inducer (3) A terminator (4) A promoter

Last Answer : (2) The inducer

Which of the following drugs attenuates the antihypertensive action of β-blockers: A. Cimetidine B. Indomethacin C. Chlorpromazine D. Imipramine

Description : Which of the following drugs attenuates the antihypertensive action of β-blockers: A. Cimetidine B. Indomethacin C. Chlorpromazine D. Imipramine

Last Answer : B. Indomethacin