DefinitionAcute tubular necrosis is a kidney disorder involving damage to the tubule cells of the kidneys, resulting in acute kidney failure.Alternative NamesNecrosis - renal tubular; ATN; Necrosis - acute tubularCauses, incidence, and risk factorsAcute tubular necrosis (ATN) is caused by lack of oxygen to the kidney tissues (ischemia of the kidneys).The internal structures of the kidney, particularly the tissues of the kidney tubule, become damaged or destroyed. ATN is one of the most common structural changes that can lead to acute renal failure.ATN is one of the most common causes of kidney failure in hospitalized patients. Risks for acute tubular necrosis include:Blood transfusion reactionInjury or trauma that damages the musclesRecent major surgerySeptic shock or other forms of shockS