Description : Helper T cells release all the following except (A) Interleukins (B) Colony stimulating factors (C) Perforins (D) Tumour necrosis factor
Last Answer : Answer : C
Description : Helper T cells release (A) Interleukins (B) Colony stimulating factors (C) Tumour necrosis factor (D) All of these
Last Answer : Answer : B
Description : TNF-ais an example of eicosanoids (a) Interleukins (b) Cytotoxic factors (c) Interferons (d) Colony stimulating factors
Last Answer : Ans: B
Description : The following are true about antigen presenting cells (APC): a. Langerhan's cells are the antigen presenting cells of the epidermis b. CD8+ cells only recognize antigen presenting cells bearing ... necrosis factor alpha (TNF ) can turn endothelial cells into antigen presenting cells d. all above
Last Answer : all above
Description : The following does not apply to cancer chemotherapy: A. Each treatment with a cytotoxic drug kills a constant number of malignant cells B. Drugs are generally used at maximum tolerated ... D. Combination regimens using several drugs in succession are superior to single drug used continuously
Last Answer : A. Each treatment with a cytotoxic drug kills a constant number of malignant cells
Description : Cytotoxic T cells release which 2 toxic proteins as they fight target cells? a. histamine and heparin b. perforin and granzymes c. interleukin and interferon d. lysozymes and cytokines
Last Answer : b. perforin and granzymes
Description : Which of the following findings is most useful for staging of a tumour C A. Presence of necrosis B. Presence of abnormal mitoses C. Presence of metastases D. Absence of apoptosis
Last Answer : Presence of metastases
Description : What drug is used to prevent embolism in the lung and during myocardial infarction? (a) Alteplase (b) Human growth hormone (c) Granulocyte–macrophage colony – stimulating factor (GM–CSF) (d) EPOGEN (EPO) (e) None of the above
Last Answer : Ans: A
Description : The following are true about interleukins 1 (IL-1): a. it is produced mainly by the neutrophils b. it stimulates the proliferation of B and T cells c. it increases bone production d. it acts on the hypothalamus to cause fever
Last Answer : it stimulates the proliferation of B and T cell
Description : Human immunodeficiency virus destroys (A) Cytotoxic T cells (B) Helper T cells (C) B cells (D) Plasma cells
Description : CD 3 complex and p 56lck proteins are present in (A) Cytotoxic T cells (B) Helper T cells (C) Both (A) and (B) (D) None of these
Last Answer : Answer : D
Description : CD 4 is a transmembrane glycoprotein present in (A) Cytotoxic T cells (B) Helper T cells (C) Suppressor T cells (D) Memory T cells
Last Answer : Answer : A
Description : CD 8 is a transmembrane glycoprotein present in (A) Cytotoxic T cells (B) Helper T cells (C) Suppressor T cells (D) Memory T cells
Description : MHC Class II proteins, in conjunction with antigens, are recognised by (A) Cytotoxic T cells (B) Helper T cells (C) Suppressor T cells (D) Memory T cells
Description : MHC class I proteins, in conjunction with antigens are recognised by (A) Cytotoxic T cells (B) Helper T cells (C) Suppressor T cells (D) Memory T cells
Description : The most abundant T cells are (A) Cytotoxic T cells (B) Helper T cells (C) Suppressor T cells (D) Memory T cells
Description : Methyl dopa decreases blood pressure by (A) Inhibiting the synthesis of catecholamines (B) Antagonising the action of aldosterone (C) Stimulating the release of renin (D) Inhibiting the breakdown of angiotensin
Description : The following are true : a. the HLA proteins are found within the cytoplasm of the cells b. HLA class I antigens are expressed on all cells with nuclei c. HLA class II antigens presents ... on chromosome 6 e. HLA tissue typing is carried out in all forms of transplantation to prevent rejection
Last Answer : HLA class I antigens are expressed on all cells with nuclei
Description : What type of immune cell may control IgE-mediated hypersensitivities? a. Suppressor T cells b. Plasma cells c. Cytotoxic T cells d. Neutrophils
Last Answer : a. Suppressor T cells
Description : The early response in asthma is due to activity. a. Cytotoxic T Cell b. Basophil c. TH2 Cell And NI( Cell d. Dendritic Cells
Last Answer : c. TH2 Cell And NI( Cell
Description : The cytotoxic T cells have a_____ co-receptor while the helper T cells have a _____ co-receptor. a. CD8. CD4 b. CD4, CD8 c. MHCI, MHCII d. MHCII, MHCI
Last Answer : a. CD8. CD4
Description : Performs and granzymes are found in a. Helper T cells. b. Antigen-presenting cells. c. Cytotoxic T cells. d. B cells.
Last Answer : c. Cytotoxic T cells.
Description : TH1 cells activate a. B cells. b. Killing of pathogens in macrophages. c. Cytotoxic T cells. d. Humoral immunity.
Last Answer : d. Humoral immunity
Description : Cytotoxic T-cells can be recognized by which of the following cell surface marker? A- CD4 B- CD7 C- CD8 D- CD9
Last Answer : CD8
Description : CD8 surface antigen is present in A- cytotoxic T cells B- .suppresssor T cells C- both (a) and (b) D- none of these
Last Answer : both (a) and (b)
Description : Cytotoxic T cells a) lyse cells infected with virus. Cytotoxic T cells play a role in graft rejection. b) are important in producing circulating antibodies. B cells are lymphocytes important in producing ... that decrease B-cell activity to a level at which the immune system is compatible with life.
Last Answer : a) lyse cells infected with virus. Cytotoxic T cells play a role in graft rejection.
Description : Type I ADR reactions is___________ a) Caused when T-cells bind to a specific antigen b) Caused by tissue injury c) IgE mediated d) Caused by cytotoxic antibodies
Last Answer : c) IgE mediated
Description : With regard to interleukins: a. IL-2 is produced mainly by CD8+ cells b. IL-3 stimulates the growth of haemopoietic stem cells c. IL-4 increases the production of IL-1 d. IL-6 stimulates acute phase protein synthesis
Last Answer : IL-6 stimulates acute phase protein synthesis
Description : The most important mechanism of antiinflammatory action of glucocorticoids is: A. Inhibition of lysosomal enzymes B. Restriction of recruitment of inflammatory cells at the site of inflammation C. Antagonism of action of interleukins D. Suppression of complement function
Last Answer : B. Restriction of recruitment of inflammatory cells at the site of inflammation
Description : Booster immunizations are used to raise the antibody level by stimulating the _____ cells to induce the secondary antibody response. a. helper T b. B c. memory d. plasma
Last Answer : c. memory
Description : Which of the following statements regarding cytokines is incorrect? A. Cytokines act directly on target cells and may potentiate the actions of one another. B. Interleukin 1 (IL-1) ... organ dysfunction syndrome because of its multiple actions and the secondary cascades that it stimulates.
Last Answer : Answer: C DISCUSSION: Cytokines are soluble peptide molecules that are synthesized and secreted by a number of cell types in response to injury, inflammation, and infection. Cytokines, which ... is thought to play a central role in the stress response, particularly in response to endotoxemia
Description : Alloxan can experimentally induce diabetes mellitus due to (A) Stimulation of α cells of the islets of langerhans (B) Necrosis of the β cells of the islets (C) Potentiation of insulinase activity (D) Epinephrine like action
Description : The following are true: a. heroin causes miosis by increasing the release of acetylcholine. b. botulinum toxin causes mydriasis by inhibiting the release of acetylcholine c. ... mydriasis by stimulating the alpha receptors d. amphetamine causes mydriasis by inhibiting noradrenaline reuptake
Last Answer : phenylephrine causes mydriasis by stimulating the alpha receptors
Description : Gonadotropin releasing hormone (GnRH) stimulates the release of: a) ACTH. b) Growth hormone. c) Leutinising Hormone (LH). d) Thyroid stimulating hormone (TSH). e) Opiate peptides.
Last Answer : c) Leutinising Hormone (LH).
Description : Which is an example of negative feedback? A) Nursing action stimulates the hypothalamus to release oxytocin that triggers mammary gland milk production. B) When the blood becomes dilute, ADH ... produce sperm or eggs. E) TRH stimulates the anterior pituitary to release thyroid-stimulating hormone.
Last Answer : B) When the blood becomes dilute, ADH is no longer released from the hypothalamus
Description : Which one of the following applies to the disease systemic lupus erythematosus (SLE)? a. It is a type of cytotoxic hypersensitivity. b. It is often accompanied by a butterfly rash. c. It is due to an overreaction of T lymphocytes. d. It is the result of a cellular hypersensitivity.
Last Answer : d. It is the result of a cellular hypersensitivity.
Description : With regard to HLA class 1 antigen: a. they are expressed on all nucleated cells b. they are essential for viral antigen recognition by cytotoxic cells c. the genes for HLA class 1 molecules are located on chromosome 6 and 15 d. all above
Description : Which of the following finding is most important for grading of tumours? C A. Presence of tumour cells in the vascular spaces B. Level of invasion C. Microscopic pleomorphism of nuclei and the number of mitoses D. degree of metastasis
Last Answer : Microscopic pleomorphism of nuclei and the number of mitoses
Description : A metastatic cancerous tumour is termed ‘sarcoma’ if the disorder is in (a) fibroblasts (b) circulatory system (c) immune system (d) epithelial cells.
Last Answer : (a) fibroblasts
Description : G-proteins: a. are activated by the binding of an extracellular ligand to a membrane receptor b. can be mutated in tumour cells c. mediate the action of glucocorticoid hormone d. they are inactivated by cholera toxins
Last Answer : are activated by the binding of an extracellular ligand to a membrane receptor
Description : Natural killer cells are involved in A- .tumour rejection B- .allograft rejection C- non-specific killing of virus transformed target cells D- all of these
Last Answer : all of these
Description : The standard management oral anticoagulant therapy for chronic treatment of venous thromboembolism is with the drug warfarin. Which of the following statement(s) is/are true concerning the administration ... warfarin be continued for at least one year after initial episode of deep venous thrombosis
Last Answer : Answer: a, b Warfarin interferes with the vitamin K dependent clotting factors II, VII, IX and X, protein C, and protein S. An important complication of warfarin is skin ... the benefit from anticoagulant therapy and thus is the basis for discontinuing warfarin administration at this time
Description : Suppuration is mainly the result of the combined action of four factors; which of the following is not one of these factors?CHECK A. Necrosis B. Presence of lymphocytes C. Collection of neutrophils D. Accumulation of tissue fluid E. Autolysis by proteolytic enzymes
Last Answer : B. Presence of lymphocytes
Description : RB 1 gene is (A) A tumour suppressor gene (B) Oncogene (C) Proto-oncogene (D) Activated proto-oncogene
Description : P 53 gene: (A) A proto-oncogene (B) An oncogene (C) A tumour suppressor gene (D) None of these
Description : Diabetes mellitus can occur due to all of the following except (A) Deficient insulin secretion (B) Tumour of β−cells (C) Decrease in number of insulin receptors (D) Formation of insulin antibodies
Description : In Cushing’s syndrome-a tumour associated disease of adrenal cortex, there is (A) Decreased epinephrine production (B) Excessive cortisol production (C) Excessive epinephrine production (D) Decreased cortsoil production
Description : B.M.R. is subnormal in (A) Addison’s disease (B) Adrenal tumour (C) Cushing’s syndrome (D) Fever
Description : What are the enzymes useful as tumour markers?
Last Answer : Regan iso-enzyme of ALP for lung tumour; tartarate labile iso-enzyme of ACP and Prostate specific antigen (PSA) for prostate carcinoma; Neuron specific enolase (NSE) for cancers of neuro-endocrine origin.
Description : Which of the following statement(s) is/are true concerning tumor necrosis factor (TNF)? a. TNF is a product of activated macrophages secreted in response to contact with endotoxin or ... completed clinical trials of anti-TNF antibody in septic patients shows a marked improvement in survival
Last Answer : Answer: a, b Tumor necrosis factor (TNF), a protein product of activated macrophages, is secreted in response to contact with endotoxin or lipopolysaccharide, antibody complexes, or ... patients utilizing infusion of monoclonal antibodies to the TNF molecule have shown no overall survival benefit