Discuss in brief disintegration test for uncoated tablet.

Discuss in brief disintegration test for uncoated tablet.
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Disintegration test: Disintegration of a tablet means to break a tablet into smaller particles after swallowing. The time required to disintegrate the tablet is called disintegration time. The apparatus consists of a rigid basket-rack assembly supporting 6 cylindrical glass tubes held vertically by two superimposed transparent plastic plates with six holes having the same diameter as the tubes. Woven wire gauze made from stainless steel is attached to the underside of the lower plate. The assembly should be raised and lowered between 28 and 32 times per minute in the liquid at 370 C. The tablets are kept immersed in the liquid within the tubes by means of cylindrical guided discs. The assembly is suspended in the liquid medium in a 1000 ml beaker. The apparatus is operated generally for 15 minutes and observed for disintegration of tablets. The tablets pass the test if all the tablets disintegrate. In case one or two tablets fail to disintegrate, repeat the test on 12 additional tablets. The tablets pass the test if not less than 16 of the total 18 tablets tested have disintegrated.  

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