Explain following evaluation test for tablet

Explain following evaluation test for tablet
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1 Answer

Answer :

(i) Friability

Friability test is performed to evaluate ability of the tablet to with stand wear and tear in Packing, handling, and transporting. The apparatus used to perform this test is known as "Friabilator".

The apparatus: consists of a plastic chamber, which is divided into two parts and itrevolves at a speed of 25 rpm. Twenty tablets are weighed and placed in a plasticchamber. The chamber is rotated for 4 minutes or 100 revolutions. During eachrevolution the tablet falls from a distance of 6 inch. The tablets are removed from thechamber after 100 revolutions and weighed. Loss in weight indicates the friability.

Result: The tablets are considered to be of good quality if the loss in weight is less than 0.8%.


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(ii) Disintegration
Disintegration of a tablet means to break a tablet into smaller particles after swallowing.
The time required to disintegrate the tablet is called disintegration time.
Method: The apparatus consists of a rigid basket-rack assembly supporting 6 cylindrical glass tubes placed with one tablet in each tubes. The assembly should be raised and lowered between 28 and 32 times per minute in the liquid medium at 370 C. The assembly is suspended in the liquid medium in a 1000 ml beaker. The apparatus is operated generally for 15 minutes and observed for disintegration of tablets.
Result: The tablets pass the test if all the tablets disintegrate. In case one or two tablets fail to disintegrate, repeat the test on 12 additional tablets. The tablets pass the test if not less than 16 of the total 18 tablets tested have disintegrated.
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