This is done to achieve maximum extraction of active constituents as well as complete exhaustion of drugs.
Double maceration:
It is carried in the same way as simple maceration.
The menstruum is divided in two parts.
The quantity of menstruum required for two macerations are calculated as.
In Double maceration drug is macerated for 48 hr for first maceration and 24 hr for second maceration.
Strain the liquid and press the marc.
Mix the liquid obtain from two maceration and keep it for 14 days and then filter.
Ex. Concentrated infusion of orange and gentian infusion.
Triple Maceration Process In this maceration process, the drug is macerated thrice by using the menstruum which is divided into three parts in such a manner that the same volume is used for each maceration.
The quantity of menstruum required for three macerations is calculated as follows:
PROCEDURE FOR TRIPLE MACERATION
The whole of the drug is macerated for one hour with part of menstruum required for first maceration and strained.
Macerate again for one hour with a part of menstruum required for second maceration and strained.
Macerate again for one hour with a part of menstruum required for third maceration and strained.
Press the marc lightly. Then combine the liquids obtained from second and third maceration and evaporate it to a specified extent.
Mix it with the liquid obtained from first maceration. Add alcohol 90% equal to l/4th of the volume of the finished product. Adjust volume with
water. Allow it to stand for 14 days and filter.