Discuss in brief about moist granulation method.

Discuss in brief about moist granulation method.
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1 Answer

Answer :

• Drug + Excipients → Blending → Formation of cohesive mass → Screening → Drying → Screening → Blending → Compression.

This method consists of the following steps: 

1. Milling of drugs and excipients such as diluents, disintegrating agent.

2. Mixing of milled powders.

3. Preparation of binder solution.

4. Mixing of binder solution with powder mixture to form a cohesive mass.

5. Course screening of the wet mass using 8-12 mesh screen.

6. Drying the moist granules at 600C in a hot air oven by spreading in trays.

7. Screening of dry granules through sieve no 20.

8) lubricating agent , glidant and disintegrating agent added/mixed.

8) Granules ready for compression

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