Describe in brief about dissolution test for tablets.

Describe in brief about dissolution test for tablets. 
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Dissolution test: The test is done for measuring the amount of time required for a given percentage of drug substance in a tablet to go into solution under specified condition in vitro. The apparatus consists a cylindrical covered vessel made of glass or other transparent material having 1000 ml capacity. The vessel is fitted with a lid having 4 holes, one for shaft of stirrer, second for placing thermometer and remaining two for removing the sample. An electric motor which is capable of rotating the basket (woven wire cloth having aperture size 425 micrometer) in the vessel at varied speed between 25 and 150 revolutions per minute. 1000 ml of water at 37 o + 0.5 o C in placed and specified number of tablets are placed in the dry basket. The motor is started and the rotation speed is adjusted to 100 rpm or as directed in the monograph. Withdraw the stated volume of solution from the vessel after 45 minutes or after the time specified in the monograph. Filter and determine the amount of active ingredient present in it. The tablets pass the test if for each of the five replicates; the amount of active ingredient in solution is not less than 70% of the stated amount. 

Diagram.

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