Description : Which of the following is a selective H1 receptor agonist: A. 4-methyl histamine B. Impromidine C. 2-Thiazolyl ethylamine D. Chlorpheniramine
Last Answer : C. 2-Thiazolyl ethylamine
Description : Which of the following is a selective H1 receptor agoinist ? (a) 4-methyl histamine (b) Impromidine (c) 2-Thiazolyl ethylamine (d) Mepyramine
Last Answer : Ans: C
Description : The following is a selective 5-HT1D receptor agonist: A. Buspirone B. Ondansetron C. Sumatriptan D. α-methyl 5-HT
Last Answer : C. Sumatriptan
Description : The action of histamine that is not mediated through H1 receptors is: A. Release of EDRF from vascular endothelium resulting in vasodilatation B. Direct action on vascular smooth muscle causing vasodilatation C. Bronchoconstriction D. Release of catecholamines from adrenal medulla
Last Answer : B. Direct action on vascular smooth muscle causing vasodilatation
Description : Benefit afforded by certain H1 antihistaminics in the following condition is not based on antagonism of histamine: A. Dermographism B. Insect bite C. Common cold D. Seasonal hay fever
Last Answer : C. Common cold
Description : While prescribing a first generation H1 antihistaminic the patient should be advised to avoid: A. Driving motor vehicles B. Consuming processed cheese C. Strenuous physical exertion D. All of the above
Last Answer : A. Driving motor vehicles
Description : The capacity of an antihistaminic to produce sedation depends on the following except: A. Relative affinity for central versus peripheral H1 receptors B. Ability to penetrate blood-brain barrier C. Individual susceptibility D. Ratio of H1:H2 blockade produced by the drug
Last Answer : D. Ratio of H1:H2 blockade produced by the drug
Description : The conventional H1 antihistaminics possess the following additional properties except: A. Local anaesthetic B. Vasopressor C. Antiarrhythmic D. Catecholamine potentiating
Last Answer : B. Vasopressor
Description : The following H1 antihistaminic has additional anti 5-HT, anticholinergic, sedative and appetite stimulating properties: A. Promethazine B. Terfenadine C. Cyproheptadine D. Hydroxyzine
Last Answer : C. Cyproheptadine
Description : H1 antihistaminics are beneficial in: A. All types of allergic disorders B. Certain type I allergic reactions only C. Certain type IV allergic reactions only D. Bronchial asthma
Last Answer : B. Certain type I allergic reactions only
Description : Select the H1 antihistaminic which is used topically in the nose for allergic rhinitis: A. Loratadine B. Cetirizine C. Fexofenadine D. Azelastine
Last Answer : D. Azelastine
Description : Fexofenadine differs from terfenadine in that: A. It undergoes high first pass metabolism in liver B. It is a prodrug C. It does not block cardiac delayed rectifier K+ channels D. It has high affinity for central H1 receptors
Last Answer : C. It does not block cardiac delayed rectifier K+ channels
Description : Prolonged airway hyperreactivity is characteristically caused by: A. Histamine B. Prostaglandin E2 C. Platelet activating factor D. Bradykinin
Last Answer : C. Platelet activating factor
Description : â-Aminoethylimidazole is? (a) 2-methyl histamine (b) Histamine (c) 2-pyridyl ethylamine (d) 4-methyl histamine
Last Answer : Ans: B
Description : The following serotonergic receptor functions primarily as an autoreceptor on neurones: A. 5-HT1A B. 5-HT2A C. 5-HT3 D. 5-HT4
Last Answer : A. 5-HT1A
Description : Actions of 5-HT2 receptor activation are primarily mediated by: A. Increased membrane permeability to Na+ ions B. Increased formation of cAMP C. Activation of guanylyl cyclase D. Generation of inositol trisphosphate and diacyl glycerols
Last Answer : D. Generation of inositol trisphosphate and diacyl glycerols
Description : Selective COX-2 inhibitors differ from nonselective COX-1/COX-2 inhibitors in that they: A. Are antiinflammatory but not analgesic B. Donot bring down fever C. Have no renal effects D. Do not inhibit platelet aggregation
Last Answer : D. Do not inhibit platelet aggregation
Description : The most important receptor involved in cytotoxic drug induced vomiting is (a) Histamine H1 receptor (b) Serotonin 5-HT3 receptor (c) Dopamine D2 receptor (d) Opioid µ receptor
Description : The following receptor has an intrinsic ion channel: A. Histamine H1 receptor B. Histamine H2 receptor C. Adrenergic alfa receptor D. GABA-benzodiazepine receptor
Last Answer : D. GABA-benzodiazepine receptor
Description : The following class(es) of drugs are clinically beneficial in bronchial asthma: A. Histamine H1 receptor antagonists B. Platelet activating factor (PAF) antagonists C. Leukotriene ( cys LT1) receptor antagonists D. All of the above
Last Answer : C. Leukotriene ( cys LT1) receptor antagonists
Description : The most important receptor involved in cytotoxic drug induced vomiting is: A. Histamine H1 receptor B. Serotonin 5-HT3 receptor C. Dopamine D2 receptor D. Opioid μ receptor
Last Answer : B. Serotonin
Description : Desmopressin is preferred over arginine vasopressin in the treatment of diabetes insipidus for the following reasons except: A. It is a more potent antidiuretic B. It is a selective vasopressin V1 receptor agonist C. It has little vasoconstrictor activity D. It is longer acting
Last Answer : B. It is a selective vasopressin V1 receptor agonist
Description : Which of the following peptides is a selective vasopressin V2 receptor agonist: A. Arginine vasopressin B. Desmopressin C. Lypessin D. Terlipressin
Last Answer : B. Desmopressin
Description : Losartan is a: A. Selective AT1 receptor antagonist B. Selective AT2 receptor antagonist C. Nonselective AT1 + AT2 receptor antagonist D. AT1 receptor partial agonist
Last Answer : A. Selective AT1 receptor antagonist
Description : Diamprit is an agonist of ______ receptors, except (a) H1 (b) H2 (c) H3 (d) All of the above
Last Answer : Ans: A
Description : High anticholinergic property is present in the following antihistaminic: A. Diphenhydramine B. Astemizole C. Cetirizine D. Terfenadine
Last Answer : A. Diphenhydramine
Description : Autacoids differ from hormones in that: A. Autacoids are involved only in the causation of pathological states B. Autacoids do not have a specific cell/tissue of origin C. Autacoids generally act locally at the site of generation and release D. Both ‘B’ and ‘C’ are correct
Last Answer : D. Both ‘B’ and ‘C’ are correct
Description : Allopurinol has a therapeutic effect in the following conditions except: A. Radiotherapy induced hyperuricaemia B. Hydrochlorothiazide induced hyperuricaemia C. Acute gouty arthritis D. Kala-azar
Last Answer : C. Acute gouty arthritis
Description : Allopurinol is indicated in the following category of chronic gout patients: A. Over producers of uric acid B. Under excretors of uric acid C. Those with tophi and/or renal urate stones D. All of the above
Last Answer : D. All of the above
Description : A 35-year-old male presented with an attack of acute gout. He was treated with a 10 day course of naproxen. His blood uric acid level is high. What future line of treatment is ... treatment with allopurinol D. Start with allopurinol + naproxen for 2 months followed by long-term allopurinol treatment
Last Answer : D. Start with allopurinol + naproxen for 2 months followed by long-term allopurinol treatment
Description : Select the drug which is used in chronic gout but is not uricosuric: A. Probenecid B. Phenylbutazone C. Sulfinpyrazone D. Allopurinol
Last Answer : D. Allopurinol
Description : Probenecid has the following action(s): A. Uricosuric B. Analgesic C. Antiinflammatory D. Both ‘A’ and ‘C’
Last Answer : A. Uricosuric
Description : The most important dose-limiting adverse effect of colchicine is: A. Sedation B. Kidney damage C. Diarrhoea D. Muscle paralysis
Last Answer : C. Diarrhoea
Description : Select the drug which is neither analgesic, nor antiinflammatory, nor uricosuric, but is highly efficacious in acute gout: A. Prednisolone B. Colchicine C. Naproxen D. Sulfinpyrazone
Last Answer : B. Colchicine
Description : Nonsteroidal antiinflammatory drugs are more commonly used than colchicine in acute gout because: A. They are more effective B. They act more rapidly C. They have additional uricosuric action D. They are better tolerated
Last Answer : D. They are better tolerated
Description : Select the first choice drug for acute gout: A. Cochicine B. Indomethacin C. Allopurinol D. Dexamethasone
Last Answer : B. Indomethacin
Description : What is true of disease modifying antirheumatic drugs: A. Their beneficial effect is manifest only after 1-3 months of therapy B. The disease does not recurr once they induce remission C. They are to be used life long D. Concurrent use of more than one disease modifying drug is not recommended
Last Answer : A. Their beneficial effect is manifest only after 1-3 months of therapy
Description : Disease modifying antirheumatic drugs are indicated in rheumatoid arthritis: A. In place of NSAIDs in patients who donot tolerate the latter B. Along with NSAIDs in patients with progressive ... to afford symptomatic relief D. In all patients irrespective of disease status/ concurrent medication
Last Answer : B. Along with NSAIDs in patients with progressive disease
Description : Sulfasalazine is used in the following disease(s): A. Bacillary dysentery B. Ulcerative colitis C. Rheumatoid arthritis D. Both ‘B’ and ‘C’ are correct
Description : Used as a remission inducing agent in rheumatoid arthritis, hydroxychloroquine: A. Is more effective than chloroquine B. Produces a lower incidence of retinal damage than chloroquine C. Is more effective and more toxic than gold D. Both ‘A’ and ‘B’ are correct
Last Answer : B. Produces a lower incidence of retinal damage than chloroquine
Description : Among the following, choose the NSAID with the highest COX-2 selectivity: A. Nimesulide B. Nabumetone C. Rofecoxib D. Celecoxib
Last Answer : C. Rofecoxib
Description : The patient taking the following non-steroidal antiinflammatory drug should be cautioned not to drive motor vehicle: A. Celecoxib B. Indomethacin C. Naproxen D. Diclofenac sodium
Description : Which of the following analgesics itself frequently causes headache as a side effect: A. Indomethacin B. Mephenamic acid C. Piroxicam D. Metamizol
Last Answer : A. Indomethacin
Description : The NSAIDs aggravate the following diseases except: A. Hypertension B. Congestive heart failure C. Peptic ulcer D. Chronic gout
Last Answer : D. Chronic gout