The following is true of raloxifene except: A. It acts as an estrogen agonist in bone B. It exerts estrogen antagonistic action on endometrium C. It increases risk of developing breast cancer D. It can induce/aggravate menopausal hot flushes

The following is true of raloxifene except:
A. It acts as an estrogen agonist in bone
B. It exerts estrogen antagonistic action on
endometrium
C. It increases risk of developing breast cancer
D. It can induce/aggravate menopausal hot
flushes
by

1 Answer

Answer :

C. It has additional androgenic acitivity
by

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Benefits of tamoxifen citrate therapy include the following except: A. Reduction in recurrence rate of breast cancer B. Improved bone mass C. Suppression of menopausal hot flushes D. Improved lipid profile

Description : Benefits of tamoxifen citrate therapy include the following except: A. Reduction in recurrence rate of breast cancer B. Improved bone mass C. Suppression of menopausal hot flushes D. Improved lipid profile

Last Answer : C. Suppression of menopausal hot flushes

What is true of tamoxifen: A. It can induce endometrial proliferation in postmenopausal women B. It exerts antiestrogenic activity in bone C. It raises LDL-cholesterol levels D. It is ineffective in estrogen receptor-negative breast cancer

Description : What is true of tamoxifen: A. It can induce endometrial proliferation in postmenopausal women B. It exerts antiestrogenic activity in bone C. It raises LDL-cholesterol levels D. It is ineffective in estrogen receptor-negative breast cancer

Last Answer : A. It can induce endometrial proliferation in postmenopausal women

The following effect(s) of tamoxifen citrate indicate(s) that it possesses tissue specific estrogenic action as well: A. Inhibition of breast cancer cells B. Endometrial proliferation C. Hot flushes in premenopausal women D. All of the above

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Last Answer : B. Endometrial proliferation

Estrogen therapy in postmenopausal women has been implicated in increasing the risk of the following disorders except: A. Gall stones B. Osteoporosis C. Endometrial carcinoma D. Breast cancer

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The following is true of loperamide except: A. It is absorbed from intestines and exerts centrally mediated antidiarrhoeal action B. It acts on the opioid receptors in the gut C. It increases tone and segmenting activity of the intestines D. It inhibits intestinal secretion by binding to calmodulin in the mucosal cells

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Last Answer : A. It is absorbed from intestines and exerts centrally mediated antidiarrhoeal action

Which of the following is a selective estrogen receptor modulator that improves bone mineral density in postmenopausal women: A. Clomiphene citrate B. Raloxifene C. Ormeloxifene D. Alendronate

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Last Answer : B. Raloxifene

Addition of a progestin for 10-12 days each month to estrogen replacement therapy in menopausal women is recommended because the progestin: A. Blocks the increased risk of myocardial infarction due to estrogen B. Blocks the increased risk of endometrial carcinoma due to estrogen C. Reverses vulval atrophy occurring in postmenopausal women D. Enhances the metabolic benefits of estrogen treatment

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The primary mechanism of action of the combined estrogen-progestin oral contraceptive pill is: A. Production of cervical mucus hostile to sperm penetration B. Suppression of FSH and LH release C. Making endometrium unsuitable for implantation D. Enhancing uterine contractions to dislodge the fertilized ovum

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he following is true of nifedipine except: A. It can aggravate urine voiding difficulty in elderly males with prostatic hypertrophy B. It promotes Na+ retention by a renal tubular action to cause ankle oedema as side effect C. It can inhibit insulin release from pancreas D. At high doses it can paradoxically increase the frequency of angina pectori

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Last Answer : B. It promotes Na+ retention by a renal tubular action to cause ankle oedema as side effect

What is true of docetaxel: A. It is used as a reserve drug for refractory breast and ovarian cancer B. It is a selective estrogen receptor modulator used for breast cancer C. It is effective only in estrogen receptor positive breast cancer D. Both 'B' and 'C' are correct

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HRT patches... have any women used HRT patches to control menopausal hot flushes/night sweats... I would very much like to hear about your experiences?

Description : HRT patches... have any women used HRT patches to control menopausal hot flushes/night sweats... I would very much like to hear about your experiences?

Last Answer : answer:All my college classmates who tried HRT post-menopause stopped because of health issues. Live with the hot flashes, if you can. (That is what I did.) Carry a small, battery-operated portable fan, lots of kleenex and some hand towels. It will pass.

Looking for an alternative solution to menopausal hot flushes, can you help?

Description : Looking for an alternative solution to menopausal hot flushes, can you help?

Last Answer : I don’t think there is a real alternative to estrogen. If they are mild you may find something. But if they are so severe they cause you to pass out you are going to need HRT.

In women of child bearing age, clomiphene citrate produces the following actions except: A. Hot flushes B. Ovulation C. Decreased FSH and LH secretion D. Polycystic ovaries

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The estrogen commonly used for hormone replacement therapy in menopausal women is: A. Ethinylestradiol B. Estradiol benzoate C. Diethylstilbestrol D. Conjugated estrogens

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In which of the following conditions estrogen is not the primary drug but is added to progestin as adjuvant: A. Dysfunctional uterine bleeding B. Menopausal syndrome C. Osteoporosis D. Atrophic vaginitis

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What is true of thalidomide: A. It exerts antitumour activity in some solid malignant tumours B. It ameliorates cancer associated cachexia C. It exerts antileprotic action D. All of the above

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Choose the selective estrogen receptor modulator that is useful in dysfunctional uterine bleeding by acting as estrogen antagonist in endometrium, but does not alter vaginal epithelium or cervical mucus: A. Ormeloxifene B. Tamoxifen C. Centchroman D. Danazol

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Choose the correct statement about aspirin: A. In an afebrile patient acute overdose of aspirin produces hypothermia B. Aspirin suppresses flushing attending large dose of nicotinic acid C. Aspirin therapy prevents granulomatous lesions and cardiac complications of acute rheumatic fever D. Long term aspirin therapy increases the risk of developing colon cancer

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In the treatment of parkinsonism, bromocriptine differs from levodopa in the following respects except: A. It does not need conversion to an active metabolite B. It has a longer duration of action C. It activates dopamine D2 receptors, with little/antagonistic action on D1 receptors D. It does not produce behavioral/psychiatric side effect

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The following is true about actions of ethylalcohol: A. It exerts anticonvulsant action followed by lowering of seizure threshold B. It lowers pain threshold C. It increases confidence and reduces number of errors D. It increases heat production and helps to keep warm in cold weather

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56 years old woman has come to you with the complaints of hot flushes irritability, joint pains with lack of sleep. Most appropriate treatment would be: a) Hysterectomy. b) Vitamins. c) Combined oestrogen, progesterone preparations. d) Phytooestrogens. e) Selective estrogen receptor modulators (SERMS).

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In parkinsonian patients levodopa exerts the following effects except: A. Reduces skeletal muscle contractility B. Decreases muscle tone C. Increases locomotor activity D. Inhibits muscle tremor

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16.18 Thyrotropin exerts the following actions on the thyroid gland except: A. Increases vascularity B. Inhibits proteolysis of thyroglobulin C. Induces hyperplasia and hypertrophy D. Promotes iodide trapping

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Omeprazole exerts practically no other action except inhibition of gastric acid secretion because: A. It transforms into the active cationic forms only in the acidic pH of the gastric juice B. Its active forms have selective affinity for the H+K+ATPase located in the apical canaliculi of gastric parietal cells C. Its cationic forms are unable to diffuse out from the gastric parietal cell canaliculi D. All of the above

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Methysergide has lost popularity as a prophylactic drug for migraine because of its: A. Poor efficacy B. Potential to cause visceral fibrosis C. Oxytocic action D. Potential to aggravate ischaemic heart disease

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he following is true of desmopressin except: A. It is nonselective V1 and V2 receptor agonist B. It is more potent and longer acting than arginine vasopressin (AVP) C. It is preferred over AVP for treatment of diabetes insipidus D. It can be administered orally

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he following anthelmintic acts as a cholinergic agonist in the nematodes and causes spastic paralysis of the worms: A. Piperazine B. Pyrantel pamoate C. Mebendazole D. Thiabendazole

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Choose the correct statement(s) about pioglitazone: A. It acts as an agonist on nuclear paroxisome proliferator receptor γ B. It enhances transcription of insulin responsive genes C. It lowers blood sugar in type 2 diabetes mellitus without causing hyperinsulinemia D. All of the above

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What is true of nimesulide: A. It exerts antiinflammatory action by several mechanisms in addition to cyclooxygenase inhibition B. It is preferred for long-term use in rheumatoid arthritis C. It is contraindicated in aspirin intolerant asthma patients D. All of the above

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Last Answer : A. It exerts antiinflammatory action by several mechanisms in addition to cyclooxygenase inhibition

Select the correct statement about tibolone: A. It is an antiestrogen used for palliative treatment of carcinoma breast B. It is an estrogenic + progestational steroid used for hormone replacement therapy in postmenopausal women C. It is an antiandrogen used for male pattern baldness D. It is a nonsteroidal estrogen used topically for senile vaginitis

Description : Select the correct statement about tibolone: A. It is an antiestrogen used for palliative treatment of carcinoma breast B. It is an estrogenic + progestational steroid used for hormone replacement ... for male pattern baldness D. It is a nonsteroidal estrogen used topically for senile vaginitis

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Select the drug for which the following instructions must be given to the patient "To be taken on empty stomach in the morning with a full glass of water (not milk, tea or coffee), to remain upright and not take any food or medicine for 30 min": A. Alfacalcidol B. Alendronate C. Glibenclamide D. Raloxifene

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Histamine exerts the following actions except: A. Dilatation of large blood vessels B. Dilatation of small blood vessels C. Stimulation of isolated guineapig heart D. Itching

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Last Answer : A. Dilatation of large blood vessels

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Last Answer : A. Dilatation of large blood vessels

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